Stop-signal Reaction Time Research Articles

Electrophysiological activity underlying motor inhibition facilitated by touch.

Tactile sensory information obtained from oneself or others may provide a calming effect and has been shown to enhance participants' motor control. The extent to which these touch activities may support motor inhibition and the related electrophysiological mechanisms remain unknown. Here, we investigated these effects in twenty healthy volunteers via electroencephalography under 3 touching conditions (self-touch, other-touch, and no-touch) during a stop-signal task. We found that both the self-touch and other-touch conditions resulted in better stopping accuracy and lower stop-signal reaction times than the no-touch condition. Additionally, these 2 touch conditions elicited larger N2 and P3 responses during successful inhibition of planned finger movements. Time-varying network analysis based on electroencephalography was further used to explore the differences in brain networks during conflict monitoring substages under different touch conditions. A top-down projection from the frontal cortex (Fz) to the parietal and occipital cortices was observed along with increased functional connectivity efficiency under touch conditions. These results indicate that tactile information may enhance neural processing efficiency in the human brain by eliciting larger event-related potential components and promoting information processing in the brain network during conflict monitoring processes, thereby contributing to the reactive inhibitory component of motor inhibition.

An exploration of relationships between associative and non-associative measures of inhibition.

Conditioned inhibition and occasion setting are two examples of inhibitory associative phenomena that have traditionally been studied in isolation from non-associative inhibition. Non-associative inhibition has been assessed using a variety of measures (e.g., stop signal reaction time and impulsivity questionnaires) and weak non-associative inhibition has been linked to a variety of disorders including addiction. However, even though both associative and non-associative inhibition have a common core-both involve suppression of behaviour, there has been relatively little study of potential relationships between these different forms of inhibition. In the current investigation, we carried out exploratory analyses to look for possible links between associative inhibition and four non-associative measures of inhibition, namely, (1) stop signal reaction time, (2) delay discounting, and scores on (3) the Behaviour Inhibition System/Behaviour Activation System and (4) Barratt Impulsivity questionnaires. Despite the fact that we carefully selected data to minimise noise in the measurement of associative inhibition, we found no clear evidence of links between associative and non-associative inhibition. We therefore conclude that while there may be superficial similarities between these different forms of inhibition they are likely to have different substrates.

How Do Common Marmosets Maintain the Balance Between Response Execution and Action Inhibition?

Socio-dynamic situations require a balance between response execution and action inhibition. Nonadaptive imbalance between response inhibition and execution exists in neurodevelopmental and neuropsychological disorders. To investigate the underlying neural mechanisms of cognitive control and the related deficits, comparative studies in human and nonhuman primates are crucial. Previous stop-signal tasks in humans and macaque monkeys have examined response execution (response time (RT) and accuracy in Go trials) and action inhibition (stop-signal reaction time (SSRT)). Even though marmosets are generally considered suitable translational animal models for research on social and cognitive deficits, their ability to inhibit behavior remains poorly characterized. We developed a marmoset stop-signal task, in which RT could be measured at millisecond resolution. All four marmosets performed many repeated Go trials with high accuracy (≥ 70%). Additionally, all marmosets successfully performed Stop trials. Using a performance-dependent tracking procedure, the accuracy in Stop trials was maintained around 50%, which enabled reliable SSRT estimates in marmosets for the first time. The mean SSRT values across sessions ranged between 677 and 1464 ms across the four marmosets. We also validated the suitability and practicality of this novel task for examining executive functions by testing the effects of a natural hormone, oxytocin, on response execution and action inhibition in marmosets. This marmoset model, for reliable (millisecond resolution) assessment of the balance between response execution and inhibition, will further facilitate studying the developmental alterations in inhibition ability and examining the effects of various contextual and environmental factors on marmosets' executive functions.

Unveiling the Distinctions: Computer Versus Sport-Specific Neurocognitive Tests.

Traditional assessments of high-order neurocognitive functions are conducted using pen and paper or computer-based tests; this neglects the complex motor actions athletes have to make in team ball sports. Previous research has not explored the combination of neurocognitive functions and motor demands through complex tasks for team ball sport athletes. The primary aim of the present study was to determine the construct validity of agility-based neurocognitive tests of working memory (WM) and inhibition. Twenty-seven athletes (5 females; mean age 24.2 [4.7]y; height 183.6 [9.1]cm; body mass 77.5 [11.2]kg) participated in the construct validity assessments that included computer-based tests (working memory capacity and stop-signal reaction time) and sport-specific assessments performed on the SpeedCourt system. Construct validity analysis of sport-specific working memory yielded acceptable construct validity (r = .465, P < .05), whereas the sport-specific stop-signal task resulted in low construct validity (r = .179, P > .05). The poor construct validity results highlight the large variance between computer-based and sport-specific neurocognitive assessments. Sport-specific assessments are more complex and include more degrees of freedom potentially due to athletes' center of mass displacement during task execution. These findings suggest that future research should focus more on the development of sport-specific assessments. These should include the cognitive and motor demands encountered during practice and competition, not use computer-based/pen and paper assessments for return to play decisions.

