This review examines the multifaceted vulnerability of Ugandan youth to HIV/AIDS, emphasising the interplay of social, economic, and behavioural dimensions. Through a comprehensive analysis of HIV prevalence rates, trends, regional variations, and gender disparities, the review highlights key risk factors, including peer pressure, cultural norms, stigma, economic hardship, and substance use. It underscores the critical role of gender dynamics, with female youth facing unique challenges such as gender-based violence and economic dependence, while LGBTQ+ youth encounter compounded risks due to societal stigma and inadequate services. We also explore the disparities between rural and urban youth in access to information and services, uncovering significant barriers they face. Youth-led initiatives are critical in addressing these challenges, with peer education programs, youth-friendly services, and innovative digital campaigns all playing a crucial role in prevention efforts. We discuss barriers to youth participation, such as stigma, cultural norms, and educational gaps, and discuss strategies to overcome them, like culturally sensitive education and improved access to resources. We highlight the role of schools and educational institutions, emphasising the importance of integrating comprehensive sex education, school-based health services, and extracurricular activities to foster awareness and preventive behaviours. The review also highlights the importance of youth advocacy and leadership in shaping inclusive policies and driving effective interventions. We present economic empowerment strategies, including skills training andmicrofinance, as complementary to health-focused efforts by addressing socioeconomic vulnerabilities. The review concludes by advocating for a holistic approach that combines education, economic empowerment, gender-sensitive interventions, and collaborative partnerships among government, NGOs, civil society, and the private sector to effectively reduce HIV prevalence and improve the well-being of Ugandan youth. Keywords: Youth, HIV/AIDS, Uganda, social, economic, and behavioural dimensions