Status Outcome In Patients Research Articles

Change in Psychosocial Distress Associated With Pain and Functional Status Outcomes in Patients With Lumbar Impairments Referred to Physical Therapy Services

Change in Psychosocial Distress Associated With Pain and Functional Status Outcomes in Patients With Lumbar Impairments Referred to Physical Therapy Services

Change in Psychosocial Distress Associated With Pain and Functional Status Outcomes in Patients With Lumbar Impairments Referred to Physical Therapy Services

Prospective, longitudinal, observational cohort design. The primary aim was to examine the association between changes in psychosocial distress (PD), and functional status (FS) and pain intensity at discharge from physical therapy. Patients with lumbar impairments seeking physical therapy commonly demonstrate elevated PD. However, it is not clear if PD changes that occur during physical therapy management are associated with improved clinical outcomes. Data from adults (n = 692) with lumbar impairment were analyzed. Patients were screened using the Symptom Checklist Back Pain Prediction Model questionnaire (SCL BPPM) to identify patients at intake and discharge into 3 levels of risk for persistent disability (high, intermediate, or low). SCL BPPM classifications allowed for 5 patterns of change in PD during therapy (decreased, stable low, stable intermediate, stable high, or increased). Associations between PD change patterns and discharge FS and pain intensity were assessed using multivariable linear regression models, controlling for selected risk-adjustment variables. Proportions of patients classified by patterns of PD change for decreased, stable low, stable intermediate, stable high, and increased were 0.34, 0.52, 0.05, 0.06, and 0.03, respectively. Compared to the decreased PD group, (1) increased, stable high, and stable intermediate PD patterns were associated with worse discharge FS scores (-7.9 [95% CI: -13.5, -2.21], -10.9 [95% CI: -15.25, -6.49], and -8.9 [95% CI: -13.65, -4.21] units, respectively), and (2) stable high and stable intermediate PD patterns were associated with higher pain intensity (2.59 [95% CI: 1.81, 3.56] and 2.14 [95% CI: 1.25, 3.04] units, respectively). Lower FS and higher pain intensity outcomes were associated in similar but not identical patterns with patients whose SCL BPPM classification of PD increased, or remained at high or intermediate levels during physical therapy. Serial assessments of change in PD during rehabilitation are recommended as a possible treatment-monitoring tool.

Abstract P164: Health Status Outcomes in Patients With Non-Obstructive Coronary Artery Disease

BACKGROUND. Approximately 20-30% of coronary angiograms undertaken for the investigation of chest pain show non-obstructive coronary artery disease (NoCAD). These patients receive little attention compared to their counterparts with obstructive coronary artery disease (CAD). The current study assessed the health outcomes of patients with NoCAD as compared with CAD over 12 months. METHOD. Consecutive patients undergoing angiography for the investigation of chest pain were recruited prior to the procedure. The following health outcomes were evaluated at baseline, 1, 6 and 12 months: (a) chest pain, (b) Seattle Angina Questionnaire (SAQ), and (c) Short-Form 36 (SF-36). RESULTS. Of the 1148 patients with chest pain recruited, 320 (28%) had NoCAD. Compared with CAD, these patients were younger (62 11 vs 57 12 years, respectively, p <0.001) and following age-adjusted analysis, were more likely to be female (29 vs 58%, respectively, p < 0.001). Baseline SF-36 and SAQ scores were similar for the two groups. Over 12 months, both patient groups showed an improvement in SF36 and SAQ scores. However, the change in SF-36 Physical Summary Score at 12 months compared to baseline was significantly lower in NoCAD patients (see plot). No longitudinal differences were seen in SAQ domain scores. Self reported chest pain was lower in the CAD patients compared with NoCAD at 1 (64% vs 68%, p>0.05), 6 (46% vs 61%, p <0 .001) and 12 months (40% vs 48%, p>0.05). CONCLUSION. Patients with NoCAD are younger and more likely to be female. After adjusting for age, they are more likely to have ongoing chest pain and impaired quality of life as assessed by the SF-36.

