Novel manufacturing process are more and more used to produce advanced structural materials such as the gamma titanium aluminide alloys (γ-TiAl). In this work we examine a Ti-48Al-2Cr-2Nb alloy obtained with an additive manufacturing technique by Electron Beam Melting (EBM) by conducting monotonic and cyclic loading experiments both on tension and compression samples to investigate the influence of the microstructure in strain accumulation process by fatigue loading. The residual strain maps corresponding to different applied stress levels, number of cycles and microstructures are obtained through the use of high- resolution Digital Image Correlation (DIC). The strain maps were overlaid with the images of the microstructure and detailed analyses were performed to investigate the features of the microstructure where high local strain heterogeneities arise. Such experiments, conducted ex-situ at room temperature, allow to characterize the effect of different microstructures on the strain accumulation process, providing additional information into the effect of the lamellar and equiaxed grains and also to capture the evolution of the local deformation process for TiAl. The measure of the residual strains provides further information on the role of the intermetallic phases on the fatigue behavior of γ-TiAl alloys. The comparison with the strain accumulation in fully lamellar microstructure with larger grain size permits to highlight the influence of the position of grain boundaries and the orientation of the lamellae for the onset of fatigue cracking. The analysis and comparison of the strain maps provide information for the selection of the microstructural parameters during material design (i.e. grain size and lamellar grains volume fraction).