Carbapenem-resistant Enterobacterales (CRE) are a global concern due to their high mortality rates and limited therapeutics. CRE-caused bloodstream infections (BSIs) are challenging to manage, especially in healthcare settings. This study aimed to investigate the predictors of mortality in BSI patients caused by CRE. A single center prospective study to examine the characteristics of BSI caused by CRE in a large academic hospital over 15 months. The main outcomes were microbiological characteristics and clinical outcomes of patients at 28 days based on a step-wise regression analysis. A total of 76 episodes of BSI due to CRE were included. The study found that the most common type of carbapenemase was OXA-48 (69.7%, n = 53), followed by the co-existence of OXA-48 and MBL (26.3%, n = 20), with Klebsiella pneumoniae being the most common (90%, n =69). Patients with OXA-48-BSI were more likely to have a urinary source of infection, while patients with MBL-BSI were more likely to have a non-urinary source of infection. All cases (100%) had medical devices. Around 30.3% of patients received effective empirical treatment, while 61.8% received adequate therapy at 48 hours. The overall mortality rate was 42.1% (n=32), and the main predictors of mortality in this study were the presence of sepsis and inadequate initial therapy, while age > 65 predicted mortality in the linear regression but not the stepwise regression model. CRE-BSIs are a serious health threat. The study highlights the need for preventive strategies focused on high-risk patients and proper device management to reduce BSI.