Strategy Execution Research Articles

Drug resistance mechanisms in cancers: Execution of pro-survival strategies.

One of the quintessential challenges in cancer treatment is drug resistance. Several mechanisms of drug resistance have been described to date, and new modes of drug resistance continue to be discovered. The phenomenon of cancer drug resistance is now widespread, with approximately 90% of cancer-related deaths associated with drug resistance. Despite significant advances in the drug discovery process, the emergence of innate and acquired mechanisms of drug resistance has impeded the progress in cancer therapy. Therefore, understanding the mechanisms of drug resistance and the various pathways involved is integral to treatment modalities. In the present review, I discuss the different mechanisms of drug resistance in cancer cells, including DNA damage repair, epithelial to mesenchymal transition, inhibition of cell death, alteration of drug targets, inactivation of drugs, deregulation of cellular energetics, immune evasion, tumor-promoting inflammation, genome instability, and other contributing epigenetic factors. Furthermore, I highlight available treatment options and conclude with future directions.

Paths and Challenges of Green Collaborative Innovation from the Perspective of High-Quality Development

This paper initiates with an overview of the prevailing landscape of green collaborative innovation, encompassing the viewpoints of policy-makers, enterprises, and academic and research institutions. A comprehensive analysis is conducted on the specific execution strategies of green collaborative innovation, which include policy formulation and guidance, technological innovation and advancement, optimization of energy structures and the promotion of multi-energy synergy, enhancement and innovation of market mechanisms, as well as the facilitation of international cooperation and open knowledge exchange. Simultaneously, the paper identifies the challenges inherent to this developmental paradigm, spanning across policy, technological, industrial, and market domains. In conclusion, the paper presents pertinent strategies and recommendations aimed at informing governmental policy-making, guiding corporate practices, and enriching scholarly research. These insights are intended to collectively steer the energy sector towards a trajectory characterized by enhanced greenness, reduced carbon footprint, and improved efficiency.

Ab. No. 59 Reliability of Dual Weighing Scale Biofeedback System (DWSBS), a New Apparatus for Assessment and Training of Weight Bearing Asymmetry (WBA)

Introduction: Weight bearing asymmetry leads to major impact on gait execution strategies post neurological conditions. A cheap and cost-effective apparatus which can be incorporated in routine use with less costs per session, will help treat asymmetry and enhance a near normal gait pattern with reduction in compensatory strategies. Introduction of new, cost effective and reliable apparatus against costly and cumbersome apparatus which is portable and needs less clinical expertise to use. Secondary objective is to target, population with neurological issues where weight bearing asymmetry leads to major gait disturbances. Methods: 56 Normal Healthy individuals (45-65 years) Instrumentation of DWSBS, by using 2 platforms for standing, measuring 12 x 12 inches each, embedded on a single platform, placed at a distance of 2 centimetres between them. A common display with digital output for both weighing scale was used. Reliability testing - 56 healthy individuals without any balance issues recruited and asked to stand bipedally, with eyes open on each of 2 weighing scales separately;post 3 trials, average of reading were documented. Data collected by 2 raters (Rater 1- reading on day 1 and 3; Rater 2 - reading on day 2) were analyzed using Cronbach’s alfa test in SPSS version 23 software. Result: Excellent reliability for Intrarater and interrater testing as per ICC values 0.9. neck ROM. Conclusion: The new apparatus has proven to be reliable and is fit to be tested for validity. Implications: DWSBS will help reduce to cost and execution-based burden for weight bearing asymmetry training.

Research on Optimization of Enterprise Strategy Execution Based on Objectives and Key Results Method (OKR)

Research on Optimization of Enterprise Strategy Execution Based on Objectives and Key Results Method (OKR)

Identifying Major Obstacles Impacting Strategy Execution in Large-Scale and Small-Scale Organizations in the U.S.

Identifying Major Obstacles Impacting Strategy Execution in Large-Scale and Small-Scale Organizations in the U.S.

