Static Control Research Articles

Signed-network-based consensus control for nonlinear multi-agent systems: a dynamic encryption–decryption approach

Abstract This paper is concerned with the bipartite secure control issue for a class of discrete-time nonlinear multi-agent systems under a dynamic encryption–decryption approach. First, the coupling relationships between agents are portrayed through a signed graph topology containing the edges of positive and negative connection weights. Next, the information transmissions between agents and their neighbors are executed via a shared communication network. The dynamic encryption–decryption approach is implemented to transform original signals into ciphertexts. Under the assumption that the signed graph is structurally balanced, a signed-network-based bipartite secure controller is designed to achieve the desired state control for the nonlinear multi-agent system and sufficient conditions are obtained for the existence of the desired signed-network-based state controller. Furthermore, a precise definition of the minimum channel capacity is proposed to understand the factors affecting the minimum channel capacity. Finally, the effectiveness of the proposed approach is illustrated by two simulation examples.

Vibration Thresholds Using Conventional Audiometry are Clinically Useful Indicators of Postural Instability in Older Adults.

Falls are a major health concern with potentially dramatic consequences for people over 65 years of age. One crucial determinant in the risk of falls in older adults is postural control, a complex process that requires the contribution of different sensory modalities, namely visual, vestibular, auditory, and somatosensory. While there are well-established methods to screen for age-related vision, hearing, tactile, and vestibular impairments, there are very few widely available methods to screen for somatosensory function, but studies indicate that ankle audiometry (vibration thresholds) using a common B-71 bone vibrator can serve that purpose. To date, unfortunately, this technique has received little attention as a tool to measure postural instability in older adults. The objective of the present study was to examine postural control in older adults with and without degradation of the somatosensory functions, as determined with ankle audiometry. This was standard group comparison. In total, 36 healthy elderly aged between 65 and 80 years old were divided into two groups (low vibration threshold [n = 18] and high vibration threshold [n = 18]). Standard audiometry, video head impulse test, vibration thresholds (big toe, ankle, and tibia), and static postural control task using a force platform were performed. Greater postural instability in participants with higher (worse) vibration thresholds as compared with participants with lower (better) vibration thresholds was observed even though both groups were comparable on hearing threshold and vestibular function. The results indicate that performing a simple vibration threshold evaluation, using a clinically available B-71 with a cut-off value of 42 dB hearing loss, could be an effective, fast, and easy-to-use procedure for detecting people at risk of falls.

Static output feedback control for positive 2D discrete systems in Roesser model

Abstract This paper investigates the output stabilization problem for multi-input multi-output positive 2D systems described by a linear discrete-time Roesser system. This kind of systems have the property that the horizontal and vertical states take non-negative values whenever the initial boundaries are non-negative. Conditions for the existence of desired static output feedback controllers guaranteeing the resultant closed-loop system to be positive and asymptotically stable are obtained. Also, the synthesis of static output feedback controllers, including the requirement of positivity of the controllers, is solved. These results are then extended to the case of uncertain plants. All of the proposed conditions are expressed in terms of Linear Programming, which can be easily verified by using standard numerical software. Finally, several numerical examples are included to illustrate the validity and the effectiveness of the developed results.

Effects of simulated microgravity on colorectal cancer organoids growth and drug response

Cellular and molecular dynamics of human cells are constantly affected by gravity. Alteration of the gravitational force disturbs the cellular equilibrium, which might modify physiological and molecular characteristics. Nevertheless, biological responses of cancer cells to reduced gravitational force remains obscure. Here, we aimed to comprehend not only transcriptomic patterns but drug responses of colorectal cancer (CRC) under simulated microgravity. We established four organoids directly from CRC patients, and organoids cultured in 3D clinostat were subjected to genome wide expression profiling and drug library screening. Our observations revealed changes in cell morphology and an increase in cell viability under simulated microgravity compared to their static controls. Transcriptomic analysis highlighted a significant dysregulation in the TBC1D3 family of genes. The upregulation of cell proliferation observed under simulated microgravity conditions was further supported by enriched cell cycle processes, as evidenced by the functional clustering of mRNA expressions using cancer hallmark and gene ontology terms. Our drug screening results indicated an enhanced response rate to 5-FU under conditions of simulated microgravity, suggesting potential implications for cancer treatment strategies in simulated microgravity.

