The species rejected by plasmapheresis membranes are cellular. Only by postulating the form and then measuring the magnitude of cell—membrane interactions can such merebranes be compared. Superficial deposition of cells followed by movement of the cell layer has been previously postulated by the authors as the important cell behavior at the merebrane. Hence the resistance of consolidated cell layers was taken to be of primary concern. Experimental values of this resistance were obtained for seven microporous films. Results with static cell layers indicate little difference among membranes in the range of pore sizes normally prescribed for plasmapheresis. If sheared, cell layers on smooth membranes, but not on rough ones, seemed to show decreased resistance. Static layers on membranes with pores either larger or smaller than commonly prescribed for plasmapheresis showed resistances different from those of layers on the other membranes tested.
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