Step In Production Research Articles

Comparison of different characterization approaches for monoelemental calibration solutions at two national metrology institutes.

Monoelemental calibration solutions are the most common reference in elemental analysis, linking measurement results to the International System of Units (SI). National Metrology Institutes (NMI) prepare these solutions as certified reference materials (CRM) and determine their elemental mass fraction with high accuracy. Characterization with high accuracy is one of the most critical steps in CRM production. This report compares the approaches taken by the NMIs of Türkiye (TÜBİTAK-UME) and Colombia (INM(CO)) in preparing and characterizing cadmium calibration solutions with a nominal value of 1 g kg-1. Each NMI produced CRMs using an independent batch of cadmium calibration solution and assigned mass fraction values to both their own solutions and those of the other NMIs. TÜBİTAK-UME employed a primary difference method (PDM) to assess the purity of a cadmium metal standard, quantifying all possible impurities using a combination of instrumental analytical techniques. The defined purity standard was used for both the gravimetric preparation of the CRM and the calibration of high-performance inductively coupled plasma optical emission spectrometry (ICP-OES) measurements. On the other hand, INM(CO) used gravimetric titration with EDTA to assay cadmium in the CRM solutions. The EDTA salt was previously characterized by titrimetry. Despite the fundamentally different measurement methods and independent metrological traceability paths to the SI, the measurement results exhibited excellent agreement within the stated uncertainties. This comparative analysis demonstrates the effectiveness of varied characterization approaches and underscores the reliability of the cadmium calibration solutions prepared by TÜBİTAK-UME and INM(CO). This collaborative effort highlights the reliability and adaptability of various measurement techniques in fulfilling rigorous metrological standards for elemental calibration solutions. Furthermore, this approach enhances the robustness of the measurements in the field of elemental analysis and contributes traceability to the SI.

Lacto-Fermented Fruits and Vegetables: Bioactive Components and Effects on Human Health.

Lacto-fermented fruits and vegetables (FVs) such as kimchi, sauerkraut, and fermented olives and nonalcoholic juices have a long history as dietary staples. Herein, the production steps and microbial ecology of lacto-fermented FVs are discussed alongside findings from human and laboratory studies investigating the health benefits of these foods. Lacto-fermented FVs are enriched in bioactive compounds, including lactic and acetic acids, phenolic compounds, amino acid derivatives such as indole-3-lactic acid, phenyl-lactic acid, γ-aminobutyric acid, and bacteriocins, and beneficial live microbes. At least 11 human studies have been performed on kimchi, whereas others have been investigated in only one or two trials. Besides exploring the health benefits, it is imperative to ensure that these foods made either commercially or at home have minimal risk for foodborne illness and exposure to undesired compounds like biogenic amines. Development of starter-culture strains and production protocols can lead to lacto-fermented FVs designed for specific health benefits.

Back electron transfer

AbstractSome photochemical synthesis methods are hampered by back electron transfer, an unproductive relaxation pathway. To prevent this, scientists have identified strategies to promote productive reaction steps: these include leaving groups, redox auxiliaries, and electrostatic interactions.

Process-level emission analysis and decarbonization pathway for BF-BOF route in Indian iron and steel industry

The blast furnace-basic oxygen furnace (BF-BOF) route contributes 46% to the production of iron and steel in India and is highly energy and emission-intensive. Its decarbonization needs to be prioritized for reducing long-term climate-related impacts. So far, studies have assessed the macro-level carbon emission and energy consumption of the entire industry (encompassing all production routes i.e., BF-BOF, EAF, DRI, SR-BOF, etc.), and lacks the specific plan for decarbonization of plants based on BF-BOF route. Secondly, these studies have focused on just a single input (raw material, energy, fuel, etc.) and the respective output (steel) and lack the analysis of detailed process-wise material and energy flow and consideration of fugitive emissions, which is needed for emission mitigation of entire BF-BOF based plants, which produces 57.37 million tons of crude steel in India. The current study addresses this gap through a case study of a BF-BOF-based plant by comprehensively analyzing the material and energy flow for each production step followed by assessing the respective carbon emissions. Further, a marginal abatement cost curve (MACC) is developed to identify the process-wise cost-effective mitigation measures. The current study shows that the implementation of proposed measures can significantly reduce carbon emissions from 3.3 to 2.43 tCO2/tcs, making it equal to the global counterparts.

