This paper presents an overview of the development of fatigue design provisions and detailing for steel bridge structures. The historical performance of welded steel bridges in the USA is reviewed with focus on fatigue cracking at cover plate and similar attachment details, as well as distortion induced cracking at web gaps. The role of materials including modern high performance steels (HPS) is reviewed. Variable amplitude loading is also examined and compared with current design of steel bridges for fatigue resistance. Also examined are methods to improve and retrofit fatigue sensitive details, including modern post-weld enhancement by ultrasonic impact treatment (UIT). Orthotropic steel decks are reviewed based on the results of two full-scale prototype laboratory fatigue tests which identified the complex behaviour that occurs at fatigue sensitive details and were verified by field measurements on field installations. The merits of thin epoxy concrete wearing surfaces is examined in terms of the critical role the deck plate thickness has on the epoxy concrete fatigue resistance and durability. The orthotropic deck is the only bridge deck system likely to provide a 100 year life when the deck plate thickness equals or exceeds 16 mm.