Statistical Manual Research Articles

Gender bias of antisocial and borderline personality disorders among psychiatrists.

Antisocial Personality Disorder (ASPD) and Borderline Personality Disorder (BPD) challenge mental health professionals with similar maladaptive behaviors. However, these two disorders differ regarding available evidence-based treatments. The Diagnostic and Statistical Manual of Mental Disorders (DSM) has been criticized as being gender-biased diagnostic construct. The present study aimed to determine the gender bias of ASPD and BPD among Turkish psychiatrists. Three case vignettes were randomly presented as male or female to the psychiatrists online. The first case was a patient with schizophrenia case to confirm the participant's ability to diagnose. The second case was a patient with ASPD, and the third one was a patient with BPD. Two hundred fifty participants diagnosed the first case correctly (n = 250). The results with statistical significance demonstrated that a female case with ASPD was 5.1 times more likely to get misdiagnosed than a male case with ASPD (p˂0.0001). Categorical classification of personality disorders in DSM leads to gender bias in in the diagnosis of ASPD and BPD. The present study shows that female cases with ASPD are misdiagnosed as BPD which may result in treatment attempts without evidence.

Initial development of a digitally based comprehensive child mental health questionnaire.

The present report describes the item development and initial validation of a comprehensive child mental health questionnaire through a series of four studies. To maximize clinical utility, the questionnaire was developed to directly reflect Diagnostic and Statistical Manual of Mental Disorders, fifth edition psychiatric criteria and diagnoses, cover all mental health conditions that present in youth, and capitalize on the benefits of digital administration, particularly tiered branching logic. Study 1 describes the item generation and development of a tiered item structure. Study 2 established internal consistency and discriminant validity in a representative community sample of 1,000 youth aged 7-17 and a parent. Study 3 examined the acceptability of the questionnaire's content and structure to families and made indicated text revisions. Finally, Study 4 cross validated the internal consistency and tiered structure of a revised version of the questionnaire in a second representative normative sample of 1,000 parent and child dyads. The four studies resulted in a questionnaire consisting of one general mental health question (parent-report only), 16 items (for both parent and child) on a diagnostic category checklist, and 40 scales with screener and follow-up items reflecting DSM-5 criteria for specific disorders (371 parent items and 326 child items). The data support the potential of the questionnaire to efficiently assess the breadth of youth psychiatric symptoms efficiently. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

The Relationship Between Brain-Derived Neurotrophic Factor and Serotonin in Major Depressive and Bipolar Disorders: A Cross-Sectional Analysis.

Background Mood disorders like major depressive disorder (MDD) and bipolar disorder (BD) involve complex interactions between brain-derived neurotrophic factor (BDNF) and serotonin. While extensive research has explored these factors individually, their combined effects and interactions in these disorders are less understood. This study uniquely addresses this gap by examining how BDNF and serotonin interact and relate to mood disorder severity, providing new insights into their joint role in MDD and BD. Objectives The objective of this study was to examine the correlation between serum BDNF and plasma serotonin levels and to assess how these correlations relate to the severity of symptoms and overall disease severity in MDD and BD. Methodology This cross-sectional study, conducted at the Khyber Medical University, Peshawar, from January to September 2023, examined the correlation between BDNF and serotonin in individuals with MDD and BD. Participants (n = 63) aged 18-65 were recruited based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria, excluding those with neurological disorders, substance abuse, or severe medical illness. A control group of 21 healthy individuals was matched by age and gender. Data collection involved demographic details, clinical history, and comorbid diagnoses assessed using the Mini International Neuropsychiatric Interview (MINI). Mood disorder severity was measured using the Hamilton Depression Rating Scale (HAM-D) for MDD and the Young Mania Rating Scale (YMRS) for BD, along with additional assessments (Beck Depression Inventory, Global Assessment of Functioning). Serum BDNF and serotonin levels were analyzed using enzyme-linked immunosorbent assay (ELISA) kits. Statistical analyses included t-tests, Mann-Whitney U tests, Pearson correlations, and subgroup analyses to assess relationships between biomarkers, mood disorder severity, and influencing factors. Results BDNF levels were found to be 20.1 ± 5.3 ng/mL in MDD, 18.5 ± 4.7 ng/mL in BD, and 25.9 ± 6.2 ng/mL in controls. Serotonin levels were 45.8 ± 12.6 ng/mL in MDD, 43.2 ± 11.4 ng/mL in BD, and 52.1 ± 14.3 ng/mL in controls. In the MDD group, significant negative correlations were observed between BDNF levels and mood disorder severity (r = -0.32, p = 0.045), whereas serotonin levels did not show significant correlations (r = -0.21, p = 0.23). In the BD group, BDNF levels also showed a significant negative correlation with manic symptoms (r = -0.28, p = 0.048), but serotonin levels showed no significant correlation. Subgroup analyses revealed that participants under 40 years had higher BDNF levels (22.8 ± 5.6 ng/mL) compared to those aged 40 and above (19.7 ± 4.3 ng/mL). Females showed higher BDNF levels (24.5 ± 6.3 ng/mL) than males (19.3 ± 3.8 ng/mL). Participants not on medication had higher BDNF levels (23.6 ± 5.1 ng/mL) compared to those on medication (17.9 ± 4.2 ng/mL). Those without comorbidities also had higher BDNF levels (23.8 ± 5.9 ng/mL) than those with comorbidities (18.2 ± 4.5 ng/mL), while serotonin levels varied similarly across these subgroups. Conclusion Lower BDNF levels are associated with mood disorders and symptom severity, indicating their potential as a biomarker.