Postural control among older adults with fear of falling and chronic low back pain

ObjectiveAltered Postural control could increase the risk of falling in older adults. Factors such as low back pain and fear of falling can be contributing factors to postural control instability. This study aimed to investigate the effect of chronic low back pain (CLBP) and fear of falling (FOF) on postural control of older adults.MethodForty-one older adults were included (27 LBP and 14 control). Among the participants, 22 people had high FOF, and 19 had low FOF based on Falls efficacy scale cut-off of ≥ 26. For postural control evaluation Center of pressure parameters (COP) of Standard deviation (Sd) of velocity, Sd of amplitude, path length and mean velocity in both Medial–lateral (ML) and Anterior–Posterior (AP) directions were measured. Mixed-model anova with two between group factor (Health status; with and without CLBP, and with high and low FES-I groups) and one within factor postural condition (four conditions with and without vision and Achill tendon vibration) was used.ResultNo significant interaction between groups (health status and FES-I) and group with condition (health status and condition or FES-I and condition) was observed for all COP parameters in both AP and ML direction. There was main effect of FES-I for all COP parameters in ML direction, with greater Sd of velocity, Sd of amplitude, path length and mean velocity in older adults with high FES-I compared to low FES-I in the ML direction.ConclusionHigh levels of FOF influenced static postural control in the ML direction. Therefore, paying attention to the lateral stability of older adults is of great importance.

Voluntary wheel running exercise rescues behaviorally-evoked acetylcholine efflux in the medial prefrontal cortex and epigenetic changes in ChAT genes following adolescent intermittent ethanol exposure.

Adolescent intermittent ethanol (AIE) exposure, which models heavy binge ethanol intake in adolescence, leads to a variety of deficits that persist into adulthood-including suppression of the cholinergic neuron phenotype within the basal forebrain. This is accompanied by a reduction in acetylcholine (ACh) tone in the medial prefrontal cortex (mPFC). Voluntary wheel running exercise (VEx) has been shown to rescue AIE-induced suppression of the cholinergic phenotype. Therefore, the goal of the current study is to determine if VEx will also rescue ACh efflux in the mPFC during spontaneous alternation, attention set shifting performance, and epigenetic silencing of the cholinergic phenotype following AIE. Male and female rats were subjected to 16 intragastric gavages of 20% ethanol or tap water on a two-day on/two-day off schedule from postnatal day (PD) 25-54, before being assigned to either VEx or stationary control groups. In Experiment 1, rats were tested on a four-arm spontaneous alternation maze with concurrent in vivo microdialysis for ACh in the mPFC. An operant attention set-shifting task was used to measure changes in cognitive and behavioral flexibility. In Experiment 2, a ChIP analysis of choline acetyltransferase (ChAT) genes was performed on basal forebrain tissue. It was found that VEx increased ACh efflux in the mPFC in both AIE and control male and female rats, as well as rescued the AIE-induced epigenetic methylation changes selectively at the Chat promoter CpG island across sexes. Overall, these data support the restorative effects of exercise on damage to the cholinergic projections to the mPFC and demonstrate the plasticity of cholinergic system for recovery after alcohol induced brain damage.

Piezoelectric silk fibroin nanofibers: Structural optimization to enhance piezoelectricity and biostability for neural tissue engineering

