Response Strategies Research Articles

Emerging Omicron Subvariants EG.5 and BA.2.86: Implications for COVID-19 Immunity and Surveillance

The SARS-CoV-2 virus, responsible for the COVID-19 pandemic, has continuously evolved since its emergence. Among its variants, the Omicron lineage has become globally dominant, displaying a diverse range of sublineages. Two significant sub lineages within Omicron are EG.5 and BA.2.8, which have gained attention due to their unique characteristics and potential implications. EG.5 is characterized by a constellation of mutations, including N501Y, L452R, and D614G. Similarly, BA.2.8 carries the L452Q and P681R mutations, which enhance its ability to evade antibodies elicited by prior infection or vaccination. Similar to those in the EG.5, the clinical severity and impact of BA.2.8 on public health measures are still being assessed. These sublineages, with their unique genetic profiles and transmissibility characteristics, pose challenges to virulence response efforts. Continued surveillance, genomic sequencing, and research are essential to understand their behavior, assess their impact, and inform public health strategies accordingly. By a comprehensive synthesis of the literature, genomic data, and epidemiological insights, this study provides an analysis of Omicron mutations’ transmission dynamics, and clinical implications associated with these variants. The significance of variant surveillance in informing public health responses to the COVID-19 pandemic is underscored, highlighting the critical role of genomic sequencing in tracking viral evolution and guiding interventions. This manuscript aimed to elucidate the mechanisms underlying variant emergence, assess vaccine effectiveness against emerging strains, and explore the broader implications for global public health. This study provides insights into vaccine-induced immunity and the potential impact of variants on vaccine efficacy. Overall, this communication aims to inform public health practitioners, policymakers, and researchers engaged in the battle against COVID-19, offering actionable insights to mitigate the spread of the virus and improve pandemic response strategies.

Syndromic Surveillance in Public Health Emergencies: A Systematic Analysis of Cases Related to Exposure to 2023 Floodwaters in Romagna, Italy.

In May 2023, Romagna, Italy, faced a devastating flood resulting in 16 fatalities, forced displacement of 26,000 citizens, and significant economic losses. Due to potential water contamination, implementing public health strategies became imperative for the Local Health Authority to mitigate the health consequences, analyze the flood's impact on the local population's health, and detect early anomalies requiring timely public health interventions. Between June and July 2023, general practitioners who were part of the RespiVirNet surveillance network completed weekly structured forms. These forms collected data on individuals exposed or not to floodwaters and clinical syndromes. Rates per 1000 resident population aged > 14 were stratified by district, week of observation, and symptomatology. Missing data were addressed by imputation using second-order autoregressive modeling. An incidence of 3.52 syndromes potentially related to flood water exposure per 1000 individuals (95% CI 2.82-4.35) was estimated. Ravenna, the city most affected by the flood, recorded the highest rate (6.05 per 1000, 95% CI 4.59-7.82). Incidence decreased in the weeks post-event. Anxiety, or trauma and stress symptoms, exhibited higher rates among the exposed, diminishing over weeks. The incidence for the non-exposed (12.76 per 1000, 95% CI 10.55-15.29) showed no significant territorial differences compared to the exposed ones. Syndromic surveillance provided timely information on the flood's health impact, revealing a higher incidence of individual syndromes among the non-exposed. This study contributes to guiding the implementation of future public health preparedness and response strategies for populations facing similar natural disasters.

Effects of plant nutrient acquisition strategies on biomass allocation patterns in wetlands along successional sequences in the semi-arid upper Yellow River basin.

