The aim of this study was to exploit mango peel waste (Mangifera indica L.) to obtain bioactive extracts. Mango peel waste was subjected to two sequential extraction steps: supercritical CO2 extraction (ScCO2), followed by pressurized ethanol (PE) from the residue of the first stage. Both extractions were carried out at 30 MPa and 40 °C.The extracts obtained were evaluated by spectrophotometric method in terms of Total Carotenoids Content (TCC), Total Phenolic Content (TPC), Total Flavonoids Content (TFC); and Antioxidant Activity (%AA) by DPPH method. Were performed in duplicate; an ANOVA and Tukey test were used. Results demonstrated that TCC value is dependent on the solvent, being high for ScCO2 with carotenoids contents of 5604.61 ± 0.51 μg β-carotene/g db in contrast to PE. Results showed that combination of extraction methods achieves satisfactory results and suggests the potential use of this residue.