We processed the data recorded by 32 continuous GPS stations from the Crustal Movement Observation Network of China and combined them with published GPS observations in a common geodetic reference frame to better depict the ongoing crustal velocities and deformation field of Northeast Tibet. The derived velocity field indicates that the deformation of Northeast Tibet is characterized mainly by crustal shortening coupled with the eastward extrusion of crustal material and clockwise block rotation. We further used the GPS velocity field to evaluate the strain rate tensors by the method of Sandwell and Wessel (2016). The strain rate field shows an obvious transition of the contraction rate from NE-SW to NEE-SWW, and a decrease in the maximum shear strain rate from west to east was observed along the East Kunlun fault and Haiyuan fault, indicating that the block rotation and lateral extrusion therein may be partitioned by NE-SW-oriented compression to some extent. The inhomogeneity of the rotation strain rate implies that Northeast Tibet does not behave like a single rigid block but instead resembles a left-lateral shear zone, supporting the hypothesis that the northward transfer of motion along the East Kunlun fault may play a significant role in the deformation style of this area. The dilatation rate verified that most of Northeast Tibet experiences crustal thickening, which coincides with the average uplift rate of ~1 mm/y revealed by GPS velocities and channel steepness indices. We also estimated the geodetic moment rates and compared them with the seismic moment rates estimated using the truncated Gutenberg-Richter earthquake distribution. The ratio of the seismic strain rate to the geodetic strain rate in the regions near the Altyn Tagh fault, the Qaidam Basin adjoining the Qilian Mountains, the Haiyuan fault and the central part of the East Kunlun fault are near unity, indicating that the deformation in these areas is dominated by seismic release and may represent fully coupled seismogenic zones. The occurrence of large earthquakes in the past (estimated magnitudes M ≥ 6) coupled with a high geodetic deformation rate in these regions could indicate overdue M ≥ 6 earthquakes. However, other factors, including the occurrence of creep and the long recurrence time of Mw ≥ 8.0 earthquakes, should be taken into consideration along the Haiyuan fault. By contrast, in other regions, including the southern and eastern parts of the Haiyuan fault, along the Elashan fault, and the northern Qilian Mountains, the geodetic moment rate is higher than the seismic moment rate by a factor between 3 and 9. We propose that this phenomenon is related to the undersampling of long-term earthquake rates within the seismic catalogue, long-term aseismic crustal deformation, or a combination of these factors. Our study has implications for better comprehending the current seismotectonic pattern of Northeast Tibet.