Neural markers of error processing relate to task performance, but not to substance-related risks and problems and externalizing problems in adolescence and emerging adulthood.

Detecting errors and adapting behavior accordingly constitutes an integral aspect of cognition. Previous studies have linked neural correlates of error processing (e.g., error-related negativity (ERN) and error-related positivity (Pe)) to task performance and broader behavioral constructs, but few studies examined how these associations manifest in adolescence. In this study, we examined neural error processing markers and their behavioral associations in an adolescent/emerging adult sample (N = 143, Mage = 18.0 years, range 11-25 years), employing a stop-signal task. Linear regressions were conducted using bootstrap resampling to explore associations between ERN/Pe peak amplitudes and latencies, stop accuracy, stop-signal reaction time (SSRT), and post-error slowing, as well as self-reported substance-related risks and problems and externalizing problems. After adjusting for age and sex, smaller frontocentral Pe amplitude and later Pe latency were associated with longer SSRT, and later Pe latency was associated with lower stop accuracy. This might indicate that the Pe, which is thought to reflect conscious error processing, reflects task performance on a response inhibition task better than the ERN, which reflects subconscious error processing. After correcting for multiple testing, there were no associations between ERN/Pe parameters and substance-related or externalizing problems, and no age interactions for these associations were detected.

The Impact of Dexamphetamine Treatment for Obesity on Executive Function: A Double-Blind Randomised Controlled Pilot Study.

Amphetamines increase dopamine levels in mid-brain regions which, in turn, impact top-down executive function. Repeated exposure is linked to substance use disorders. Nonetheless, amphetamines are used to manage attention-deficit/hyperactivity disorder (ADHD) and eating-related disorders. In ADHD, amphetamines upregulate a system characterised by low dopaminergic tone, assisting to improve executive function. A similar process might be at play with eating disorders; however, the effect of amphetamine treatment on executive function in this case has not been thoroughly considered. Participants (N = 52, Mage = 47.06, SD = 12.29) with a body mass index of 25-60 were randomised to treatment (6-week dexamphetamine titration) or control (placebo) groups. They completed an executive function measure-Barkley Deficits in Executive Functioning Scale (BDEFS-SF)-and response inhibition task-Stop-Signal Task (SST)-at Baseline, throughout titration, at Maintenance, and at Follow-up. Mixed effects models examined whether BDEFS-SF score or the SST variable, stop-signal reaction time (SSRT), changed across sessions as a function of treatment. There was no effect of group (p = 0.440), but an effect of session (p = 0.024) on BDEFS-SF, with scores at Time 2 (p = 0.011, 95% CI [0.47, 3.49]) and Maintenance (p = 0.022, 95% CI [-4.89, -0.39]), respectively, higher and lower than other timepoints. There was no group by session interaction (p = 0.659). R2 (conditional) = 0.74; ICC = 0.73. There was an effect of group (p = 0.039) and session (p < 0.001) on SSRT, but no interaction (p = 0.707). Baseline SSRT was significantly longer than the mean of all subsequent timepoints (p < 0.001, 95% CI [16.29, 33.84]). R2 (conditional) = 0.47; ICC = 0.39. There was no discernible impact of amphetamine treatment for obesity on executive function. Our results suggest some variation related to sample size and/or practice effects. Thus, while treatment appears unlikely to render individuals susceptible to substance use disorders, parallels with ADHD might be overstated.

Comparison of Cognitive Functions Between Individuals With Chronic Low Back Pain With High and Low Pain Catastrophizing and Pain-free Controls: A Cross-sectional Study.

