Health Strategy Research Articles

Effects of green tea based oral health strategies on disease activity in rheumatoid arthritis

AimIn this study, we aimed to evaluate oral health strategies in rheumatoid arthritis (RA) patients with periodontitis.MethodsWe enrolled 110 RA patients with periodontitis who were diagnosed in a Grade A tertiary hospital into an oral health strategies program. The control and test groups comprised 55 cases each. The management effect was evaluated by self-care ability, oral health-related quality of life, RA-related clinical indicators, and the DAS28 score. The control group received routine nursing, whereas the test group was in a self-health management program for 3 months.ResultsAfter the intervention, compared to the control group, the test group showed better self-care ability, oral health-related quality of life score, RA-related clinical indicators, and DAS28 score (P < 0.05).ConclusionOur oral health strategies program slowed down the progression of the disease and can be popularized in patients.

Age-Specific Seroprevalence of Hepatitis A Virus in Turkey Between 2000 and 2023: Systematic Review and Meta-Analysis

Background: Hepatitis A virus (HAV) is a leading cause of acute viral hepatitis and is primarily transmitted by the fecal–oral route. The clinical presentation and progression of the disease varies according to the age of the patient. Turkey is classified as a moderately endemic country, and HAV infection continues to be an important public health problem worldwide. Methods: In this study, a systematic meta-analysis was conducted to evaluate age-specific HAV seroprevalence rates in Turkey between 2000 and 2023. A comprehensive literature review identified 57 articles that met the inclusion criteria. The studies were assessed for quality, and seroprevalence rates were evaluated across four different age groups. Statistical analyses were performed using Comprehensive Meta-Analysis (CMA) software (CMAVersion 3.0) and SPSS (SPSS Statistics 25.0). Results: HAV seroprevalence rates were found to be 73.18% in the 0 < 5 age group and 90.90% in the >35 age group. The overall seroprevalence estimated using a random effects model was 64.5% (95% CI: 58.3–70). High heterogeneity was observed among the studies, and the prevalence estimates changed when low-quality studies were excluded. Conclusions: This meta-analysis suggests that the increasing trend in HAV IgG seroprevalence in Turkey, especially among young populations, is likely due to the vaccination program initiated in 2012. Furthermore, the heterogeneity observed among regions highlights the importance of regional public health strategies. Future studies should focus on providing more detailed data to evaluate the long-term effects of vaccination and to explain regional differences in HAV seroprevalence.

Association of laughter and social communication with oral frailty among residents in Fukushima: a cross-sectional study.

Oral frailty (OF) is a form of frailty. Laughter and social communication such as talking and participating in community activities, contribute to extending healthy life expectancy by reducing stress and increasing physical activity. However, limited research exists on the association between laughter and social communication and OF. This cross-sectional study aimed to explore the association of laughter and social communication with the risk of developing OF using the eight-item OF Index among Fukushima residents. In 2020-2021, 916 residents aged 60-79 were surveyed regarding OF and psychosocial factors. Binomial logistic regression analysis was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for psychosocial factors associated with the OF prevalence. The OF prevalence was 41.5%. The sex- and age-adjusted ORs (95% CIs) for psychosocial factors associated with OF prevalence were 0.38 (0.26-0.57) for daily laughter, 0.51 (0.35-0.76) for laughter 1-5 times/week, 0.42 (0.20-0.89) for daily talking, 0.40 (0.22-0.72) for participating in community activities more than once/week, and 0.29 (0.20-0.43) for no depressive symptoms. After multivariate adjustment, only daily laughter and no depressive symptoms were associated with OF. As a public health strategy, increasing laughter and social communication frequencies, along with reducing depressive symptoms, may enhance healthy life expectancy through improved frailty.

