Disorganized State Research Articles

Pirarucu hydroxyapatite applied to ternary competitive adsorption of synthetic basic dyes as contaminants of emerging concern: kinetic, equilibrium, and ANN studies.

This study investigated the single and multicomponent adsorption of three emerging pollutants, the basic dyes Rhodamine 6G (R6G), Auramine-O (AO), and Brilliant Green (BG) by using hydroxyapatite synthesized from Pirarucu scales as adsorbent (HAP). The adsorption process was studied using seven different systems: AO-single, R6G-single, BG-single, R6G + AO, BG + AO, BG + R6G, and R6G + AO + BG. For kinetics, the initial concentration of each adsorbate per system was 50 mg/L, the results showed that the singular adsorption of these dyes was best-represented by the pseudo-second-order model (qAO = 62.54 mg/g, qR6G = 7.91 mg/g, qBG = 62.40 mg/g), however, the multicomponent adsorption was well-fitted by a pseudo-first-order model (ternary system: qAO = 56.21 mg/g, qR6G = 14.95 mg/g, qBG = 60.62 mg/g). For equilibrium, the initial concentration of each adsorbate per system was 10-300 mg/L, and the single adsorption systems were best represented by the Langmuir model. Nonetheless, the results displayed in the multicomponent mixture showed the presence of inflection points of AO and R6G whenever BG was present in solution with C0 > 150 mg/L, thus indicating that BG has greater affinity with HAP. The presence of inflection points in the curves represented a limitation for applying traditional equilibrium models, thus, an artificial neural network (ANN) was applied to non-linear curve fit this process and satisfactorily predicted the kinetics and equilibrium data. Finally, the analysis of thermodynamics for the ternary mixture revealed that the adsorption process is spontaneous (ΔG < 0), endothermic (ΔH > 0), and increases to a disorganized state as the temperature rises (ΔS > 0).

Processus de maternité et fonctionnement limite : une approche longitudinale à l’aide du Rorschach

ObjectivesThis article aims to study the psychic changes during maternity in primiparous women without psychic and organic disorders and to put into perspective the reorganizations during the maternity process in patients with a borderline psychic functioning. MethodThis paper is based on longitudinal data collected with the Rorschach test. Two clinical cases revealing this processual dynamic will be analyzed and discussed. ResultsThe analysis of Rorschach protocols of two women with different psychic elaboration capacities reveals an experience of boundary invasions linked to the precariousness of psychic envelopes between the end of pregnancy and the beginning of postpartum, followed by a reinforcement of certain defensive mechanisms post-delivery in order to compensate for the state of disorganization linked to the processes of motherhood. DiscussionThe analysis of these data will allow us to observe modalities of psychic arrangements specific to the maternity process as well as reorganizations, close to a “symbolization catastrophe”. ConclusionThe psychic dispositions of women during maternity allow us to detect borderline arrangements of psychic functioning during this period.

Exacerbation of Pica as a Precursor of Psychosis

Abstract Pica is a sustained, compulsive eating behavior of nonedible substances. Pica has been described as sequelae of psychosis due to its state of disorganization; however, temporal and causal relationship between the two has not been reported in the context of exacerbation of pica before psychosis. Various causes of pica have been identified including malnutrition, iron-deficiency anemia, zinc deficiency, intellectual disability, and obsessive and impulse control disorders. Here, we describe a case of worsening pica which preceded exacerbation of psychosis in an 18-year-old female which was managed with antipsychotics along with complete remission of psychosis and improvement in the severity of pica. The present case highlights the association between psychosis and pica. There has been a rising voice in academia to reclassify pica alongside obsessive–compulsive disorder (OCD) with no absolute consensus. In conclusion, our findings suggest that the exacerbation of pica preceded psychosis and can be construed as an indicator for an upcoming psychotic episode or as a prodromal aspect of psychosis and may be useful for early identification and initiation of treatment in cases of relapsing psychosis.

