To enhance food safety, whole carcass decontamination during slaughter has been considered as a control measure to reduce pathogen concentrations on meat. The effect of such decontamination is usually measured in terms of the mean log reduction in concentration. However, the variation in this reduction may also contribute to the overall impact of the decontamination measure. Therefore, this study focuses on the relative contribution of mean and variation for the effect of decontamination in the slaughter-line expressed in terms of the effect on human health risk.A stochastic risk model is developed to assess the potential effects of pig carcass decontamination at the end of slaughter on the risk of salmonellosis for Danish consumers. Salmonella concentrations are represented by a lognormal distribution fitted to microbiological data, characteristic for Salmonella numbers on carcasses at the end-point of Danish slaughterhouses. Decontamination scenarios are represented by various gamma distributions with different means and standard deviations. The values chosen for these parameters are based on experimental data of the effect of real decontamination procedures applied to pork.Results show that the variation of decontamination has a relevant effect on risk reduction for the consumer: the higher the variation, the lower the overall risk reduction. This effect is particularly evident for procedures with a lower mean reduction (≤2.5 log10), but less so for highly efficient decontamination procedures (>2.5 log10 mean reduction). This difference is affected by the initial level of carcass contamination with Salmonella. With increasing mean and standard deviation of initial bacterial concentrations, it becomes increasingly relevant to account for the variation of the decontamination action, even if the mean decontamination effect is high.We conclude that for decontamination procedures with an overall mean reduction effect of 1–2 log10, it is important to consider the variation in effect: if the variation is large, the final effect of decontamination can be considerably smaller than expected on the basis of the mean only and efforts should be put in place to reduce the variation of the procedure. However, when a treatment of high mean reduction (>2.5 log10) is used, the impact of variation becomes smaller and may be negligible.