State Of Autonomic Regulation Research Articles

Функциональное состояние педагогов северного университета при переходе к дистанционному формату работы

The purpose of this paper was to perform a comprehensive study of the functional state of male and female teachers of a northern university during the quarantine due to the coronavirus pandemic, when they had to switch from on-campus to distance teaching. Materials and Methods. The study involved 56 teachers (36 men and 20 women) from Surgut State Pedagogical University, who were examined before and after the switch to distance teaching. The functional state of the central nervous system (CNS) was evaluated according to the data of simple visual-motor reaction. The state of autonomic regulation was characterized based on the dynamics of heart rate variability at rest and during active orthostatic test. Peripheral systolic and diastolic blood pressure and central systolic aortic pressure were measured. The psychophysiological state was analysed using the Maslach Burnout Inventory and Eysenck’s “Self-assessment of anxiety, frustration, aggressiveness and rigidity”. The quality of life was evaluated using the Short Form (36) Health Survey. Results. During on-campus teaching, female university teachers showed more pronounced impairments of autonomic regulation and functional state of the CNS compared to their male colleagues. In addition, women experienced professional burnout more often, while an increase in central and peripheral blood pressure was less common among them. After the transition from on-campus to distance teaching during the COVID-19 quarantine, functional disorders of autonomic hear rate regulation and haemodynamics were more pronounced in men than in women. Women under the same conditions had greater impairments of the functional state of the CNS, while demonstrating improvements in the psychophysiological state. Thus, the research found that changes in the form of teaching produce different effects on the functional state of male and female university teachers.

Comparative Analysis of Complex Programs of Renewal Treatment of Patients with Chronic Pancreatitis

Aim: To conduct a comparative analysis of the dynamics of heart rate variability parameters in CP patients with autonomic dysfunction under the influence of the proposed complex treatment programs with the additional inclusion of the vegetative stabilizing agent memoplant and a combination of complex bioregulatory drugs. Materials and Methods: Statistical and spectral parameters of heart rate variability were analyzed in 69 patients with CP before and after outpatient treatment. Patients were divided into 3 groups of 23 patients with CP: group 1 – received conventional treatment (CT) according to the clinical diagnosis and the protocol proposed by the Ministry of Health of Ukraine (Order No. 638 of 10.09.2014); group 2 – CT enhanced with a course of the vegetative-stabilizing drug ginkgo biloba (memoplant); 3 group – CT with a course of memoplant and complex bioregulatory therapy (BRT): momordica compositum, traumeel S and neurexan according to the proposed scheme. Results: In group 1, the stress index (SI) decreased by 18.49%, p<0.05, vegetative reactivity (VR) increased by 21.31%, p<0.05, IARS decreased by 25.79%, p<0.01. In group 2, a more significant decrease in sympathicotonia was observed: SI decreased by 38.17% (p<0.01), mode amplitude (АМо) by 14.57% (p<0.05), the range of variation (X) increased by 12.78% (p<0.05); IARS decreased by 44.55 % (p<0.01) to moderate tension. There was an increase in the total spectrum power (TP) (by 29.21%, p<0.01) and components: LF increased by 37.03% (p<0.01) relative to the initial level, HF by 64.01% (p<0.01), VLF by 8.75% (p<0.05). In patients of group 3, normalization of SI and АМо was observed (indicators decreased by 48.42% and 19.98%, p<0.01), X increased by 17.35%, p<0.01; The VR level did not differ significantly from the control (1.16±0.06 and 1.25±0.10, respectively). IARS decreased by 56.18% (p<0.01); TP increased by 49.61% (p<0.01), LF by 76.78% (p<0.01), HF by 117.67% (p<0.01), VLF by 8.41% (p<0.05). Conclusions: In patients with CP, a higher efficiency of treatment programs with the inclusion of ginkgo biloba and complex bioregulatory therapy on the state of autonomic regulation was established compared to the generally accepted program in terms of spectral and statistical parameters of heart rate variability.

