Lifecycle Management Strategies Research Articles

Economic Value Creation and Management Strategies in the Lifecycle of Geological Research Projects

Geological research projects play a crucial role in resource exploration, development, and environmental protection. Maximizing economic value at each stage of the project lifecycle has become a key issue in research management. This paper explores the definition and phase division of the geological research project lifecycle, analyzes the economic value potential at each stage, and identifies key drivers of economic value creation, such as technological innovation, resource utilization efficiency, financial management, and risk management. Furthermore, this paper proposes lifecycle management strategies, resource optimization methods, and approaches for outcome transformation (outcome transformation refers to the transformation of research results into practical applications), aiming to enhance the overall effectiveness of geological research projects. Through a systematic analysis of management strategies, this paper provides theoretical guidance and practical references for creating economic value in geological research projects.

Transition from Electric Vehicles to Energy Storage: Review on Targeted Lithium-Ion Battery Diagnostics

This paper examines the transition of lithium-ion batteries from electric vehicles (EVs) to energy storage systems (ESSs), with a focus on diagnosing their state of health (SOH) to ensure efficient and safe repurposing. It compares direct methods, model-based diagnostics, and data-driven techniques, evaluating their strengths and limitations for both EV and ESS applications. This study underscores the necessity of accurate SOH diagnostics to maximize battery reuse, promoting sustainability and circular economy objectives. By providing a comprehensive overview of the battery lifecycle—from manufacturing to recycling—this research offers strategies for effective lifecycle management and cost-effective, environmentally sustainable secondary battery applications. Key findings highlight the potential of second-life EV batteries in ESSs. The integration of the considered diagnostic methods was shown to extend battery lifespan by up to 30%, reduce waste, and optimize resource efficiency, which is crucial for achieving circular economy objectives. This paper’s insights are crucial for advancing sustainable energy systems and informing future research on improving diagnostic methods for evolving battery technologies.

Case Studies on Changes and Proposed Process Development Approaches reflecting applicability of PDA Technical Report No. 89 Strategies for Vaccine Development and Lifecycle Management.

Vaccines are complex and a very diverse group of products with relatively long product lifecycles. The manufacturing programs for these vaccines need to be continually updated to comply with evolving regulatory expectations. Members of the Parenteral Drug Association (PDA) Vaccines Interest Group (VIG) authored and published PDA Technical Report No. 89 Strategies for Vaccine Development and Lifecycle Management (TR 89) which seeks to provide context to vaccine developers and manufacturers regarding key aspects of new or legacy vaccines such as control strategy from process development to vaccine lifecycle management, comparability and lifecycle management including technical, validation, quality and regulatory perspectives. To further explain and illustrate the concepts and topics discussed, seven relevant situations were selected as either case studies associated with changes implemented or proposed process development strategies, which are discussed in this article. The situations described are: working cell bank, modification or update of externally supplied product contact components for vaccine manufacturing, raw material change, new product at an existing site, vaccine development acceleration by leveraging existing platforms, selection and implementation of potency method, and modeling for stability forecast prediction. For each situation, the applicable key concepts from TR#89 are discussed as follows: Control Strategy, Prior Knowledge, Relying on PQS, Classification of Parameters, Validation Approach, Use of a Risk-based Approach, Comparability, Use of ICHQ12 and Additional Regulatory Considerations.

Managing Growth of Product Lifecycle at Maturity Level: A Systematic Literature Review

Through the synthesis and analysis of 64 papers, from JSTOR, ScienceDirect, and Google Scholar data bases, include 2010-2024 of 15 years duration paper works. this systematic literature review identified major themes and provided insights into growth management strategies, marketing tactics, challenges, and opportunities, benefits, that managers confront in their quest to sustain competitiveness and profitability in mature markets. Product diversification, market segmentation, innovation management, cost-effective lifecycle planning, price strategies, market expansion, client retention, alliances, and collaboration are a few examples of important tactics. The difficulties include growing rivalry, market saturation, shrinking profit margins, and shifting consumer tastes. To maintain competition, there are nevertheless still chances to take advantage of economies of scale, brand equity, and customer loyalty. The review's insights deepen our understanding of how businesses may best manage opportunities and overcome obstacles to maximize product lifecycle management at various stages of maturity. By providing a comprehensive understanding of the existing body of knowledge, this review offers valuable insights for practitioners, managers, and researchers aiming to enhance product lifecycle management (PLM) strategies at the maturity level, ultimately contributing to the development of more resilient and adaptive business models and research gaps have identified that enabled to provide future research directions.