Researchers suggested that the interruptive effects of chronic pain on cognitive functions may be modulated by the level of pain catastrophizing (PC). However, in individuals with chronic low back pain (CLBP), domains of cognitive function that may be affected by the level of PC remain largely unclear. Therefore, this study aimed to compare cognitive functions between individuals with CLBP with high and low PC and pain-free controls. This cross-sectional study examined cognitive functions of 42 individuals with CLBP and 21 pain-free controls. The PC scale was used to stratify participants with CLBP into high and low PC. Participants performed 5 cognitive tests from the Cambridge Neuropsychological Test Automated Battery, namely 5-choice reaction time, rapid visual processing, spatial working memory, attention switching task, and stop signal task. The statistical analyses revealed that compared with individuals with CLBP with low PC and pain-free controls, individuals with high PC demonstrated greater values of the between errors ( P =0.01), reaction latency ( P <0.001), and stop signal reaction time variables ( P =0.004, 0.003, respectively) but lower values of probability of hit ( P =0.02, 0.01, respectively), A' ( P =0.01, <0.001, respectively), and percent correct trials variables ( P =0.002, <0.001, respectively). The results of the current study showed deficits in sustained attention, working memory, cognitive flexibility, and inhibitory control in individuals with CLBP with high PC. From a clinical perspective, therapeutic interventions targeting PC should be considered to decrease catastrophic thinking about pain in individuals with CLBP. Additional research is warranted to explore cognitive functioning as an outcome of these interventions in individuals with CLBP.

Dorsolateral prefrontal cortex to ipsilateral primary motor cortex intercortical interactions during inhibitory control enhance response inhibition in open-skill athletes

Numerous studies have reported that long-term sports training can affect inhibitory control and induce brain functional alterations. However, the influence of environmental dynamics in sports training on inter-cortical connectivity has not been well studied. In the current study, we used twin-coil transcranial magnetic stimulation to investigate the functional connectivity between dorsolateral prefrontal cortex (DLPFC) and ipsilateral primary motor cortex (M1) during proactive and reactive inhibition in participants with sports skills in dynamic environment (open-skill experts), stable environment (closed-skill experts), and no sports skills (controls). Using a modified stop signal task, proactive inhibition was measured by the response delay effect (RDE), and reactive inhibition was measured by the stop-signal reaction time (SSRT). Intra-hemispheric DLPFC-M1 interactions and single pulse motor-evoked potentials (MEPs) were measured during the task. A stronger inhibitory effect of the DLPFC over M1 was observed during early reactive control stages compared to baseline levels. In addition, this inhibitory effect was pronounced when comparing open-skill experts to non-athlete controls, a relationship that was significantly correlated with superior reactive control performance. Furthermore, DLPFC to M1 influencing direction shifted from late proactive control to reactive control. Behavioral results also demonstrated enhanced proactive control abilities in open-skill experts relative to controls. Such enhancement may be due to the combination of environmental complexity and physical fitness in long-term skill training.

Developmental patterns of inhibition and fronto-basal-ganglia white matter organisation in healthy children and children with attention-deficit/hyperactivity disorder.

There is robust evidence implicating inhibitory deficits as a fundamental behavioural phenotype in children with attention-deficit/hyperactivity disorder (ADHD). However, prior studies have not directly investigated the role in which white matter properties within the fronto-basal-ganglia circuit may play in the development of inhibitory control deficits in this group. Combining recent advancements in brain-behavioural modelling, we mapped the development of stop-signal task (SST) performance and fronto-basal-ganglia maturation in a longitudinal sample of children aged 9-14 with and without ADHD. In a large sample of 135 ADHD and 138 non-ADHD children, we found that the ADHD group had poorer inhibitory control (i.e., longer stop-signal reaction times) across age compared to non-ADHD controls. When applying the novel parametric race model, this group effect was driven by higher within-subject variability (sigma) and higher number of extreme responses (tau) on stop trials. The ADHD group also displayed higher within-subject variability on correct responses to go stimuli. Moreover, we observed the ADHD group committing more task-based failures such as responding on stop trials (trigger failures) and omissions on go trials (go failures) compared to non-ADHD controls, suggesting the contribution of attentional lapses to poorer response inhibition performance. In contrast, longitudinal modelling of fixel-based analysis measures revealed no significant group differences in the maturation of fronto-basal-ganglia fibre cross-section in a subsample (74 ADHD and 73 non-ADHD children). Finally, brain-behavioural models revealed that age-related changes in fronto-basal-ganglia morphology (fibre cross-section) were significantly associated with reductions in the variability of the correct go-trial responses (sigma.true) and skew of the stop-trial distribution (tauS). However, this effect did not differ between ADHD and typically developing children. Overall, our findings support the growing consensus suggesting that attentional deficits subserve ADHD-related inhibitory dysfunction. Furthermore, we show novel evidence suggesting that while children with ADHD are consistently performing worse on the SST than their non-affected peers, they appear to have comparable rates of neurocognitive maturation across this period.

