Stimulation Of Exocrine Secretion Research Articles

An increase of tissue cyclic AMP level by adenosine in the dog pancreas without stimulation of exocrine secretion.

In the vascularly isolated and self-hemoperfused dog pancreas, secretin (0.025 clinical units) and adenosine (1.0 mg) administered intra-arterially (i.a.) increased tissue cyclic AMP level by about 46% and 37%, respectively. Although the increases in the nucleotide were not statistically different, only secretin stimulated exocrine secretion. The increase in cyclic AMP induced by adenosine was significantly reversed by pretreatment with theophylline (0.3 mg, i.a.). These results suggest that the effect of adenosine on cyclic AMP formation occurs mainly in the non-exocrine system of the dog pancreas through A2/Ra-receptors.

An Increase of Tissue Cyclic AMP Level by Adenosine in the Dog Pancreas without Stimulation of Exocrine Secretion

An Increase of Tissue Cyclic AMP Level by Adenosine in the Dog Pancreas without Stimulation of Exocrine Secretion

Gastrin-releasing peptide: effect on exocrine secretion and release from isolated perfused porcine pancreas.

The effect of gastrin-releasing peptide (GRP) on pancreatic exocrine secretion was studied by infusing it at four dose levels (0.01, 0.1, 1.0, and 10 nmol/l) into the arterial line of the isolated perfused porcine pancreas. At 1.0 nmol/l GRP stimulated protein (37-fold), fluid (13-fold), and bicarbonate secretion (12-fold). Atropine at 1 mumol/l diminished the protein secretion in response to infusion of GRP at a dose of 1 nmol/l to 45% of control. Fluid and bicarbonate responses were not affected by atropine treatment. Electrical stimulation of the vagus nerves resulted in an increase in pancreatic output of GRP and a concomitant stimulation of exocrine secretion. Infusions of acetylcholine, carbachol, pilocarpine, or dimethylphenylpiperazinium had no effect on the output of GRP, although hexamethonium abolished the response to vagal stimulation. It is concluded that GRP in conjunction with acetylcholine is likely to play a prominent part in parasympathetic regulation of pancreatic exocrine secretion.

The relationship between the secretion of amylase and epidermal growth factor in the mouse submandibular salivary gland

Isoprenaline, a stimulant of exocrine secretion by the submandibular salivary glands of mice, does not produce depletion of the glandular epidermal growth factor. This supports the proposition that salivary glands in rodents may have an endocrine-like as well as an exocrine function.

Lipoprotein lipase activity in the dog pancreas and pancreatic juice.

Summary1. Lipoprotein lipase (LPL) activity was demonstrated in canine pancreatic juice and pancreas. 2. The LPL activity of the pancreatic juice was augmented by stimulation with secretin and pancreozymin, the known hormonal stimulants of exocrine secretion of the pancreas. 3. An inhibitor(s) of the pancreatic LPL activity was suggested by dilution studies in pancreatic juice and in the pancreas. 4. The possible relationship of the pancreatic LPL activity and its inhibitor(s) to the lipemia accompanying acute pancreatitis is discussed.