The Human‐Technology Spectrum: A Framework for Evaluating Sociotechnical System Function Allocation, Risk, and Performance

AbstractThis paper investigates the interplay of human and technological elements performing functions within socio‐technical systems. With rapid technological advancements, understanding the various possible human‐technology configurations, and their unique implications, is crucial. This research proposes a conceptual schema to demarcate particular kinds of human‐technology relationships, as it pertains to function allocation, and aims to guide system design and risk management. The Human‐Technology Spectrum (HTS) framework considers a continuum of systemic risks, lifecycle management strategies, and evaluation processes, offering a valuable resource for engineers and designers. For each stage along the HTS, we provide examples and discuss function across types of sociotechnical systems. We conclude with a discussion on the importance of understanding the tradeoffs between humans versus technologies enacting system functions.

Overview and Lifecycle Management of Generic Pharmaceutical Drugs in Mexico, Guatemala and Brazil

Objective: The generic pharmaceutical markets in Mexico, Guatemala, and Brazil are influenced by distinct regulatory frameworks, production and distribution dynamics, and marketing strategies, which shape lifecycle management. Regulatory policies, market competition, and healthcare initiatives impact accessibility, affordability, and quality, presenting both challenges and opportunities for enhancement in these areas. Summary: This thesis offers an in-depth examination of lifecycle management strategies in the generic pharmaceutical markets of Mexico, Guatemala, and Brazil. Generic drugs are crucial for increasing access to affordable healthcare, especially in emerging economies. Through comparative analysis, this research explores the regulatory frameworks, market dynamics, and key challenges in the development, approval, marketing, and post-marketing surveillance of generic drugs in these three Latin American countries. The study starts with an overview of the regulatory landscape for generic pharmaceuticals in Mexico, Guatemala, and Brazil, highlighting similarities and differences in registration requirements, approval processes, and post-approval obligations. It investigates the roles of regulatory agencies like COFEPRIS, DIGEMID, and ANVISA in ensuring the quality, safety, and efficacy of generic drugs throughout their lifecycle. Additionally, the research delves into the strategies used by pharmaceutical companies for lifecycle management of generic drugs, including variations, biowaivers, and labeling changes. Real-world case studies illustrate post-approval changes and their regulatory implications in each country, providing insights into the complexities of managing generic drug portfolios in different regulatory environments. The thesis also examines the market dynamics affecting the availability, pricing, and accessibility of generic drugs in Mexico, Guatemala, and Brazil. Factors such as patent expirations, competition, healthcare policies, and public procurement practices are analysed to understand their impact on market entry, competition, and the affordability of generic drugs. Furthermore, the study addresses the challenges and opportunities in pharmacovigilance and post-marketing surveillance of generic drugs, emphasizing the need for robust systems to detect and manage adverse drug reactions and ensure patient safety. Conclusion: The key findings highlight regulatory frameworks, market dynamics, and lifecycle management strategies in the generic pharmaceutical markets, identifying challenges and opportunities. The study reflects on implications for stakeholders and suggests areas for future research to enhance accessibility, affordability, and quality.

