Rest State Research Articles

Low-dose esketamine improves acute postoperative pain in patients undergoing thoracoscopic surgery

PurposeThe current study was designed to investigate the analgesic effect of esketamine on patients underwent thoracoscopic surgery and the underlying mechanism.MethodsIn this randomized, double blind, placebo-controlled study, 60 patients scheduled to undergo thoracoscopic lobectomy or segmentectomy were randomized to two groups to receive esketamine (group ESK) or saline (group SAL), respectively. 0.25 mg·kg−1 esketamine was given in group ESK for induction of anesthesia, and 0.12 mg·kg−1·h−1 esketamine for intraoperative maintenance. Group SAL received an equal volume of saline. The primary outcomes were the visual analogue scale (VAS) pain scores at rest and deep cough state which evaluated at departure from post-anesthesia care unit (PACU) (T1), 6 h, 24 h and 48 h after surgery (T2–T4). The secondary outcomes included the levels of white blood cell (WBC) count, absolute neutrophil count (ANC), interleukin-6 (IL-6), procalcitonin (PCT), anxiety/depression scores at T3, oxygen saturation (SpO2), and adverse reactions.ResultsEsketamine significantly decreased both rest and cough VAS pain scores at T1, and rest pain scores at T1, T2 and T4. Patients in ESK group had significantly lower WBC and ANC levels than SAL group, while the alteration of IL-6 and PCT levels between groups showed no significance. The anxiety scores of patients in both groups were significantly decreased after surgery. However, the depression scores of patients in ESK group did not decrease after surgery when compared with the preoperation. The postoperative SpO2 and the incidence of adverse reaction including postoperative nausea, vomiting, dizziness and dissociative symptom showed no significant difference between two groups (p > 0.05).ConclusionEsketamine can alleviate the acute postoperative pain of patients undergoing thoracoscopic surgery without increasing adverse reactions, and the underlying mechanism may be associated with the reduction of postoperative inflammation.Trial registrationRegistered at Chinese Clinical Trial Registry on February 7, 2022 (ChiCTR 2200056524).Graphical

Nonlinear Heart Rate Variability Analysis for Sleep Stage Classification Using Integration of Ballistocardiogram and Apple Watch.

Wearable or non-contact, non-intrusive devices present a practical alternative to traditional polysomnography (PSG) for daily assessment of sleep quality. Physiological signals have been known to be nonlinear and nonstationary as the body adapts to states of rest or activity. By integrating more sophisticated nonlinear methodologies, the accuracy of sleep stage identification using such devices can be improved. This advancement enables individuals to monitor and adjust their sleep patterns more effectively without visiting sleep clinics. Six participants slept for three cycles of at least three hours each, wearing PSG as a reference, along with an Apple Watch, an actigraphy device, and a ballistocardiography (BCG) bed sensor. The physiological signals were processed with nonlinear methods and trained with a long short-term memory (LSTM) model to classify sleep stages. Nonlinear methods, such as return maps with advanced techniques to analyze the shape and asymmetry in physiological signals, were used to relate these signals to the autonomic nervous system (ANS). The changing dynamics of cardiac signals in restful or active states, regulated by the ANS, were associated with sleep stages and quality, which were measurable. Approximately 73% agreement was obtained by comparing the combination of the BCG and Apple Watch signals against a PSG reference system to classify rapid eye movement (REM) and non-REM sleep stages. Utilizing nonlinear methods to evaluate cardiac dynamics showed an improved sleep quality detection with the non-intrusive devices in this study. A system of non-intrusive devices can provide a comprehensive outlook on health by regularly measuring sleeping patterns and quality over time, offering a relatively accessible method for participants. Additionally, a non-intrusive system can be integrated into a user's or clinic's bedroom environment to measure and evaluate sleep quality without negatively impacting sleep. Devices placed around the bedroom could measure user vitals over longer periods with minimal interaction from the user, representing their natural sleeping trends for more accurate health and sleep disorder diagnosis.