Silk fibroin (SF) has garnered significant interest in tissue engineering due to its excellent biocompatibility and bioactivity. Notably, SF exhibits piezoelectric properties that can be harnessed to electrically stimulate cells, enhancing tissue morphogenesis. However, a systematic approach to control SF's piezoelectricity and biodegradation, and its application in neural morphogenesis, has not been fully explored. In this study, SF was electrospun into nanofibers of various sizes and subjected to a post-electrospinning chemical treatment to examine the effects of phase composition, especially the β-sheet formation, on the piezoelectricity and biostability of SF. The optimized SF scaffolds having a nanofiber diameter of 750 nm and a scaffold thickness of 250 µm allowed for the maintenance of nanofibrous structure for at least 6 weeks in aqueous environments while maintaining piezoelectric potential outputs of at least 200 mVp-p. This enabled cell membrane depolarization over an extended cell culture duration, facilitating the functional maturation of human neural stem cells (hNSCs). Specifically, acoustic piezo-activation of the SF scaffolds, resulting in mechano-electrical stimulation (MES) of the cells, accelerated their differentiation into neurons, astrocytes, and especially oligodendrocytes, leading to robust axon myelination within two weeks. Furthermore, MES enhanced neural connectivity and functional maturity, as evidenced by significant increases in excitatory and inhibitory synapse formation (46 % and 58 %, respectively), action potential amplitude (252 %), and velocity (210 %) compared to static control conditions. These findings demonstrate the potential of biodegradable electrospun SF nanofibers with balanced piezoelectricity and biostability for advancing neural tissue engineering.

Static and dynamic open loop control of selective laser flash sintering conducted with direct current electric fields

AbstractSelective laser flash sintering utilizes a scanning laser as a heat source to locally initiate flash sintering in the regions scanned by the laser. A key challenge towards utilizing this process for additive manufacturing (AM) is the induced electrical current that arises during flash sintering. With traditional scan patterns conducted with static electric fields, electrical and thermal runaway and associated thermal shock cracking occur. In this study, several open‐loop control strategies with static and dynamic applied electric fields were utilized to control peak currents. These strategies were shown to be effective in reducing peak currents to below 1.0 µA and reducing the severity of, but not completely eliminating cracking. Alternative strategies are suggested that could lead to complete elimination of cracks.

Event‐Triggered Secure Control of Positive Networked Control Systems Under Multi‐Channels Attacks

ABSTRACTThis paper focuses on the secure control of positive networked control systems under multi‐channel attacks characterized by a Bernoulli distribution. Specifically, the sensor‐to‐controller channel suffers from false data injection (FDI) attacks, whereas the controller‐to‐actuator channel suffers from denial of service (DoS) attacks. The objective is to design a static output feedback controller that guarantees the positivity and stochastic stability of the closed‐loop system in the presence of DoS and FDI attacks. To conserve communication resources, we employ an event‐triggered scheme to reduce the frequency of information transmission. Due to the positivity of the system, the proposed event‐triggering mechanism employs the 1‐norm form instead of the 2‐norm form, which allows that the controller parameter is determined via linear programming rather than LMI technique. Finally, two simulation examples are provided to verify the effectiveness of our methods.

Plantar massage or ankle mobilization do not alter gait biomechanics in those with chronic ankle instability: a randomized controlled trial

ABSTRACT Objectives Chronic ankle instability (CAI) is characterized by persistent neuromechanical impairments following an initial lateral ankle sprain. Ankle joint mobilization and plantar massage have improved the range of motion and static postural control in those with CAI. This study aimed to determine the impact of two-week joint mobilization and plantar massage interventions on gait kinematics and kinetics in individuals with CAI. Methods A single-blind randomized trial was conducted with 60 participants with CAI, randomized into three groups: joint mobilization (n = 20), plantar massage (n = 20), and control (n = 20). The two treatment groups received six 5-min sessions manual therapy over a 2-week, while the control group received no intervention. Gait biomechanics were assessed on an instrumented treadmill before and after the intervention using 3D kinematics and kinetics analysis. Analyses compared biomechanical outcomes from each treatment group to the control group individually using a 1-dimensional statistical parametric mapping. The alpha level was set at p < 0.05. Results Eighteen participants per group were part of the final analysis. No significant main or interactions effects were found for ankle sagittal or frontal plane positions following either intervention (p > 0.05 for all comparisons). COP location relative to the lateral border of the foot also did not change (p > 0.05). Conclusion The findings suggest that two-week joint mobilization and plantar massage interventions do not significantly alter gait biomechanics in individuals with CAI. These results support the need for gait-specific interventions to modify biomechanics in this population.