Analysis the Gaps in Adopting Quality System as per the National Standard of Accreditation on Territory Care Hospital with Reference to NABH Standards

This research paper delves into the pivotal role of product management and market research analysis in the context of pharmaceutical companies. It explores how these strategic tools contribute to business development amidst the intricate landscape of the pharmaceutical industry, characterized by rapid scientific advancements, evolving market dynamics, and stringent regulatory requirements. The paper emphasizes the evolution of product management within the pharmaceutical sector, highlighting its transition from a focus on research and development to encompassing comprehensive lifecycle management and commercialization strategies. Through a review of literature and data analysis, the paper examines various facets such as patientcentric innovation, regulatory compliance, digital transformation, competitive landscape analysis, and cross-functional collaboration. The study aims to shed light on the significance of integrating product management and market research analysis for driving sustainable business growth, enhancing competitiveness, and delivering impactful healthcare solutions in pharmaceutical companies

The Role of Product Management and Market Research Analysis for Business Development in Selected Pharmaceutical Companies

This research paper delves into the pivotal role of product management and market research analysis in the context of pharmaceutical companies. It explores how these strategic tools contribute to business development amidst the intricate landscape of the pharmaceutical industry, characterized by rapid scientific advancements, evolving market dynamics, and stringent regulatory requirements. The paper emphasizes the evolution of product management within the pharmaceutical sector, highlighting its transition from a focus on research and development to encompassing comprehensive lifecycle management and commercialization strategies. Through a review of literature and data analysis, the paper examines various facets such as patient-centric innovation, regulatory compliance, digital transformation, competitive landscape analysis, and cross-functional collaboration. The study aims to shed light on the significance of integrating product management and market research analysis for driving sustainable business growth, enhancing competitiveness, and delivering impactful healthcare solutions in pharmaceutical companies.

Full life cycle changes of low impacted mandibular third molar associated cystic lesions and adjacent tooth root resorption: a retrospective study

ObjectiveLow impacted third molars are usually asymptomatic and are often found by X-ray examination. The removal of asymptomatic low impacted third molars is one of the most controversial clinical issues in oral and maxillofacial surgery.MethodsIn this study, 806 patients with low impacted mandibular third molars (LIMTMs) (full bony impaction) were analyzed to determine the prevalence and risk factors for cystic lesions and adjacent tooth root resorption throughout the patients’ entire life cycle.ResultsThe results showed that the prevalence of adjacent tooth root resorption and cystic lesions was age-related, exhibiting a trend of first increasing and then decreasing; prevalence peaked at the age of 41 to 45 years old, the prevalence rates were 12.50% and 11.11% respectively. And the lowest prevalence rate was 2.86% and 2.44% in ≥ 61 group and 56- to 60-year age group respectively. Age was an independent risk factor for adjacent tooth root resorption of LIMTMs, whereas age and impaction type (especially inverted impaction) were independent risk factors for cystic lesions.ConclusionsThe full life cycle management strategy for LIMTMs may need to be individualized. Surgical removal is recommended for LIMTMs in patients younger than 41 to 45 years, especially for inverted, mesioangular, and horizontally impacted LIMTMs. LIMTMs in patients older than 41 to 45 years may be treated conservatively with regular follow-up, but surgical removal of inverted impacted LIMTMs is still recommended to avoid cyst formation.

OPTIMIZATION OF THE TOOL MANAGEMENT SYSTEM IN THE IMPLEMENTATION THE PROJECT LIFECYCLE MANAGEMENT CONCEPT AT THE ENTERPRISES OF THE “ALMAZ – ANTEY”

Production project lifecycle management is a complex and capacious process of development, planning and production. The concept of the project life cycle, lifecycle management strategy and its structuring are considered. The relevance of the implementation of the concept to optimize the tool management system at the enterprises of the “Almaz – Antey” ASD Corporation” has been formulated. Software products of lifecycle management control system are considered. An Ishikawa causal diagram assessing the problem of the current tool management system is presented. A map of the flow of creating the value of selection and testing of prefabricated metal cutting tools in the “before” and “after” optimization states has been formed. Ways to improve the tool management system are proposed, its effectiveness after the introduction of lean production tools is analyzed.