Analysis of EEG and ECG time series in response to olfactory and Cognitive tasks

The human body can be viewed as a collection of distinct subsystems called organs that work together to execute a specific function. Even though a comprehensive understanding of the relationship between the structural and functional links between various organs appears impossible, unravelling the inter-organ dependence could be used as a risk predictor in many instances of pathological conditions. The purpose of this study is to comprehend the interactions between the heart and brain stimulated by the sense of smell (natural whole cinnamon, green chilli, crushed pepper, and camphor) while performing cognitive tasks. Permutation entropy was used to extract the measure of variability in the information contained in the EEG and ECG signals, which served as the basis for understanding the highly correlated behaviour of the heart and brain. As per the findings, there was a significant correlation between the recorded EEG and ECG signals under various conditions, including state of rest, presence of olfactory stimuli, cognitive task and aromatherapy. The individual's engagement during cognitive activities was found by computing the coefficient of similarity between the recorded ECG signal and, the EEG signals obtained from the right and the left frontal regions of the brain measured using the Eight-channel EEG head band. The heart rate variability (HRV) from the ECG signal and the power contained in the individual frequency regions of the EEG signal were used as indicators of cognitive task engagement and relaxation during aromatherapy. These findings may be beneficial for selecting the appropriate olfactory stimuli for maintaining a healthy mental state, whether cognitive or relaxing and sleep conditioning.

CONDITIONS FOR THE FORMATION OF WATER QUALITY WITH THE BIOLOGICAL CLEANING METHOD

Many organizations, especially the IMO (International Maritime Organization), began to conduct research on the dangerous impact of polluted waters on public health. Therefore, these waters undergo purification, after regeneration they are returned to circulation, and only after the impossibility of regeneration has been determined, they are averaged and transferred to factory treatment facilities and disposed of. Methods of cleaning polluted industrial waters can be combined into the following groups: mechanical, physical, physico-mechanical, chemical, physico-chemical, biological, complex. The method of purifying sewage and reservoir water from toxicants using the eichhornia plant differs in that, before water purification, the toxicant that limits the purification process is first determined, and then, before planting in the water to be purified, the eichhornia plant is moved into a solution of the toxicant, which is administered in small doses with by adding a plant growth stimulator and/or an oxidation catalyst that limits toxicants, and the cleaning is carried out in a state of rest of water, movement or bubbling with water vapor and/or air with a temperature from 2 to 50°.

ABHD6 drives endocytosis of AMPA receptors to regulate synaptic plasticity and learning flexibility

Trafficking of α‐Amino‐3–hydroxy‐5–methylisoxazole‐4–propionic acid (AMPA) receptors (AMPARs), mediated by AMPAR interacting proteins, enabled neurons to maintain tuning capabilities at rest or active state. α/β-Hydrolase domain-containing 6 (ABHD6), an endocannabinoid hydrolase, was an AMPAR auxiliary subunit found to negatively regulate the surface delivery of AMPARs. While ABHD6 was found to prevent AMPAR tetramerization in endoplasmic reticulum, ABHD6 was also reported to localize at postsynaptic site. Yet, the role of ABHD6 interacting with AMPAR at postsynaptic site, and the physiological significance of ABHD6 regulating AMPAR trafficking remains elusive. Here, we generated the ABHD6 knockout (ABHD6KO) mice and found that deletion of ABHD6 selectively enhanced AMPAR-mediated basal synaptic responses and the surface expression of postsynaptic AMPARs. Furthermore, we found that loss of ABHD6 impaired hippocampal long-term depression (LTD) and synaptic downscaling in hippocampal synapses. AMPAR internalization assays revealed that ABHD6 was essential for neuronal activity-dependent endocytosis of surface AMPARs, which is independent of ABHD6's hydrolase activity. The defects of AMPAR endocytosis and LTD are expressed as deficits in learning flexibility in ABHD6KO mice. Collectively, we demonstrated that ABHD6 is an endocytic accessory protein promoting AMPAR endocytosis, thereby contributes to the formation of LTD, synaptic downscaling and reversal learning.