Unifying Static and Dynamic Intermediate Languages for Accelerator Generators

Compilers for accelerator design languages (ADLs) translate high-level languages into application-specific hardware. ADL compilers rely on a hardware control interface to compose hardware units. There are two choices: static control, which relies on cycle-level timing; or dynamic control, which uses explicit signalling to avoid depending on timing details. Static control is efficient but brittle; dynamic control incurs hardware costs to support compositional reasoning. Piezo is an ADL compiler that unifies static and dynamic control in a single intermediate language (IL). Its key insight is that the IL’s static fragment is a refinement of its dynamic fragment: static code admits a subset of the run-time behaviors of the dynamic equivalent. Piezo can optimize code by combining facts from static and dynamic submodules, and it opportunistically converts code from dynamic to static control styles. We implement Piezo as an extension to an existing dynamic ADL compiler, Calyx. We use Piezo to implement a frontend for an existing ADL, a systolic array generator, and a packet-scheduling hardware generator to demonstrate its optimizations and the static–dynamic interactions it enables.

Temporal adaptation of the postural control following a prolonged fin swimming.

Postural control deteriorates following a transition between two environments, highlighting a sensory conflict when returning to natural conditions. Aquatic immersion offers new perspectives for studying postural control adaptation in transitional situations. Our aim is to study immediate and post-task static postural control adaptation on land after a prolonged fin swimming exercise in total immersion. Standing static postural control was assessed in 14 professional or recreational SCUBA divers (11 men, 3 women; 33.21 ± 10.70years), with eyes open and closed, before, immediately after, and in the following 20min following a fully-immersed 45-min fin swimming exercise. Centre-of-pressure metrics (COP) including average position, amplitude, velocity, length and 95% ellipse were evaluated in medial-lateral (x-axis) and anterior-posterior (y-axis) directions with a force platform. The Romberg ratio was also assessed for each metric. A two-way repeated measures analysis of variance revealed a significant effect of the measurement period on COPx vel (p = 0.01), COPy vel (p < 0.01) and Length (p < 0.01), and of the visual condition on COPy vel (p < 0.01) and Length (p < 0.01). Eyes closed measures were systematically higher than eyes open measures despite there being no significant difference in the Romberg ratio in all periods. Post-immersion, the velocity and total trajectory of the centre of pressure remained systematically lower than baseline values in both visual conditions. Post-immersion, COP velocity and length significantly decreased, suggesting a sensory reweighting strategy potentially associated with ankle stiffening.

Factors Affecting Dynamic Postural Control Ability in Adolescent Idiopathic Scoliosis.

Research on postural control in patients with adolescent idiopathic scoliosis (AIS) has focused on static postural control, with few studies assessing dynamic postural control. We aimed to identify factors affecting index of postural stability (IPS), a dynamic postural control parameter, in patients with AIS. The participants comprised 50 female patients with AIS. We measured the IPS using stabilometry to evaluate dynamic postural control ability. We investigated age of the participants, major curve position (thoracic or thoracolumbar/lumbar), Cobb angle, and coronal balance. We then assessed the relationships between stabilometry parameters and other variables. IPS was analyzed with a linear regression model. Coronal balance, major curve position, and age each correlated with dynamic postural control ability. The Cobb angle showed no correlation with any of the parameters. Our results offer new insights into the assessment of postural control in patients with AIS.

Iterative control decoupling tuning for precision MIMO motion systems: A matrix update method