The ecological environment of wetlands in semi-arid regions has deteriorated, and vegetation succession has accelerated due to climate warming-induced aridification and human interference. The nutrient acquisition strategies and biomass allocation patterns reflect plant growth strategies in response to environmental changes. However, the impact of nutrient acquisition strategies on biomass allocation in successional vegetation remains unclear. We investigated 87 plant communities from 13 wetland sites in the semi-arid upper Yellow River basin. These communities were divided into three successional sequences: the herbaceous community (HC), the herbaceous-shrub mixed community (HSC), and the shrub community (SC). The nutrient composition of stems and leaves, as well as the biomass distribution above and belowground, were investigated. Results revealed that aboveground biomass increased with succession while belowground biomass decreased. Specifically, SC exhibited the highest stem biomass of 1,194.53 g m-2, while HC had the highest belowground biomass of 2,054.37 g m-2. Additionally, significant positive correlations were observed between leaf and stem biomasses in both HC and SC. The nitrogen (N) and phosphorus (P) contents within aboveground parts displayed an evident upward trend along the succession sequence. The highest N and P contents were found in SC, followed by HSC, and the lowest in HC. Stem N was negatively correlated with stem, leaf, and belowground biomass but positively correlated with root-shoot ratio. Leaf P displayed positive correlations with aboveground biomass while showing negative correlations with belowground biomass and root-shoot ratio. The ratios of C:N, C:P, and N:P in stem and leaf exhibited positive correlations with belowground biomass. The random forest model further demonstrated that stem N and leaf P exerted significant effects on aboveground biomass, while leaf P, stem N and P, and leaf C:P ratio had significant effects on belowground components. Additionally, the root-shoot ratio was significantly influenced by leaf P, leaf C:P ratio, and stem N, P, and C:P ratio. Therefore, the aboveground and belowground biomasses exhibited asynchronism across successional sequences, while plant nutrient acquisition strategies, involving nutrient levels and stoichiometric ratios, determined the biomass allocation pattern. This study offers valuable insights for assessing vegetation adaptability and formulating restoration plans in the semi-arid upper Yellow River basin.

Evaluation of stress, bio-psycho-social response and coping strategies during the practical training in nursing students: a cross sectional study

BackgroundThe aim of the study was to identify stress level, bio-psycho-social response and coping behavior of nursing students during the practical training.MethodsA cross-sectional study was carried out with the 1st, 2nd, 3rd, 4th-year nursing students (n = 1181) between September 2018-may 2019. Data was collected using by Socio-Demographic Questionnaire, The Student Nurse Stress Index, The Bio-Psycho-Social Response Scale and Coping Behavior Inventory.ResultsThe fourth-grade nursing students’ stress level was found to be statistically significantly higher than of other graders. Nursing students have shown emotional symptoms and social-behavioral symptoms the most. To cope with stress, nursing students used the strategies transference, staying optimistic, problem-solving and avoidance, respectively.ConclusionsThese findings highlight the need to routinely evaluate nursing students for stress, bio-psycho-social response, and coping strategies during practical training. Thus, counseling units can be constituted by the nursing schools, and nursing students who have higher stress levels and inadequate coping strategies benefit from these units.

Resource dependence in football clubs: An analysis of the interplay between capital gains from athletes and media revenues in Italian Serie A League

This study delves into the financial strategies of Italian Serie A football clubs, focusing on the relationship between revenues obtained through the sale of players' tags and those from broadcasting and media rights. Using Resource Dependence Theory (RDT) as lens, this research aims to understand how clubs strategically manage these two critical revenue streams amidst external pressures and dependencies. The analysis of balance sheet data, from nine clubs over eight seasons, reveals a significant negative correlation between the two variables for "long-lasting" clubs, suggesting a potential shift in strategies in response to external market conditions, while it finds different results from incoming and/or growing ones. The findings offer insights for stakeholders in the football industry, emphasizing the need for agile management and governance structures.

Assessing risk indicators of intimate partner femicide considering victim's coping strategies to violence: A dynamic multilevel linear mixed model based on genetic algorithms

Intimate partner femicide (IPF) is a grave social and health concern affecting women worldwide, with approximately 30,000 deaths annually at the hands of their current or former intimate partners. Previous studies have focused on identifying risk factors for IPF and developing risk assessment tools to identify high-risk cases. However, an important aspect that has been overlooked in these studies is victims' coping strategies in response to intimate partner violence. Understanding victims' coping strategies can provide valuable insights into how they deal with the abuse and can inform the development of effective interventions and prevention strategies. This study aims to address this gap by developing a multilevel linear mixed model (LMM) to analyze the impact of engagement and disengagement coping on the likelihood of IPF and identify common and specific IPF risk indicators for these coping strategies. A total of 491 Spanish cases of violence against women by current or former intimate partners were analyzed from penal sentences issued by Spanish provincial and supreme courts from 2019 to 2022. The LMM model obtained from the study has competitive performance in identifying IPF and non-IPF cases, including risk indicators of prior history of injuries, history of sexual aggression, frequency and escalation of violence, physical violence, place of crime, lonely place of crime, and community presence. Victims with engagement coping and disengagement coping share some risk indicators, while others belong to just one category. Overall, the results suggest that victims with disengagement coping are more predisposed to suffer IPF than victims with engagement coping. This evidenced-based knowledge emphasizes the significance of considering coping strategies in predicting and preventing IPF, with further implications discussed at the end of this paper.