Investigating Landmodulin's EF Hands in Relation to Lanthanide Recycling Methods

Rare earth elements (REEs) have distinct and varied electronic properties that have been applied for military and civilian use in electronics, such as cell phones and computer chip technologies. The recycling methods for REEs are complex and require a multitude of resources that prompt new studies to improve REEs separations. Lanmodulin (LanM), a protein that naturally bind to lanthanides, may provide a biological route for REE separation. Understanding the structure of LanM’s EF‐hands will explain how the lanthanides bond to them and lead to a greater understanding of how LanM can be used to recycle REEs to benefit our environment. The Summit Country Day School MSOE Center for BioMolecular Modeling MAPS Team used 3D modeling and printing technology to examine structure‐function relationships of EF1‐3 hands on lanmodulin. LanM has three tight binding EF‐hands, EF1 (D35‐E46), EF2 (D59‐E70), and EF3 (D84‐ E95), which are abundant in carboxylate side chains that bind the lanthanides. Lanthanide binding promotes a large conformational shift of the protein from a disorganized state to an organized state. The interior of the protein is a condensed helical bundle, and the majority of the exterior is composed of the EF hands, making bonding with lanthanides easier due to the EF hands being solely on the exterior. These three hands contain a higher number of coordination numbers (8‐9) compared to only 7 in Calmodulin (CaM), resulting in more specialized bonding properties. LanM also has a conserved proline between the first and second putative metal‐coordinating residues in each of the four EF hands, which is unique to this protein and may play a role in reducing affinity for calcium ions. In conclusion, analyzing the properties of the binding sites of EF1‐3 in LanM through 3D modeling can reveal insights on utilizing proteins as a method to extract and recycle REE in order to be environmentally cognizant.

Pandémie de COVID-19 : attachement, anxiété, régulation émotionnelle et stratégies de coping chez les enfants d’âge scolaire

IntroductionAn impact of the COVID-19 pandemic on the emotions and behaviors of children has been found in several studies. However, this impact is not found in all studies. Attachment could be linked to different reactions and levels of anxiety. ObjectiveThe main aim of this study was to analyze the links between children's insecure attachment and variables related to anxiety, emotional and behavioral management of children during the pandemic. MethodStudy participants (n=83 parents and their child aged 6 to 12) completed anonymously online questionnaires assessing attachment insecurity, state-anxiety, coping strategies and emotional regulation. They also answered socio-demographic questions related to their context of life and experience of the pandemic. ResultsState-anxiety is significantly related to children's emotional dysregulation but not to emotion-oriented coping strategy. Significant links were observed between attachment insecurity on the one hand, and children's state-anxiety, emotion-oriented coping strategy and children's emotional dysregulation on the other hand. Emotional dysregulation mediates the link between disorganized attachment and state anxiety. ConclusionThe links between attachment insecurity and children's state-anxiety on the one hand, and the emotion-oriented coping strategy on the other hand highlight the importance of taking individual and interactional factors into account in children's socio-emotional manifestations during the COVID-19 pandemic.

P 63 Does the Anna Karenina principle apply to vestibular migraine and Meniere's disease?

Introduction: To date it is unclear how Meniere’s disease (MD) and vestibular migraine (VM), which often appear in clinically similar attacks, differ from healthy controls (HC) in functional brain connectivity (measured by fcMRI), especially during the interictal phase. The central functional connectivity feature of VM and MD might be “disorganization” relative to HC, due to unpredictable attacks that cannot be compensated for. This “Anna Karenina principle” states that all HCs are very alike while all patients are very dissimilar from each other and the HCs. Here we examined the distribution parameters of functional connectivity between HC, VM and MD to elucidate the state of disorganization in the interictal phase. Methods: 93 patients (42 VM, 51 MD) and 50 HCs underwent fMRI while resting in a 3T MRI (Siemens). Resting-state fMRI connectivity measures were extracted via dual regression and normalized in mean and standard deviation relative to HCs. Robust distribution parameters for all voxels in the grey matter were compared between groups. Results: Distribution parameters were compact for HCs, while those of VM and MD patient groups were significantly more dispersed, i.e., disorganized (Figure 1), permutation test with 10000 permutations. In Figure 1 the bulk of values for the HCs were marked by black outline and superimposed onto the values for the MD and VM groups. Conclusion: Resting-state functional connectivity measures imply disorganized interactions between patients relative to HCs, even in the interictal phase. VM and MD patients are very different in functional connectivity, suggesting that the Anna Karenina principle might apply to these patients. References 1) Dieterich et.al. J Neurol (2016); 2) Liu & Xu, Behav Neurol (2016); 3) Tabet & Saliba, J Clin Med Res (2017) Figure 1. Distribution parameters per voxel relative to healthy control (HC) group. Values for healthy controls (HC) were marked with a black line and superimposed on Meniere disease (MD) and vestibular migraine (VM) group data. Color of dots indicates the median relative to the HC group (blue to yellow). The data of the healthy controls was normalized to mean of 0 and standard deviation 1, and these parameters were used to normalize the MD and VM patients, i.e., everything is presented in the scale of the HC group such that parameters can be compared visually.

