Introduction THROUGH their classical investigations concerning the analysis of bone form and bone transformation, Wolff and the earlier writers in the second half of the last century presented us with an understanding of bone architecture. Surprisingly enough this has never been followed by a systematic and detailed analysis of the skeleton as it presents itself in the living by means of the x-ray method. Here we see the three dimensions of bodily form, lacking depth, projected on the film in two planes only, thus making definition of the bony pattern an object of special analytical investigation. While study of the x-ray pattern of bones is based essentially on analysis of the bone architecture advanced by anatomists, roentgenology may, on the other hand, furnish information valuable to the anatomist. An impression of “the typical” (Francke) features of bone architecture, which cannot be secured by study of separate bone sections, will be produced by an x-ray image, which is the resultant of all the superimposed layers of bone in a given projection. Furthermore, radiographic study is the only method of analysis of normal and pathologic bone structure in the living, and in valuable anatomical specimens which should not be subjected to dissection. Most authors who have concerned themselves with interpretation of the x-ray pattern of bones have used the method of comparative study of object and radiogram. This in itself proved insufficient to solve the more difficult problems of radiographic analysis. The study of Spalteholz specimens, i.e., of bones made translucent by chemical treatment, while of distinct advantage in the analysis of radiograms, is of limited value for many of the problems of this paper. Besides, good results on larger and more complicated adult bones are hard to obtain and the specimens on the market are rather expensive. Stereography, although well fitted to give us an image comparable to the true object, is also unable to supply us with exact information as to the anatomical substrate of a certain line in the x-ray film. “Summation pictures cannot be united to a stereo effect since the real points pertaining to them are present neither on the picture nor in the object” (Francke). The object of the present report is the systematic analysis of the roentgenogram of the knee joint which requires detailed study on account of its complicated appearance and the clinical importance of the region. Methods of Study Four experimental methods of x-ray analysis were utilized. Roentgenograms were made before and after the following procedures: (1) Chemical decalcification of the bony cortex or the spongious structure. Details of this method, which was used to determine the limitations of x-ray diagnosis of osteoporosis, are discussed in a previous paper (Lachmann and Whelan).