Identifying and Reducing Waste in the Chicken Carcass Production Process at PT. Ciomas Adisatwa

PT. Ciomas Adisatwa unit Berbah is one of the Poultry Slaughterhouses (PSh) in Yogyakarta, producing 2,000 chickens/hour. However, some production steps do not increase the value of the finished product. Because of that, wasteful and non-value-added production processes must be eliminated to reduce the risk of contamination in PSh products and make the production process more efficient. Therefore, this study aims to identify the causes of waste and find an appropriate system to reduce the waste process. The methods used in this study include the Value Stream Analysis Tools (VALSAT) technique and future state mapping. Lean manufacturing is a concept used to reduce or eliminate waste in a production process. The wastes identified in the PT Ciomas Adisatwa production process include waiting activity, inappropriate processing, and unnecessary motion. The material weighing process identified the waiting activity because it was waiting for the Delivery Order (DO). Inappropriate processing occurs in hair removal rework in a clean area. The third waste is unnecessary motion, movement that is not needed occurs in cutting operators and dirty processes. The proposed improvements to address these wastes include enhancing the integration of information flow systems using a computer network, adding a plucker machine, and clarifying the division of tasks for each workstation to avoid unnecessary motion.

Metamaterial-based injection molding for the cost-effective production of whole cuts

The escalating global demand for meat products has intensified ecological concerns, underscoring the need for sustainable meat alternatives. Although current methods effectively imitate ground meat, mimicking whole cuts, which constitute 54% of the global market, remains challenging due to the lack of scalable technology. Injection molding is a massively scalable manufacturing technology developed for the polymer industry. Here, we introduce two injectable metamaterials: a thermally irreversible fat composite we named proteoleogel, and a multi-scaled meat analog produced by low-temperature extrusion. Viscoelastic screening of plant proteins identifies mung bean for its ability to stabilize complex oleogel structures, mimicking the mechanics of adipose tissue. Mechanical analysis reveals that low-temperature extrusion produces microscale isotropic fibers and mesoscale anisotropic structures mimicking muscle and fascia. These metamaterials can be injection-molded into various whole cuts, from chops to T-bones. Blinded taste tests indicate a 43% preference for our plant-based steak analog. Moreover, technical economic analysis shows injection molding is more cost-effective than 3D printing, costing $9/kg compared to $38/kg. This research represents a step in sustainable food production, offering cost-effective and scalable solutions for the entire meat market.

A detailed kinetic model of Eastern equine encephalitis virus replication in a susceptible host cell.

Eastern equine encephalitis virus (EEEV) is an arthropod-borne, positive-sense RNA alphavirus posing a substantial threat to public health. Unlike similar viruses such as SARS-CoV-2, EEEV replicates efficiently in neurons, producing progeny viral particles as soon as 3-4 hours post-infection. EEEV infection, which can cause severe encephalitis with a human mortality rate surpassing 30%, has no licensed, targeted therapies, leaving patients to rely on supportive care. Although the general characteristics of EEEV infection within the host cell are well-studied, it remains unclear how these interactions lead to rapid production of progeny viral particles, limiting development of antiviral therapies. Here, we present a novel rule-based model that describes attachment, entry, uncoating, replication, assembly, and export of both infectious virions and virus-like particles within mammalian cells. Additionally, it quantitatively characterizes host ribosome activity in EEEV replication via a model parameter defining ribosome density on viral RNA. To calibrate the model, we performed experiments to quantify viral RNA, protein, and infectious particle production during acute infection. We used Bayesian inference to calibrate the model, discovering in the process that an additional constraint was required to ensure consistency with previous experimental observations of a high ratio between the amounts of full-length positive-sense viral genome and negative-sense template strand. Overall, the model recapitulates the experimental data and predicts that EEEV rapidly concentrates host ribosomes densely on viral RNA. Dense packing of host ribosomes was determined to be critical to establishing the characteristic positive to negative RNA strand ratio because of its role in governing the kinetics of transcription. Sensitivity analysis identified viral transcription as the critical step for infectious particle production, making it a potential target for future therapeutic development.