Decreased brain network global efficiency after attachment memories retrieval in individuals with unresolved/disorganized attachment-related state of mind

The main aim of the study was to examine how brain network metrics change after retrieval of attachment memories in individuals with unresolved/disorganized (U/D) attachment-related state of mind and those with organized/resolved (O/R) state of mind. We focused on three main network metrics associated with integration and segregation: global (Eglob) efficiency for the first function, local (Eloc) efficiency and modularity for the second. We also examined assortativity and centrality metrics. Electroencephalography (EEG) recordings were performed before and after the Adult Attachment Interview (AAI) in a sample of 50 individuals previously assessed for parenting quality. Functional connectivity matrices were constructed by means of the exact Low-Resolution Electromagnetic Tomography (eLORETA) software and then imported into MATLAB to compute brain network metrics. Compared to individuals with O/R attachment-related state of mind, those with U/D show a significant decrease in beta Eglob after AAI. No statistically significant difference among groups emerged in Eloc and modularity metrics after AAI, neither in assortativity nor in betweenness centrality. These results may help to better understand the neurophysiological patterns underlying the disintegrative effects of retrieving traumatic attachment memories in individuals with disorganized state of mind in relation to attachment.

The Role of Complex Trauma and Attachment Patterns in Intimate Partner Violence.

ObjectiveEven if the relationship between adverse childhood experiences and intimate partner violence (IPV) has already been established, there are no sufficient studies examining the relationships between these factors and attachment representations, specifically attachment disorganization. Thus, this study aimed to explore, in a sample of women who experienced IPV (a) the presence of interpersonal adversities during childhood, and (b) attachment representations, with a particular focus on disorganization.MethodsWomen’s representations of attachment experiences were investigated through the Adult Attachment Interview, while the presence of various forms of interpersonal adversities during childhood was assessed using the Complex Trauma Questionnaire. The results of the IPV group (n = 98) were compared with those of women with no history of IPV (control group, n = 81).ResultsWomen in the IPV group showed higher values of multiple forms of adverse experiences within their caregiving system. They presented significantly higher rates of disorganized states of mind regarding attachment, indicative of a lack of resolution regarding traumatic experiences, and of disorganized working models resulting from complex trauma. Our results highlighted that, more than the presence of traumatic experiences, it is their irresolution – reflected in the disorganized states of mind regarding attachment at the Adult Attachment Interview – to be a significant predictor of IPV.ConclusionThese results suggest underline the significance of offering a trauma- and attachment-informed therapy to those who experience IPV. Such results could help both clinicians and researchers in formulating clearer guidelines for IPV interventions.

ATTACHMENT AND MEMORY STABILITY

ABSTRACT Previous studies confirm that attachment representations are very stable and are rooted in semantic and episodic autobiographic memory systems. The Adult Attachment Interview (AAI) provides a means to assess secure, insecure, and disorganized (U) states of mind; it incorporates a fine-grained analysis of attachment-related memories. The AAI is not a measure to determine false versus true memories or to claim it can identify veridical truth; however, longitudinal research studies demonstrate that the AAI is highly stable in how (degree of coherence) the speaker discusses past events. This IRB approved study (n = 130) examined a non-clinical sample of active individuals. The results indicated that passive states of mind was a predictor variable for unresolved loss and unresolved childhood abuse and both passive states of mind and more Adverse Childhood Experiences (ACEs) predicted overall lack of resolution (U). Lack of memory and dissociative amnesia were not significant predictors. This study and previous studies demonstrate that retrospective reporting of ACEs remain stable over time. These findings suggest that clinical focus should follow the attachment protocol of examining the state of mind of the speaker. Autobiographical memory systems reveal enduring Internal Working Models (IWMs) that influence how memories are stored and recounted.