THE ROLE OF NUTRITIONAL STATUS IN THE PERSISTENCE OF MEASLES IMMUNITY AMONG CHILDREN: A MULTIVARIATE ANALYSIS

<p><strong>Background:</strong> The persistence of measles immunity in children is influenced by multiple factors, including nutritional status. This study aimed to assess the role of body mass index (BMI) as a proxy for nutritional status in the persistence of measles immunity, alongside other socio-demographic factors, in a pediatric population. <strong>Methods:</strong> A multivariate logistic regression analysis was conducted on 200 children (2-15 years) attending the University Teaching Children's Hospital in Lusaka, Zambia. Immunity retention was measured through IgG serology. BMI represented nutritional status, and the analysis adjusted for key variables such as HIV status, breastfeeding history, sex, and education level. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to determine the association between nutritional status and immunity persistence. <strong>Results:</strong> Children categorized as well-nourished had significantly lower odds of waning immunity (OR = 0.37, 95% CI = 0.16–0.83, p = 0.016). However, for children with over or under malnutrition, the association was not statistically significant (OR = 0.23, 95% CI = 0.03–1.62, p = 0.140). Additionally, HIV-positive status was associated with decreased immunity retention (OR = 0.28, 95% CI = 0.14–0.56, p < 0.001). Breastfeeding was positively associated with immunity persistence (OR = 3.34, 95% CI = 1.53–7.29, p = 0.003), while other socio-demographic factors such as sex and education level showed no significant effect. <strong>Conclusion:</strong> Nutritional status, as measured by BMI, plays a significant role in the persistence of measles immunity among children, with over- and under-nourished children being associated with lower immunity retention. These findings suggest that nutritional interventions may be necessary to improve vaccine efficacy, particularly in populations with high rates of malnutrition or obesity. The results also highlight the need for further investigation into the mechanisms linking nutritional status to immune response and the development of targeted public health strategies to optimize measles immunization outcomes in children.</p><p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0722/a.php" alt="Hit counter" /></p>

Advances in Yeast Probiotic Production and Formulation for Preventative Health

The use of probiotics has been gaining popularity in terms of inclusion into human diets over recent years. Based on properties exerted by these organisms, several benefits have been elucidated and conferred to the host. Bacteria have been more commonly used in probiotic preparations compared to yeast candidates; however, yeast exhibit several beneficial properties, such as the prevention and treatment of diarrhea, the production of antimicrobial agents, the prevention of pathogen adherence to intestinal sites, the maintenance of microbial balance, the modulation of the immune system, antibiotic resistance, amongst others. Saccharomyces boulardii is by far the most studied strain; however, the potential for the use of other yeast candidates, such as Kluyveromyces lactis and Debaryomyces hansenii, amongst others, have also been evaluated in this review. Furthermore, a special focus has been made regarding the production considerations for yeast-based probiotics and their formulation into different delivery formats. When drafting this review, evidence suggests that the use of yeasts, both wild-type and genetically modified candidates, can extend beyond gut health to support skin, the respiratory system, and overall immune health. Hence, this review explores the potential of yeast probiotics as a safe, effective strategy for preventative health in humans, highlighting their mechanisms of action, clinical applications, and production considerations.

Household Consumption of Adequately Iodized Salt: A Multi-Country Analysis of Socioeconomic Disparities.

Despite global efforts to promote universal salt iodization, iodine deficiency remains a public health issue in developing countries. This study assessed the proportion and sociodemographic characteristics of households consuming adequately iodized salt in 49 low- and middle-income countries. Data from DHS surveys of 49 low- and middle-income countries (2005-2021) were used to analyze household iodized salt prevalence. R version 4.0 was employed for statistical analyses. A random-effects meta-analysis was conducted to estimate overall and regional prevalence. We found that 83.4% of households consume adequately iodized salt, although with high heterogeneity (I2 = 100.0%). The East Asia and Pacific and the Europe and Central Asia regions showed high consumption rates of 87.6% and 87.7%, respectively, while Latin America and the Caribbean presented a significantly lower proportion of 30.8%. The study highlights the need for enhanced public health strategies to increase iodized salt consumption, especially in low-income and rural households. Addressing disparities in access, education, and affordability is crucial for improving iodine intake and preventing deficiency disorders, particularly among vulnerable populations like children and pregnant women.

