This research aims to examine the influence of sense of humor and social support on academic burnout in students at Padang State University. This research is also to test the influence of each independent variable (sense of humor and social support) on the dependent variable (academic burnout). The sample consisted of 340 students at Padang State University taken using purposive sampling technique. The data collection instrument uses an academic burnout measuring tool developed by Schaufeli and Salanova (2007), namely the Maslach Burnout Inventory – Student Survey (MBI-SS) and has been used and modified by Sulthon (2021), a social support measuring tool developed by Zimet et al . (1988) and has been modified and translated into Indonesian and has been tested and modified by Fadillah (2022), and a sense of humor measuring instrument based on the theory of Thorson and Powell (1993) which has been used and modified by Putri (2017). in this research with multiple linear analysis using SPSS Statistics 20.0 for Windows software. The results show a significance value of 0.382 and 0.115, the R Square value is 0.221. The results show that there is a positive influence of sense of humor and social support on academic burnout.