EFFECTIVE STRATEGY IMPLEMENTATION: A LITERATURE REVIEW OF SUCCESS FACTORS IN PUBLIC SECTOR

This study aimed to conduct a literature review of factors critical to strategy implementation in public sector from empirical studies conducted between 2015 and 2024 with the objective to identify and establish such factors to enhance effective strategy implementation in public sector. Scholarly articles on the subject matter from 2015 to 2024 which were available under open access were well-thought-out and afterward carefully selected from notable scholarly publications using scholarly database search engines, namely; Emarald, Research Gate and Google Scholar. After initial search, screening and thorough review, thirty-eight articles were included for further analysis in relation to the context of this study. In the order of frequency of appearance; the study has found that leadership, communication, skills availability, alignment, organization structure, organization culture and engagement carry much weight in enabling successful strategy implementation in public sector. The findings of this study therefore provide theoretical contribution on the development of a model for effective strategy implementation in public sector, and further assist public sector practitioners by providing them with the focus areas should they wish to experience successful implementation of their strategies. Since this study was only a literature review of empirical studies to identify and establish critical factors for successful strategy implementation in public sector, future studies may be conducted on how the identified success factors fit into a complete strategy execution model to effectively address strategy implementation gap in the public sector.

GREEN STRATEGIES IN ACTION: ASSESSING ITS IMPACT ON ORGANIZATIONAL PERFORMANCE IN CONTEXT OF GREEN STRATEGIES

The purpose of this study, titled "green strategies in action," is to investigate the intricate relationship between green marketing, green leadership, and sustainability as mediator & greenwashing as a moderator in relationships to organizational performance. Thus, quantitative surveys and qualitative interviews with corporate executives are used in conjunction with a mixed -methods approach in order to investigate the complex relationships that exist within environmental sustainability projects. Ultimately, the purpose of this study is to determine how green leadership and green marketing work together to have a synergistic effect on sustainability, which in turn has an effect on organizational performance. Moreover, research examines potential moderating influence of greenwashing, highlighting importance of real environmental commitment at the same time. The findings provide organizations with useful insights that can be used to navigate difficulties and possibilities allied with execution of effective green strategies. This helps organizations nurture holistic approach toward sustainable practices and organizational success.

PESTLE Analysis and Sustainable Event Marketing - Evidences from Mount Kinabalu International Climbathon Destination, Borneo

As an industry practitioner, this research strives to explore and engage in intellectual discourse on the current theoretical paradigm practice of sustainable marketing efficiency strategy design for tourism, hospitality establishments, and event staging from the viewpoints of Destination management organisations (DMOs). Critically, this industry-academic writing is committed to contributing to a better interpretation and, possibly, an assessment of the current marketing principle application by highlighting a potential gap between theory (academic) and practice (industry), accompanied by recommendations on holistic marketing, thereby bridging between conventional and sustainable marketing. A systematic qualitative review using explorative content analysis combined with PESTLE feasibility studies of the destination. Approximately 60 journals, book chapters, and relevant newspaper topics, including pertinent literatures, were screened for analysis. The PESTLE approach to DMOs marketing covers direction, product, service, positioning, branding, and niche segmentation. It also explores Muslim-friendly marketing ideas and their role in compelling destination and event hospitality management. The findings provide analytical perspectives of future hallmarks events for developing countries. Furthermore, it presents a distinct and explicit sustainable marketing policy for event marketers, event organisers, DMOs, and relevant bodies to embed sustainable marketing strategy execution in the event hospitality segment. Additionally, it includes an illustration of a sustainable framework for the future Mount Kinabalu International Climbathon (MKIC) event, recommended to the respective DMOs and event organisers.Keywords: Sustainable Marketing Plan; Marketing Design; Destination Management Organisations DMOs; Mount Kinabalu International Climbathon Event (MKIC); PESTLE analysis.

Research on the Marketing Strategy of POP MART Based on Chinese Market

POP MART has grown from a humble toy collection store to a well-known IP brand, mainly focusing on its proprietary products. POP MART’s triumphant journey in designer toys and collectibles is a testament to its masterful execution of price, place, product, and promotion strategies. This study delves into POP MART’s market strategies, marketing tactics, and the key factors behind its success in the Chinese market. First of all, this article aims to study the marketing strategy of POP MART in the context of the Chinese market. This article will start with a literature review and theoretical background, obtain information data, and summarize and analyze the existing information. Secondly, the research will use questionnaires to evaluate and analyze the existing strategies of POP MART and determine the trend of POP MART’s business strategy and consumer preferences. POP MART stands tall as a dominant force in the designer toy and collectibles industry, shaping trends and delighting collectors worldwide with its creative and customer-centric approach.