Effect of Fear-Avoidance Beliefs of Physical Activities on a Model That Predicts Risk-Adjusted Functional Status Outcomes in Patients Treated for a Lumbar Spine Dysfunction

Retrospective analysis of a prospective, longitudinal cohort study of 30 858 patients being treated for a lumbar spine dysfunction in outpatient physical therapy. To determine effect of adding a single-item screening variable classifying patients with elevated versus not-elevated scores of fear-avoidance beliefs of physical activities at intake, on a model predicting risk-adjusted functional status (FS) outcomes. Outcomes must be risk-adjusted before making meaningful interpretations. Elevated fear-avoidance beliefs scores have been predictive of poor outcomes. But the importance of elevated fear-avoidance scores in a multivariable model predicting FS outcomes needs further study. Using retrospective analyses, predictive ability (R2) of multivariable linear regression models of discharge FS with and without classification by elevated versus not-elevated fear-avoidance scores were compared, while controlling for intake FS, age, symptom acuity, surgical history, gender, number of comorbidities, and payer. Percent variance controlled and beta coefficients (95% confidence intervals) of each variable in both models were compared. A split-half design was used for model cross-validation. Predictive ratios (predicted FS, divided by actual discharge FS) were assessed. Adding fear-avoidance beliefs classification to the discharge FS model improved (P<.001) model predictive ability but only slightly (R2 without, and with, fear-avoidance classification, 0.2997 and 0.3010, respectively). Variables impacted models similarly (95% confidence intervals not different). Fear-avoidance classification added 0.2% data variance control to the existing model. Cross-validation was supported. Predictive ratios were 1.09 and 1.10, without and with fear-avoidance, respectively. Although screening for elevated fear-avoidance beliefs of physical activities significantly improves the FS outcomes predictive model, the amount of additional meaningful interpretation of FS outcomes was minimal. Exploration of other clinically relevant variables designed to improve outcomes prediction is warranted. Prognosis, level 2c.

Function and Health Status Outcomes Following Soft Tissue Reconstruction for Limb Preservation in Extremity Soft Tissue Sarcoma

While advances in reconstructive surgery have facilitated limb preservation in extremity soft tissue sarcoma (ESTS), limited information exists as to the functional outcome of patients with these reconstructed extremities. The primary objective of this study is to evaluate the impact of flap reconstruction on postoperative function and health status in patients undergoing limb-salvage surgery for ESTS. Clinical and outcome data for eligible patients were extracted from a prospectively maintained database of sarcoma patients. Four outcome measures were used to assess three domains of function (impairments, activity limitations, and participation restrictions), and health status. The effect of soft tissue reconstruction on function and health status at 1-2-year follow-up was analyzed using univariate and multivariate regression. Two hundred and forty-seven patients met eligibility criteria, including 56 patients receiving flap reconstruction and 191 patients treated with primary closure. Patients receiving flaps had larger (9.8 versus 7.1 cm; P = 0.003), higher-grade (93% versus 72%; P = 0.001) tumors, and more frequently received radiotherapy (89% versus 72%; P = 0.007), and bone (20% versus 4%; P = 0.001) and motor nerve resection (21% versus 10%; P = 0.032). Flap reconstruction was associated with more postoperative impairments [Musculoskeletal Tumor Society (MSTS) score 30.4 versus 32.2; P = 0.004] and activity limitations [Toronto Extremity Salvage Score (TESS) score 83.3 versus 89.5; P = 0.0132] on univariate analyses, but did not significantly predict postoperative function or health status outcomes on multivariate analyses. Flap reconstruction was not an independent predictor of function and health status outcomes in patients with ESTS. However, ESTS patients receiving flaps had other clinical features placing them at risk for worse postoperative outcomes.

Health Status Outcomes in Patients with Non-Obstructive Coronary Artery Disease

Health Status Outcomes in Patients with Non-Obstructive Coronary Artery Disease

Using the common sense model of illness perceptions to examine osteoarthritis change: A 6-year longitudinal study.

