Ionospheric irregularities are well-known phenomena associated with ionospheric scintillation. These irregularities comprise steep electron density gradients in the equatorial F region some 1 to 2 h after sunset in regions close to the geomagnetic equator. Using the IGS network of GNSS receivers spread across the low-latitude region over the African sector, we present the monthly trends in ionospheric irregularity activity levels based on Rate of TEC Index (ROTI) during the declining phase of solar 24. The monthly trends are statistically represented by counts of the night time ROTI values exceeding a threshold of 0.4 TECU/min. A clear trend emerges on the irregularity occurrence across the African sector: during the first four months of the year, the irregularity occurrence is highly pronounced on the western side of the region. The irregularity occurrence then shifts to the eastern side during the months of May, June, July, and August. During the last four months of the year, the irregularity occurrence is again more intense on the western side of Africa than on the eastern side. The occurrence of irregularity structures on only one side of the region during a given night is an unusual feature reported here for the first time.