Effect of sinusoidal pressure gradient on MHD flow of viscoelastic fluid in a channel

Unsteady Hydro Magnetic oscillatory flow of incompressible viscoelastic fluid in a channel packed with porous material is investigated under the influence of oscillatory pressure gradient. Moreover, the applied magnetic field of moderate strength interacts with electrically conducting fluid, to generate a resistive volumetric body force. In addition to it, viscoelastic fluidity, characterizing the non-Newtonian behavior in conjunction with permeability of the medium as well as sinusoidal sheared flow due to imposed favorable pressure gradient, contribute to the novelty of the study. The previous work was confined to constant motion of the lower plate but the present work includes the sinusoidal motion of the lower plate in addition to the constant motion. The importance lies with the fact that the coupling effect of sinusoidal fluctuation and viscoelastic fluidity go hard in industrial applications, particularly in process industry. The governing equations characterizing the flow are solved analytically. The striking results of this study are: the formation of inverted boundary layer in case of oscillatory lower plate with moderately escalated time span but such instability leading to flow reversal, does not appear in case of constant motion of the lower plate. Hence, it is recommended that for stability of flow and to avoid flow reversal, higher frequency of oscillation as well as larger time span is not desirable. The elastico-viscosity property reduces the volume flow rate which may be useful to control the efflux and differentiates the state of motion (resulting low skin friction) and state of rest (resulting high skin friction) in respect shearing effects at the bounding surfaces.

Local Anesthetics: Review of Pharmacological Considerations

Local anesthetics have an impressive history of efficacy and safety in medical and dental practice. Their use is not so regular, and the negative effects are so low, that providers can overlook a lot of their pharmacotherapeutic principles understandable. The purpose of this continuing education article is important for various local anesthesia formulas in current use. Local anesthetics inhibit nerve conduction by inhibiting the passage of sodium ions through channels or ionophores within neural membranes. Usually these channels are present at rest, during which access to sodium ions is prohibited. When the neuron is excited, the channel adopts an activated or open state, in which sodium ions spread to the cell and begin depolarization. After a sharp change in membrane voltage, the sodium channel adopts an inactive state, at which point the active transport mechanisms return sodium ions outward. After this repolarization, the canal receives a normal state of rest. Valuing these sodium channel States helps explain the privileged sensitivity of local anesthetics for different classes of neuronal fibers

Cortical activity associated with focal muscle vibration applied directly to the affected forearm flexor muscle in post-stroke patients: an fNIRS study.