العلاقة بين الإكتئاب وأساليب المعاملة الوالدية لدى الشباب والراشدين (دراسة حالة)

The current research aimed to reveal one of the reasons supporting the exacerbation of depression disorder among young people, and to study their cases, where the research tried to answer the following questions: What is the degree of depression in a sample of depressed young people? And what is the relationship of parents in the emergence of depression? To answer the research questions and test the hypotheses, we used the clinical approach in studying one of the cases in adulthood. To collect information, the Eysenck Personality Inventory, Hamilton Depression Scale, and Beck Depression Scale were used. Then, we prepared detailed clinical reports and psychological reports, and created a complete diagnosis by referring to the Diagnostic and Statistical Manual of Mental and Psychiatric Disorders. The results of the research showed: Children who are treated well by their parents are more psychologically and socially compatible, and they are more distinguished in masculine and feminine behavior than children who are treated poorly and are exposed to cruelty, rejection, neglect, or excessive pampering. The sound psychological and social development of children is linked to several factors that we will clarify below: A- Psychological and social compatibility. B- Psychological and social tendencies and interests and their proper satisfaction. C- Feeling of security, reassurance, love and affection. D- Family guidance and counseling.

Suicidal thoughts and behaviors in adults with hoarding disorder

BackgroundHoarding disorder (HD) is characterized by difficulty discarding possessions and clutter that impairs daily functioning. Previous research has demonstrated a high correlation between hoarding behaviors and suicidal thoughts and behaviors; however, there is limited research on suicidal thoughts and behaviors in individuals meeting Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for HD. Our aim in this study was to report our findings about suicidal thoughts and behaviors in a HD sample. MethodsWe used existing data from participants meeting DSM-5 criteria for HD (n = 99). Data about suicidal thoughts and behaviors was collected using a structured instrument, the Columbia-Suicide Severity Rating Scale (C-SSRS). ResultsAmong the 99 participants, 49.5 % and 26.3 % had passive and active suicidal ideation (SI), respectively. Of those with active ideation, 11 participants endorsed thinking about overdose during their most severe SI. 13 participants reported attempting suicide at least once in their lifetime. ConclusionsTo our knowledge, this is the first study examining suicidal thoughts and behaviors in HD using the structured assessment C-SSRS. In this HD data set, participants reported suicidal thoughts and behaviors at higher rates than the general U.S. population. Our study highlights the importance of screening for suicidal thoughts and behaviors in individuals with HD.

Comparative analysis of the identification efficacy of the bipolarity index and diagnostic and statistical manual of mental disorders, 5th edition, for bipolar disorder screening among college students