The Impact of Strategy Implementation on the Performance of Ugandan State Agencies: A Quantitative Study

This study examines how strategy implementation affects Ugandan state agencies’ performance. It conceptualizes strategy implementation as operationalization and institutionalization, and measures performance by efficiency and effectiveness. This study surveyed 160 state agencies using a cross-sectional design and a structured questionnaire. The top management team (TMT) members of each agency, including CEO/Managing Director, Deputy/Assistant CEO, Corporation Secretary, and Heads of Department, were the respondents. At least three TMT members from each agency participated in the online survey, which was chosen due to the COVID-19 restrictions. The data analysis methods were factor analysis, descriptive, and multilinear regression analysis. The study adhered to the ethical principles of informed consent, confidentiality, and anonymity. Ugandan state agencies perform better when they implement their strategies effectively. The statistical analysis reveals that institutionalization is a key driver of performance outcomes, with a positive and highly significant coefficient (p < 0.000). On the other hand, operationalization has a positive but insignificant coefficient (p = 0.140), indicating a weak link between operationalization and performance. These findings highlight the importance of aligning the strategy with the organization’s internal environment. The study provides invaluable contribution the realm of strategic management, particularly within the public sector, focusing primarily on the performance of state agencies in Uganda. It is groundbreaking research that explores this relationship in a developing country. It methodically examines the profound effect that the execution of various strategies has on these entities. This study contributes to the strategic management literature in the public domain. The insights and recommendations derived from this study are valuable for professionals and policymakers involved in creating and implementing strategic plans within the public sector. This study offers practical and theoretical contributions for strategy implementation and performance in public sector contexts. It suggests that state agency managers and policymakers should foster a supportive culture, enhance leadership skills, facilitate communication channels, allocate adequate resources, and adapt to environmental changes to improve strategy execution and outcomes. It also adds to the literature on strategic management in public sector contexts, especially in developing countries.

UD Packs Dodol Processing in Wonosari, Bengkalis District, Bengkalis Regency

The purpose of this study is to determine the marketing strategy for UD Kemas home industry dodol, which is situated in Bengkalis District, Bengkalis Regency. Additionally, the study will investigate the opportunities, threats, strengths, and weaknesses that are related with the marketing of UD Kemas dodol. The method of data analysis that is utilised is a descriptive analysis that draws upon the strengths, weaknesses, opportunities, and threats analytical approach. First, the internal factor evaluations (IFE) and the external factor evaluations (EFE) are determined using this approach. Next, the right strategy is determined by employing the IE matrix and the SWOT matrix. Finally, the process concludes with the determination of the appropriate strategy. Taking into consideration the results of this research, it is possible to draw the conclusion that the execution of a progressive strategy at dodol UD Kemas, which is situated in the Bengkalis District of the Bengkalis Regency, is indicative of a healthy business that has the potential to be developed. Using the SO strategy that was generated from the findings of the questionnaire, it is possible to grow demand for UD Kemas dodol even further by ensuring that product excellence is maintained and maintained. Strategic locations can be utilized to make the product sales process easier.

The role of the industry marketing model in increasing the internal cost of light industry products of the Republic of Kazakhstan

Kazakhstan economy is now deeply entwined with the global economic relations framework. An increase in the amount of imports into the nation is a result of economic progress, which draws in capital and technology as well as increasing consumer spending. The needs of economy for consumer, investment, and intermediate products are all met by the expansion in import deliveries, which puts some strain on the balance of payments' current account. This begs the question of how reasonable the current level of imports in relation to other nations is at this point in the country's development. Increasing the domestic value added to this sector's products is a major way to boost its economic impact. The goal of the article is to assess the light industry and develop a marketing strategy to raise the value of goods inside the nation. This article is centered on the creation and execution of strategies to enhance domestic value in the Republic of Kazakhstan (RK) light industry sector. These strategies are in line with the country's objective of attaining a minimum of 90% share of domestic purchases by 2021. The research focuses on the five safeguards included in the "Kazakhstan–2050" development plan, which are meant to support and preserve regional producers.

