Statistical Software Package Research Articles

Impact of Anti Tubercular Drugs on Biochemical Changes in Newly Diagnosed Tuberculosis Patients

Background: The disease tuberculosis (TB) continues to be a major global health concern, with high rates of morbidity and mortality, particularly in developing nations. It affects multiple organs and has the ability to alter metabolic processes. The purpose of this study was to ascertain how patients' serum biochemical markers were affected by tuberculosis and the medications used to treat it. Objective: The aim of this study is to evaluate impact of anti-tubercular drugs on biochemical changes in newly diagnosed tuberculosis patients. Methods: The cross-sectional observational study was conducted in Netrokona Medical College Hospital, Netrokona, from 1st January 2022 to 31st December 2023. A total of 120 newly diagnosed cases of pulmonary tuberculosis were enrolled and analyzed in this study. The questionnaire was pretested, corrected and finalized. Data were collected by face-to-face interview and analyzed by appropriate computer based programmed software Statistical Package for the Social Sciences (SPSS), version 24. Results: In this study, majority 48 (40.0%) of the patients were in 31 - 40 years age group and 28 (23.3%) patients were in 41 - 50 years age group, Mean±SD of age was 36.13±11.03 years. Most of the patients 69 (57.50%) were male and 51 (42.50%) patients were female. Most of the patients 87 (72.5%) were in normal range (18.5 – 29.9 kg/m2), 15 (11.7%) of the patients were underweight (<18.5) and 19 (15.8%) of the patients were overweight (>30). Serum Glutamic Oxaloacetic Transaminase and Serum Glutamic Pyruvic Transaminase level were 18.00 (4.01), 21.04 (3.16) before treatment but after treatment the level became 20.10 (3.52), 22.57 (4.41). Urea and Creatinine level were 18.20 (2.31), 0.63 (0.15) before treatment but after treatment 20.01 (5.34) and 0.53 (0.13). After treatment by anti-tubercular drug gastrointestinal adverse drug effects were nausea 3 (2.5%), vomiting 6 (5.0%), diarrhea 3 (2.5%) and abdominal pain 5 (4.2%), followed by itching ......

Comparison between Highly Sensitive C - Reactive Protein in Subjects with Preeclampsia with Severe Features and Preeclampsia without Severe Features

Background: Preeclampsia (PE) develops in 4-5% of pregnancies in humans. It appears after 20 weeks of gestation and is defined by increased blood pressure and proteinuria. When convulsions occur or the hemolysis, high liver enzymes, and low platelet count (HELLP) condition materializes, PE can lead to eclampsia. It is well recognized that eclampsia and HELLP syndrome are linked to serious side effects include liver hemorrhage, lung edema, brain hemorrhage, and renal failure. Objective: The aim of this study is to compare between highly sensitive c- reactive protein in subjects with preeclampsia with severe features and preeclampsia without severe features. Methods: This case-control study was carried out in the Department of Obstetrics & Gynecology of Dhaka Medical College Hospital, Dhaka, from January 2023 to December 2023. A total of 68 patients were enrolled and analyzed in this study. The questionnaire was pretested, corrected and finalized. Data were collected by face-to-face interview and analyzed by appropriate computer based programmed software Statistical Package for the Social Sciences (SPSS), version 24. Results: In this study, maximum study subjects were in 21 – 30 years age group. Mean age of the study subjects was 26.12 ± 4.02 and 24.04 ± 4.32 years in PE with severe features and PE without severe features respectively. Majority of the patients 27(79.4%) and 25 (73.5%) were housewife in both cases. Illiterate 2 (5.9%), higher secondary 9(26.5%) and graduate 10(29.4%) were higher in PE with severe features than PE without severe features. Most of the patients 25 (73.5%) and 21 (61.8%) came from rural area. Nullipara was higher in PE with severe feature and multigravida was higher in PE without severe features. Antenatal care was found more irregular in PE patients with severe features subjects than PE without severe features. Preterm pregnancy was higher in PE with severe feature than PE without severe features. Systolic and diastolic blood pressure were found significantly higher in PE patients with severe features than without severe features. hsCRP was found significantly higher in PE with severe features than PE without severe features. APGAR score of the neonate was significantly better of PE patients without severe features than with severe features patients both at birth and at 5 minutes. Average birth weight of the neonate was found higher of the PE patients without severe features than with severe features patients. There was 6(17.6%) very LBW of neonates of PE with severe features patients but none in PE without severe features patients. Intrauterine growth retardation, and prematurity were found higher in PE with severe features patients comparing PE without severe features. Conclusion: Women with PE have higher serum hsCRP levels. Clinical and biochemical markers of PE are linked with elevated serum levels of hsCRP in preeclamptic women. Serum hsCRP levels can be measured to determine the severity of PE.