Association between body mass index (BMI), respiratory symptoms, and asthma prevalence among the population in Khulna City, Bangladesh: an in-depth cross-sectional investigation

BackgroundAsthma, a chronic respiratory disease, has been steadily increasing in prevalence and significantly impacts global health. In Bangladesh, it remains a major public health concern. The relationship between asthma and body mass index (BMI) is complex, with higher rates observed among overweight individuals. This study aims to explore the association between BMI, respiratory symptoms, and asthma in Khulna City, Bangladesh, addressing the lack of comprehensive data for this region.MethodsThis study was a cross-sectional study. For data collection purposes, we considered Khulna Medical College and Hospital (KMC). Data collection involved a well-structured questionnaire during in-person meetings held from September 18 to November 6, 2022. We selected a total of 310 participants through simple random sampling and performed statistical analyses, including chi-square tests and logistic regression, to examine associations.ResultsThe majority of participants were aged above 60 years (36.5%), with most having a normal BMI (74.8%) and being male (69.0%). We found significant associations between the prevalence of asthma, age, BMI categories, and respiratory symptoms such as wheezing, coughing, chest tightness, and shortness of breath. Overweight individuals showed a higher likelihood of developing asthma (AOR 7.01; 95% CI 5.04–7.11), as did those with primary education (AOR 1.51; 95% CI 1.11–2.95) and smokers (AOR 2.80; 95% CI 1.27–6.15).ConclusionThis study identifies a higher asthma prevalence in Khulna City, associated with older age, overweight status, primary education level, and respiratory symptoms such as wheezing, coughing, chest tightness, and shortness of breath. Smoking further exacerbates the severity of the condition. We recommend public health strategies such as promoting healthier lifestyles, improving healthcare access, raising awareness about smoking risks, enhancing air quality, and establishing specialised asthma clinics for effective management and improved quality of life.

Prevention and Treatment of HIV/AIDS: The Gates Foundation’s Role in Reducing Incidence and Extending Lives

HIV/AIDS remains a critical global health challenge, with profound social and economic impacts exacerbating existing inequalities and straining healthcare systems. Since its inception, the Bill & Melinda Gates Foundation has been at the forefront of combating this epidemic through its comprehensive and strategic approach. This review examines the foundation’s role in reducing HIV incidence and extending lives by focusing on prevention and treatment strategies. The foundation’s key initiatives include advancing scientific research and innovation, expanding access to antiretroviral therapy (ART), supporting pre-exposure prophylaxis (PrEP), and integrating HIV care with other health services. The foundation also emphasizes policy advocacy and global leadership, collaborating with international organizations to shape health strategies and reduce stigma. The review highlights the impact of these efforts in high-burden regions, particularly sub-Saharan Africa, and explores emerging challenges such as drug resistance and health inequities. Future directions include embracing innovative solutions, expanding access to advanced prevention methods, and ensuring the sustainability of HIV/AIDS programs in resource-limited settings. The Gates Foundation’s multifaceted approach serves as a model for global health initiatives, demonstrating how strategic investment and collaboration can drive significant progress in the fight against HIV/AIDS. Keywords: HIV/AIDS, prevention strategies, treatment programs, antiretroviral therapy (ART), pre-exposure prophylaxis (PrEP).

“Design of a Trustworthy Cloud-Native National Digital Health Information Infrastructure for Secure Data Management and Use”

Abstract Since 2022, Malawi Ministry of Health (MoH) designated the development of a National Digital Health Information System (NDHIS) as one of the most important pillars of its national health strategy. This system is built upon a distributed computing infrastructure employing the following state-of-art technologies: (1) digital healthcare devices to capture medical data; (2) Kubernetes-based Cloud-Native Computing architecture to simplify system management and service deployment; (3) Zero-Trust Secure Communication to protect confidentiality, integrity and access rights of medical data transported over the Internet; (4) Trusted Computing to allow medical data to be processed by certified software without compromising data privacy and sovereignty. Trustworthiness, including reliability, security, privacy and business integrity, of this system was ensured by a peer-to-peer network of trusted medical information guards deployed as the gatekeepers of every computing node on this system. This NDHIS shall facilitate Malawi to attain universal health coverage by 2030 through its scalability and operation efficiency. It shall improve medical data quality and security by adopting a paperless approach. It will also enable MoH to offer data rental services to healthcare researchers and AI model developers around the world. This project is spearheaded by the Digital Health Division (DHD) under MoH. The trustworthy computing infrastructure was designed by a taskforce assembled by the DHD in collaboration with Luke International in Norway, and a consortium of hardware and software solution providers in Taiwan. A prototype that can connect community clinics with a district hospital has been tested at the Taiwan Pingtung Christian Hospital.