Impaired Reactive Control But Preserved Proactive Control in Hyperactive Children

Objective: To examine the manifestation of cognitive control deficit of children with different levels of hyperactivity, an “at risk” dimension for ADHD. Method: A group of children with high hyperactivity (N = 40) and another group of children with low levels of hyperactivity (N = 38) performed a modified stop-signal anticipation task, a revised Go/NoGo task, and the AX-continuous performance test (AX-CPT). Results: Children with higher levels of hyperactivity displayed: (1) significantly prolonged stop signal reaction time (SSRT) in the modified stop-signal anticipation task; (2) no notable differences in commission errors in the revised Go/NoGo task; (3) increased reaction time (RT) in stop-signal task and Go/NoGo task with increased probabilities of stop or NoGo signal; and (4) positive proactive behavioral index scores in AX-CPT. Conclusion: The results suggested that children with heightened hyperactivity exhibited impaired reactive control, especially for responses already underway, but preserved proactive control. Further studies concerning these children are warranted.

Cognitively engaging exercise predicts executive functioning on laboratory tasks

The cognitive engagement hypothesis claims that regular exercise must be cognitively engaging in order to benefit executive functioning. However, the available evidence for this hypothesis is circumstantial. Here we test it directly in two studies. In Study 1, 145 young adults first reported the extent to which their primary exercise and non-exercise leisure activities were cognitively engaging. They then completed two well-known laboratory tasks measuring executive function: a flanker task to index inhibitory control and a backward digit span task to assess working memory. Structural equation modeling revealed that when participants reported that their exercise relied on inhibitory cognitive control, they performed better on the flanker task, and, when their exercise demanded cognitive flexibility, they performed better on a backward digit task. These relationships did not hold for their primary reported leisure activity. Study 2 confirmed this finding with an independent sample of 227 undergraduates and two different executive function tasks: a stop-signal task to index inhibitory control and a trail making B task to assess cognitive flexibility. When participants reported that their regular exercise relied on inhibitory control they had faster stop-signal reaction times and made fewer trail making errors, and, when their exercise relied on cognitive flexibility, they had slower stop-signal reaction times and longer trail making B completion times. These relationships were again not found for participants’ leisure activities. These findings support the claim that exercise is associated with cognitive performance on laboratory tasks, provided the exercise is itself cognitively demanding.

Comparing self-other distinction across motor, cognitive and affective domains.

The self-other distinction (SOD) is a process by which humans disentangle self from other-related mental representations. This online study investigated two unresolved questions: (i) whether partially the same processes underpin SOD for motor, cognitive and affective representations, and (ii) whether SOD overlaps with domain-general cognitive control processes. Participants (N = 243) performed three SOD tasks (motor: automatic imitation inhibition (AIT); cognitive: visual perspective-taking (VPT); affective: emotional egocentricity bias (av-EEB) tasks) and two cognitive control tasks (Stroop and stop-signal reaction time (SSRT) tasks). Correlation analyses showed no associations among the motor, cognitive and affective SOD indexes. Similarly, distinct SOD clusters emerged in the hierarchical clustering dendrogram, indicating clear separations among SODs. However, the results of multidimensional scaling suggested a tendency towards two clusters, as evidenced by the proximity of AIT and VPT indexes in relation to EEB indexes. AIT spatial laterality and Stroop domain-general cognitive control confounded AIT and VPT indexes, albeit slightly differently depending on the analysis method used. SSRT showed neither associations with SODs nor with other domain-general indexes. These findings underscore the complexity of SOD processes and have notable implications for basic and applied research, e.g. in the domain of clinical disorders affected by deficiencies in SOD.

Acute immune system activation exerts time-dependent effects on inhibitory control: Results of both a randomized controlled experiment of influenza vaccination and a systematic review and meta-analysis – ISPNE 2024 Dirk Hellhammer Award

Although coming down with an illness or receiving a vaccine are both common experiences, the influence of such acute immune system activations on cognitive processes, such as inhibitory control, has received relatively little attention. We addressed that issue by assessing the effects of acute immune system activation on inhibitory control in a randomized controlled experiment, and by conducting a meta-analysis of similar studies in humans. In our experiment, we found—somewhat surprisingly—that influenza vaccination improved performance on both of our inhibitory control outcomes (i.e., stop-signal reaction times and flanker interference effects). At the meta-analytic level, we found that at a short delay (1.5–4 hours post-injection) between immune activation and inhibitory control assessment, such activation impaired multiple forms of inhibitory control, whereas after a longer delay (e.g., > 18 hours post-injection), such activation improved inhibitory control—consistent with our experiment. Moreover, proinflammatory cytokine activity predicted poorer interference control but better response inhibition, even with a long delay between injection and testing. Together, these results highlight nuanced, time-dependent, and—perhaps—multiple-mechanism-driven effects of acute immune system activity on inhibitory control.

