This study covers the stationary analysis of an unreliable Markovian queueing system with feedback based on a hybrid vacation policy. Customers arrive at the station at random using a Poisson process. Service time is distributed exponentially. The necessary and sufficient requirements for system stability have been demonstrated. Many performance metrics of this queueing system, such as the stationary queue length distribution, have been obtained from the steady-state probability distribution of the queueing model and the steady-state queue length using the matrix geometric method. To establish the model’s performance indicators, a few formulas have also been developed. The Adaptive Neuro-Fuzzy Inference System (ANFIS) was used to develop rules from the input datasets and generate different performance indices. Finally, the impact of system parameters and cost analysis was studied using numerical examples.