Mindfulness-Based Student Training Improves Vascular Variability Associated With Sustained Reductions in Physiological Stress Response.

In today's fast-paced society, chronic stress has become an increasing problem, as it can lead to psycho-physiological health problems. University students are also faced with stress due to the demands of many courses and exams. The positive effects of mindfulness-based stress reduction (MBSR) on stress management and self-regulation have already been studied. We have developed a new mindfulness intervention tailored for students—the Mindfulness-Based Student Training (MBST). In this study, we present longitudinal results of the MBST evaluation. Biosignal analysis methods, including pulse wave variability (PWV), heart rate variability, and respiratory activity, were used to assess participants' state of autonomic regulation during the 12-week intervention and at follow-up. The progress of the intervention group (IGR, N = 31) up to 3 months after the end of MBST was compared with that of a control group (CON, N = 34). In addition, the long-term effect for IGR up to 1 year after intervention was examined. The analysis showed significant positive changes in PWV exclusively for IGR. This positive effect, particularly on vascular function, persists 1 year after the end of MBST. These results suggest a physiologically reduced stress level in MBST participants and a beneficial preventive health care program for University students.

The State of Vegetative Regulation in Patients with Ischemic Stroke in the Acute and Peracute Periods: an Observational Cohort Study

Background. The high number of stroke cases is predetermined by risk factors, pathogenetic heterogeneity, genetic predisposition to the disease. Neurovascular changes can serve as a marker for the severity of the patient’s condition. By means of cardiointervalography, the reactions of the autonomic nervous system in patients with ischemic stroke were studied, depending on the territory of the cerebral infarction and its period. With a favorable outcome of the disease, the detected changes in regulatory mechanisms can be considered adaptive, while with fatal outcome — disadaptive. Objectives. Determination of the state of the autonomic nervous system by means of cardiointervalography in patients with stroke in various pools of blood supply.Methods. 52 patients with a verifi ed diagnosis of ischemic stroke in the acute and peracute periods were examined. All patients were divided into 3 groups. Group 1 — patients with ischemic stroke in the middle cerebral artery territory on the left. Group 2 — with ischemic stroke in the middle cerebral artery territory on the right. Group 3 — with ischemic stroke in the vertebrobasilar territory. Patients with a fatal outcome are separately described. The functional state of the autonomic nervous system was assessed by the method of mathematical analysis of heart rate variability according to R.M. Baevsky (1984). Cardiointervalography was performed in the morning on the 1st day from the onset of the stroke and on the 10th day.Results. The state of autonomic regulation in patients with ischemic stroke depends on the localization and size of the lesion. According to cardiointervalography, parasympathetic effects on the rhythm of the heart prevailed in patients with ischemic stroke in the middle cerebral artery territory on the left and in the vertebrobasilar territory in the peracute period, while the sympathetic one predominated in patients with ischemic stroke in the middle cerebral artery territory on the right. In the acute period, the general tendency for the increase in activity of the opposite part of the autonomic nervous system was observed.Conclusion. Statistically signifi cant changes in the indicators of the total power of the wave oscillation spectrum and the indicator of ultra-low-frequency waves in the peracute and acute periods of stroke in the examined patients indicate the importance of neurohumoral mechanisms of regulation in the dynamics of the pathological state

Функциональное состояние центральной и вегетативной регуляции у врачей экстренной помощи молодого возраста в северном регионе

