Resolution Of Stimulation Research Articles

Optimization of cochlear implant stimulation resolution using an intracochlear electric potential model

Designing an electrode array with a high stimulation resolution (SR) is the main challenge in cochlear implant development. In this work, a thin-film electrode array (TFEA) and partial tripolar (pTP) mode were combined in the design stage to optimize the SR. A finite-element model of the intracochlear electric potential Ve incorporating a TFEA and pTP mode was built and validated using previous experimental measurements. Based on this model, the SR was analyzed by using a defined stimulation factor Vs, which takes both the amplitude and bandwidth of Ve into account. A co-simulation method integrating the model and genetic algorithm was employed to maximize Vs with an optimized parameter set including the electrode diameter d, electrode interval g, and compensation coefficient σ. The results indicated that a TFEA combined with pTP mode outperforms their individual utilization to improve the SR and that d has an independent negative correlation with the SR, but it is more effective and feasible to consider all three parameters in the design stage with the proposed model and co-simulation optimization method. In our design, the optimized parameters were d = 150 μm, g = 200.5 μm, and σ = 0.746.