Applications and Risk Assessments of Ionic Liquids in Chemical and Pharmaceutical Domains: An Updated Overview

Abstract: The objective of this review is to evaluate the toxicological profiles and environmental sustainability of Ionic Liquids for chemical applications. Data from in vitro assays, Danio rerio embryo tests and computational models were herein analyzed. The development and properties of 'green' Ionic Liquids were also assessed. Safety evaluations indicate that Ionic Liquids exhibit various toxicological behaviors, challenging the assumption that they are categorically safe for environmental exposure. 'Green' Ionic Liquids show enhanced biodegradability and lower ecotoxicity but are not universally benign. Some Ionic Liquids present toxicological properties that conflict with being environmentally safe. It is, therefore, essential to conduct comprehensive assessments before deeming them environmentally safe. Lifecycle management strategies incorporating circular economy principles are promising but require further validation and detailed analysis for sustainability confirmation.

Probabilistic condition assessment of reinforced concrete sanitary sewer pipelines using LiDAR inspection data

Frequent inspections of reinforced concrete sanitary sewer pipelines (RCSSPs) are crucial for performing a proper life cycle management strategy; however, due to the large inventory of SSPs, only limited inspection data is typically available. In this work, a data-driven method for condition assessment of RCSSPs is developed in a probabilistic framework, wherein the pipe wall erosion is evaluated using LiDAR inspection data. Results indicate that the deteriorated inner concrete wall geometry of RCSSPs is best characterized by the half-normal probability density function (PDF). The final product of the proposed condition assessment algorithm is a probabilistic estimate of remaining service life using the inspection LiDAR point cloud data (PCD). The effect of different reliability methods are compared with the proposed methodology. The results are validated using available closed-circuit television (CCTV) images, previous research that employs the same inspection data, and Monte Carlo Simulation (MCS) method. The proposed algorithm provides an automated framework that can be utilized with any PCD associated with non-destructive inspections.

Development of Computer Modeling Tools for Infrastructure Construction Facilities

One of the directions of digital transformation of the national economy is the transition to a life cycle management system for capital construction projects, including infrastructure facilities using information modeling technologies. In connection with this circumstance, it is necessary to develop computer modeling tools, first of all, domestic software. The article presents an overview of software tools for creating an information model of objects of water supply and sanitation systems. A number of problematic issues have been identified at the stages of promoting these software products on the market, their maintenance and modernization. Recommendations are proposed for developers when forming a lifecycle management strategy for such specialized software. The implementation of the research results will allow developers to increase the competitiveness of their software systems in the market, attract new users and accelerate the processes of digital transformation in infrastructure construction.

A Combined Reverse Engineering and Multi-Criteria Decision-Making Approach for Remanufacturing a Classic Car Part

Engineering Design and Additive Manufacturing (AM) technologies play a significant enabling role for business models with a proposed contribution to lifecycle management strategies for extending product life and enabling more efficient production via the digitisation of product design and production processes. This paper demonstrates a strategic approach for reverse engineering (RE) to support new business models capitalising on economic and organisational contexts such as on-demand and decentralised manufacturing and digital automation without the requirement for tooling. Additionally, it integrates a decision-making tool to evaluate the strategy of the various RE processes. This study provides an informed comparison between workflows of non-contact data acquisition using photogrammetry, metrology grade laser scanner, and 3D re-modelling using scanned data as a reference. This approach creates a digital thread for end-of-life (EOL) parts and enables remanufacturing using AM processes. The workflows are documented and assessed based on the manufacturing triangle of cost, time, and quality as application-relevant design pillars for evaluating the suitability of the business case proposed, namely, remanufacturing of parts for classic car restoration projects. The calculated and measured results based on the three different approaches were assessed through a Multi-Criteria-Decision-Making (MCDM) process, more precisely, the Analytic Hierarchy Process (AHP). The outcome of the study shows the general applicability of the proposed workflow. The combination of the measured and calculated data of the remanufactured parts and the decision-making tool provided the following ranking of the proposed work to the practitioner: (1) laser scanning, (2) 3D modelling, and (3) photogrammetry.