Challenges in Influenza Control and Surveillance in the Republic of Kazakhstan

The COVID-19 pandemic has significantly disrupted the circulation of influenza viruses in Kazakhstan, highlighting the vulnerabilities in the country’s public health infrastructure. This review critically examines the challenges faced in infiltrating and controlling influenza in Kazakhstan, particularly in light of the shifting epidemiological landscape post-pandemic. Key issues include the decline in influenza cases during the pandemic, which complicates the assessment of influenza epidemiology, vaccine effectiveness, and planning of vaccination campaigns. Although part of the Global Influenza Hospital Surveillance Network (GIHSN), Kazakhstan's surveillance systems face data collection, coordination, and public awareness gaps. The review discusses the prevalence of various influenza strains, the impact of zoonotic infections, and the necessity for improved monitoring frameworks. Additionally, the historical context of infectious disease control in Kazakhstan is explored, emphasising the need for enhanced international collaboration and targeted public health strategies. The findings underscore the importance of vaccination and robust surveillance to mitigate the risks of seasonal and pandemic influenza, advocating for a comprehensive approach to safeguard public health in Kazakhstan.

Combatting rabies outbreaks in Vietnam: High time to enforce restrictions on dog meat farming, a key source of transmission

In Vietnam, farming dogs for meat is not illegal but is increasingly marginalized as dog meat consumption comes under heightened social scrutiny. This loosely regulated practice likely increases the risk of rabies transmission to humans. At a time when human-wildlife conflict has become a major discussion point for global health, stray dogs escaping or being deliberately released from dog farms is a cause for serious concern. The first half of 2024 saw a significant spike in incidence of human rabies cases, occurring in not just rural hot spots but also urban conurbations. Bites from rabid feral dogs are the primary source of infection, the distribution of which often clusters in the vicinity of battery farms or slaughter houses that have recently downscaled or closed their business. Addressing this risk requires pursuing a One Health strategy that focuses on catching and euthanizing rabid dogs, vaccinating healthy dogs, implementing safety measures during dog slaughtering, and regulating dog meat trade. By robust enforcement of this comprehensive plan, it is hoped to prevent rabies outbreaks and protect public health. Already, Hanoi is taking a lead in introducing measures to avert a rabies crisis in the Vietnamese capital.

Induction of an 11 KDA Protein Epitope For Reducing Mrsa Bacterial Colony Counts Via Cellular and Humoral Adaptive Immune Responses In Postpartum MUS Musculus Infected With MRSA: A Strategy for Enhancing Public Health and Combating Antibiotic Resistance

Objective: This study investigates how the 11 kDa protein epitope, from the cross-reaction between MRSA bacteria and L. reuteri, reduces MRSA colonies through adaptive immune responses (Th17, Th2), cytokines (IL-4, IL-22), and innate immunity (IgG antibodies) in postpartum Mus musculus. Method: A true experimental design was applied using Balb/c mice divided into seven groups, including controls and those treated with different combinations of L. reuteri, MRSA proteins, and peptides. Cellular immunity (Th17, Th2), cytokines (IL-4, IL-22), IgG antibodies, and MRSA colonies were measured post-treatment. Results & Discussion: The candidate vaccine enhanced cellular adaptive immunity (Th2, Th17), cytokine responses (IL-4, IL-22), and reduced MRSA colonies. IgG levels were notably higher in Groups K3 and K6 compared to K1. Conclusion: The 11 kDa protein epitope, from the MRSA-L. reuteri cross-reaction, effectively modulates adaptive immunity, reducing MRSA colonies in postpartum Mus musculus.

Students Exploring Health Disparities in Undergraduate Kinesiology Course

ABSTRACT Kinesiology courses that implement health disparities (HD) topics into the undergraduate curriculum engage students in critical and conscious thinking about health outcomes and strategies as they prepare for careers as future health and medical professionals. Health disparities are disproportionate differences in health based on race, gender, socioeconomic status, sexuality, and environmental factors that are preventable for providing opportunities to achieve optimal health. Implementing HD topics into undergraduate courses increases knowledge and awareness and inspires long-term interest in health equity work. This ethnographic case study assessed how 142 undergraduate Kinesiology majors navigated HD topics with critical consciousness as a guiding framework. Three themes emerged from student exploration: eye-opening experiences, lived experiences, and learning experiences. Upper-level students reported an increase in HD (75%–95%) awareness of the meaning of the term and the communities impacted. The lack of prior engagement (29%) with HD ignited tensions around learning experiences. Students who engage in HD topics earlier in their academic programs increase their knowledge and strategies for integrating HD into future learning and practices.

