Stochastic Lung Model Research Articles

Monte Carlo Model for Aerosol Deposition in Human Lungs

A stochastic lung model and a computer code based on it have been developed for the calculation of inhalation, deposition, and exhalation of aerosol particles in human lungs. This stochastic model reflects the variability of the structural components of the lung. The structure of the model, the features of the computer program, the required input data and some illustrative preliminary results are presented in this paper.

Aerosol deposition calculations with a stochastic lung model

Inhalation, deposition and exhalation of aerosol particles in the human respiratory tract are computed by the Monte Carlo code IDEAL. The random selection of the diameters, lengths and branching angles of the tubes is based on statistical analysis of the largest data base available. Deposition probabilities are determined analytically. Sensitivity of the deposited fraction to the variation of several geometrical parameters is studied.

Analysis of human lung morphometric data for stochastic aerosol deposition calculations

A stochastic lung model is proposed for aerosol deposition calculations. Airway geometry is selected randomly to reflect intrasubject variations in the human airway system. This may also be justified to take intersubject variations into account. The statistical analysis of the human airway geometry used is based on morphometric data measured at the Lovelace Inhalation Toxicology Research Institute. Average values and distributions of airway diameters and lengths, distributions of branching angles and criteria for determination of the pathway (when the alveolar region is reached) are presented. Correlations between the cross sections of tubes of succeeding generations and those between diameters and lengths of the same generation are also given.