ObjectiveThis study aims to explore the differences in the identification efficacy of the Bipolarity Index (BPX) and the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5), as screening approaches for bipolar disorder (BD). MethodsA total of 150 college students with depressive episodes who underwent outpatient and inpatient treatment at Central China Normal University Hospital and the Renmin Hospital of Wuhan University between January 2021 and December 2022 were selected as research participants. We used a self-developed general data questionnaire to collect comprehensive demographic and clinical data from all participants. This questionnaire covered various aspects including gender, age, occupation, education level, drinking habits, age at onset, disease duration, frequency and duration of the current episode, comorbidities, family history of genetic conditions, diagnosis and prognosis. Participants were evaluated using the BPX, the DSM-5 and the International Classification of Diseases, 10th Revision (ICD-10). Clinical diagnosis based on the ICD-10 served as the standard against which the BPX and DSM-5 were compared for sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV). Additionally, we conducted a multivariate logistic regression analysis to evaluate risk factors associated with BD. ResultsThe sensitivity, specificity, accuracy, PPV and NPV were 85.34%, 81.90%, 84.00%, 87.21% and 79.69% for the BPX screening, and 72.73%, 90.32%, 80.00%, 91.43% and 70.00% for the DSM-5 screening, respectively. The study also identified significant clinical characteristics that differentiated those who screened positive for BD using the BPX. These characteristics included a younger average age at onset, a higher prevalence of atypical depression and more frequent prior affective episodes compared with those who did not meet the BPX criteria for BD. Risk factors associated with BD included atypical depression, history of suicide attempts, four or more previous affective episodes, borderline personality disorder, mixed states and a family history of BD. ConclusionIn conclusion, our findings suggest that the BPX exhibits superior sensitivity in screening for BD among college students compared with the DSM-5. Additionally, the study identifies significant risk factors (e.g., atypical depression, history of suicide attempts and multiple previous affective episodes), which are crucial for early detection and management.

Improving the DSM-5 approach to cognitive impairment: Developmental prosopagnosia reveals the need for tailored diagnoses.

The Diagnostic Statistical Manual of Mental Disorders (DSM-5) recommends diagnosing neurocognitive disorders (i.e., cognitive impairment) when a patient scores beyond -1 SD below neurotypical norms on two tests. I review how this approach will fail due to cognitive tests' power limitations, validity issues, imperfect reliabilities, and biases, before summarizing their resulting negative consequences. As a proof of concept, I use developmental prosopagnosia, a condition characterized by difficulties recognizing faces, to show the DSM-5 only diagnoses 62-70% (n1 = 61, n2 = 165) versus 100% (n1 = 61) through symptoms alone. Pooling the DSM-5 missed cases confirmed the presence of group-level impairments on objective tests, which were further evidenced through meta-analyses, thus validating their highly atypical symptoms. These findings support a paradigm shift towards bespoke diagnostic approaches for distinct cognitive impairments, including a symptom-based method when validated effective. I reject dogmatic adherence to the DSM-5 approach to neurocognitive disorders, and underscore the importance of a data driven, transdiagnostic approach to understanding patients' subjective cognitive impairments. This will ultimately benefit patients, their families, clinicians, and scientific progress.

Prevalence and Risk Factors of PTSD, Depression, and Grief Among Survivors of 2023 Türkiye Earthquake.

This study investigated the prevalence and risk factors of probable posttraumatic stress disorder (PTSD), depression, and complicated grief among 529 adults residing in a container city, 4 months after the 2023 earthquakes in Türkiye. Participants were assessed using the PTSD Checklist for Diagnostic and Statistical Manual of Mental Disorders, 5th Edition, the Hamilton Depression Scale, and the Inventory of Complicated Grief. The prevalence rates of probable PTSD, depression, and complicated grief were 21.4%, 15.9%, and 64.7%, respectively. Logistic regression analyses indicated that PTSD was significantly associated with the loss of a loved one, fear of future earthquakes, and decreased perceived life control. Similarly, depression was associated with being trapped under debris, experiencing fear during the earthquake, and reduced perceived life control. These findings suggest that individuals presenting these risk factors warrant closer follow-up for potential psychological issues. Additionally, the impact of fear related to the earthquake and the role of perceived life control emerge as crucial considerations for psychological interventions.

Prevalence of Attention Deficit Hyperactivity Disorder among Primary School Children in Hyderabad, South India

Purpose: Attention deficit hyperactivity disorder (ADHD) is among the most prevalent neurodevelopmental disorders in childhood, and its incidence has increased in recent years. However, the frequency of ADHD varies significantly across different countries and regions. This study aimed to determine the prevalence of ADHD among primary school children in Hyderabad, India, as well as to raise awareness about ADHD among teachers.Methods: This descriptive cross-sectional study included 700 school-aged children between 5 and 12 years old, selected according to specific inclusion and exclusion criteria. The teachers' version of the Vanderbilt Assessment Scale, a rating scale grounded in Diagnostic and Statistical Manual of Mental Disorders (DSM) diagnostic criteria, was employed to diagnose ADHD. Results: The prevalence of ADHD in this study was 9.57% (67 out of 700), with a mean age of 8.9 years. ADHD was more prevalent in boys than in girls, with a sex ratio of 3:1. The combined type of ADHD was the most common (52.3%), followed by the attention deficit type (29.8%) and the hyperactive-impulsive type (17.9%). Conclusion: The prevalence of ADHD among schoolchildren in middle-income countries, such as India, is sufficiently high to impose a significant societal burden. Therefore, it is imperative that all elementary school teachers receive training on how to screen for indicators of ADHD.