A Comprehensive Review: Transdermal Drug Delivery System: A Tool For Novel Drug Delivery System

In the recent decade, skin delivery (topical and transdermal) has gained an unprecedented popularity, especially due to increased incidences of chronic skin diseases, demand for targeted and patient compliant delivery and interest in life cycle management strategies among pharmaceutical companies. Transdermal drug delivery system was presented to overcome the difficulties of drug delivery especially oral route. Transdermal drug delivery refers to a means of delivering drugs through the surface of the skin for local or systemic treatment. The drug functions after absorption through the skin into the systemic circulation via capillary action at a certain rate. Transdermal patches are now widely used as cosmetic, topical and transdermal delivery systems. These patches represent a key outcome from the growth in skin science, technology and expertise developed through trial and error, clinical observation and evidence-based studies that date back to the first existing human records. A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through skin and into the bloodstream. An advantage of a transdermal drug delivery route over other types of delivery system such as oral, topical, intravenous (i.v.), intramuscular (i.m.), etc. is that the patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive. The main disadvantage to transdermal delivery systems stems from the fact that the skin composition offers very effective barrier that allow only small molecule based drugs to penetrate the skin and pass through the barrier. Sildenafil citrate (SLD) is a selective cyclic guanosine monophosphate-specific phosphodiesterase type 5 inhibitor used for the oral treatment of erectile dysfunction and more recently, it has been used for the treatment of pulmonary arterial hypertension and the enhancement of uteroplacental perfusion in case of fetal growth retardation. The challenges facing the oral administration of the drug include poor bioavailability and short duration of action that requires frequent administration. The main objective of transdermal drug delivery system is to deliver drugs into systemic circulation through skin at predetermined rate with minimal inter and intrapatient variations. Keyword: Skin delivery, Transdermal drug delivery, Oral rout, Sildenafil citrate, Pulmonary arterial hypertension

Pharmaceutical Portfolio Development: Strategic Rationale, Challenges & Solutions

Seeking revenue growth has always been one of the key strategic priorities of business entities in the biopharmaceutical industry. The path to such growth can take diverse forms shaped by factors such as business context, strategic and operational capabilities, asset profiles, resources, and competition. Developing assets (whether organic or acquired) with a strategy that seeks to build, maintain, optimize and grow a portfolio of assets offers a reliable path to reducing risks presented by organic development or through mechanisms such as partnering, mergers & acquisitions. The benefits of achieving profitable growth with a portfolio strategy span the asset life cycle continuum, from influencing asset development programs, shaping investment decisions, determining commercialization choices, informing launch planning, and driving corporate priorities. This article outlines the rationale for crafting and adopting a portfolio strategy since it improves the design of corporate, development, commercialization and lifecycle management strategies. Through cases based on the author’s engagements, this article highlights common challenges and creative solutions that lead to the development and execution of viable portfolio strategies implemented by firms of diverse sizes and corporate objectives.

Nested Lifecycles-Improving the Visibility of Product Lifespans in Smart Factories

Within the smart factory environment, we have a complex system of systems composed of Industry 4.0/digital technologies and assets with varying lifespans. Different degrees of innovation maturity and different lifespans of integrated assets within the industrial internet of things (IIOT) are considered problematic and lead to different perspectives on asset lifecycles as they impact significantly on the asset lifespans. This leads to the loss of a clear end-of-life phase defined in existing Product Lifecycle Management (PLM) models. Through an integrative literature review, this study introduces the concept of nested lifecycles that takes a systems perspective to asset management, and considers subsystems with different lifespans that must be managed holistically by different actors with different perspectives. Additionally, this study provides a framework to derive strategies for lifecycle management by allowing the nested lifecycles to be clearly identified and then addressed. From the theoretical perspective, the notion of nested lifecycles provides a novel viewpoint for the asset management and PLM research community. From the managerial perspective, the proposed framework will help managers identify why and where collaboration between different actors may create difficulties due to their varying outlooks and training.