Development of an Effector-Specific Stop Signal Task with Higher Complexity: A Proof-of-Concept Study

The present study aims to develop and present a proof-of-concept for a stop signal task with effector-specificity and higher complexity. Sixteen participants performed a stop signal task developed for lower extremities using Fitlight System™. The effect of four different delays and two sessions on response time, stop signal reaction time and accuracy was assessed using two-way repeated-measures ANOVA. The reliability of outcomes was assessed using intraclass correlation coefficients. There was a significant main effect of delay on all outcomes and an interaction of delay and session on accuracy. The reliability of outcomes was substantial with dependency on delays. Our preliminary findings suggest the feasibility of stop signal principles within more complex movements and provide an example for the development of further tests in sports context.

The causal role of the subthalamic nucleus in the inhibitory network.

The neural network mediating successful response inhibition mainly includes right hemisphere activation of the pre-supplementary motor area, inferior frontal gyrus (IFG), subthalamic nucleus (STN), and caudate nucleus. However, the causal role of these regions in the inhibitory network is undefined. Five patients with Parkinson's disease were assessed prior to and after therapeutic thermal ablation of the right STN in two separate functional magnetic resonance imaging (fMRI) sessions while performing a stop-signal task. Initiation times were faster but motor inhibition with the left hand (contralateral to the lesion) was significantly impaired as evident in prolonged stop-signal reaction times. Reduced inhibition after right subthalamotomy was associated (during successful inhibition) with the recruitment of basal ganglia regions outside the established inhibitory network. They included the putamen and caudate together with the anterior cingulate cortex and IFG of the left hemisphere. Subsequent network connectivity analysis (with the seed over the nonlesioned left STN) revealed a new inhibitory network after right subthalamotomies. Our results highlight the causal role of the right STN in the neural network for motor inhibition and the possible basal ganglia mechanisms for compensation upon losing a key node of the inhibition network.

Effects of bilateral tDCS over DLPFC on response inhibition, craving, and brain functional connectivity in Internet gaming disorder: Arandomized, double-blind, sham-controlled trial with fMRI.

Impaired inhibitory control accompanied by enhanced craving is hallmark of addiction. This study investigated the effects of transcranial direct current stimulation (tDCS) on response inhibition and craving in Internet gaming disorder (IGD). We examined the brain changes after tDCS and their correlation with clinical variables. Twenty-four males with IGD were allocated randomly to an active or sham tDCS group, and data from 22 participants were included for analysis. Participants self-administered bilateral tDCS over the dorsolateral prefrontal cortex (DLPFC) for 10 sessions. Stop-signal tasks were conducted to measure response inhibition and participants were asked about their cravings for Internet gaming at baseline and post-tDCS. Functional magnetic resonance imaging data were collected at pre- and post-tDCS, and group differences in resting-state functional connectivity (rsFC) changes from the bilateral DLPFC and nucleus accumbens were examined. We explored the relationship between changes in the rsFC and behavioral variables in the active tDCS group. A significant group-by-time interaction was observed in response inhibition. After tDCS, only the active group showed a decrease in the stop-signal reaction time (SSRT). Although craving decreased, there were no significant group-by-time interactions or group main effects. The anterior cingulate cortex (ACC) showed group differences in post- versus pre-tDCS rsFC from the right DLPFC. The rsFC between the ACC and left middle frontal gyrus was negatively correlated with the SSRT. Our study provides preliminary evidence that bilateral tDCS over the DLPFC improves inhibitory control and could serve as a therapeutic approach for IGD.