Cyberbullying and Internet Gaming Disorders in Pakistan: Strategies for Mitigation

Dear Editor,Cyberbullying and internet gaming disorders (IGDs) have emerged as significant concerns in Pakistan, particularly among adolescents. This editorial explores the prevalence, impacts, and potential interventions for these issues, drawing on recentresearch and literature. The need for a multifaceted approach involving parents, educators, communities, and government is emphasized to protect vulnerable populations and promote a healthier digital environment. The advent of widespread internet access in Pakistan has brought numerous benefits, yet it has also introduced challenges such as cyberbullying andinternet gaming disorders (IGDs). These phenomena have serious implications for the mental health and well-being of adolescents. Given the relative novelty of these issues in the local context and the paucity of research, it is crucial to develop a comprehensive understanding and effective strategies for mitigation. According to a met analysis of earlier research, Asianyouth have a high IGD prevalence 1 Defining Cyberbullying and IGDs Cyberbullying lacks a universally accepted definitiondue to its complexity. Alipan and Skues provide a useful framework, describing it as behavior that intentionally harms victims using information and communication technology, perceived as harmful by victims, and witnessed by bystanders as negative2 . IGDs are recognized in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) as a condition warranting further study. Vulnerability of Adolescents Adolescents are particularly susceptible to cyberbullying and IGDs due to the developmental changes they experience. The American Academy of Pediatrics recommends against providing personal mobile phones to children under 13 years old, highlighting their vulnerability to risky behaviors3. The prefrontal cortex, responsible for decision making and impulse control, is not fully developed in adolescents, making them prone to impulsive and risky behaviors, including cyberbullying and excessive gaming.

Comparative Efficacy of Lorazepam and Risperidone in Hospitalized Cannabis-induced Psychotic Disorder

Abstract Background: There is a lack of a standardized treatment protocol for cannabis-induced psychotic disorder (CIPD). Current practice involves using antipsychotics and benzodiazepines concurrently for treating CIPD. Aim: The index study aimed to assess and compare the efficacy of lorazepam against risperidone in patients with CIPD. Methods: Hospitalized patients with a diagnosis of CIPD according to the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition were randomized to receive either lorazepam or risperidone orally. Positive and Negative Syndrome Scale (PANSS), Young Mania Rating Scale (YMRS), Cannabis Withdrawal Scale, and the Marijuana Craving Questionnaire were administered at baseline and daily to assess the improvement in psychopathology, withdrawal, and craving over a period of 10 days. Monitoring was also done for any adverse effects associated with treatment. Results: A total of 40 patients with a diagnosis of CIPD were included; 20 each in lorazepam and risperidone group. Both groups were comparable with respect to baseline PANSS (P = 0.13) and YMRS (P = 0.92) scores. The baseline withdrawal score was higher in the risperidone group (P = 0.03). There was a significant reduction in PANSS and YMRS scores in both groups by day 5 and day 10 (values of <0.001). However, there was no significant difference between the two groups. The degree of improvement during the initial 5 days was significantly more (P ≤ 0.001) than that observed from day 5 to day 10 in both groups. Conclusion: There was no statistically significant difference between lorazepam and risperidone groups in terms of improvement in PANSS and YMRS scores. The use of antipsychotic did not have any additional benefit in CIPD and was rather associated with more adverse effects.

Between mourning and hope: A mixed-methods study of ambiguous loss and posttraumatic stress symptoms among partners of Israel defence force veterans.

