This paper uses concepts in strategic management and entrepreneurship cognition research to deepen understanding of the entrepreneur’s mental processes, when addressing strategic problems (issues). In this paper three main mental structures of the entrepreneur- thinking, forming and change, are envisaged, sixteen (16) propositions from which specific hypothesis can be developed for further research are proposed as well as four main questions, forming the basis of the entrepreneur’s cognition processes, when addressing strategic problems are envisaged. An explanatory conceptual framework describing the cognitive structures of the entrepreneur, when addressing strategic problems, is developed.