Characterization of Andiroba Oil Production (Carapa guianensis AUBL.) Of Riverside Women Communities of Mutuacá Island, Cametá-PA

Objective: This study aimed to understand the importance of andiroba oil production by riverside women of Mutuacá island from the municipality of Cametá-PA in addition to describe the oil production steps. Theoretical Framework: Extractive process was understood as first form of economic exploitation, limiting the collection of products existing in nature, with low productivity mainly in off-season of product, the need to rationalization and source in income for traditional populations of the riverside areas. Method: The construction and production of information and data methodology adopted was qualitative and quantitative research modality. Data collection was conducted by participant observation and open-ended interviews. It was possible to identify and describe the artisanal extraction of andiroba oil process and its importance in the riverside women´s lives. The research included on 26 women extractivists participation who worked in the collection and processing of seeds. Results and Discussion: The results obtained revealed that age range of extractivists varied within the 21 to 60 years old, that in all production stages, female gender stands out considerably and that the peak of seed fall occurs in December month, the rainiest time of the year, when the açaí fruit harvest is ending. Research Implications: The research stands out that women extractivists have taken the role over main character in andiroba oil production, which involves on female empowerment, good seed processing practices and financial management. Originality/Value: This study contributes to use of good management practices to facilitate licensing, certification and improvement of quality seals, making the product and by-products more valued, thus guaranteeing financial resources for the sustenance of riverside families.

Economic and Environmental Impact Analysis of Innovative Peeling Methods in the Tomato Processing Industry

Peeling is a key step in the industrial production of canned peeled tomatoes, vital for optimizing efficiency, yield, product quality, waste reduction, and environmental impact. This study presents a comparative assessment of the economic and environmental impacts of adopting innovative peeling technologies, including infrared (IR), ohmic heating-assisted lye (OH-lye), and ultrasound-assisted lye (US-lye) peeling, relative to conventional steam and lye peeling methods. Focusing on a medium-sized Italian tomato processor, the impacts of these methods on productivity, water and energy consumption, wastewater generation, and environmental footprint using Life Cycle Assessment (LCA) methodology, were evaluated. Findings indicated that adopting IR, OH-lye, and US-lye methods enhanced peelability (ease of peeling > 4.5) and increased production capacity by 2.6–9.2%, while reducing solid waste by 16–52% compared to conventional steam and lye methods. LCA results showed IR as the most environmentally favorable method, followed by steam, OH-lye, and US-lye, with conventional lye peeling being the least sustainable. OH-lye and IR methods also significantly reduce water and energy use, while US-lye shows higher demands in these areas. Additionally, OH-lye and IR methods require little or no NaOH, minimizing chemical consumption and wastewater production, which offers notable environmental and cost advantages. Overall, this preliminary study underscores economic and environmental potential for novel peeling technologies, encouraging industry consideration for adoption.