Control decoupling is the basic control step for precision MIMO (Multi-Input-Multi-Output) motion systems. After decoupling, the MIMO logical controlled plant can be diagonal dominant so that the control design for each DOF (Degree of Freedom) can be separately treated. However, due to the manufacturing tolerances and the assembling errors, the actual CoG (Center of Gravity) and actuator positions are inconsistent with the designed values. The nominal static control decoupling matrix is inaccurate, which significantly deteriorates the decoupling performance. To address the problem, this paper develops a matrix update based iterative control decoupling tuning method. Tuning with feedback control signals to achieve accurate tuning is its first distinct feature. By employing rigid-body model information to construct more accurate basis functions, fast tuning can also be achieved, especially for relatively low control bandwidth occasions. Differing from the feedforward compensation based iterative control decoupling tuning method, the matrix update method improves the dynamics of the logical controlled plant, does not increase the control complexity and is more robust to the inaccuracy of the model information. Experimental results on the short-stroke module of a precision motion stage which is the key subsystem of the lithographic projection lens testing system present significant control decoupling performance improvement (for example the peak value of the Rx-DOF servo error caused by the Z-DOF movement is reduced from 1.29 ×10−5 m to 3.19 ×10−6 m) after just two trials.

Go with the flow: An in vitro model of a mature endothelium for the study of the bioresponse of IV injectable nanomedicines

The first exposure of intravenously (IV) administered nanomedicines in vivo is to endothelial cells (ECs) lining blood vessels. While it is known that in vitro endothelium models to assess responses to circulating nanoparticles require shear stress, there is no consensus on when and how to include it in the experimental design. Our experimental workflow integrates shear stress by featuring a flow-induced mature endothelium (14 days) and a flow-mediated nanoparticle treatment. The mature endothelium model exhibited distinct features that indicated a structurally stable and quiescent monolayer. Upon treatment with iron sucrose under dynamic conditions, there was a lower nanoparticle uptake, lower cytotoxicity, and decreased expression of activation markers compared to the static control. This response was attributed to glycocalyx expression, predominantly observed on the mature endothelium. In conclusion, our proposed in vitro endothelium model can be leveraged to understand the dynamics of IV injectable nanomedicines at the initial nano-bio interface in veins immediately post-injection.

Perfusion Bioreactor Conditioning of Small-diameter Plant-based Vascular Grafts.

Vascular grafts are mainly composed of synthetic materials, but are prone to thrombosis and intimal hyperplasia at small diameters. Decellularized plant scaffolds have emerged that provide promising alternatives for tissue engineering. We previously developed robust, endothelialized small-diameter vessels from decellularized leatherleaf viburnum. This is the first study to precondition and analyze plant-based vessels under physiological fluid flow and pressure waveforms. Using decellularized leatherleaf viburnum as tissue-engineered grafts for implantation can have profound impacts on healthcare due to their biocompatibility and cost-effective production. A novel perfusion bioreactor was designed, capable of accurately controlling fluid flow rate and pressure waveforms for preconditioning of small-diameter vascular grafts. A closed-loop system controlled pressure waveforms, mimicking physiological values of 50-120mmHg at a frequency of 8.75Hz for fluid flow reaching 5mL/min. Plant-based vascular grafts were recellularized with endothelial and vascular smooth muscle cells and cultured for up to 3weeks in this bioreactor. Cell density, scaffold structure and mechanics, thrombogenicity, and immunogenicity of grafts were evaluated. Bioreactor treatment with fluid flow significantly increased luminal endothelial cell density, while pressure waveforms reduced thrombus formation and maintained viable vascular smooth muscle cells within inner layers of grafts compared to static controls. Suture retention of grafts met transplantation standards and white cell viability was suitable for vascular remodeling. Low thrombogenicity of endothelialized leatherleaf viburnum holds great potential for vascular repair. This study provides insight into benefits of conditioning plant-based materials with hemodynamic forces at higher frequencies that have not previously been investigated.

Enriching central memory T cells using novel bioreactor design for T cell manufacturing

The manufacturing of T cell therapies aims to achieve high yields of product with potent phenotypes. We have developed a novel bioreactor, Bioreactor with an Expandable Culture Area – Dual Chamber (BECA-D), which has previously demonstrated functionality for scaled T cell manufacturing. In this study, incorporation of a stirring mechanism into the double-chamber bioreactor design was tested to homogenize the media components between the two chambers. In addition to the improved media homogenization, the stirring culture was also observed to have higher yield and enrichment of central memory T cells, a T cell subpopulation that has been associated with improved therapeutic efficacy, as compared to a static control. BECA-D with a stirring mechanism (BECA-DS+), was evaluated for its performance in culturing T cells in comparison to a static control, BECA-D, and an industry benchmark, G-Rex10. BECA-DS+ was able to preferentially promote the enrichment of central memory T cells compared to the static cultures, indicative of the effect of the stirring mechanism. By achieving high T cell yields with a favorable subpopulation profile, the mechanical method of incorporating stirring into a double-chamber bioreactor such as BECA-D carries great potential as a useful research and manufacturing tool to support advanced T cell therapy manufacturing.