Different drought-tolerance strategies of tree species to cope with increased water stress under climate change in a mixed forest.

Trees' functional strategies to cope with extreme drought are essential under climate change. In a mixed Mediterranean forest, we analyzed the functional strategy in response to drought of four co-occurring species (Pinus pinea, Pinus pinaster, Juniperus oxycedrus, and Quercus ilex) during two years. Specifically, we assessed functional traits related to tree water status, leaf water relations, and gas exchange. Different trait-syndrome metrics and the functional strategies under water stress observed suggested a species drought-tolerance differentiation, with the more anysohidric Q. ilex and J. oxycedrus showing a much higher drought tolerance than the more isohydric P. pinea and P. pinaster. All species recovered from negative leaf turgor reached during peak water stress in summer. Q. ilex and J. oxycedrus kept lower leaf osmotic potentials and lower sensitivity of leaf gas exchange and leaf photochemistry to water stress. In contrast, the pine species exhibited more drought-avoidant and water-conservative strategies, yet this behavior was less effective in mitigating water stress's impact on their physiology. The pine species were the most affected by drought, with prolonged near-zero net photosynthesis during summer. P. pinaster was more isohydric than P. pinea and exhibited a lower capacity to maintain leaf turgor. Physiological processes regulating leaf turgor under drought constitute a key functional strategy involved in the carbon and water-related mechanisms, ultimately inducing mortality under hot drought. The currently observed mortality dynamics for P. pinaster, and to a lower extent in P. pinea, may be exacerbated by loss of functional homeostasis.

A novel, scenario-based approach to comparing non-pharmaceutical intervention strategies across nations.

Comparing COVID-19 response strategies across nations is a key step in preparing for future pandemics. Conventional comparisons, which rank individual non-pharmaceutical intervention (NPI) effects, are limited by: (i) a focus on epidemiological outcomes; (ii) NPIs typically being applied as packages of interventions; and (iii) different political, economic and social conditions among nations. Here, we develop a coupled epidemiological-behavioural-macroeconomic model that can transfer NPI effects from a reference nation to a focal nation. This approach quantifies epidemiological, behavioural and economic outcomes while accounting for both packaged NPIs and differing conditions among nations. As a first proof of concept, we take Germany as our focal nation during Spring 2020, and New Zealand and Switzerland as reference nations with contrasting NPI strategies. Our results suggest that, while New Zealand's more aggressive strategy would have yielded modest epidemiological gains in Germany, it would have resulted in substantially higher economic costs while dramatically reducing social contacts. In contrast, Switzerland's more lenient strategy would have prolonged the first wave in Germany, but would also have increased relative costs. More generally, these findings indicate that our approach can provide novel, multifaceted insights on the efficacy of pandemic response strategies, and therefore merits further exploration and development.

COVID-19 vaccination campaigns in fragile and conflict-affected settings, Somalia.

By 31 December 2021, only 5.5% (861 879/15 670 530) of the Somali population had been fully vaccinated against coronavirus disease 2019 (COVID-19). To rapidly increase COVID-19 vaccine coverage in 2022, the health ministry and its partners (World Health Organization and United Nations Children's Fund) adopted a more responsive strategy. This strategy included careful microplanning, better targeting of populations and providing people-centred vaccination services close to their homes. These services were combined with childhood vaccination and basic health-care provision using the existing polio network and community health workers. Additionally, a digital tool for recording COVID-19 vaccination data and a mobile phone-based electronic registration system were introduced. Somalia, a fragile and conflict-affected state, faced challenges when implementing COVID-19 vaccination, including inexperience in managing mass adult vaccination, inadequate infrastructure and health workforce. Furthermore, insecurity in some areas and severe drought resulted in large-scale displacement of people. The implementation of a more context-specific strategy helped Somalia reach substantially more people with COVID-19 vaccination and 42.1% coverage by 31 December 2022. Additionally, 84 600 zero-dose children received their first childhood vaccine during the integrated campaigns. The increased coverage has led to public health benefits that outweigh the investment in the COVID-19 vaccination campaigns. Successful roll-out of adult vaccination is achievable even in a fragile and conflict-affected setting through implementation of a tailored contextualized approach. Key factors include good microplanning, use of digital tools, better population-targeting, bundling vaccines together and delivering vaccination services close to people's homes.