Voyages pathologiques : actualités du concept et caractérisation d’une cohorte dans un service d’urgences psychiatriques

ObjectivesPathological Journey or Pathological Trip is a concept often used but defined imprecisely in the recent scientific literature and usual classifications. After a brief history of this concept, appeared in France in the 19th century [5], we suggest a definition to differentiate pathological journey from other clinic entities, such as fugue or wandering. The pathological journey would be a departure to a specific destination, induced by delusional ideas or by a state of disorganization. MethodsWe led a retrospective study from patients in the biggest French psychiatric emergencies unit, in Paris, admitted for a pathological journey in 2019. Socio-demographics data (gender, age, professional activity, financial resources, place of life, marital status, family and friendly entourage), medical history, clinical features (such as delusional or suicidal ideas, hallucinations, diagnostic hypothesis), trip characteristics (such as place of departure, final wanted destination, duration of the trip) and orientation at the end of the consultation (hospitalization or not) have been notified. A comparative study between patients according to the reason of departure (to run away from something or to look for something) has been led too. ResultsA total of 217 patients are included. Men are majority, with an average age of 40 years, with psychiatric history (89%) and diagnosis of delusional disorder (F20-29 according to the ICD-10, 87%) or mood disorder (10%). They are still followed by a psychiatrist and still take their medication for the most part. They often haven’t hotel or other place to live at the destination or during the trip (62%) and the trip has often begin recently, less than 10 days for 75%. 95% of patients require an hospitalization, without the patient consent in the most part, and only 5% needed a physical restraint in the unit. The comparative study between patients by the reason of departure finds no significant result. DiscussionWe don’t find here specific characteristics by the motivation of departure, but these patients are often homeless and without ressources during the pathological trip. A particular care of these vulnerable and at-risk patients should be accentuated by the care teams and physicians. Complementary studies are necessary to identify specific characteristics and to improve the patient care management, and maybe to avoid departures of these vulnerable patients in the future. ConclusionsPathological trip is a still-used concept, described for more a century, and is frequently observed in general and psychiatric emergencies units. Its definition is not precise and is not mentioned by the actual references (ICD-10, DSM-5), and it could make the identification of this behavior more difficult. These units are often the first to meet and identify this behavior and to guide to offer adequate care to these vulnerable patients.

Review essay: Between the Material and the Ephemeral

Review essay: Between the Material and the Ephemeral

A Study on the Holistic Concept of Psychomotorik and the Aspect of Convergence

The upcoming scientific technology of the Fourth Industrial Revolution after the pandemic of COVID 19 cannot replace the interaction of human mind and body. The research of psychomotricity in Korea, however, has been done in a way separating psychology from motricity, which has made the disorganized and fragmented state of this academic domain. This paper reviews the original and philosophical concept of psychomotricity by looking into its history from a holistic angle and referring to the preceding material from European countries including Germany. This article study the holistic tradition of Europe emphasizing the human social nature, the function and contents of psychomotricity, and Laban s analysis of movement. Next, the noncompetitive and voluntary attributes of Ernst Kiphard s psychomotor theory is discussed. All this review leads to pursuing the convergence of psychomotricity by consolidating all the related academic information and knowledge with providing the examples of application. Lastly, this paper argues that the research range of psychomotricity should be expanded into the area of therapy besides education by inviting all the efforts related to the interaction between mind and body for developing the human welfare.

КРИЗОВА СИТУАЦІЯ ЯК ДЖЕРЕЛО РОЗВИТКУ ОСОБИСТОСТІ

У статті подано результати досліджень психологічного змісту понять «криза», «критична ситуація», «кризова ситуація». Розглянуто можливі варіанти поведінки суб’єкта кризових ситуацій: конструктивний та деструктивний. З позицій діяльнісного підходу доведено, що кризова ситуація є джерелом розвитку особистості, при цьому рушійною силою розвитку є особистісна активність суб’єкта саморозвитку, яка і визначає модель поведінки людини в кризових ситуаціях.

Distortions of the Rain Distribution With Warming, With and Without Self-Aggregation.

We investigate how mesoscale circulations associated with convective aggregation can modulate the sensitivity of the hydrologic cycle to warming. We quantify changes in the full distribution of rain across radiative-convective equilibrium states in a cloud-resolving model. For a given Sea Surface Temperature (SST), the shift in mean rainfall between disorganized and organized states is associated with a shift in atmospheric radiative cooling, and is roughly analogous to the effect of a 4K SST increase. With rising temperatures, the increase in mean rain rate is insensitive to the presence of organization, while extremes can intensify faster in the aggregated state, leading to a faster amplification in the sporadic nature of rain. When convection aggregates, heavy rain is enhanced by 20%-30% and nonlinear behaviors are observed as a function of SST and strength of aggregation feedbacks. First, radiative- and surface-flux aggregation feedbacks have multiplicative effects on extremes, illustrating a non-trivial sensitivity to the degree of organization. Second, alternating Clausius-Clapeyron and super-Clausius-Clapeyron regimes in extreme rainfall are found as a function of SST, corresponding to varying thermodynamic and dynamic contributions, and a large sensitivity to precipitation efficiency variations in some SST ranges. The potential for mesoscale circulations in amplifying the hydrologic cycle is established. However, these nonlinear distortions question the quantitative relevance of idealized self-aggregation. This calls for a deeper investigation of relationships which capture the coupling between global energetics, aggregation feedbacks and local convection, and for systematic tests of their sensitivity to domain configurations, surface boundary conditions, microphysics, and turbulence schemes.