The purpose of this research was to analyse the functional state of the central and autonomic nervous systems in young emergency physicians working in the northern region. Materials and methods. We examined 33 emergency physicians of a multidisciplinary hospital in Khanty-Mansi Autonomous Okrug – Yugra aged 25 to 43 years (19 men and 14 women). The functional state of the central nervous system (CNS) was assessed using the method of simple visual-motor reaction (SVMR) and criteria developed by T.D. Loskutova – system’s functional level (SFL), reaction stability (RS) and level of functional abilities (LFA) – as well as attention stability, working memory and Whipple’s accuracy index. The state of autonomic regulation was evaluated according to the dynamics of heart rate variability (HRV) at rest and during active orthostatic test (AOT). Results. We found that male emergency physicians have higher rates of psychomotor reactions, SFL, RS, and LFA than their female colleagues. SVMR showed pathological reactions of the CNS in subjects of both sexes. The body’s adaptive capabilities due to autonomic regulation were preserved in most emergency physicians. However, a pathological response to AOT was found in both men and women. The pathological basis for impaired autonomic regulation and the development of maladaptive reactions in the subjects was a deterioration of the current functional state of the body, excessive activation of the sympathoadrenal system and a decrease in parasympathetic regulation. Responses to AOT in male emergency physicians were accompanied by a decrease in the total power (TP) of the HRV spectrum by 24.7 %, and an increase in low frequency (LF) to high frequency (HF) ratio by a factor of 2.6; while in female doctors, by a decrease in TP by 11.5 % and an increase in LF/HF ratio by a factor of 1.7. The median of 30/15 coefficient was 1.48 for men and 1.45 for women. Thus, in the course of professional selection of doctors to provide emergency care under unfavourable climatic conditions of the North, it is advisable to conduct a comprehensive examination of the functional state of the central nervous system and autonomic regulation to identify a risk group with impaired adaptation mechanisms. For citation: Popova M.A., Scherbakova A.E., Karimov R.R. Functional State of the Central and Autonomic Regulation in Young Emergency Physicians in the Northern Region. Journal of Medical and Biological Research, 2021, vol. 9, no. 4, pp. 374–384. DOI: 10.37482/2687-1491-Z075

Вертеброгенная боль шейно-плечевой локализации у лиц молодого возраста: некоторые психоэмоциональные особенности и состояние вегетативных функций

В статье приведены результаты сравнительного исследования психоэмоционального, вегетативного статуса и выраженности болевого синдрома у 96 пациентов в возрасте от 18 до 35 лет, страдающих острыми (50 человек) и хроническими (46 пациентов) вертеброгенными болевыми синдромами в области шеи и плечового пояса. Нами установлено, что у исследуемых больных был синдром вегетативной дисфункции с нарушениями вегетативного гомеостаза и гомеокинеза. Вегетативный дисбаланс проявлялся в симпатической направленности вегетативних функций при исследовании вегетативного тонуса и недостаточных гомеостатических реакциях, выявленных при исследовании проб на вегетативную реактивность, которые были более выраженными у больных, страдающих хронической болью. Вегетативное обеспечение физической и эмоциональной деятельности оказалось преимущественно избыточным (при остром болевом синдроме) или преимущественно недостаточным (при хроническом), что свидетельствовало об истощении гомеокинетических механизмов и декомпенсации вегетативной регуляции при хронической боли. Вегетативная дисфункция сочеталась с тревожными и депрессивными нарушениями, частота и выраженность которых зависела от длительности боли и влияла на ее восприятие.

Стан серцево-судинної системи кваліфікованих спортсменок з настільного тенісу на етапі змагальної діяльності