Blockchain and Traceability of Geographical Indication Products

Traceability plays a significant role in food supply chains by ensuring food safety through piloting risks and quality. It helps to ensure that all production steps meet specification and quality requirements. It is also a very important tool for geographical indication products as it proves the authenticity of products, indicates their origin and, consequently, prevents counterfeiting. The system must be efficient and have anti-tampering features. Using blockchain technology can render these systems nearly perfect

Characterizing Changes in Paddy Rice Flooding Time over the Sanjiang Plain Using Moderate-Resolution Imaging Spectroradiometer Time Series

Rice is a primary food crop, and rice production ensures food security and maintains social stability with great significance. Flooding paddy rice fields as an important step in rice production affects the entire growth process of rice. The selection of flooding time is highly correlated with paddy rice yield and water resource utilization. In the background of global warming, early flooding in high-latitude paddy rice planting areas can ensure that rice has sufficient growing time to increase yield. However, overly early flooding may cause waste of water resources due to insufficient heat. Currently, research on flooding timing is relatively lacking, and monitoring of temperature during flooding is particularly deficient. To respond to climate change, it is necessary to explore whether the current flooding schedule meets the actual needs. Based on MODIS surface reflectivity data, we identified the First Flooding Day (FFD) and Peak Flooding Day (PFD) in the Sanjiang Plain. Using MODIS Land Surface Temperature (LST) data and meteorological station-provided air temperature data, we analyzed the corresponding LST and air temperature for PFD from 2008 to 2024. The main conclusions are as follows: (1) both FFD and PFD in the Sanjiang Plain have a trend of advancing year by year, with PFD showing stronger advancement than FFD; (2) the LST and air temperature during flooding in the Sanjiang Plain show a downward trend year by year; and (3) by 2024, the flooding temperature of paddy rice fields in the Sanjiang Plain has generally met the needs for the next step of production. This study first attempts to use high-temporal-resolution remote sensing images to identify the flooding time of paddy fields and achieve timely monitoring of flooding and changes in flooding temperature.

Evaluation of the Efficacy of the Vaccine Production Process in Removing Residual Host Cell DNA from the Vero Cell Rabies Vaccine.

The Vero cell rabies vaccine is currently the most widely used human rabies vaccine. However, owing to the presence of residual host cell DNA (HCD) in the final product and the potential tumorigenicity of the DNA of high-passage Vero cells, the WHO not only sets a limit on the number of times cells used in production can be passaged, but also imposes strict requirements on the amount of residual HCD in the final vaccine product. To systematically reduce the HCD level in the final vaccine product, multiple purification steps are included in the vaccine production process. This study investigated the effectiveness of key production steps in antigen recovery and DNA removal. The residual HCD fragment content and size distribution were detected using fluorescence quantitative PCR (qPCR) and capillary gel electrophoresis (CGE), and the rabies virus glycoprotein antigen content was detected using enzyme-linked immunosorbent assay (ELISA). The antigen recovery rate and HCD removal rate in each key process were calculated to evaluate the scientific basis and effectiveness of each production step. Additionally, the stability of the process was studied using multiple commercial batches of the product. The results revealed that the total antigen recovery rate in the production process described in this report was no less than 8.5%, and the effective removal rate of residual HCD was not lower than 99.99%. Moreover, the amount of residual HCD in the final product was far below the quality standard of 2 ng/dose, and most of the residual HCD fragments were smaller than 200 bp. The results of the process stability studies on multiple commercial batches showed that the bulk human rabies vaccine produced by this process had excellent safety and efficacy and that the production process was stable and thus suitable for large-scale batch production. The production process described in this study achieved effective recovery of viral antigens and efficient removal of residual HCD, and the process was stable and controllable, enabling the continuous and stable production of vaccine products that meet WHO recommendations and the relevant requirements of the current edition of the Chinese Pharmacopeia. In addition, this study provides theoretical guidance for optimizing the vaccine production process.

Amino Acid Composition of Dried Bovine Dairy Powders from a Range of Product Streams.