A LITERATURE REVIEW ON MITIGATION STRATEGIES FOR ELECTRICAL COMPONENT OBSOLESCENCE IN MILITARY-BASED SYSTEMS

The aim of this research is to conduct an all-inclusive investigation on past studies of obsolescence, the issues involved, and tactics for mitigation in military-based systems. This research investigates four categories: 1. Obsolescence Consequences, 2. Life Cycle Stages and Strategies for Life Cycle Management, 3. Design for Obsolescence and Cost Optimisation, and 4. Management and Tools. A quantitative approach was used to determine the key topics of the 55 articles used in this literature review. A keyword and topic matrix was used to determine the six main areas of concern in current research, and then broken down further into the four categories discussed in this paper. A deep dive into the literature shows that the main areas of concern for obsolescence are cost optimisation, obsolescence management, system life cycle, design/system refresh planning, architecture/open systems, and end-of-life (EOL) predictions. In the EOL predictions category, only one article proposed the idea of machine learning as a forecasting method. This effort suggests a need for a more streamlined management approach to tackling obsolescence. Newer research shows an interest shift from system life cycle management towards forecasting techniques and looking towards future proactive management improvements. This study demonstrates opportunities and challenges for entities dealing with component obsolescence and methods for minimising the issues that go along with it. This paper identifies current practices for obsolescence management, and points to areas for further research development. Keywords Obsolescence; diminishing manufacturing sources and material shortages (DMSMS); forecasting; electrical component; machine learning

System of Systems Lifecycle Management—A New Concept Based on Process Engineering Methodologies

In order to tackle interoperability issues of large-scale automation systems, SOA (Service-Oriented Architecture) principles, where information exchange is manifested by systems providing and consuming services, have already been introduced. However, the deployment, operation, and maintenance of an extensive SoS (System of Systems) mean enormous challenges for system integrators as well as network and service operators. The existing lifecycle management approaches do not cover all aspects of SoS management; therefore, an integrated solution is required. The purpose of this paper is to introduce a new lifecycle approach, namely the SoSLM (System of Systems Lifecycle Management). This paper first provides an in-depth description and comparison of the most relevant process engineering methodologies and ITSM (Information Technology Service Management) frameworks, and how they affect various lifecycle management strategies. The paper’s novelty strives to introduce an Industry 4.0-compatible PLM (Product Lifecycle Management) model and to extend it to cover SoS management-related issues on well-known process engineering methodologies. The presented methodologies are adapted to the PLM model, thus creating the recommended SoSLM model. This is supported by demonstrations of how the IIoT (Industrial Internet of Things) applications and services can be developed and handled. Accordingly, complete implementation and integration are presented based on the proposed SoSLM model, using the Arrowhead framework that is available for IIoT SoS.

Life-cycle modelling of concrete cracking and reinforcement corrosion in concrete bridges: A case study

The development of effective life cycle management strategies for transport infrastructure assets is of importance for meeting the defined public policies and levels of service. In the last decades, much progress has been made in assessing the life-cycle performance of bridges using reliability-based approaches. However, the goal of developing a comprehensive life-cycle performance assessment framework for bridges has not been fully achieved. This is due to the uncertainties surrounding model parameters as well as the correlation between these parameters (e.g. the complex correlation between the reinforcement corrosion and the concrete cracking). It becomes more challenging due to the limited access to bridge inspection data by bridge research communities resulting from confidentiality issues. Using a typical highway concrete bridge as a case study, the present study systematically investigated the impact of concrete crack induced reinforcement corrosion on the serviceability of concrete bridges by developing an engineering reliability-based approach involving an auto-regressive crack propagation model and a steel corrosion prediction model. The model parameters were calibrated using the eight-year inspection data of an operating bridge. The influence of different external environments in the reinforcement corrosion, ultimately the residual life of the bridges, was also investigated through conducting a series of parametric studies. Based on the collected bridge inspection data, the model results predict that, although the surface crack of a RC bridge is repairable through periodic maintenance, the corrosion of the steel bars in the bridge still continues over time with a corrosion rate which depends on different maintenance intervention cycle periods (Tcycle). For example, reducing Tcycle from 12 years to 4 years could potentially prolong the service life of the bridge by around 15 years. The developed model could assist bridge managers to estimate the optimal Tcycle to prolong the service life of bridges.