Apelin-13-Loaded Macrophage Membrane-Encapsulated Nanoparticles for Targeted Ischemic Stroke Therapy via Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis.

Ischemic stroke is a refractory disease wherein the reperfusion injury caused by sudden restoration of blood supply is the main cause of increased mortality and disability. However, current therapeutic strategies for the inflammatory response induced by cerebral ischemia-reperfusion (I/R) injury are unsatisfactory. This study aimed to develop a functional nanoparticle (MM/ANPs) comprising apelin-13 (APNs) encapsulated in macrophage membranes (MM) modified with distearoyl phosphatidylethanolamine-polyethylene glycol-RVG29 (DSPE-PEG-RVG29) to achieve targeted therapy against ischemic stroke. MM were extracted from RAW264.7. PLGA was dissolved in dichloromethane, while Apelin-13 was dissolved in water, and CY5.5 was dissolved in dichloromethane. The precipitate was washed twice with ultrapure water and then resuspended in 10 mL to obtain an aqueous solution of PLGA nanoparticles. Subsequently, the cell membrane was evenly dispersed homogeneously and mixed with PLGA-COOH at a mass ratio of 1:1 for the hybrid ultrasound. DSPE-PEG-RVG29 was added and incubated for 1 h to obtain MM/ANPs. In this study, we developed a functional nanoparticle delivery system (MM/ANPs) that utilizes macrophage membranes coated with DSPE-PEG-RVG29 peptide to efficiently deliver Apelin-13 to inflammatory areas using ischemic stroke therapy.MM/ANPs effectively cross the blood-brain barrier and selectively accumulate in ischemic and inflamed areas. In a mouse I/R injury model, these nanoparticles significantly improved neurological scores and reduced infarct volume.Apelin-13 is gradually released from the MM/ANPs, inhibiting NLRP3 inflammasome assembly by enhancing sirtuin 3 (SIRT3) activity, which suppresses the inflammatory response and pyroptosis. The positive regulation of SIRT3 further inhibits the NLRP3-mediated inflammation, showing the clinical potential of these nanoparticles for ischemic stroke treatment. The biocompatibility and safety of MM/ANPs were confirmed through in vitro cytotoxicity tests, blood-brain barrier permeability tests, biosafety evaluations, and blood compatibility studies. MM/ANPs offer a highly promising approach to achieve ischemic stroke-targeted therapy inhibiting NLRP3 inflammasome-mediated pyroptosis.

Anger expressions of social media users following different crisis response strategies towards health emergency

Anger expressions of social media users following different crisis response strategies towards health emergency

Assessing crisis spillover risks: The role of perceived severity and corporate response effectiveness in China

AbstractAlthough the spillover effect of crises represents an emerging area of interest within crisis communication studies, the perspective of consumers on the risk of crisis spillover as a result of corporate misconduct by another company remains underexplored in emerging markets like China. This study aims to fill the void through assessing how the severity of a crisis and the strategic responses by companies influence consumer perceptions of spillover risks from corporate misconduct by another company. A pre‐test (N = 120) determined two corporate misconducts as characteristic for the automotive industry in China. These scenarios were utilized in an online experiment (N = 320) to examine the effects of two crisis response strategies (issuing a denial vs. giving no response) by a competitor automaker. The results reveal that when a corporate misconduct is perceived as more severe, the perceived crisis spillover risks to the industry is higher; this perceived risk mediates the impact of crisis severity on negative word‐of‐mouth. Issuing a denial is more effective than giving no response, and leads to more positive consumer outcomes. This research unravels the complex dynamics at play in shaping consumer attitudes towards companies indirectly impacted by a crisis through a spillover effect.

The Impact and Response of China's Capital Market Opening Policy on the Financial System

Due to the liberalization of the Chinese capital market in recent years, many foreign investors have entered the country's capital market. This article outlines the history and present state of China's relative policy, gathers and evaluates pertinent policies, examines the policy's turning points, and finally highlights the difficulties and issues at hand. Based on this, it examines how this act affects financial institutions and presents three arguments for why bringing in foreign money will strengthen the financial market's vibrancy, encourage its modernization, and increase its size. Drawing from the aforementioned analysis, this article puts forth a response strategy aimed at promoting financial institutions' risk control and institutional innovation through capital market liberalization. Additionally, it suggests that the state enhance its oversight of foreign capital inflows to ensure a consistent flow of capital. To sum up, as China's capital market becomes more open to the outside world, it will be important to take advantage of the chances for innovation and growth while also managing the risks and difficulties that come with it. This paper seeks to be able to offer pertinent recommendations for the market's continued development and liberalization.