The amino acid (AA) content of multiple samples of various dairy powders was determined, providing a comprehensive evaluation of the differences in AA profiles attributable to distinct manufacturing processes. Products examined included whole milk powder (WMP), skim milk powder (SMP), cheese whey protein concentrate (WPC-C), lactic acid casein whey protein concentrate (WPC-L), high-fat whey protein concentrate (WPC-HF), hydrolyzed whey protein concentrate (WPH), whey protein isolate (WPI), and demineralized whey protein (D90). WMP and SMP exhibited broadly similar AA profiles, with minor differences likely due to the minimal milk fat protein content, which is nearly absent from SMP. Comparative analysis of WPC-C and WPC-L indicated higher levels of threonine, serine, glutamic acid, and proline in WPC-C but lower levels of tyrosine, phenylalanine, and tryptophan, attributed to the different methods of separation from casein proteins. WPI and WPC-HF originate from similar sweet whey streams but follow divergent processing methods; consequent on this were variations in the levels of all AAs except histidine. The nanofiltration step in D90 production retains its non-protein nitrogen content and affects its AA profile; consequently, D90 consistently exhibited lower AA levels than WPC-C. These findings underscore the significant impact of manufacturing processes on dairy powder AA composition.

Study on the reaction mechanism and kinetics of limestone hydrogenation by micro fluidized bed: Effect of H2 concentration and natural limestone

Limestone decomposition is the first step in cement production, which produces a significant amount of CO2 and poses a significant challenge to achieve carbon neutrality. Hydrogenation of limestone can produce CO or CH4 instead of CO2, which can be considered as a new way of carbon capture, making it a promising method for carbon emission reduction. In this work, pure CaCO3 and several natural limestone samples were hydrolyzed under varying H2 concentration using a micro fluidized bed (MFB) reactor combined with online mass spectrometry to reveal the mechanism and kinetics of limestone hydrogenation.The main gases produced by hydrogenation at 1 atm are CO and CO2. The CO2 comes from the calcination of CaCO3. The CO comes from 2 steps: the first step is the in-situ hydrogenation of CaCO3 and the second step is the Reverse Water Gas Shift (RWGS) reaction. The activation energy (Ea) of CO2 formation in H2 atmosphere is lower than in Ar atmosphere. However, there is no obvious effect of different H2 concentrations on the Ea of CO2 formation. The Ea of CO in situ formation is 72.70 KJ/mol, 54.53 KJ/mol, 71.34 KJ/mol and 60.29 KJ/mol in 10%, 30%, 50% and 70% H2 atmosphere, respectively. The H2 concentration also has no significant effect on the in-situ CO evolution. However, the H2 concentration can affect the Ea of CO produced by RWGS. The Ea is 75.67 KJ/mol, 167.59 KJ/mol and 221.47 KJ/mol in 10%, 30% and 50% H2 atmosphere, and this reaction doesn't occur in 70% H2 atmosphere. Compared with the pure CaCO3, the hydrogenation of limestone can produce more CO and less CO2. In limestone, impurity elements are the main factor affecting the reaction kinetics. Transition metals can increase the rate of CO2 production, but have no apparent effect on CO. The CO2 yield of high impurity limestone is higher than that of limestone with low impurities. Transition metals can also reduce the Ea of CO2 formation and the RWGS reaction. In the 50% H2 atmosphere, the Ea of CO2 formation is 88.87 KJ/mol and the Ea of CO from RWGS is 137.60 KJ/mol. However, under the same conditions, the Ea of pure CaCO3 is 126.91 KJ/mol and 221.47 KJ/mol.

Additive Manufacturing of Personalized Brain-Computer Interface Headsets Reinforced by Scientific Visualization