Spouses of military combatants often experience adverse outcomes, including posttraumatic stress symptoms (PTSS) in the event of ambiguous loss (AL). AL refers to an uncertain situation regarding a person's status as alive or as cognitively present. The former ambiguity is categorized by the term physical AL (PAL), which refers to the continued psychological presence of a person, despite their physical absence. The latter ambiguity, categorized by the term psychological AL or ambiguous presence, refers to when a person is emotionally absent, despite their physical presence. Though AL has been widely researched, there are still gaps around the AL-posttraumatic stress disorder (PTSD) relationship, especially regarding dyadic variables that can moderate this relationship. Also, most of the AL military-related studies are qualitative, with only a few that combine qualitative and quantitative research methods. We address these gaps in an innovative mixed-methods study examining the emotional experience of Israeli veterans' spouses with a focus on the relationship between AL, PTSS, and dyadic adjustment (DA). The study included 63 participants, all spouses of Israeli veterans. We used self-report questionnaires (AL, Dyadic Adjustment Scale, and PTSD Checklist for Diagnostic and Statistical Manual of Mental Disorders, fifth edition) and a semistructured narrative interview. Our results revealed positive correlations between AL-PTSS and PAL-PTSS. Also, an interaction effect was found in which the lower the DA level, the stronger the PAL-PTSS correlation. Conversely, the higher the DA level, the stronger the ambiguous presence-PTSS correlation. Qualitative findings identified themes in the experience of these situations, including uncertainty and ambivalence. Our qualitative and quantitative results combined suggest that the way military couples deal with AL may be an important emotional experience requiring specific attention from mental health professionals. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Drug Addiction Clinical Study Among Patients Admitted to the Alqana Center for Social Rehabilitation

Background: Drug addiction is a worldwide issue; 5.6% of the world's population aged 15 to 64 took drugs at least once in 2016. For the majority of medicines, younger individuals use them more than older people do. Drug abuse seems to be on the increase in several ASEAN (Association of Southeast Asian Nations) countries, particularly among young men aged 15 to 30. Illicit drug abuse account for around 14% of the overall health burden among young males. Younger individuals are also more prone to die from drug abuse issues. Aims of study is to assess the severity of problems related to drug addiction. in Baghdad city and to study epidemiological features of drug addiction among Patients Admitted to the Alqana Center for Social Rehabilitation. Patients and methods: An analytical cross-sectional study of 300 individuals diagnosed as a drug addiction patient according to the criteria established by the "Diagnostic and Statistical Manual of Mental Disorders", Fifth Edition, text revision, often called the DSM-V-TR or DSM-5-TR. From the medical department at Alqana Center for Social Rehabilitation in Baghdad. The research was carried out from 25/December/2023 to 30/June/2024. Results: the demographic characteristics of the study sample. In with a mean and a standard deviation (SD) of age of 29.33±18.68. Individuals aged 20-29 year had the highest proportion to addiction, with a rate of 42.7%. Conversely, 89.3% of the participants were male. The majority,86.7%, live in urban regions. The majority of patients had 51.7% unmarried, with only 36.0% being married and 12.3% was divorced. The main rate among drug addiction patients was 38.7% primary education ,33.0% secondary education, and 16.0% was illiterate patient, while lowest patient 12.3% at collage. According to the statistics in the table,76.3% of the participants were free business. 95.0% cigarette smoker. presented the result of psychological symptoms as show 93.0% of study addictive patient have mood swings, and in the same table the behavioral and social symptoms showed as 97.0% of study patient had poor performance and/or attendance at work or school. Also, physical symptoms of addiction showed as 74.7% of patient suffering from disrupted sleep patterns, including insomnia Regarding to the withdrawal symptoms of drug addiction presented in Table (3), results showed as 95.7% fatigue, 85.3% muscle pain or aches, 81.0% irritability and agitation, 76.0% trembling and tremors, 69.3% hunger, 50.7% anxiety, 36.7% sweating, 30.7% insomnia, 25.3% loss of appetite, 22.7% depression, 20.7% confusion, 22.3% nausea, 9.3% seizures, 8.0% dilated pupils, 3.3% vomiting, and 2.3% paranoia. Conclusion: the majority of addicted patient was male. the main symptoms were Poor performance and/or attendance at work or school and mood swing. The highly complication was fatigue. Regarding the way of addiction, the tablets is vast majority and enjoyment is the most common cause of addiction. Recommendations: It's possible that other important differences between the factors seen in this study would become clearer if multicenter study, the sample size was larger and the duration of the addiction study had been longer.

Risk and protective factors associated with posttraumatic stress disorder among layperson responders to opioid overdose incidents.

