Management of groundwater systems in urban areas is necessary and can be reliably performed by means of mathematical modeling combined with geospatial analysis. A conceptual approach for the study of urban hydrogeological systems is presented. The proposed approach is based on the features of Bucharest city (Romania) and can be adapted to other urban areas showing similar characteristics. It takes into account the interaction between groundwater and significant urban infrastructure elements that can be encountered in modern cities such as subway tunnels and water-supply networks, and gives special attention to the sewer system. In this respect, an adaptation of the leakage factor approach is proposed, which uses a sewer-system zoning function related to the conduits’ location in the aquifer system and a sewer-conduits classification function related to their structural and/or hydraulic properties. The approach was used to elaborate a single-layered steady state groundwater flow model for a pilot zone of Bucharest city.