To examine the association between changes in common sense models and changes in functional status over a 6-year follow-up in patients with osteoarthritis. At baseline and follow-up, osteoarthritis outpatients (N = 241) recruited from a university medical center completed the Illness Perception Questionnaire-Revised (IPQ-R), the Australian/Canadian Osteoarthritis Hand Index, and the Western Ontario and McMasters Universities Osteoarthritis Index. Also, their physician-assessed pain intensity, and biomedical, and clinical measures of medical severity of osteoarthritis were recorded. Functional disability, pain intensity. Over 6 years, functional disability and pain intensity increased. The IPQ-R dimensions of timeline, personal control, and illness coherence became more negative, and emotional representations became less negative (i.e., more accepting). Patients identified as sharing a similar profile of negative changes on the IPQ-R had significantly worse functioning on 2 of 3 outcomes, independent of objectively measured osteoarthritis severity. Changes in illness perceptions were associated with changes in outcomes. Interventions to prevent increasingly negative patterns of illness perceptions over time, with an emphasis on strengthening control cognitions, may benefit functional status outcomes in patients with osteoarthritis.

P01-276 - Depression and heart failure outcomes

Chronic illnesses such as HF may precipitate depression. In either case, there are both behavioral and pathophysiologic mechanisms by which depressive symptoms may lead to adverse outcomes in patients with HF.Depressive symptoms are common in patients with HF, and are associated with markedly worse baseline health status, and are a strong predictor of worsening of HF symptoms, functional status, and quality of life over time and leads to increased hospitalization and rate of mortality.Depression is an independent risk factor for HF mortality, either through direct pathophysiological mechanisms of neurohormonal activation, arrhythmia, inflammation and hypercoagulation or through behavioral mechanisms.A meta-analysis has demonstrated that patients with depression were three times more likely to be nonadherent with treatment recommendations. As for the treatment of obesity, poor nutritional habits, smoking, and sedentary lifestyles, patient non-adherence can complicate physician attempts to modify psychosocial risk factorsIn this article we review and synthesizes the research assessing the effects of depression as mental disorder in HF treatment and prognosis and can arise many unresearched issues regarding the future managment difficulties in untreated and undiagnosed depressive disorder and his outcomes.Clinicians should be aware of the strong link between depressive symptoms and adverse health status outcomes in patients with HF and the treatment of non-physical aspects of chronic disease should be considered as part of the management of HF, in order to reduce anxiety, depression, and disturbances of social function.

The Effect of Left Ventricular Size on Right Ventricular Hemodynamics in Pediatric Survivors with Hypoplastic Left Heart Syndrome

Outcome status in patients with hypoplastic left heart syndrome (HLHS) is partially dependent on right ventricular (RV) systolic function. In other disease states, ventricular function is impacted by anatomy and physiology of the contralateral ventricle. In HLHS, it is suggested that a relatively larger left ventricular (LV) size may negatively impact RV function because it becomes a "passenger" without providing any systolic or diastolic physiologic benefit. The purpose of this study was to determine whether LV size adversely affects RV systolic function in surviving patients with HLHS. The hospital database was searched for all patients with HLHS and technically adequate echocardiograms born in the last 6 years and who had survived at least the Norwood procedure. LV size was assessed by echocardiographic measurement of LV end-diastolic short-axis and apical area. RV function was assessed by short-axis and apical fractional area change as well as the myocardial performance index (Tei). Measurements were made at up to 4 time points depending on duration of follow-up (1 - pre-Norwood; 2 - pre-Glenn; 3 - pre-Fontan; and 4- post-Fontan). A total of 48 patients were studied. LV size showed sufficient variability in the patient population (1.0-21 cm(2)/body surface area, pre-Norwood). RV function tended to worsen across the time periods but these changes did not reach statistical significance. Regression analysis showed no effect of LV size on RV function before Norwood operation. Significant correlations existed between LV size indices and RV functional indices before Glenn shunt but these were inconsistent in the direction of their effect. Only before Fontan operation did the correlation between LV size and RV function become both consistent and statistically significant; specifically larger LV size correlated significantly with poor RV systolic function (short-axis RV fractional area change vs LV area r = -0.4, P = .03 and RV Tei vs LV area r = 0.5, P = .02). These relationships were not apparent after Fontan operation. In surviving patients with HLHS, larger LV size does not seem to negatively impact RV function before or after Norwood procedure nor does it seem to have an adverse effect on RV function chronically (after Fontan). However, further study with larger population size will be necessary to see whether these findings remain negative and are true for nonsurvivors as well.