Symptoms of depression, but not PTSD, influence cognitive performance in healthy Army National Guard Soldiers.

Research suggests that comorbid depression and PTSD may contribute to cognitive impairment. However, few studies have explored this dynamic in military personnel who report only subclinical symptoms of PTSD and depression. Army National Guard Soldiers (ARNG; N = 1415) completed the Automated Neuropsychological Assessment Metrics (ANAM), the PTSD Checklist (PCL), and the Center for Epidemiological Studies Depression Scale (CES-D). The effects of PTSD and depression symptoms on ANAM performance were examined using multiple linear regression analyses. Exploratory factor analysis and regression models examined the relationship between symptom clusters and ANAM performance. Six factors were identified: avoidance/flashbacks, cognitive/social difficulty, depressed mood, positive mood, sleep difficulty, and hypervigilance. Elevated symptoms of depression (measured using factor scores) were associated with poorer attention (β range -0.19-0.18, p range < 0.01-0.04, f2 effect size range 0.02-0.94). Depression symptoms were associated with diminished attentional performance in a large sample of ARNG Soldiers who reported no clinical diagnosis. This study was limited in that unmeasured factors other than depression, PTSD, or demographics may explain much of the variance in cognitive performance. These findings highlight the importance of careful mental health screening and strategies to heighten awareness of the potential detrimental effects of depression and PTSD on health and performance.

Association of Area Deprivation Index With Mortality in Critically Ill Adults With COVID-19.

Various social determinants of health have been established as significant risk factors for COVID-19 transmission, prevalence, incidence, and mortality. Area deprivation index (ADI, a composite score made up of educational, housing, and poverty markers) is an accepted multidimensional social determinants of health measure. Little is known about how structural social determinants of health before hospitalization, including ADI, may affect mortality related to COVID-19 in critically ill patients. To examine the association of ADI with intensive care unit (ICU) mortality in patients with COVID-19 and compare its predictive power with that of clinical factors. This was a retrospective cohort study of critically ill adults with COVID-19 in 3 hospitals within a single health system. Multivariable logistic regression models (adjusted for demographic and clinical variables) were used to examine the association of ADI with ICU mortality. Data from 1784 patients hospitalized from 2020 to 2022 were analyzed. In multivariable models, no association was found between national ADI and ICU mortality. Notable factors associated with ICU mortality included treatment year, age, van Walraven weighted score, invasive mechanical ventilation, and body mass index. In this study, clinical factors were more predictive of mortality than ADI and other social determinants of health. The influence of ADI may be most relevant before hospital admission. These findings could serve as a foundation for shaping targeted public health strategies and hospital interventions, enhancing care delivery, and potentially contributing to better outcomes in future pandemics.

The research of influence factors that possibly lead to cardiovascular disease

Abstract. The emergence of cardiac disease is influenced by numerous variables. Every year a large percentage of people around the world die from heart attacks. This study was to look at how important clinical variables are connected to the chance of having CVD. The analysis used a Kaggle dataset with details from 70,000 patients and 10 different variables. The study examined how factors such as age, gender and changes in cardiac activity during exercise affect overall heart health. Multiple linear regression models were used to analyze these effects. The results show a significant correlation between these factors and an increased risk of heart disease. This emphasizes the importance of these predictors in clinical assessments. It can be concluded from this study that regular medical check-ups, early prevention and treatment should be carried out for these vulnerable groups. The general prevalence of heart disease in the nation can be decreased by implementing these strategies. According to the study, personalized health strategies have the potential to improve CVD outcomes and strengthen preventive measures. All of the experimental results suggest that continued documentation and study of these pathogenic factors in medical diagnostics and experiments could aid in drug development as well as improve medical technology and help more patients with cardiovascular disease recover.

