This paper focuses on the problem of steel members of open double symmetrical cross-sections in transverse compression. First, the problem is introduced with examples of its application in steel structures of buildings and followed by the overview of selected substantial literature resources and current design codes provisions. The essential part of the paper is a presentation of results of experimental tests and advanced numerical analysis of members subjected to selected cases of transverse compression. Where possible, the results are compared with resistances obtained using provisions in currently valid design codes for steel structures. The influence of selected parameters on the resistance in transverse compression is quantified within the evaluation with specific attention paid to plate buckling of the web. Based on data obtained from the experimental and numerical investigations, the most notable findings are summarized.