On the Foundations of Psychology: the Problem Is Grammatical, Not Theoretical.

Zagaria et al. (Integrative Psychological and Behavioral Science, X 1-44, 2020) argue that psychology is a science marked by theoretical chaos and that it is possible to rectify this by letting the theoretical framework of evolutionary psychology serve as a foundation for psychology at large. While agreeing to the fact that psychology lacks direction, I maintain that this problem is not theoretical and hence, not rectifiable through the postulations of a theory. Following Wittgenstein, I argue that the disorganised state of psychology is due to an insufficient sensitivity to the meaning of psychological terms in ordinary language. In short, psychology's problem is grammatical. Hence, what needs to be done is to examine the grammar of psychological concepts. Many scholars have contributed to this kind of examination but few as extensively as Harré, who stressed the primacy of the concept of a person for discourses about human mental powers and their exercise. This is the Taxonomic Priority Principle. Grounding psychological research in evolutionary theory would amount to a violation of it and thus, I claim that it is mistaken to do so. The approach best suited to administer this principle is that of cultural psychology.

A Dashboard for Supporting Slow Tourism in Green Infrastructures. A Methodological Proposal in Sardinia (Italy)

Spatial planning and territorial promotion can benefit largely from the application of the Information Communication Technology (ICT) at different scales. From knowledge acquisition to management and planning, their role in building an image of the territory, and constantly updating it to the benefit of users and planners, is of paramount importance. Institutional channels, together with social networks, are the means by which both a local community and a wider community of users share experiences and perceptions. ICTs are therefore strategic in supporting and promoting a sustainable tourism development of territories. Data and information aggregators as dashboards represent examples of decision support systems where digital data are organized and processed to produce an information output. The present paper is part of a wider research, related to the valorization of a former mining area in the Sulcis-Iglesiente area (Sardinia, Italy), where the extraction activity has left the place to abandonment, and only recently to tourism, stressing the concept of slow tourism. Such new opportunity has been launched with the Santa Barbara Walk (SBW), an ancient mining route currently trying to consolidate as a tourism attraction area. Such a territory is in constant transition with unique characters of anthropic and naturalistic characterization, setting itself as a green infrastructure, capable also of attracting a wide community of regional and extra-regional users. However, its digital network—consisting of intangible infrastructure and flows—is fragmented in terms of policies and contents. Additionally, a state of disorganization in slow tourism promotion activities can be observed. To implement the SBW capabilities, the present paper aims to develop a proposal for the framework of a circular dashboard applied to the SBW. In particular, we implement a set of indicators of performance of the SBW for the organization of information on the walk’s main characters, to facilitate a shared governance and an effective tourism promotion. The SBW is recognized as a network connecting the main points of interest preferred by the slow tourism (This paper is based on the Research project TSULKI—Tourism and Sustainability in the Sulcis (Sardinia-Italy)—and on the agreement protocol between DICAAR Department of Cagliari University and Foundation of the Santa Barbara Walk, signed in December 2018).

Unpleasant Bodily Odour in a Psychoanalytic Treatment: Bridge or Drawbridge to a Troubled Past?

In this paper, I explore the topic of primitive bodily communications and countertransference enactments, with a particular focus on the part played by bodily odour. To explore this topic, I discuss a two‐year treatment with a patient who presented with a mix of borderline and narcissistic diagnostic features. I describe meaningful aspects of the difficulties faced in countertransference work when receiving and making sense of the patient's use of primitive defences and I highlight their expression through a very uncomfortable symptom: an extremely unpleasant bodily smell. My thesis is that the smell communicated preverbal and unsymbolized experiences of early physical and emotional neglect, as well as evacuating the toxicity of those experiences. In this way the smell acted both as a bridge, which could help me reconstruct my patient's early traumatic past, and as a drawbridge, to keep me at distance and maintain his past dissociated. The invasive and aversive nature of the smell can also be seen as representing the approach‐avoidance dilemma typical of a disorganized attachment state of mind, acting both as a bridge and as a drawbridge to attachment and relating.