The condition of the cardiovascular system is one of the important criteria for assessing the impact of sports training on the human body. According to the indicators characterizing the state of the cardiovascular system, it is possible to trace the changes associated with fluctuations in the level of training, as well as to identify signs of overload as early as possible. The study of adaptive reactions of the cardiovascular system in athletes under physical activity is an important indicator for sports practice. The purpose of the study was to investigate the quantitative criteria for assessing the state of the cardiovascular system and approaches to correct the functional state of qualified athletes specializing in table tennis. Materials and methods. Studies of heart rate variability, quantitative and qualitative indicators that sufficiently reflect the autonomic functions of the body were used in order to assess the state of autonomic regulation in highly qualified athletes. Systematic physical activity causes a significant restructuring of the cardiovascular system and leads to morphofunctional changes in the mechanisms of the heart. Depending on the autonomic regulation of heart rhythm, there are different ways of myocardial adaptation processes. The balance of sympathetic and parasympathetic links of autonomic rhythm regulation is reflected in the activation of the left ventricle. Results and discussion. Adaptive changes of the cardiovascular system to competitive and training loads in the competitive period in qualified athletes are characterized by a significant decrease in heart rate (from 84.75±1.74 beats / min to 74.8±0.38 beats / min). In addition, a significantly faster process of restoring heart rate was established after exercise in the group of qualified athletes, compared with athletes of the category 1 at 4 (p >0.05) and 5 (p >0.05) minutes, respectively. According to the indicators of autonomic regulation of heart rhythm, activation of the parasympathetic link prevails in athletes of the category 1 in comparison with qualified athletes activation (according to high-frequency component, p <0.05). Significantly higher rates of individual parts of the body compared to low-skilled athletes were found out: the hormonal system (the indicator responsible for the hormonal part of the body – very low-frequency component) and the nervous system (indicators of the sympathetic nervous system – low frequency component). There are significantly higher values of the magnitude of the heart rate spectrum and high-frequency component at p <0.05, which indicates a higher power of all units of the parasympathetic regulation in the category 1 in relation to masters of sports and candidates masters of sports. Conclusion. Systematic physical activity causes a significant restructuring of the cardiovascular system and leads to morphofunctional changes in the mechanisms of the heart. Depending on the autonomic regulation of heart rhythm, there are different ways of myocardial adaptation processes. The balance of sympathetic and parasympathetic links of autonomic rhythm regulation is reflected in the activation of the left ventricle. The analysis showed that the spectral characteristics of heart rate variability significantly differ between groups of athletes with different dominance that are observed only in terms of high-frequency component, which in turn led to a change in the sympathetic-vagal balance

Heart Rate Variability of Children with Mitral Valve Prolapse in Orthostatic Test

The purpose of the research was to study the state of autonomic regulation in prepubertal children with mitral valve prolapse during an orthostatic test Materials and methods. The study involved 2 groups: the main – 26 children aged 10-11 years with mitral valve prolapse, and a control group – 22 relatively healthy children. The adaptive mechanisms were monitored by analyzing heart rate variability. All children participated in a cardiorhythmic examination at rest lying down and during an active orthostatic test. Results and discussion. Among the indicators that had significant differences, the indicators of regulatory process adequacy index and mode amplitude should be noted. In the group of children with mitral valve prolapse, an increase of the regulatory process adequacy index indicated the predominance of the functioning of the sinus node over the activity of the sympathetic division of the autonomic nervous system. An increase in the adequacy index and mode amplitude indicates the connection of the central structures of rhythm control (subcortical rhythms) during a change in body position. Stress index also increased. This index of tension of regulatory systems shows the activity of the mechanisms of sympathetic regulation, the state of central regulation. Children in the control group had a well-coordinated response of the sympathetic nervous system to the orthostatic test: the low frequency spectrum and very low frequency indicators increased. While in main group, the value of low frequency spectrum (the work of the sinus node) increased, the value of very low frequency (the reaction of the central structures of the nervous system) decreased. This indicates dysfunction of the most important reactions, which also affects the daily activities of children, increases the risk of mitral valve prolapse complications. Conclusion. In children with mitral valve prolapse, the absence of a pronounced typical reaction to an ortho test is a reflection of an adaptive-regulatory overstrain in conditions of morphological determinacy of connective tissue dysplasia, which are trying to ensure the adequacy of intracardiac hemodynamics. The data obtained will be useful for predicting the reaction of the body of children with mitral valve prolapse to physical activity of varying intensity

State of Autonomic Regulation of Heart Rhythm in Young and Old Rats before and after the Application of Different Regimens of Rhythmic Extreme Cooling

