The vortex photon beam induced nuclear reaction is studied. The interaction formalism of nuclei with vortex photons is developed and incorporated into the statistical reaction model to calculate reaction cross-sections. For 138 nuclei of high nuclear astrophysics and structure interest, the cross-sections of Îł-ray emission and neutron production from the decay of the giant resonances (GR) populated by vortex photons, e.g., (Îłvo,Îłemit) and (Îłvo,nprod.), are computed. It is shown that for the (Îłvo,Îłemit) and (Îłvo,nprod.) cross-sections, the GR contribution of an individual L is either enhanced or suppressed depending on the parameters of vortex Îł-rays, and the contribution from the GR of a specific L can be identified and deduced. To this end, a novel method to exclusively determine the Îł-strength function (ÎłSF) for the GR of a specific L is proposed considering the (Îłvo,Îłemit) and (Îłvo,nprod.) measurements, and the feasibility studies demonstrate that the ÎłSF for the giant quadrupole resonance can be extracted. Furthermore, the astrophysical reaction rates of the vortex photon induced reactions in p-process are investigated. It is indicated that photo-nuclear reactions induced by vortex photons will bring new insights in nuclear physics and astrophysics research.