The purpose of this study was to utilize functional near-infrared spectroscopy (fNIRS) to identify changes in cortical activity caused by focal muscle vibration (FMV), which was directly administered to the affected forearm flexor muscles of hemiplegic stroke patients. Additionally, the study aimed to investigate the correlation between these changes and the clinical characteristics of the patients, thereby expanding the understanding of potential neurophysiological mechanisms linked to these effects. Twenty-two stroke patients with right hemiplegia who were admitted to our ward for rehabilitation were selected for this study. The fNIRS data were collected from subjects using a block-design paradigm. Subsequently, the collected data were analyzed using the NirSpark software to determine the mean Oxyhemoglobin (Hbo) concentrations for each cortical region of interest (ROI) in the task and rest states for every subject. The stimulation task was FMV (frequency 60 Hz, amplitude 6 mm) directly applied to belly of the flexor carpi radialis muscle (FCR) on the affected side. Hbo was measured in six regions of interest (ROIs) in the cerebral cortex, which included the bilateral prefrontal cortex (PFC), sensorimotor cortex (SMC), and occipital cortex (OC). The clinical characteristics of the patients were assessed concurrently, including Lovett's 6-level muscle strength assessment, clinical muscle tone assessment, the upper extremity function items of the Fugl-Meyer Assessment (FMA-UE), Bruunstrom staging scale (BRS), and Modified Barthel index (MBI). Statistical analyses were conducted to determine the activation in the ROIs and to comprehend its correlation with the clinical characteristics of the patients. Statistical analysis revealed that, except for right OC, there were statistically significant differences between the mean Hbo in the task state and rest state for bilateral SMC, PFC, and left OC. A positive correlation was observed between the muscle strength of the affected wrist flexor group and the change values of Hbo (Hbo-CV), as well as the beta values in the left SMC, PFC, and OC. However, no statistical correlation was found between muscle strength and Hbo-CV or beta values in the right SMC, PFC, and OC. The BRS of the affected upper limb exhibited a positive correlation with the Hbo-CV or beta values in the left SMC and PFC. In contrast, no statistical correlation was observed in the right SMC, PFC, and bilateral OC. No significant correlation was found between the muscle tone of the affected wrist flexor group, FMA-UE, MBI, and Hbo-CV or beta values of cortical ROIs. FMV-evoked sensory stimulation applied directly to the FCR belly on the paralyzed side activated additional brain cortices, including bilateral PFC and ipsilesional OC, along with bilateral SMC in stroke patients. However, the clinical characteristics of the patients were only correlated with the intensity of ipsilesional SMC and PFC activation. The results of this study provide neurophysiological theoretical support for the expanded clinical application of FMV.

Intrinsic neural timescales relate to the dynamics of infraslow neural waves

The human brain is a highly dynamic organ that operates across a variety of timescales, the intrinsic neural timescales (INT). In addition to the INT, the neural waves featured by its phase-related processes including their cycles with peak/trough and rise/fall play a key role in shaping the brain's neural activity. However, the relationship between the brain's ongoing wave dynamics and INT remains yet unclear. In this study, we utilized functional magnetic resonance imaging (fMRI) rest and task data from the Human Connectome Project (HCP) to investigate the relationship of infraslow wave dynamics [as measured in terms of speed by changes in its peak frequency (PF)] with INT. Our findings reveal that: (i) the speed of phase dynamics (PF) is associated with distinct parts of the ongoing phase cycles, namely higher PF in peak/trough and lower PF in rise/fall; (ii) there exists a negative correlation between phase dynamics (PF) and INT such that slower PF relates to longer INT; (iii) exposure to a movie alters both PF and INT across the different phase cycles, yet their negative correlation remains intact. Collectively, our results demonstrate that INT relates to infraslow phase dynamics during both rest and task states.

Numerical Study of Forced Nonlinear Acoustic Gas Oscillations in a Tube under the Action of Two Pistons with Phase Shift

Nonlinear acoustic oscillations of large amplitude created in a gas-filled tube under the action of two pistons located at the ends of the pipe are numerically investigated. The pistons oscillate according to the harmonic law at one of the natural frequencies and with different values of phase shift. The movement of the gas is described by mathematical equations of conservation for the main determining relations for the flow, which are estimated by applying the finite volume method based on OpenFOAM package. The non-stationary forced oscillatory motion of a gas inside an axisymmetric tube from a state of rest to a periodic steady motion is investigated. The features of nonlinear acoustic fluctuations of gas in cylindrical duct under the action of two pistons are found. The effect of the phase shift value has a strong effect on the oscillation amplitude of gas, when pistons oscillating at equal natural frequencies, in turn, when the pistons oscillate at different natural frequencies, the effect is very small. In particular, resonant oscillations are detected when the pistons vibrate at the same frequency values equal to odd values of their own higher harmonics in the absence of a phase shift value. In the case when the frequency values are equal to even values of the natural harmonics, resonant oscillations occur when the pistons move in anti-phase. The numerical method appears to work well and would be hoped for practical computations of different resonators.

