Fast and efficient fault monitoring and diagnostics methods are essential for fault diagnosis and prognosis tasks in Health Monitoring Systems. These tasks are even more complicated when facing dynamic systems with multiple operation points. This article introduces a symbiotic solution for fault detection and isolation, based on the integration of two complementary techniques: Possible Conflicts (PCs), a model-based diagnosis technique from the Artificial Intelligence (AI) community, and Principal Component Analysis (PCA), a Multivariate Statistical Process Control (MSPC) technique. Our proposal improves the PCA-based fault detection in systems with multiple operation points and transient states and provides a straightforward fault isolation stage for PCA. At the same time, the proposal increases the robustness for fault detection using PCs through the application of PCA to the residual signals. PCA has the ability to filter out residual deviations caused by model uncertainties that can lead to a high number of false positives. The proposed method has been successfully tested in a real-world plant with accurate fault detection results. The plant has noisy sensors and a system model without the same accuracy at each operation point and transient states.