Leveraging AI and ML for Next-Generation Cloud Security: Innovations in Risk-Based Access Management

In the increasing reliance on the cloud computing era, securing digital assets against sophisticated cyber threats has become a critical concern for organizations globally. Traditional security mechanisms, which often rely on static and pre-defined access control policies, must be revised to address these threats' dynamic and evolving nature. This study investigates the application of Artificial Intelligence (AI) and Machine Learning (ML) in enhancing cloud security through the development of advanced Risk-Based Access Management (RBAM) systems. The primary objective is to evaluate how AI and ML can improve dynamic access control, threat prediction, and mitigation strategies within cloud environments. The research adopts a mixed-methods approach, combining quantitative analysis of RBAM system performance with qualitative insights from cybersecurity experts. AI/ML models were developed using extensive historical access log datasets and integrated into a cloud-based RBAM prototype. The system's performance was assessed based on its accuracy in threat detection, reduction in false positives, and effectiveness in dynamically adjusting access controls. Results indicate that the AI-enhanced RBAM system significantly outperforms traditional methods, achieving a 30% reduction in false positives and a 25% decrease in unauthorized access incidents. Additionally, AI-driven threat prediction models demonstrated high accuracy, enabling preemptive actions to mitigate potential security breaches. These findings highlight the transformative potential of AI and ML in cloud security, providing a more adaptive and proactive defense against emerging threats. The study concludes with recommendations for refining AI/ML models and exploring their application in other areas of cloud security, emphasizing the need for continued innovation to safeguard the increasingly complex digital landscapes that organizations operate within today.

Estimation and Control of Positive Complex Networks Using Linear Programming

This paper focuses on event-triggered state estimation and control of positive complex networks. An event-triggered condition is provided for discrete-time complex networks by which an event-based state estimator and an estimator-based controller are designed through matrix decomposition technology. Thus, the system is converted to an interval uncertain system. The positivity and the L1-gain stability of complex networks are ensured by resorting to a co-positive Lyapunov function. All conditions are solvable in terms of linear programming. Finally, the effectiveness of the proposed state estimator and controller are verified by a numerical example. The main contributions of this paper are as follows: (i) A positive complex network framework is constructed based on an event-triggered strategy, (ii) a new state estimator and an estimator-based controller are proposed, and (iii) a simple analysis and design approach consisting of a co-positive Lyapunov function and linear programming is presented for positive complex networks.

Subtalar joint pronation: Who is the real enemy, presence or severity: A cross-sectional study?

The study aims to compare static and dynamic postural stability, navicular drop, dorsiflexion range of motion, and jumping performance of individuals with neutral, prone, and hyperprone foot postures. Forty-eight participants between the ages of 18 and 40, were categorized into neutral (n=16), prone (n=16), and hyperprone (n=16) according to foot posture index (FPI). Static and dynamic postural control evaluations (with the Biodex Balance System SD), navicular drop test (NDT) weight-bearing lunge test, countermovement jump test without arm swing, and drop vertical jump tests have been completed. In the results, the average age of participants in the NG, PG, and HPG are 22.31 ± 2.75, 23.87± 3.72, and 22.37 ± 1.28 years and BMI are 22.6 ± 3, 23.4 ± 3.8, and 21.4 ± 2.24 (kg/m²), respectively. The demographic data of the participants showed a homogeneous distribution. There were no significant differences in none of the outcomes except the NDT. Navicular drop amount is positively correlated by the subtalar joint pronation. An increase in subtalar joint pronation does not have a significant effect on static and dynamic stability, jump performance, or dorsiflexion range of motion in healthy individuals.