Entrepreneurship education resource allocation involves the strategic distribution of resources to support programs and initiatives aimed at fostering entrepreneurial skills and mindset among students. These resources can include funding, faculty support, curriculum development, mentorship opportunities, and access to networks and facilities. Effective resource allocation ensures that entrepreneurship education programs are adequately equipped to provide students with the knowledge, skills, and support needed to succeed as entrepreneurs. By prioritizing resource allocation to areas such as experiential learning, incubation spaces, and networking events, institutions can create a vibrant ecosystem that nurtures innovation and encourages entrepreneurial ventures. This paper presents an innovative approach to optimizing the resource allocation of university innovation and entrepreneurship education through the application of a collaborative filtering algorithm, enhanced by Flemingo Optimized Collaborative Filtering Classification (FOCFC). The study aims to address the challenge of efficiently allocating resources such as funding, mentorship, and infrastructure to support innovation and entrepreneurship initiatives within universities. Through simulated experiments and empirical validations, the effectiveness of the FOCFC-enhanced collaborative filtering algorithm is evaluated in recommending resource allocations tailored to the unique needs and preferences of students and entrepreneurial ventures. Results demonstrate significant improvements in accuracy and efficiency compared to traditional methods, with the FOCFC model achieving a precision rate of 95% in recommending resource allocations. Additionally, the model provides valuable insights into emerging trends and opportunities in the innovation and entrepreneurship ecosystem, enabling universities to adapt their resource allocation strategies proactively. These findings highlight the potential of collaborative filtering algorithms with FOCFC in optimizing resource allocation for university innovation and entrepreneurship education, fostering a supportive and conducive environment for entrepreneurial success.