Background & Purpose: To date, it is unclear whether robotic-assisted gait training is effective at restoring walking ability in hemiparetic stroke subjects. This case study provides an example of when a robotic gait-orthosis provides distinct advantages over conventional over-ground gait training strategies focused on gait restoration. Case Description: In February 2006 a 48 year old caucasian female presented with right quadrant pain, headaches, blurry vision and weakness in all four extremities. She was diagnosed with cortical blindness, bilateral occipital/parietal infarcts right greater than left secondary to necrotizing vasculitis. Upon transfer to the National Rehabilitation Hospital in March 2006, patient presented with impairments in multi-systems resulting in poor posture and motor control, increased extensor tone, decreased body awareness, localized hypersensitivity to touch, decreased skin integrity, decreased perceptual skills, decreased recent memory and hypothetical problem solving. During the first month the treatment focused on stability in sitting and increasing body awareness. Treatment progressed to learning how to initiate gross motor movement with breathing strategies. Visual training was incorporated into every session initially to track objects with her eyes with stationary head then with head turning. She advanced to localizing and reaching for objects. During the next four weeks standing activities and gait were the focus. Attempts at gait training were not successful as patient could not initiate stepping. An over ground body-weight support system was trialed for two weeks. Though able to take steps with body weight support, there was no carry over to functional walking when unweighted. Finally the patient was trialed on the Lokomat (Hocoma AG, Volketswil, Switzerland) a robotic-gait orthosis suspended over a treadmill. The patient was trained three times a week on the Lokomat for 5 sessions progressing from approximately 50% to 20% body weight, walking duration from 9 minutes to 30 minutes at 1.5 Km/hr to 2.0 Km/hr. Outcomes: Over the first two months of therapy the patient showed slow yet steady improvements in functional mobility skills, increase in sitting control and static standing control. Her ability to take steps only occurred with body-weight support. She was not able to transfer those movements to walking without body-weight support in the parallel bars. However, after the patient trained in the Lokomat, within two sessions, she was able to take steps in the parallel bars without body-weight support. Discussion: The use of a robotic-gait orthosis may offer advantages over conventional approaches for improving walking ability, particularly in individuals with multiple sensorimotor impairments. Devices such as the Lokomat can help initiate and maintain stepping patterns, which when combined with body-weight support, provides unique therapeutic advantages.