High Sensitivity C-Reactive Protein as an Independent Risk Factor for Preeclampsia with Severe Features

Background: One of the most dangerous complications of pregnancy and a major contributor to maternal and perinatal morbidity and death is preeclampsia. The goal of the current study was to measure the level of inflammation in severe preeclampsia by measuring serum high-sensitive C-reactive protein (hs-CRP) and establishing a relationship between hs-CRP and blood pressure. Objective: The aim of this study is to evaluate the impact high sensitivity C-reactive protein as an independent risk factor for preeclampsia with severe features. Methods: The cross-sectional study was carried out in the Department of Obstetrics & Gynecology of Dhaka Medical College Hospital, Dhaka, from July 2022 to June 2023. A total of 200 patients were enrolled and analyzed in this study. The questionnaire was pretested, corrected and finalized. Data were collected by face-to-face interview and analyzed by appropriate computer based programmed software Statistical Package for the Social Sciences (SPSS), version 24. Results: In this study, majority 95 (47.5%) of the patients were in 21 – 30 years age group and 60 (30.00%) patients were in >30 years age group, Mean±SD of age was 27.12 ± 4.12 years. Most of the patients 150 (75.00%) were housewife and 50 (25.00%) patients were service holder. About 55 (27.5) patients were completed their graduation, 50 (25.00%) were completed higher secondary and 20 (10) were illiterate, most of the patients 145 (72.5%) came from rural area and 55(27.5) patients came from urban area. Nullipara was found in 75 (37.5%) patients and multigravida was found in most of the patients 110 (55.00%). Antenatal care was found irregular in 105 (52.5%) patients. Preterm pregnancy was found in majority 145 (72.5%) of the patients. Systolic and diastolic blood pressure were found higher and hsCRP was also found higher in PE with severe features. APGAR score was found less in 65 (32.5%) neonate at birth and APGAR score was found good in 55 (27.5%) neonate at 5 minutes. Average birth weight was found in 75 (37.5%) neonates, LBW was found in 85 (42.5) neonates and very LBW was found in 40 (20.00%) neonates of PE with severe features patients. Intrauterine growth retardation and prematurity were found in 75 (37.5%) and 20 (10.00%) neonates, admission to NICU was needed for 45 (22.5%) neonates, birth asphyxia was found in 15 (7.5%) neonates and stillbirth was occured in 35 (17.5%) cases. Conclusion: An exaggerated systemic inflammatory response, which may produce reactive oxygen species and worsen endothelial dysfunction, is present in preeclampsia. Clinical signs of hypertension and proteinuria in preeclampsia result from this. Preeclampsia-related maternal mortality and systemic complications may be reduced with early identification. hsCRP may therefore be a valuable gauge of preeclampsia severity.

Prevalence and Risk Factors Associated with the Psychological Maltreatment and Neglect of Child Laborers in Rural Bangladesh

Globally, child labor and maltreatment are considered serious public health concerns. Many child laborers in the informal sector are subjected to psychological abuse and neglect that is often akin to slavery. Our study examined the prevalence of these two forms of maltreatment among child laborers in rural Bangladesh, as well as the associated risk factors. Based on the snowball sampling technique, this study surveyed 100 child laborers employed in agricultural and domestic work in rural areas of the Sunamganj district, Bangladesh. The structured questionnaire utilizes the ICAST-CH instrument. To analyze the data, both simple and multiple linear regression analyses were conducted using two statistical software packages, SPSS and STATA. The study concluded that more than half of the child laborers have experienced psychological maltreatment “sometimes” in the form of being screamed at and insulted over the past year. In the past year, over 40% of respondents indicated they were “sometimes” deprived of food and drink and were not well cared for when they became ill. Multivariate analysis demonstrated that parents of psychologically maltreated child laborers had low educational backgrounds. A higher risk of neglect was observed among child laborers who worked for extended hours for their employers and whose families possessed limited land. In spite of the high prevalence of psychological maltreatment and neglect of child laborers in Bangladesh, the issue appears to be ignored. More comprehensive and rigorous scientific studies are required to bring about policy change.