Alternatif Pengobatan Hipertensi dalam Program Pengabdian Masyarakat STIKES Nasional di Desa Kwarasan, Grogol, Sukoharjo

Hypertension is an increase in systolic blood pressure of more than 140 mmHg and diastolic blood pressure of more than 90 mmHg on two measurements with an interval of five minutes in a state of sufficient rest, calm. Treatment of hypertension can use medicinal plants, namely bay leaves and soursop leaves. Bay leaves and soursop leaves have antioxidant activity that can counteract free radicals so that they can lower blood pressure, while bay leaves themselves contain flavonoids that can reduce the risk of cardiovascular disease. This activity program uses the method of giving local seminars and workshops directly to the PKK group in Kwarasan Village, Grogol District, Sukoharjo Regency. The results of real work lecture program showed an increase in participants' knowledge which was evaluated through an average increase in the pretest score from 86 to 94 during the posttest as well as an increase in the skills of participants in workshop activities.

Development of a scale to evaluate the rest levels of male workers

Objectives "Rest" has two aspects: "repose," to recover from physical or mental fatigue, and "restore," to re-establish physical, mental, and social health. Many male workers work for prolonged hours, and despite stress, they do not apply coping behaviors, unlike female workers. Consequently, taking sufficient rest is difficult for male workers. The aim of this study was to develop a scale incorporating multiple factors to evaluate the state in which male workers take rest.Methods A questionnaire survey was conducted involving 330 male workers aged 20-59 years who had been engaged in two manufacturing industries. The questionnaire items were created with reference to an interview survey of male workers in the literature. After discussing with industrial hygiene experts and conducting a pretest to obtain surface validity, 70 items were used for analyses. In the exploratory factor analysis, promax rotation was used with the maximum likelihood method. In the confirmatory factor analysis, goodness of fit was confirmed with the covariance structure analysis. Health-related quality of life, job stress, work engagement, sleep, and self-assessment of rest were used to examine concurrent validity.Results With the exploratory factor analysis, we introduced a scale containing 15 items, including three subscales: filling with spirit, enthusiasm for work, and recovery from fatigue. The reliability coefficient (Cronbach's alpha) of the three subscales and the overall scale ranged from 0.79 to 0.88 and 0.89, ensuring internal consistency. The confirmatory factor analysis showed a generally good fit. Their scores were correlated with many items of the health-related quality of life, job stress, work engagement, sleep, and self-assessment of rest.Conclusions A 15-item "Rest Evaluation Scale" was created to evaluate the state in which male workers in the manufacturing industries take rest. Since the validity, reliability, and concurrent validity of this scale were satisfactory, this scale was considered to be an index evaluating the state of rest of male workers.

Mindfulness-based therapy improves brain functional network reconfiguration efficiency

Mindfulness-based interventions are showing increasing promise as a treatment for psychological disorders, with improvements in cognition and emotion regulation after intervention. Understanding the changes in functional brain activity and neural plasticity that underlie these benefits from mindfulness interventions is thus of interest in current neuroimaging research. Previous studies have found functional brain changes during resting and task states to be associated with mindfulness both cross-sectionally and longitudinally, particularly in the executive control, default mode and salience networks. However, limited research has combined information from rest and task to study mindfulness-related functional changes in the brain, particularly in the context of intervention studies with active controls. Recent work has found that the reconfiguration efficiency of brain activity patterns between rest and task states is behaviorally relevant in healthy young adults. Thus, we applied this measure to investigate how mindfulness intervention changed functional reconfiguration between rest and a breath-counting task in elderly participants with self-reported sleep difficulties. Improving on previous longitudinal designs, we compared the intervention effects of a mindfulness-based therapy to an active control (sleep hygiene) intervention. We found that mindfulness intervention improved self-reported mindfulness measures and brain functional reconfiguration efficiency in the executive control, default mode and salience networks, though the brain and behavioral changes were not associated with each other. Our findings suggest that neuroplasticity may be induced through regular mindfulness practice, thus bringing the intrinsic functional configuration in participants’ brains closer to a state required for mindful awareness.

