Hybrid modelling is classically defined as the coupling of a continuous approach with a discrete one, in order to model a (complex) phenomenon that cannot be described in a standard homogeneous way. This is often the case with multiscale phenomena, where the most macroscopic part usually have a continuous nature (chemical fields, concentration of populations, etc) whereas the microscopic part reveals the discrete nature of its elements (particles, individuals, etc). Consequently, hybrid models usually take the form of a system of partial differential equations (PDEs, e.g. for reaction-diffusion equations), or a system of ordinary differential equations (ODEs, e.g. for kinetics reactions), coupled with an individual based model, such as a cellular automaton (CA) or an agent-based model (ABM) both operating from a set of either deterministic or stochastic rules. In a wider sense, hybrid modelling corresponds to any mixed approaches and this includes, for example, the coupling of deterministic and stochastic models which can either be discrete or continuous. Back to the nineties, mathematical biology was mostly dominated by the use of PDEs and ODEs, i.e. continuous models of equations. The rise of discrete approaches occurred from this period and it coincides with the evolution of processors and the resulting computing capabilities of desktop computers that have permitted to simulate scientifically relevant discrete models. The shift from pure mathematical approaches (mostly continuous) to more computational approaches (mostly discrete) is observed from those years, and correspond to the emergence of a still growing number of hybrid models. We observe that as a consequence mathematical biology has, through the recent years, been overwhelmed by computational biology. Multiscale modelling, and hence the development of hybrid models, was especially stimulated in the context of systems biology. This consists in studying a phenomenon as a whole, requiring the integration of the spatial scales from molecules (nanometre) to organs (centimetre) and temporal scales from reaction kinetics (microsecond) to developmental scales (months to years), rather than considering the phenomenon at the different scales independently, which would provide too little insights and make no sense in modern biology. In cell biology, hybrid modelling has permitted to reach a higher level of understanding between experimentalists and theoreticians, since the level of abstraction in the discrete part of the models is often lower. It usually consists in the definition of a set of rules that are based on direct experimental observations or measurements. It then makes it easier to compare both qualitatively and
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