Examining the Moderating Role of Firm Characteristics in the Corporate Governance-Financial Reporting Quality Nexus: Evidence From a Developing Country

Corporate governance is a stewardship system where directors are expected to provide leadership and supervision of the management of an organization and communicate to the absentee owners on the progress and performance of the organization, including through financial reporting. International Financial Reporting Standards (IFRS) were created to ensure corporate transparency, comparability, consistency and integrity of financial reporting. Since corporate governance is to ensure the effective operation of an organization, it is assumed that corporate governance will lead to quality financial reporting all other things being equal. Despite the existence of numerous publications on the relationship between corporate governance and financial reporting quality, the scientific literature still lacks comprehensive studies on the impact of individual firm characteristics on this relationship. The objective of this study is to assess how firm characteristics such as Firm size, Firm age, and ROA influence the relationship between corporate governance and the quality of financial reporting. A regression analysis based on balanced panel data of 598 observations from 46 companies in Ghana with full annual reports from 2009 to 2021 allowed us to assess the impact of such corporate governance variances as Board Size, Board Gender Diversity, and Independence of the Audit Committee on IFRS compliance. Mitigating effects and hypothetical correlations between variables were assessed using the STATA software package. Using the Hausman test, the appropriateness of the fixed effects model was substantiated (model specifications for proxy variables and moderating variables were built). The first part of the study was based on the results of linear regression. The linear regression results suggest that Board Size significantly predict IFRS compliance with a coefficient of 0.003 and p-value of 0.028. The independence of the Audit Committee exhibits a positive and statistically significant relationship with IFRS compliance, with a coefficient of 0.027 and a p-value of 0.018. Board Gender Diversity, despite having a coefficient of 0.024, does not display a statistically significant relationship with IFRS compliance (p=0.682). The second part of the study involved analysis to assess the moderating effect of firm characteristics on the relationship between corporate governance and financial reporting quality (an effect that occurs when a third variable changes the nature of the relationship between a predictor and an outcome, especially in analyses such as multiple regression). In this case, the results were different. In particular, Board Size does not significantly influence IFRS compliance with a coefficient of 0.001 and p-value of 0.477. Board Gender Diversity negatively influences IFRS compliance with a coefficient of -0.882 and is highly significant at the 1% level. The Independence of the Audit Committee is positively associated with IFRS compliance, with a coefficient of 0.233 and significance at the 1% level. In terms of firm characteristics, Firm Size and Return on Assets both exhibit significant negative relationships with IFRS compliance, while Firm Age (FA) has a positive effect, all significant at the 5% level. Again, the findings of the study showed that the relationship between board size and IFRS compliance changes depending on the firm’s return on assets and that there is a significant positive interaction between Board Gender Diversity and firm characteristics. While firm size and firm age significantly moderate the relationship between the independence of the audit committee and IFRS compliance. The findings of the study indicated a significant impact of both Board Gender Diversity and Independence of the Audit Committee on the level of compliance with International Financial Reporting Standards (IFRS). Specifically, the link was shown to be highly influenced by firm characteristics such as size, age, and return on assets. Thus, the study allowed us to confirm the hypothesis that the success of corporate governance in guaranteeing high-quality financial reporting depends on certain characteristics of the organisation. It is advisable for regulatory agencies to consider the modification of governance principles to align with the unique characteristics of specific firms. There is a growing call for firms to actively promote and support gender diversity among their Board of directors, as well as prioritize the independence of their Audit committees. Furthermore, it is advisable for organisations to adopt a proactive stance to enhance internal controls and implement targeted training programmes for board members, with the aim of effectively addressing unique issues faced by the organisation.