Production costs and total completion time minimization for three-stage mixed-model assembly job shop scheduling with lot streaming and batch transfer

Assembly scheduling problems have broad applications in discrete manufacturing enterprises and hence gained extensive attention in academics. However, some important and actual factors including lot streaming, batch transfer of components and mixed-model assembly are yet not well studied. To adapt to actual production and enhance competitiveness, a three-stage mixed-model assembly job shop scheduling with lot streaming and batch transfer is investigated in this work. To tackle this problem, spatial-temporal links among three stages with differentiated production lot size are established and a novel mathematical model is formulated to minimize total completion time and production costs including setup costs, transport costs, and inventory costs. Besides, an improved multi-objective coevolutionary simulated annealing algorithm is developed. To promote the coevolution of processing, transfer, and assembly sub-problems, the multi-attribute combination rule, similarity rule, and consistency rule are respectively designed for each sub-problem. An adaptive execution strategy of sub-problems is trained by Q-learning to maximize the overall benefits. Experimental results show that both the discovered rule and the adaptive strategy are effective, and the proposed algorithm significantly outperforms seven competitive multi-objective algorithms in fixing the studied problem. More importantly, the developed production mode of “processing with lot streaming-batch transfer-mixed-model assembly considering pull production” has a better comprehensive performance than the other three actual production modes.

THE IMPACT OF LEADERSHIP ON ESPORT TEAM PERFORMANCE

This study explores the impact of leadership on team performance in competitive game situations. The purpose of the study is to understand the importance of effective leadership strategies to maximise team performance and team success. The study uses a combination of literature review and use SMARTPLS as measuring tools. Research results show that effective leadership has a positive impact on team performance in esports. The study concludes that leadership has a significant impact on esports team performance. An effective leadership style that focuses on psychological factors and the role of the coach contributes to better team cohesion, better communication, and better execution of strategy. This paper highlights the importance of customised leadership strategies that consider the unique challenges and characteristics of the esports industry.

Product Patrolling: Learning Recall execution Strategies through Case studies

There has been an increasing trend in the number of prescribed and over-the-counter drug recall over the last few years. The recall is usually due to company’s discovery, customer’s complaint or Food and Drug Administration (FDA) observation. The process of recall involves a planned specific course of action, which addresses the depth of recall, need for public warning, and the extent of effectiveness checks for the recall.This abstract explores the critical aspects of pharmaceutical drug product recalls, focusing on their classification, recall levels, and effective recall strategies. The pharmaceutical industry faces challenges in ensuring the safety and efficacy of drug products, necessitating a robust recall framework. We delve into the classification of recalls, ranging from voluntary actions to mandated recalls, emphasizing the importance of prompt and transparent communication. Recall levels, categorized based on the severity of potential health risks, are examined to provide a comprehensive understanding of the regulatory landscape. Furthermore, this abstract highlights innovative recall strategies, encompassing technology-driven traceability, stakeholder collaboration, and crisis communication. By addressing these key elements, this research contributes to enhancing the efficiency and reliability of drug product recall processes, ultimately safeguarding public health and bolstering industry resilience.

Symbolic analysis and parameter synthesis for networks of parametric timed automata with global variables using Maude and SMT solving

This paper presents a rewriting logic “interpreter” for networks of parametric timed automata with global variables (NPTAVs) in Real-Time Maude style. Since explicit-state analysis is not sound and complete for such dense-time systems, we explain how our real-time rewrite theory can be systematically transformed into a rewrite theory that is amenable to symbolic analysis using the integration of Maude with SMT solving. We show that symbolic reachability analysis using Maude-with-SMT of the resulting rewrite theory is sound and complete for the NPTAV reachability problem. We extend and optimize standard Maude-with-SMT reachability analysis with folding and merging of symbolic states, so that the analysis terminates when the symbolic state space of the NPTAV is finite. These procedures rely on a subsumption relation that requires eliminating existentially quantified SMT variables. We have therefore implemented the Fourier-Motzkin quantifier elimination algorithm, thereby making our rewrite theory executable with any SMT solver connected to Maude. We show how we can provide most reachability and parameter synthesis analysis methods provided by Imitator, a state-of-the-art tool for NPTAVs. We compare the performance of our analysis methods with those of Imitator on a wide range of benchmarks, with the expected outcome. The practical contributions are two-fold: providing new analysis methods for NPTAVs—e.g., allowing more general state properties and supporting reachability analysis combined with user-defined execution strategies—not supported by Imitator, and developing symbolic analysis methods for both real-time rewrite theories and rewrite theories in general.

