Background and Aims: Malignant gastric outlet obstruction is a late and common complication of intra-abdominal malignancies, particularly primary pancreatic or gastric carcinomas. The majority of patients considered as unsuitable for curative surgical treatment require palliative treatment methods. Recently, endoscopic self-expendable metal stent placement, which is a minimally invasive method compared with surgery, has been performed more frequently than palliative surgery. The aim of this retrospective study was to evaluate the safety and efficacy of self-expendable metal stent placement in patients with inoperable malignant gastric outlet obstruction. Materials and Methods: This study analyzed the data of patients who underwent endoscopic uncovered self-expendable metal stents placement in the duodenum for treating malignant gastric outlet obstruction during a period of 5 years in our endoscopy unit. Technical and clinical success of the placement of duodenal self-expendable metal stents and the complications of the procedure were evaluated. Results: A total of 28 patients with malignant gastric outlet obstruction underwent endoscopic self-expendable metal stent placement. Technical success was achieved in all patients, while clinical success was observed in 25 patients (89%). According to the gastric outlet obstruction scoring system, the mean score of the patients was 0.536 before stent placement and improved significantly to 2.39 at the second week after stent placement (p = 0.0001). Major complications were observed in two patients (7.14%), and minor complications were observed in another two patients (7.14%). Conclusion: These findings indicate that endoscopic self-expendable metal stent placement was a safe and efficient palliative procedure for patients considered as unsuitable for curative surgical treatment of malignant gastric outlet obstruction.