Fatal and nonfatal overdoses involving opioids have increased to crisis levels in recent years. Laypersons have been increasingly tasked with responding to these events by administering naloxone, performing rescue breaths/cardiopulmonary resuscitation, and calling for medical assistance. However, little is known about the development of posttraumatic stress disorder (PTSD) related to opioid overdose responding among laypersons. To this end, we sought to determine the factors associated with PTSD stemming from responding to an opioid overdose event. From April 2021 to October 2021, structured interviews were conducted with layperson responders who had responded to an opioid overdose. Participants were administered structured diagnostic interviews, Clinician-Administered PTSD Scale for Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), and completed validated self-report measures. In total, 101 layperson adults who responded to an opioid overdose were recruited for the present study (Mage: 34, 65% identified as women, 79% as White, and 11% as Hispanic/Latino). Of the 80 participants who completed the Clinician-Administered PTSD Scale for DSM-5, 100% met Criteria A for PTSD related to overdose responding, and over one quarter (27.5%) met current PTSD diagnosis criteria related to overdose responding. Current PTSD related to overdose responding was associated with depression symptoms, generalized anxiety symptoms, and presence of law enforcement or professional first responders during the most distressing overdose responding event. Responding to opioid overdoses is traumatizing for many and results in a considerable burden of PTSD among layperson responders. As such, we call for trauma-informed interventions that cater to the unique experiences of layperson opioid overdose responders. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Evaluating the Effects of Ketamine on Serum Glutamate Dehydrogenase, Glutamine Synthetase and Asparagine Synthetase Levels in Patients with Major Depressive Disorder Before and After Ketamine Treatment

Introduction: It has been revealed that major depressive disorder (MDD)is a common and debilitating psychiatric disorder. Dysfunctional enzymes involved in neurotransmission glutamate dehydrogenase (GDH), Glutamine synthetase (GS) and Asparagine synthetase (ASNS) may underlie the pathophysiology of MDD. The present project aimed to explore the effects of Ketamine on GDH, GS and ASNS in MDD patients. This study provides evidence of interactions between ketamine and GDH, ASNS and GS levels in patients with MDD. Materials and Methods: Patients with MDD are referred to the psychiatric ward of Shaheed Yahyanejad Hospital for regular follow-up. Patients diagnosed with MDD were based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), structured clinical interviews, as well as the severity of depression based on clinical criteria determined by a specialist physician. Serum samples from MDD patients before and after ketamine administration were taken to examine the changes in GDH, ASNS and GS levels. In this project, 29 patients with MDD therapy were evaluated with ketamine (0.75 mg/kg). Results: Our study showed that after administrating ketamine, the level of ASNS and Glutamate dehydrogenase GDH in patients with MDD was reduced compared to pre-treatment. However, the level of GS was increased compared to before treatment. The results show that ketamine occurs at the metabolism level in MDD patients. Also, our results demonstrated that GDH, ASNS, and GS levels can be measured to evaluate the effect of Ketamine on MDD patients. Conclusions: Patient success has improved depression after two months of administrating ketamine. Marginally, more than 80% of patients diagnosed with MDD treated with ketamine showed complete remission. Current results may be helpful in understanding the mechanisms responsible for ketamine’s clinical efficacy.

The relationship between insight and coping attitudes in bipolar disorder patients

ABSTRACT Bipolar disorder is thought to determine the insights and coping attitudes that affect a patient’s compliance with treatment, which can positively affect the prognosis of the disease. This study aimed to investigate the relationship between insight and coping attitudes in bipolar disorder patients. This descriptive study was carried out with 127 volunteer patients who were diagnosed with bipolar disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and who were in a euthymic state. The Personal Information Form, Beck Cognitive Insight Scale (BCIS) and Scale of Coping Attitudes (COPE) were used as data collection tools. We found positive correlations between the total COPE score, the total BCIS score and the self-reflectivity subscale score of the BCIS. A positive and significant correlation was also determined between the BCIS subscales and total scores and coping attitudes toward adaptation with the COPE subscales (p < 0.05). A positive and significant relationship was found between the insight scores and total coping scores of the patients and their coping attitudes toward adaptation. We found that when patients’ levels of insight increased, their coping attitudes toward adaptation were used more frequently. This study revealed that individuals with high self-reflectivity can cope more effectively with the situations they face.