Assessing feasibility and sex-related inequity in the cardiac rehabilitation quality indicators in Manitoba.

The cardiac rehabilitation quality indicators (CRQIs) developed by the Canadian Cardiovascular Society provide a means to standardize program assessment and identify sex-related inequities. No formal evaluation of the CRQIs has been conducted in Manitoba. An environmental scan for the CRQIs was performed using data in the electronic medical record at two cardiac rehabilitation (CR) sites in Winnipeg for 2016-2019 referrals. Of the 8116 referrals, 7758 (5491 males and 2267 females) had geographical access and were eligible for CR. The Manitoba Centre for Health Policy Data Quality Framework informed the data quality assessment. Thirteen CRQIs were available; four were considered high quality; nine demonstrated moderate to significant missing data. In addition to missing values, potential misclassification of risk (CR-4) and physiologically implausible and invalid dates were assessed and identified (CR-13 and CR-17). Each site had a physician medical director (CR-31) and a documented emergency response strategy (CR-32). Only high-quality data were evaluated for sex-related differences using chi-square and median tests. Women had lower enrollment (CR-3), and more women enrolled after the median of 41 days (CR-2b). Engagement with CR partners, including frontline staff, and utilizing strategies to assess and limit physiologically implausible values and dates will enhance data capture and quality.

Building Resilient Food Security Against Global Crisis: New Evidence From China

ABSTRACTThe existing literature addresses the importance of food system disruptions and the risk of the global food crisis. However, there is insufficient understanding of response strategies and their effectiveness evaluations. This study offers a comprehensive introduction to China's food security policies and evaluates their effectiveness in enhancing the nation's risk resistance capability. Utilizing the Entropy Weight Method (EWM) and the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS), we evaluated China's provincial food security resilience (FSR) from 2003 to 2020 and adopted the ArcGIS platform to map spatiotemporal trends. Our findings reveal significant improvements in FSR nationwide, with a notable average annual growth rate of 1%–5%. However, regional disparities persist, with higher resilience observed in eastern provinces compared to the west. The study emphasizes the effectiveness of China's food security policies, which have synergistically enhanced grain production, agricultural mechanization, and farmers’ economic conditions. The article offers policy recommendations aimed at bolstering China's FSR and challenges with global implications. Our study contributes to the broader discourse on global food security by offering a nuanced understanding of the effectiveness of policy interventions in a major agricultural economy.

“Crisis situations of the recovery period” represent a feature of the legal regulation of the transition from the wartime period to the provision of military security during the wartime period

One of the postulates of systems theory is the tendency of any system to seek a stable state and avoid chaos. Stability is associated with overcoming crises, which are considered obstacles to development. Crises can serve various functions: destructive, threatening the viability of the system; destructive, leading to further development; and crises that are merely disruptions of equilibrium. In the context of transitioning from repelling armed aggression to ensuring military security in the post-war period, it is appropriate to describe the crisis phenomena and situations of the recovery period, which encompass the real crises of the recovery period. Special attention should be paid to the classification of crises, modeling their development, establishing crisis communications and decision- making in crisis conditions, developing state policy and crisis response strategies, as well as devising methods for crisis prevention. Situation centers play a key role in forecasting the security situation, preparing stabilization operations, and coordinating the actions of various security and defense structures. Their tasks include conveying decisions to personnel and the local population, organizing management and interaction, informing about the development of events, and controlling the execution of decisions. The centers also collect and analyze operational information for timely response to crisis situations. In legal science, the concept of a “crisis of the recovery period” is not widespread, but it may be useful for describing emergencies in the post-war period. The definition of such crises should consider the specific impacts of hazardous factors on national interests. The modern concept of national security of Ukraine envisages the integration of various security sectors, including economic, political, social, and legal aspects. According to legislation, the national security system in the recovery period should be an organized set of entities united by common goals and tasks regarding the protection of national interests. These entities participate in military-civil relations, coordinate their actions, and develop crisis response strategies.

A regional One Health approach to the risk of invasion by Anopheles stephensi in Mauritius.