The clinical utility of the GOLD classification of COPD disease severity in pulmonary rehabilitation

The Global Initiative for Chronic Obstructive Lung Disease (GOLD) has introduced a four-stage classification of chronic obstructive pulmonary disease (COPD) severity. The present study investigated the discriminatory capacity of the GOLD classification for health status outcomes in patients with COPD. An additional analysis was performed to investigate the discriminatory capacity of a multidimensional staging system, i.e. the Body-Mass Index, Degree of Airflow Obstruction and Dyspnea, and Exercise Capacity Index (BODE index) for the outcome of quality of life. Retrospective analysis was performed on 253 COPD patients (30% stage II, 48% stage III, 22% stage IV), referred for outpatient pulmonary rehabilitation. Pulmonary function, exercise capacity, dyspnoea and quality of life were evaluated. Analyses of variance were used to detect differences between GOLD stages and BODE index quartiles, and scatterplots of individual responses were produced as well. The GOLD classification discriminated between stages for pulmonary function (p<0.001), exercise capacity (p<0.001), dyspnoea (p<0.001) and the activities section (p=0.001) of the St. George Respiratory Questionnaire (SGRQ). The BODE index discriminated between quartiles for the activities section (p<0.001), impacts section (p=0.04) and the total score (p=0.01) of the SGRQ. Scatterplots revealed marked inter-individual variation within each GOLD stage or BODE index quartile, and considerable overlap between stages for all health status outcomes. These findings show that the GOLD classification indeed can be used to discern groups of COPD patients, but due to large inter-individual variability it does not seem adequate as a basis for individual management plans in rehabilitation. The BODE index appeared to discriminate slightly better for quality of life, however, it still leaves a significant part of the variance unexplained.

Patient Outcome Following Rehabilitation for Rotator Cuff Repair Surgery: The Impact of Selected Medical Comorbidities

Prospective, multicenter research design. To assess functional and health status outcomes in patients following a physical therapy program after rotator cuff repair surgery, and to determine the impact of selected patient medical comorbidities on rehabilitation outcomes. While authors have studied the influence of multiple factors on patient outcomes after rotator cuff repair surgery, little research has been done on the impact of comorbidities, particularly as it relates to establishing an accurate patient prognosis. eighteen patients who had recently undergone a rotator cuff repair surgical procedure were recruited at 1 of 30 Physiotherapy Associates, Inc outpatient clinics located in 13 states. A rehabilitation protocol was implemented and included the following interventions, as indicated: therapeutic exercise, manual therapy, electrotherapeutic modalities, and physical agents. Patient health history factors were documented during the initial examination, including age, race, body mass index, smoking, rotator cuff tear size, type of surgical procedure, and selected medications and comorbidities. The Disabilities of the Arm, Shoulder, and Hand (DASH) and the Short-Form-36 (SF-36) were completed prior to rehabilitation, at discharge, and at 6 months postdischarg DASH andmost SF-36 domain mean scores obtained postrehabilitation were significantly improved from pretherapy scores. Most health status outcomes were maintained at 6-month follow-up, with slight further improvement noted in SF-36 physical dimensions and DASH scores. Having a greater number of comorbidities was associated with worse postrehabilitation SF-36 scores, but not with the DASH shoulder function scores. The mean change scores (difference between prerehabilitation and postrehabilitation status) for the DASH and SF-36 were not significantly different for patients with 0 to 1, 2, or at least 3 or more comorbidities (except for emotional role). In regression analyses a model with baseline physical function score (P = .0001), age (P = .03), and number of comorbidities (P = .003) fitted the data well and explained 38% of the variance in the physical function score at discharge. A higher number of comorbidities had a negative effect on general health status outcomes but not on shoulder function outcomes at the time of patient discharge following rehabilitation. Despite a negative effect of more comorbidities on health status outcomes, the specific number of medical comorbidities did not affect the overall level of improvement prerehabilitation to postrehabilitation in function and health status. The findings describing the influence of comorbidities on rehabilitation outcomes may assist therapists in establishing accurate patient prognosis.