Tobacco Treatment Disparities among California Medicaid Members with and without Chronic Disease who Smoke

Introduction: People who are covered by Medicaid have a higher smoking prevalence than the general population and are at increased risk for tobacco-related disease, a major driver of Medicaid costs. California has the largest Medicaid program, called Medi-Cal, whose members also have higher tobacco use rates and tobacco-related disease. Quitting is beneficial at any age and health professional advice and assistance is a key indicator of smoking cessation. As Medi-Cal transforms to improve population health and health equity, this study aimed to understand both prevention and treatment of tobacco-related disease by comparing health professional advice and assistance among all Medi-Cal members with and without chronic disease who smoke. Materials and Methods: Using data from the California Health Interview Survey (2014, 2016-2018), we examined 3,517 Medi-Cal current smokers (age ≥18) who consulted a health professional and reported about having a chronic disease. The outcomes were receipt of health professional advice or assistance to quit smoking. Adjusted logistic regression models were conducted to examine the association between chronic disease and the outcomes, including adjusting for frequency of office visits. Results: Among 1,227,154 Medi-Cal members who smoke, over half (51.9%) of whom had at least one chronic disease, approximately half received cessation advice, and less than one-third received smoking cessation assistance. Smokers with chronic disease, compared to those without chronic disease, were more likely to receive health professional advice (63.9% vs. 33.7%, P < .001) and assistance (37.7% vs. 20.5%, P < .001). In adjusted models, smokers with chronic disease, compared to those without chronic disease, were almost twice as likely to receive advice (OR=1.97, 95% CI: 1.39, 2.78) and 1.5 times as likely to receive assistance (OR=1.50, 95% CI: 0.94, 2.38), but the latter was not statistically significant. Conclusions: Medi-Cal members who smoke have tobacco treatment disparities by whether they are with or without chronic disease, even after adjusting for the number of office visits. Medi-Cal population health strategies for tobacco cessation treatment will need to improve prevention, not just treatment, of tobacco-related disease to reduce the long-term burden on the health care system and associated costs.

Prevalence and Associated Risk Factors of Brucella abortus and Brucella melitensis in Humans and Cattle Populations: A Comprehensive Study

A zoonotic disease unique to South Asia, brucellosis causes major public health and financial problems, notably in Pakistan. This research aimed to ascertain the molecular frequency of Brucella abortus and Brucella melitensis in humans and cattle and to pinpoint related risk factors in the Southern Khyber Pakhtunkhwa, Pakistan, districts. A total of 800 blood samples, 600 from cattle and 200 from humans, were gathered and examined using traditional PCR targeting the IS711 locus. In humans, the molecular frequency of Brucella melitensis and Brucella abortus was 16.5%; in cattle, it was 9.1%. Risk factor analysis in cattle revealed that seasonality, geographic location, sex, and insemination method significantly impacted brucellosis prevalence· Higher risk was observed in female cattle, those naturally inseminated, and during the summer months, particularly in regions such as Bannu· In humans, univariate logistic regression identified potential risk factors, including age (25–50 years), rural residency, lower socioeconomic status, female gender, direct contact with animals, and consumption of raw animal products. However, none of these factors reached statistical significance. The findings underscore the importance of continuous surveillance and targeted preventive measures to control brucellosis transmission between cattle and humans. Understanding the molecular prevalence and risk factors can guide public health strategies and improve livestock management practices to mitigate this zoonotic disease.

Link between gender inequality and women’s satisfaction with maternal healthcare services: a cross-sectional study in Khulna, Bangladesh

BackgroundGender inequality within households remains a significant barrier to accessing maternal healthcare services in many low-resource settings, including Bangladesh. Understanding the relationship between the gender inequality faced by women in...

Advancing preventive health care for men across the lifespan.

Historically, cisgender men have been found to be reluctant to utilize healthcare services, particularly preventive care services. NPs can bridge this gap to address health disparities among men, who are more likely to develop life-threatening conditions and who generally face higher mortality at younger ages than women. Focusing on advancing preventive care among men strengthens family, community, and societal health, and the NP is crucial in fostering a culture of preventive care in this population. To help drive this change, use of a life-stage approach that incorporates a preventive care mindset is critical. The NP should tailor health strategies to each life phase to ensure that men receive the best preventive care possible across the lifespan.