Genetic networks suggest Asperger’s syndrome as a distinct subtype of autism spectrum disorders

BackgroundThe Diagnostic and Statistical Manual of Mental Disorders (DSM-V) issued new diagnostic criteria for autism spectrum disorders (ASD) which resulted in missing the diagnosis of some cases of Asperger’s syndrome (AS). This negatively affected the support received by those affected. In this study, we explored if AS could be biologically stratified from the broader spectrum through a gene co-expression network preservation analysis. MethodsWe analysed the GEO microarray data of 24 individuals with Asperger’s syndrome and 72 individuals with autism. Then, we used a weighted gene co-expression network (WGCNA) pipeline to construct gene co-expression networks. We explored whether these modules share the same co-expression patterns between autism and Asperger’s syndrome using network preservation analysis. ResultsOur results showed that all co-expression modules of autism are preserved into the Asperger’s syndrome. However, three modules of Asperger’s syndrome out of 30 modules were not preserved in autism.Gene enrichment analysis revealed that these modules were involved in chromatin remodelling, immune and neuroinflammatory response, synaptic and neuronal development. Brain enrichment analysis showed significant downregulation of neurodevelopment genes in different brain regions associated with impaired social recognition in Asperger’s syndrome. ConclusionsThe identified genetic and molecular profiles suggest that Asperger’s syndrome, despite sharing numerous similarities with autism, possesses a distinct genetic profile that makes it a distinct subtype of autism. This distinction could have significant implications for the management and treatment strategies tailored to individuals with Asperger’s syndrome.

The relationship between addiction profile and parental attitudes in patients with opioid use disorder

ABSTRACT Background and objective We aimed to compare the perceived parental attitudes experienced by adults with opioid use disorder (OUD) with a healthy group and to examine its effect on the addiction profile. Methods Our study included 71 male patients diagnosed with OUD based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria and 71 male volunteers. Patients included in the study and healthy control group were subjected to the Sociodemographic Data Form (SDF), Young Parenting Inventory (YPI), Childhood Trauma Questionnaire (CTQ), and Addiction Profile Index (API) after the psychiatric examination. Results Most YPI subscales were significantly higher in the OUD group compared to the healthy control group (p < .05). A multivariate regression analyses model was statistically significant (x2 = 81,969, p < .001) with a Nagelkerke R2 value of 0.58. Family history of alcohol use disorder/substance use disorder (AUD/SUD), YPI belittling/criticizing (mother), YPI overprotective/anxious (mother), YPI pessimistic/fearful (mother), YPI restricted/emotionally inhibited (mother), and YPI pessimistic/fearful (father) were found to be independent predictors of the risk of developing OUD. Conclusion Critical, overprotective, and withdrawn parental attitudes, along with a family history of AUD/SUD, may predict OUD risk. This suggests the potential value of integrating parental-focused therapy into OUD treatment.

Role of vesicular monoamine transporter-2 for treating attention deficit hyperactivity disorder: a review.

The Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) classifies attention deficit hyperactivity disorder (ADHD) as a neurodevelopmental disorder that interferes with human functioning and development. As the clinical presentation of ADHD involves a deficiency in executive function, neurocognitive deficits involving distinctive neuropathological changes must be present for clinical diagnosis. The vesicular monoamine transporter (VMAT), specifically VMAT-2, plays a role in ADHD pathogenesis. In addition, experimental data show that the stimulants (amphetamines and methylphenidate) are first-line treatments for the condition because of their extensive interaction with VMAT-2. The interactions of peptides, bupropion, and nutritional supplements with VMAT-2 receptors have been researched, but more evidence is needed to elucidate their pharmacodynamic properties. Therefore, this literature review evaluated the current pharmacological treatment modalities, peptides, and nutritional supplements for ADHD that target the VMAT-2 system. We obtained relevant studies from several platforms, including the National Center for Biotechnology, Clinical Key, Access Medicine, and PubMed. From the results of these studies, we observed that stimulants interact highly with the VMAT-2 transporter, with omega-3 fatty acids, peptides, and bupropion exerting some modulatory activity on VMAT-2. These agents should be considered for the future treatment of ADHD, although clinical-level research involving human participants is necessary.

Supplemental Material for An Evaluation of Measurement Invariance of Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition Borderline Personality Disorder Criteria Across Heterosexual, Lesbian, Gay, and Bisexual Adults

Supplemental Material for An Evaluation of Measurement Invariance of Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition Borderline Personality Disorder Criteria Across Heterosexual, Lesbian, Gay, and Bisexual Adults