BRIEF REPORT: Patient-physician agreement as a predictor of outcomes in patients with back pain.

To determine whether a patient-physician agreement instrument predicts important health outcomes. Three hundred eighty patients with back pain were enrolled in a comparison of rapid magnetic resonance imaging with standard x-rays. One month later, patients rated agreement with their physician in the following areas: diagnosis, diagnostic plan, and treatment plan. Outcomes included patient satisfaction with care at 1 and 12 months and functional and health status at 12 months. Urban academic and community primary care and specialty clinics. Higher agreement at 1 month (using a composite sum of scores on the 3 agreement questions) was correlated in univariate analysis with higher patient satisfaction at 1 month (R=.637, P<.001). In multivariate analysis, controlling for 1-month satisfaction and other potential confounders, higher agreement independently predicted better 12-month patient satisfaction (beta=0.188, P=.003), mental health (beta=1.080, P<.001), social function (beta=1.124, P=.001), and vitality (beta=1.190, P<.001). Agreement between physicians and patients regarding diagnosis, diagnostic plan, and treatment plan is associated with higher patient satisfaction and better health status outcomes in patients with back pain. Additional research is required to clarify the relationship between physician communication skills, agreement, and patient outcomes.

Clinical and echocardiographic correlates of health status in patients with acute chest pain.

To assess the ability of echocardiographic data to predict important functional status outcomes in patients with chest pain. Prospective cohort study. A large, urban teaching hospital. Three hundred thirty-three patients admitted from the Emergency Department for evaluation of chest pain. Patients underwent two-dimensional and Doppler echocardiography as well as a face-to-face interview during their initial hospitalization and a telephone interview 1 year thereafter. The interview included the Medical Outcomes Study 36-Item Short Form (SF-36) health inventory, a generic health status instrument with a physical function subscale. The relation between clinical and echocardiographic factors and functional status was explored by univariable and multivariable linear regression and logistic regression analyses. Multiple clinical and echocardiographic factors correlated significantly with functional status measures at 1 year. For the SF-36 score at 1 year, age, male gender, white race, the presence of rales, and a comorbidity score were independently predictors in multivariate analysis; echocardiographic findings of severe left ventricular dysfunction (parameter estimate [PE] -27.6; 95% confidence interval [CI] -43.1, -12.2) and aortic insufficiency (PE -16.7; 95% CI -26.4, -7.0) added independent predictive information. Explanatory power (r2) for models using clinical and demographic variables was .27 and increased after inclusion of echocardiographic data to an r2 of .35. Results in the subset of patients (n = 148) with acute coronary syndromes such as unstable angina or myocardial infarction were qualitatively similar. Selected factors (rales on examination, electrocardiographic changes suggestive of ischemia, and moderate to severe mitral regurgitation) also predicted which patients would die or have a decline in their functional status. In multivariate analysis, only rales remained an independent predictor of poor outcome (odds ratio 2.4; 95% CI 1.2, 4.5). Echocardiographic data are correlated with measures of functional status in patients with chest pain, but the ability to predict future functional status from clinical or echocardiographic information is limited. Because functional status cannot be predicted adequately from either patients' characteristics or echocardiographic testing, it must be assessed directly.

The contribution of brain injury to the overall injury severity of brain-injured patients.

Several recent population-based studies of the incidence of head injury have identified cases by screening hospitalized patients. This method assumes a close relationship between severity of head injury and overall injury severity, since it is the latter that determines hospital admission. Thus, a patient whose overall injury severity is high will be admitted to the hospital regardless of the degree of his head injury. Similarly, since a patient's outcome status after treatment depends on his response to all his injuries, studies of the prognosis of various types of head injury also assume a close relationship between head injury severity and overall injury severity. The present study examines the relationship between brain injury severity and overall injury severity in a series of hospitalized head-injured patients with evidence of actual or probable brain trauma. Among these patients, brain injury severity was closely related to overall injury severity. Head injury severity and head and neck injury severity were also closely related to overall injury severity. For all other body regions, injury severity was not closely related to overall injury severity in this group of patients.