Recently, a large attention has been attracted to the brain-computer human-machine interfaces (BCI) based on electroencephalography (EEG). This emerging technology allows touchless control over digital systems, in which the commands are based on human brain activity. In the ideal case, it means controlling the systems virtually by thoughts, but in reality, also simpler approaches are highly demanded like reacting to concentration, relaxation, or specific emotions. Modern BCIs are based on detecting so-called brain waves, the electromagnetic field oscillations induced by brain neurons. These waves are captured by electrodes either intruded into the brain or placed on top of the head. Obviously, placing electrodes on the head is more demanded for non-medical applications of BCI because it is absolutely harmless for the person. To achieve this, special headsets are needed which can be put on the head like a helmet and ensure the correct positions for the electrodes mounted on them. In this regard, wearing comfort and anatomical accuracy of headsets play an important role in ensuring both ergonomics and precision of BCI. This paper focuses on automation of the personalized EEG headset manufacturing for BCI. The technological chain is proposed and corresponding software tools are developed to foster the complete cycle of BCI headset production for a particular person. The production steps include 3D scanning of the head, interactive editing of the electrodes’ location system, and automatic generation of a collapsible head cap model with sockets for EEG electrodes optimized for 3D printing. The performance of the pipeline has been validated in practice. The accuracy of electrodes’ placement has been evaluated by comparison with the head cap from professional medical equipment and is established as sufficient for BCI. The headset model editing and customizing tools are powered with scientific visualization and cognitive graphics techniques to be friendly for a wide range of users including those with no dedicated IT skills.

Using a Single-Atom FeN4 Catalyst on Defective Graphene for the Efficient Reduction of NO to Alanine: A Computational Study

The use of a single-atom FeN4 catalyst on defective graphene (Fe-NC) has recently emerged as an effective method for the synthesis of amino acids. Herein, we investigated the mechanism of alanine formation on FeN4-doped graphene using comprehensive density functional theory (DFT) computations. The alanine formation reaction begins with the activation of NO molecules on the surface, followed by their reaction with hydrogen atoms provided in the system. The computational results show that NO molecules can be effectively activated on Fe-NC, facilitating the subsequent alanine formation at a relatively lower potential. The potential-limiting step in alanine production involves either the formation of HNO* or HNOH* intermediates on Fe-NG, as the free energy changes (ΔG) in these two elementary steps are nearly equivalent. Notably, the formation of HNO* exhibits a higher activation energy (Ea) compared to HNOH* formation. This study provides valuable insights into the C–N coupling reaction and the mechanism of amino acid synthesis on single-atom catalysts.

Recent Advancements in Co3O4-Based Composites for Enhanced Electrocatalytic Water Splitting.

The pursuit of efficient and economical catalysts for water splitting, a critical step in hydrogen production, has gained momentum with the increasing demand for sustainable energy. Among the various electrocatalysts developed to date, cobalt oxide (Co3O4) has emerged as a promising candidate owing to its availability, stability, and catalytic activity. However, intrinsic limitations, including low catalytic activity and poor electrical conductivity, often hinder its effectiveness in electrocatalytic water splitting. To overcome these challenges, substantial efforts have focused on enhancing the electrocatalytic performance of Co3O4 by synthesizing composites with conductive materials, transition metals, carbon-based nanomaterials, and metal-organic frameworks. This review explores the recent advancements in Co3O4-based composites for the oxygen evolution reaction and the hydrogen evolution reaction, emphasizing strategies such as nanostructuring, doping, hybridization, and surface modification to improve catalytic performance. Additionally, it examines the mechanisms driving the enhanced activity and stability of these composites while also discussing the future potential of Co3O4-based electrocatalysts for large-scale water-splitting applications.

Video Profile As a Promotional Media in The Semesta Store Malang City

Purpose: Profile videos as promotional media can be utilized across multiple platforms, including social media, websites, portfolios, YouTube, presentations, marketing initiatives, events, and webinars. This promotional material is crucial for enhancing sales and motivating people to make purchases. When utilized effectively, promotional media can enhance a company's exposure and appeal, positively influencing sales. Method: The process consists of three stages: pre-production, which involves conducting a SWOT analysis, brainstorming concepts, and creating storyboards. The production step involves video editing, followed by the post-production stage, which entails releasing the video on social media. Practical Applications: The anticipated outcomes of producing a profile video include a substantial enhancement in brand awareness, the engagement of the target audience, and the cultivation of stronger customer relationships through the effective communication of the company's vision, mission, and values, thereby fostering conversions and increased loyalty in the future. Conclusion: This profile video functions to promote the shop through publications on social media such as websites, Facebook, Instagram and YouTube. Choosing a strategy for using profile videos can function as promotional media on various online platforms in the current digital era, in order to increase company visibility and have a positive impact on company sales and revenues.