On the Stability of Stationary Solutions of the Equations of Motion of the Goryachev–Sretensky Gyrostat

The equations of motion of the Goryachev–Sretensky gyrostat are studied. It has been established that one component of the angular velocity vector oscillates with zero average value on all solutions outside the set of zero level of the area integral. All stationary solutions are found, including two states of rest and two parametric families of permanent rotations. Using Chetaev’s method of integral connectives, sufficient conditions for the stability of stationary solutions are obtained. Based on the analysis of the roots of the characteristic equation, instability conditions were obtained. The possibility of gyroscopic stabilization due to the moment of circular-gyroscopic forces under certain conditions has been established.

Effect of 3 Weeks of Strict Head‑Down Tilt Bed Rest on Human Muscle Fuction and Architecture

The aim of this study was to first, experimentally measure in vivo changes in the length, fiber angle and thickness of the medial gastrocnemius muscle (MG) in young men in response to changes in foot position and joint moment during isometric plantar flexion and, in secondly, to compare the changes in the above characteristics of the muscular architecture that occur during the transition from a state of rest to a given isometric intensity during plantar flexion. The internal architecture of the MG was determined after 21-day of strict head‑down tilt bed rest (HDT). MG scanning was performed using ultrasound at rest at ankle joint angles of –15° (dorsiflexion), 0° (neutral), +15° and +30° (plantar flexion). Additional ultrasounds were performed during maximal voluntary contraction (MVC) and additionally at 80, 60, 40, and 20% of the MVC with the ankle in neutral position. In each position, longitudinal ultrasound images of the MG were obtained in a relaxed (passive) state with the determination of the length (Lf) and angles of fascicles (Θf) relative to the aponeurosis. After HDT, the thickness of the MG during graduated isometric force up to 80% of the MVC in the neutral position of the ankle joint remained constant. Various Lf and Θf and their changes after HDT can be a limiting factor in the generation of muscle contractile functions. The results of the study show that the change in muscle structure during contraction compared to rest, as measured by changes in muscle architecture, can be used to assess muscle mechanical output.

A feasibility study on using fNIRS brain signals to recognize personal thermal sensation and thermal comfort conditions.

Many studies have shown some relationships between thermal perception (including thermal sensation and thermal comfort) and human physiological parameters, such as brain signals. However, further research is still needed on how these parameters can help recognize the state of a human's personal thermal perception. This study aims to investigate the potential of using fNIRS brain signals to evaluate and predict personal thermal perception and cognitive performance in a steady-state temperature. The present study investigated changes in the fNIRS signal during ambient temperature manipulation. Thirty healthy young individuals were selected as the subjects, and they were exposed to two steady temperatures of 28.8 and 19 °C. After acclimatizing to either temperature, the oxy/deoxy-hemoglobin changes of the prefrontal cortex (PFC) were measured in both rest and cognitive task states using 16-channel fNIRS. Results showed that exposure to different temperatures was significantly associated with the brain signals recorded during the task state. Many significant correlations were discovered between fNIRS signals and thermal perceptionindices. Furthermore, subjects' performance changes led to changes in the fNIRS signals. Logistic regression showed that fNIRS can determine whether a person is thermally comfortable or uncomfortable.

FUNCTIONAL CONDITION OF YOUNG SWIMMERS. PSYCHOPHYSICAL INDIKATORS

In the problem of studying the implementation of complex motor reactions in conditions of sports activity and their tolerance, along with generally accepted psychological and pedagogical measures, the study of psychophysiological functions is used. The physiological mechanism for the implementation of complex motor functions in health and in pathology has been studied by many authors [1,2,3etc.], mainly in a state of rest. However, there are many controversial issues related to the influence of complex coordination loads, such as swimming, on the mechanisms of implementation of the contractile function in young athletes, even at the initial stages of training. Quantitative assessment of the state of the somatosensory system, which ensures the performance of a special motor function of young athletes, characteristic of a specific type of motor activity, consists in the insufficiency of methodological criteria.

