Yttrium aluminum garnet (YAG)-based optical fiber is one of the research hotspots in the field of fiber lasers due to its combined advantages of a wide doping range of rare earth ions and the high mechanical strength of YAG material, as well as the flexibility and small size of the fiber structure. YAG-based optical fibers and related laser devices can be used in communication, sensing, medicine, etc. A comprehensive review of YAG-based optical fibers is provided in this paper. Firstly, the fabrication processes of YAG-based optical fibers are summarized and the structure and properties of fibers are classified and compared. Secondly, according to the optical wavelength regions, rare earth-doped YAG-based optical fibers for the applications of single-frequency and mode-locked fiber lasers are summarized. Lastly, the development challenges in both the fabrication and applications of YAG-based optical fibers are discussed.