Acute effects of a vigorous-intensity warm-up on response suppression and decision-making of football referees

ABSTRACT This study investigates the acute effect of physical exercise simulating a standard pre-competitive warm-up on the response suppression and decision-making of football referees. Thirty-four referees (n = 17 – regional level; n = 17 – national level) participated in the study. A Stop-Signal Task (SST) and a decision-making video test were used to evaluate the referees’ perceptual-cognitive functions. The findings revealed that the vigorous aerobic exercise acutely impacted basic cognitive functions, as indicated by decreased reaction time and decreased choice accuracy. However, higher-order cognitive functions such as response suppression and decision-making did not exhibit significant changes post-exercise. Based on these results, there is no evidence to suggest that a vigorous-intensity warm-up is likely to favour response suppression and decision-making factors in the initial phases of the game. National referees showed superior response suppression abilities (shorter stop-signal reaction times and lower probability of responding to the stop-signal) than regional referees, indicating that higher-level referees possess enhanced perceptual-cognitive skills, likely influenced by their experience. Further studies are required to determine whether these variables can be acutely improved through physical exercise. In this regard, our results suggest the need for alternative strategies in pre-competitive referee warm-ups if aiming to improve perceptual-cognitive skills in the initial phases of the game.

Extended ambulatory assessment of executive function: within-person reliability of working memory and inhibitory control tasks

ABSTRACT Introduction Ambulatory assessment of executive function – particularly in the form working memory (WM) – is increasingly common. Few studies to date, however, have also incorporated ambulatory measures of inhibitory control. Critically, the extended within-person reliability of ambulatory tasks tapping each of these constructs has been largely overlooked. Method Participants (N = 283, M age = 23.74 years, SD = 9.04) received notifications every 3 days (for 4 weeks) to undertake ambulatory assessment versions of the n-Back and Stop-Signal Tasks (SST) via the smartphone application CheckCog. Within-person reliability of these measures was explored. Results Compliance ranged from 66% (for eight sessions) to 89% (for four sessions). Our results reveal significant changes in performance within the first two sessions for both the n-Back and SST, with performance remaining largely consistent across the remaining (two to eight) sessions. In terms of test–retest reliability, the ICC (C, 1) values ranged from .29 to .68 on the n-Back (with overall accuracy being .51) and .31–.73 on the SST (with stop-signal reaction time being .53). Conclusion The results of the current study contribute to the literature by demonstrating the reliability of brief measures of executive function – in the form of inhibitory control and WM – delivered using smartphones in participants’ natural environments. Based on our findings, the CheckCog app reliability tracks baseline systematic changes in WM and response inhibition across multiple time points and for an extended period in healthy individuals.

Network-targeted transcranial direct current stimulation of the hypothalamus appetite-control network: a feasibility study.

The hypothalamus is the key regulator for energy homeostasis and is functionally connected to striatal and cortical regions vital for the inhibitory control of appetite. Hence, the ability to non-invasively modulate the hypothalamus network could open new ways for the treatment of metabolic diseases. Here, we tested a novel method for network-targeted transcranial direct current stimulation (net-tDCS) to influence the excitability of brain regions involved in the control of appetite. Based on the resting-state functional connectivity map of the hypothalamus, a 12-channel net-tDCS protocol was generated (Neuroelectrics Starstim system), which included anodal, cathodal and sham stimulation. Ten participants with overweight or obesity were enrolled in a sham-controlled, crossover study. During stimulation or sham control, participants completed a stop-signal task to measure inhibitory control. Overall, stimulation was well tolerated. Anodal net-tDCS resulted in faster stop signal reaction time (SSRT) compared to sham (p = 0.039) and cathodal net-tDCS (p = 0.042). Baseline functional connectivity of the target network correlated with SSRT after anodal compared to sham stimulation (p = 0.016). These preliminary data indicate that modulating hypothalamus functional network connectivity via net-tDCS may result in improved inhibitory control. Further studies need to evaluate the effects on eating behavior and metabolism.

Effect of emotional stimulus on response inhibition in people with mild cognitive impairment: an event-related potential study.

A few studies are emerging to explore the issue of how aging promotes emotional response inhibition. However, there is a lack of empirical study concerning the impact of pathological cognitive impairment on emotional response inhibition. The present study investigated the effect of emotion on response inhibition in people with mild cognitive impairment, the stage of cognitive impairment before dementia. We used two emotional stop-signal tasks to explore whether the dual competition framework considering limited cognitive resources could explain the relationship between emotion and response inhibition in mild cognitive impairment. The results showed that negative emotions prolonged N2 latency. The Go trial accuracy was reduced in the high-arousal negative conditions and the stop-signal reaction time was prolonged under high-arousal conditions. This study also verified impaired response inhibition in mild cognitive impairment and found that negative emotions prolonged P3 latency in mild cognitive impairment. Emotional information interferes with response inhibition in mild cognitive impairment populations, possibly because emotional information captures more attentional resources, thus interfering with response inhibition that relies on common-pool resources.