Informativen of system indicators regeistered during the wedge-orthostatic test for assessing the state of working capacity of swimmers

Many researchers in the program of physiological examination of swimmers, related to the determination of their working capacity and its physiological correlates, include both an assessment of the state of rest and reactions to physical exertion of various strengths. It is very desirable to be able to have indicators of the level of working capacity already on the basis of indicators of rest (criteria of working ability based on indicators of rest). The purpose of our study was to determine which of the functional indicators of the wedge-orthostatic test can be physiological correlates of work capacity. Male swimmers (29 people) aged 17-23 took part in the experiment, sports qualification - KMS and MS. The paper presents the materials obtained when athletes specializing in swimming performed an active wedge-orthostatic test and step-increasing load on a treadmill. With the help of correlation analysis, it was established that the values of heart rate and blood pressure were the most informative for the possibility of performing a large amount of work. in a sitting position; AT swing in a standing position in the initial part of the test. Heart rate values during work depend on the functional reserve of the athlete's body, which is expressed in low heart rate values during the wedge-orthostatic test and its load based on the amount of carbon dioxide released. The level of energy supply of the work depends on the adrenergic background of rest and the load of the wedge-orthostatic test. Based on the obtained results of the reaction to the proposed test, it is possible to predict the adaptation of the athletes' body to physical exertion.

Keynesian Equilibria as Centers of Gravitation?

ABSTRACT Starting from some of Geoff Harcourt’s contributions, this article deals with the problem of macroeconomic equilibria as centers of gravitation from a Keynesian perspective. It is argued that the Keynesian notion of short-period underemployment equilibrium (or rest state) represents a sustainable analytical notion of center of gravitation in so far as a static state is assumed. If the economy grows over time, dealing with the problem of centers of gravitation requires a long-period perspective, which, however, cannot be reduced to the use of equilibrium growth models. A more general approach to the dynamics of market economies is a better way to support Keynes’s idea that the economy tends to fluctuate around positions characterized by the unemployment of resources.

Assessment of the activities physiological cost of the defense forces officers in Ukraine using miniature ECG device.

In the principles of the organization of armed struggle of the defense forces of most developed countries of the world, considerable attention is paid to the evaluation of combat readiness of the military personnel. This procedure is conditioned by such interconnected goals of the armed struggle as the maximum realization of the combat potential and the minimization of personnel losses. The purpose of the work is to determine the physiological cost of the activities of the soldiers of the Defense Forces of Ukraine with the help of miniature electrocardiographic hardware and software complexes. In the research, ultra-miniature ECG devices worn on the body for a long time, so-called wearable "on-body" ECG patch devices, were used in various combat conditions. When analyzing the data, the principle of multi-faceted ECG analysis was implemented, which allows you to obtain complete and physiologically based information, which includes 4 blocks: heart rate variability (HRV), amplitude-time indicators of the ECG, heart rhythm disorders, and psycho- emotional state. In this study, a complex index of the functional state formed based on estimates of generally accepted and original indicators of heart rhythm variability, the shape of the teeth and complexes of the electrocardiogram, as well as an index of the psycho-emotional state formed according to the same principles based on the analysis of heart rhythm variability according to the modified McCraty algorithm (USA) was evaluated. Examination with the help of the complex is carried out in a state of rest, sitting or lying down. The sensitivity of the developed monitoring system is good enough to detect the changes in the functional state both in the case of short-term (for hours) intense physical or psycho-emotional stress and more chronic (for days and weeks) stress depending on the nature of the task being done. The proposed methods and means can be considered an important tool to support the commander's decision-making regarding the ability of personnel from the point of view of their functional state to perform combat tasks.