Anopheles stephensi is an invasive malaria vector in Africa that threatens to put an additional 126 million people at risk of malaria if it continues to spread. The island nation of Mauritius is highly connected to Asia and Africa and is at risk of introduction due to this connectivity. For early detection of An. stephensi, the Vector Biology and Control Division under the Ministry of Health in Mauritius, leveraged a well-established Aedes program, as An. stephensi is known to share Aedes habitats. These efforts triggered multisectoral coordination and cascading benefits of integrated vector and One Health approaches. Beginning June 2021, entomological surveys were conducted at points of entry (seaport, airport) and on ships transporting livestock in collaboration with the Civil Aviation Department, the Mauritian Port Authority and National Veterinary Services. A total of 18, 39, 723 mosquito larval surveys were respectively conducted in the airport, seaport, and other localities in Mauritius while two, 20, and 26 adult mosquito surveys were respectively conducted in the airport, seaport, and twenty-six animal assembly points. Alongside adult mosquito surveys, surveillance of vectors of veterinary importance (e.g.- Culicoides spp.) was also carried out in collaboration with National Parks and Conservation Service and land owners. A total of 8,428 adult mosquitoes were collected and 1,844 larval habitats were positive for mosquitoes. All collected mosquitoes were morphologically identified and 151 Anopheles and 339 Aedes mosquitoes were also molecularly characterized. Mosquito species detected were Aedes albopictus, Anopheles arabiensis, An. coustani, An. merus, Culex quinquefasciatus, Cx. thalassius and Lutzia tigripes. Anopheles stephensi was not detected. The One Health approach was shared with the French Agricultural Research Centre for International Development (CIRAD), strengthening collaboration between Mauritius and Réunion Island on vector surveillance at entry points and insecticide resistance monitoring. The Indian Ocean Commission (IOC) was also alerted to the risk of An. stephensi, leading to regional efforts supporting trainings and development of a response strategy to An. stephensi bringing together stakeholders from Comoros, Madagascar, Mauritius, Réunion Island and Seychelles. Mauritius is a model system showing how existing public health entomology capabilities can be used to enhance vector surveillance and control and create multisectoral networks to respond to any emerging public and veterinary health vector-borne disease threat.

Polar response strategies across modalities: Evidence from German Sign Language (DGS)

Polar response strategies across modalities: Evidence from German Sign Language (DGS)

Analyzing UNESCO’s Report on Global Educational Challenges Amidst The COVID-19 Pandemic

This article presents an analysis of the UNESCO report on global educational challenges in the context of the Coronavirus Disease 2019 (Covid-19) pandemic. This paper examines the ways in which the pandemic has served to exacerbate pre-existing educational and gender inequalities, as outlined in the UNESCO report. The paper considers the United Nations' assessment and response strategies, evaluating their effectiveness in mitigating these disparities. A detailed analysis of the UNESCO report's findings and recommendations reveals significant deficiencies in addressing educational inequities during the pandemic. Moreover, it elucidates the broader implications for equitable access to education.

헬스케어 공급망 리스크 주요 이슈 분석: 뉴스기사를 중심으로

This study investigates the major risk issues and their causes in healthcare supply chains, using network analysis and qualitative analysis of news media publications, and then proposes response and operational strategies for managing healthcare supply chain risks. We divided our study into two time periods for a comparative analysis of key risk issues in different degrees of environmental uncertainty. The year 2020 marked the emergence of the COVID-19 pandemic. The first period of our analysis is four years covering 2016-2019, prior to COVID-19 disruptions. The second period is also four years during 2020-2023 when the full force of COVID-19 disruptions affected healthcare supply chains. The keywords used to collect news media publications were “healthcare,” “healthcare industry,” “healthcare services,” “hospital,” “health center,” and “medicine.” The results of the study indicated that the major risks experienced in healthcare supply chains were due to the following factors: the type of patients who needed healthcare services, care services provided (lab tests, treatment, prescriptions, etc.), care service methods used (surgery, utilization of medical devices), and examination and diagnostics (clinical kits, etc.). While these factors were identified as possible causes of risk in the healthcare supply chains involving procurement of supplies and raw materials, these risks tend to intensify in the increased disruption period (year 2020-2023). Managing these risk issues in the disruptive periods contributes significantly not only to the performance of healthcare organizations but also to the well-being of the society at large. This study offers theoretical implications in that it analyzes the causes of risks in the healthcare supply chains and provides a basis for a comparative analysis of the relationships of risk factors in healthcare supply chains during a normal environment and a very disruptive environment. From a practical perspective, this study suggests effective countermeasures for managing healthcare supply chain risks with examples that can be used as a guideline by healthcare executives, managers, and policy-makers of healthcare services.