State of Autonomic Regulation of Heart Rhythm in Young and Old Rats before and after the Application of Different Regimens of Rhythmic Extreme Cooling

Влияние геомагнитных и метеофакторов в различные сезоны года на состояние вегетативной регуляции сердца у молодых мужчин

Влияние геомагнитных и метеофакторов в различные сезоны года на состояние вегетативной регуляции сердца у молодых мужчин

СТАН ВЕГЕТАТИВНОЇ РЕГУЛЯЦІЇ В ОСІБ ІЗ ВИСОКИМ РІВНЕМ ПРОФЕСІЙНО ЗУМОВЛЕНОГО ПСИХОЕМОЦІЙНОГО НАВАНТАЖЕННЯ – ВОДІЇВ ПАСАЖИРСЬКОГО ЕЛЕКТРОТРАНСПОРТУ

Метою дослідження стало вивчення стану вегетативної регуляції в осіб із високим рівнем професійно зумовленого психоемоційного навантаження – водіїв пасажирського електротранспорту. Стан вегетативної регуляції визначали за даними варіабельності ритму серця (методом кардіоінтервалографії), активності та біоритміки гормонів стресу – кортизолу та катехоламінів. Стан вегетативної регуляції варіабельності ритму серця в обстеженого контингенту відзначався суттєвим підвищення ролі центрального контуру керування та значною компенсаторною активністю парасимпатичної ланки вегетативної регуляції із суттєвим зростанням активності автономного контуру керування. Стан активності та біоритміки гормонів стресу характеризувався суттєво вищим рівнем вмісту в крові катехоламінів, більш низьким рівнем кортизолу вранці та більш високим рівнем кортизолу ввечері, зменшенням різниці між ранковим і вечірнім рівнями кортизолу порівняно з працівниками без психоемоційного навантаження. Загалом, результати дослідження встановили, що у водіїв пасажирського електротранспорту підвищену активність симпато-адреналової системи організму та гормонів стресу і перекручення біологічного ритму регуляції вегетативних механізмів адаптації.

The level of anxiety and state of autonomic regulation depending on the predicted examination grades in students living under unfavorable environmental conditions

The examination situation evokes psychoemotional and autonomic reactions with different degrees of intensity depending on the predicted grades in first-year students living under unfavorable conditions of the middle Ob’ River basin. All the examined students (residents of the middle Ob’ River basin) were found to have a high or super high level of trait and state anxiety. The unfavorable emotional state was accompanied by different degrees of the strengthening of parasympathetic effects on cardiac activity and the tension of regulatory systems that were at a maximum in students who expected a C grade. Irrespective of the predicted result, the highest levels of anxiety and increase in the stress of regulatory systems were observed in female students.

Influence of the personality traits of the parents and children on the autonomic regulation of the heart rate in children of preschool age and adolescents

The relationship between personality traits and autonomic regulation of heart rate in children of preschool age and adolescents was studied. Significant positive correlations of the parameter of trait anxiety in children of preschool age with the index of tension (IT) of the cardiovascular system and of the value of extro/introversion of parents (mothers) with the IT of children were obtained. A relationship was revealed between school anxiety and the state of autonomic regulation of the heart rate in children of preschool age and adolescents.

The state of autonomic regulation in patients with postcastration syndrome after transplantation of human fetal tissues

The functional state of the autonomic nervous system was evaluated in 38 women after total ovariectomy. Clinical analysis of autonomic disorders and challenging tests indicated the disturbance of autonomic regulation and inhibition of vascular reactivity against the background of total autonomic lability. One month after transplantation of fetal human tissues vascular responses were improved: the number of positive dialatatory reactions increased and moderate pulse waves were recorded. The general condition of the patients improved, their work capacity increased, and sleep patterns normalized, which led to a reduction of anxiety. However, the transplantations had varying effects on hot flashes, which may be associated with their diverse nature. The positive effect that transplantation of fetal human tissues elicited in most patients may be attributed to normalization of their hormonal status.