ANALISIS RISIKO K3 DENGAN METODE HIRARC PADA PROSES BENDING SEMI FINISH PLATE BUMPER HM400 KOMATSU DI PT. KHARISMA LOGAM UTAMA BEKASI

The increasing competition in the industrial sector has driven companies to enhance productivity while maintaining the safety standards. PT. Kharisma Logam Utama (KLU), a manufacturing company specializing in metal and machinery components, is a key partner for PT. Komatsu Indonesia, producing parts for heavy equipment such as the KOMATSU HM400 articulated dump truck. The bending process of semi-finished plates, an essential step in bumper production, poses significant risks to worker safety. This study aims to analyze occupational health and safety (OHS) risks using the Hazard Identification, Risk Assessment, and Risk Control (HIRARC) method. Data collection was conducted through direct observation and interviews over August to September 2024. The findings highlight that most risks in the bending area are categorized as Level II (acceptable with monitoring), constituting 45% of identified activities. Level I risks, deemed acceptable, made up 35%, while Level III (problematic, requiring immediate action) constituted 15%. The highest risk level, IV (unacceptable), accounted for 5% and demands urgent corrective measures due to potential serious injuries or fatalities. The analysis identified mechanical hazards such as cuts, pinches, and material falls as prevalent. Implemented controls included personal protective equipment (PPE) like anti-impact gloves, safety boots, and safety goggles, alongside procedural guidelines. The application of the HIRARC method proved effective in prioritizing risk mitigation measures and improving workplace safety, ultimately contributing to a safer production environment.

Scaling up Solid State Battery Research at Fraunhofer FFB

All-solid-state batteries (ASSBs) hold immense promise for revolutionizing the future of energy storage due to their enhanced safety and higher potential energy density. Within the context of the federally funded FoFeBat project dedicated to production research for batteries, this abstract outlines the overarching goals and collaborative strategies of the Fraunhofer Research Institution for Battery Cell Production FFB in advancing ASSB production.In five designated so-called innovation laboratories, which are run in close collaboration with some of the leading academic battery research institutions in Germany, including Universities of Muenster, Giessen and Aachen, as well as Research Center Juelich (FZJ), Fraunhofer FFB addresses the problems in scaling up solid state battery and solid electrolyte production. The planned research activities include upscaling the synthesis of polymer-, oxide- and thiophosphate-based solid electrolytes to the kg-scale. The in-house produced materials are used to study the production process of ASSB electrodes with different cathode active materials and how different forms of pressure application (warm-isostatic pressing, calendaring) influence the resulting electrode composite. This includes the evaluation of the influence of different binder materials and solvents on the production process of the electrodes. For the cell assembly, a prototype-scale production line will be established, where the different sheets (electrodes, separator) will be combined, and environmental influences can be studied by the application of sealed mini environments at the different assembly steps. The finalized cells are electrochemically characterized to study the influence of different operating conditions (temperature, pressure) on the cell performance. In addition to this, safety evaluation of the different materials and the fully assembled cells is part of this project. The establishment of the innovation laboratories for ASSB research provide the unique opportunity to test the acquired parameters on the pilot scale production line of the Fraunhofer FFB, which will help to evaluate the transferability of the different production steps into a full-scale lithium-ion-battery production line at FFB.Scaling up these processing steps will produce challenges that are currently being investigated by various companies without the possibility of accessing the acquired knowledge. Solving these challenges and making the obtained knowledge publicly available through scientific journal publications, will help speed up the development of solid-state batteries.