The Effect Of Strategic Implementation on Organizational Performance of Saccos In Southwestern Uganda

The purpose of the study was to examine the effect of strategy implementation on organizational performance of SACCOS in Uganda Case of Lyamujungu SACCO in Kabale District- Southwestern Uganda. The study employed a case study research design. It involved quantitative and qualitative methods which enabled the study to evaluate the relationship between the study variables at a snap shot. A sample of 140 respondents were selected using simple random sampling and purposive sampling techniques. The quantitative and qualitative data from the respondents was analyzed using SPSS Version 21.0 and thematic analysis respectively. Quantitative results in form of descriptive statistics, correlations and regressions were presented in tables based on the study objectives. The study found out that strategy implementation, has a positive significant relationship with organizational performance (r = .315, P≤.01). According to the study's conclusions, the Lyamujungu SACCO instance illustrates how strategy execution impacts organizational performance. According to the report, Lyamujungu SACCO's board of directors should implement its strategy effectively as staff members and clients carry out their job duties. The organization will be able to accomplish its goals of turning a profit thanks to this

Implementation of Metacognitive Strategies on Students' Ability to Read English Texts

Reading is one of the crucial language skills for learners, especially when they are learning English. English learners can usually read texts well, but many of them cannot understand the content of the text. This study aims to determine how to implement metacognitive strategies to learn reading skills. Results showed that students had a good awareness of metacognitive reading strategies. However, it did not affect students' reading comprehension test results much. This is because several other factors, such as interest, background knowledge of students, and teachers' role, also significantly influence students' reading comprehension. This study used a case study approach to its analysis. This research demonstrates the efficacy of self-planning, self-monitoring, and self-evaluation as three phases of metacognitive strategy execution. These steps are accomplished via friendly conversation with the pupils. Five pupils in particular shown exceptional levels of motivation, success, self-awareness, and independence in their reading comprehension and other academic endeavours.

Dengue virus infection and neurological manifestations: an update.

Dengue virus is a flavivirus transmitted by the mosquitoes, Aedes aegypti and Aedes albopictus. Dengue infection by all four serotypes (DEN 1 to 4) is endemic globally in regions with tropical and subtropical climates, with an estimated 100-400 million infections annually. Among those hospitalized, the mortality is about 1%. Neurological involvement has been reported to be about 5%. The spectrum of neurological manifestations spans both the peripheral and central nervous systems. These manifestations could possibly be categorized into those directly related to dengue infection, i.e. acute and chronic encephalitis, indirect complications leading to dengue encephalopathy, and post-infectious syndrome due to immune-mediated reactions, and manifestations with uncertain mechanisms, such as acute transverse myelitis, acute cerebellitis and myositis. The rising trend in global dengue incidence calls for attention to a more explicit definition of each neurological manifestation for more accurate epidemiological data. The actual global burden of dengue infection with neurological manifestation is essential for future planning and execution of strategies, especially in the development of effective antivirals and vaccines against the dengue virus. In this article, we discuss the recent findings of different spectrums of neurological manifestations in dengue infection and provide an update on antiviral and vaccine development and their challenges.

Application of environmental management accounting and strategy to company innovation with research and development effort and company size as control variables

The global industrial world is significantly impacted by technological advancements, necessitating the establishment of regulations to enhance organizational implementation inside companies and attain optimal objectives. The norms of management accounting provide the provision of precise information for strategic and tactical decision-making in management. The objective of this study is to analyze the direct and indirect impact of accounting, environmental management, and strategy on company innovation. The study will also consider research and development activities and company size as control factors. Primary data will be used for the analysis. The sample size for this study consisted of 155 employees. The investigation involved collecting 112 samples using the Slovin formula. The analysis approach employed was multiple linear regression analysis. The study findings indicate that all variables exert a favorable impact on firm innovation. Therefore, the utilization of environmental management accounting and the execution of strategies in a reputable company will result in multiple innovations and strategies, including the reduction of product waste pollution, mitigation of global warming impacts, heightened awareness of minimizing environmental costs that may harm the environment, and the creation of new prospects for producing impeccable quality products.