Refractory epilepsy poses a significant challenge in neurology due to approximately 30% of patients being resistant to conventional pharmacological treatments. This study investigates the efficacy and safety of vagus nerve stimulation (VNS) as a therapeutic alternative for these patients. The primary objective is to analyze the reduction in seizure frequency and improvements in the quality of life of patients treated with VNS. Additionally, the study aims to identify and categorize the side effects associated with the use of VNS. The methodology adopted included a qualitative bibliographic review covering renowned databases such as Scielo, Google Scholar, specialized scientific journals, academic repositories, and virtual libraries. Inclusion criteria considered studies that directly addressed the use of VNS in the treatment of epilepsy, while exclusion criteria eliminated duplicate and methodologically inadequate publications. Results indicate that VNS is effective in reducing seizures and improving quality of life, despite potential side effects. It is concluded that VNS is a viable and cost-effective therapeutic option for patients with refractory epilepsy, highlighting the need for future research to optimize stimulation parameters and minimize adverse effects.