The Government of Uganda (GoU) has prioritized Science, Technology, and Innovation (STI) in its pursuit of a knowledge-based economy. While scholars have identified a positive association between innovation investment and performance, the role of R&D grants and investment in the commercialization of innovations and their influence on innovation performance require further clarification. The objective of this study is to examine the contribution of R&D funding and investment to the commercialization of innovations in Uganda. A qualitative research method was employed using case study and interview approaches. This method involves gathering various types of evidence including document reviews, field visits, and interviews with key informants and focus groups. Data analysis was conducted by matching themes derived from document reviews, case studies, and interviews. The study findings highlight the need for GoU to prioritize institutional development, address structural problems to innovation input, promote talent flow, and rationally build regional knowledge value chains to improve innovation and commercialization efficiency. The Uganda National Council for Science and Technology (UNCST) must maintain momentum in gathering STI indicators to support the evidence-based formulation of effective STI policies. This study provides theoretical and policy-oriented insights by emphasizing the significance of R&D funding and investment in facilitating the commercialization of innovations in Uganda.
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