A Suicidal Adolescent: The Rocky Path from Physical Pain to Psychological Awareness

ABSTRACT This article tracks detailed process material – extracted from an especially disturbing three-week period during a four-year analysis – of a suicidal adolescent. The analyst-in-training’s exploration of therapeutic action to make meaningful contact with her patient is demonstrated. In particular, how her patient moves from a state of disorganization to thoughtful self-reflection and the use of concurrent work with parents are highlighted.

Abstract A102: pHLIP technology for targeting acidity at surface of tumor cells and extracellular and intracellular delivery of imaging and therapeutic agents

Abstract pH-Low Insertion Peptides (pHLIP® peptides) are a platform technology for targeting of acidity at the surface of individual cells within tumors. Most proteins that are located across membranes have one or more helical segments that cross the lipid bilayer, and studies of these membrane proteins revealed pHLIPs, which could fold from disorganized (unstructured) states outside of a membrane to form a helix across the membrane in response to local acidity. Because tumor cell surfaces are acidic as a result of their active metabolism, versions of pHLIP® peptides were extensively investigated and tested as possible tumor targeting agents. Our studies showed that an extensive variety of cargoes can be targeted to cell surfaces and that a surprising range of cargoes can be delivered across membranes into cells if their surfaces are acidic, creating opportunities to detect and treat tumors. pHLIP® peptides can be used to target and tether cargo molecules to the surfaces of cells in low pH environments of acidic diseased tissues. The cargo can be an optical marker, a PET, a SPECT, or a MR imaging agent, or an antigen or a protein delivered to induce certain cellular or immune responses. We are translating pHLIP®-based imaging agents to the clinic for diagnostic PET imaging, fluorescence-guided surgical procedures and photo-acoustic pre-operative imaging. pHLIP® peptides can also be used for the intracellular delivery of payloads, facilitating the translocation of therapeutic cargoes across the membranes of cells with low extracellular pH, such as those cells found in acidic diseased tissue. These payloads are conjugated to the membrane-inserting end of pHLIP® peptide, typically via a link that is unstable inside the cell. Thus, pHLIP® peptide targets a payload to acidic diseased cells and flips the cargo across the plasma membrane, releasing it in the cytoplasm. Therapeutic cargoes may include toxins, metabolic activators/inhibitors, chemotherapeutic agents, or agents to alter gene expression. *YKR, OAA, and DME are founders of pHLIP, Inc. and have financial interests in the company. Citation Format: Yana K Reshetnyak, Oleg A Andreev, Donald Engelman. pHLIP technology for targeting acidity at surface of tumor cells and extracellular and intracellular delivery of imaging and therapeutic agents [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics; 2019 Oct 26-30; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2019;18(12 Suppl):Abstract nr A102. doi:10.1158/1535-7163.TARG-19-A102

The importance of loneliness in psychotic-like symptoms: Data from three studies

Poor social connection or loneliness is a prominent feature of schizotypy and may exacerbate psychosis risk. Previous studies have examined the inter-relationships between loneliness and psychosis risk, but critically, they have largely been conducted in non-clinical samples or exclusively used laboratory questionnaires with limited consideration of the heterogeneity within schizotypy (i.e., positive, negative, disorganized factors). The present study examined links between loneliness and psychotic-like symptoms across the dimensions of schizotypy through cross-sectional, laboratory-based questionnaires (Study 1; N = 160), ambulatory assessment (Study 2; N = 118) in undergraduates, and ambulatory assessment in inpatients in a substance abuse treatment program (Study 3; N = 48). Trait positive schizotypy consistently predicted cross-sectional and state psychotic-like symptoms. Loneliness, assessed via cross-sectional and ambulatory means, was largely linked with psychotic-like symptoms. Importantly, psychotic-like symptoms were dynamic: psychotic-like symptoms largely increased with loneliness in individuals with elevated positive and disorganized schizotypal traits, though there were some inconsistency related to disorganized schizotypy and state psychotic-like symptoms. Negative schizotypy and loneliness did not significantly interact to predict psychotic-like symptoms, suggesting specificity to positive schizotypy. Ambulatory approaches provide the opportunity for ecologically valid identification of risk states across psychopathology, thus informing early intervention.