Navigating the digital frontier: a comparative examination of Central Bank Digital Currency (CBDC) and the Quantum Financial System (QFS)

In the global financial landscape, a transformational shift towards digitization is known, and a comparative analysis of two key components is of particular relevance: central bank digital currency (CBDC) and quantum financial system (QFS). This article explores the dynamic relationship between traditional monetary instruments and new digital currencies, considering the transformative impact and regional nuances of CBDC. The article provides a historical overview of the evolution of the development and implementation of CBDC in the world, analyzes the key factors affecting its implementation in different regions, identifies key technological advances that are the disruptive force of QFS, as well as their impact on the transformation of traditional financial transactions. In the context of the development of CBDC and QFS, the legal frameworks that regulate their work, facilitate or hinder their broad integration into existing financial systems, their impact on traditional monetary policy and, accordingly, on economic stability, inflation and interest rates, and the format of the technological infrastructure are determined, which must be ensured for their successful implementation and operation, as well as the main challenges related to this and ways to solve security and privacy problems in their application. The paper combines qualitative and quantitative analysis to provide a comprehensive and validated dataset for a thorough understanding of digital financial paradigms. Qualitative research was conducted based on structured interviews with experts in the development and implementation of CBDC and QFS, as well as reporting and analytical information on central banks, regulators, and other financial institutions. The empirical study is based on the built OLS model, which describes the dependence coefficient using CBDC (the share of the population that uses it) on the traditional interest rate set by the central bank (taking into account the corrections for the possibility of variation of its changes and unobservable factors). The Python programming language with R libraries and the Stata software package are used for modeling. Tests confirmed the model’s statistical significance and high R-squared value (0.756 ) to begin its ability to explain a significant portion of the variability in CBDC adoption rates. The results showed that, on average, per skin unit increase in the traditional interest rate, post-CBDC rate growth is expected to be 1.74%; when the conventional interest rate is zero, the settlement rate after CBDC is 11.14%. The results of this study can be used to predict the dynamics of public perception of digital currencies. In addition, central banks can adjust interest rates to stimulate or moderate the adoption of CBDCs based on broader strategic macroeconomic measures: 1) during economic downturns, higher interest rates can be used to stimulate the adoption of digital currencies as an alternative financial instrument; 2) during periods of economic growth, interest rates may be lowered to mitigate the intended overheating of CBDC adoption.

A STATISTICAL ANALYSIS OF GEOLOGICAL AND ENGINEERING PREDICTORS OF OILFIELD PERFORMANCE RESPONSE: A CASE STUDY OF OILFIELDS ON THE UK CONTINENTAL SHELF

Oilfield production is controlled by a wide range of geological and engineering parameters, many of which are at least partially interrelated. This paper uses multivariate statistical methods (principal component analysis, regression analysis and analysis of variance) to determine how these parameters are related, and which of them are most significant in controlling and predicting oilfield performance. The analysis is based on a database of publicly available oilfield data from the United Kingdom Continental Shelf (UKCS), from which a series of geological, engineering and fluid‐related control variables from 136 fields were pre‐processed and analyzed. This dataset is a subset of a much wider project database for UKCS oil, gas and condensate fields. For this study, the project database was divided into two datasets: a first dataset with 10 parameters from 136 fields, and a second, more detailed dataset with 27 parameters from 38 fields. Both datasets were analysed using principal component analysis in order to investigate possible correlations between numerically/statistically interrogable predictor variables such as porosity, permeability, number of production wells, gas‐oil ratio and reservoir temperature. A regression analysis was then carried out on the predictor variables in order to obtain a ranking of predictability (i.e. how indicative a predictor is of a particular outcome) and sensitivity (how sensitive an outcome is to slight changes in a predictor) in relation to recovery factor based on R‐squared and regression coefficient values. The results showed that key variables from the principal component analysis included field size, number of production wells, PVT, gross depositional environment and reservoir quality. High‐ranking parameters of predictability and sensitivity from the regression analysis were found to include API, net‐to‐gross, porosity and reservoir depth. These results are consistent with previous studies and suggest that it should be possible to forecast oilfield recovery based on only a few selected input variables. As a preliminary test of forecasting ability of the variable permutations put forward, a best‐subsets multiple regression was carried out using a statistical software package and yielded results which corroborated the main findings.

Complications and outcomes after three-column osteotomy: a 5-year follow-up

BACKGROUNDThree-column spinal osteotomies (3-CO) are powerful techniques used to correct spinal deformity. These surgeries are associated with an elevated risk of complications. While outcomes have been reported in the literature with 2 years follow-up, longer-term outcomes of three-column osteotomies remain understudied. OBJECTIVESThis study aims to examine patient reported outcomes and complications for three-column osteotomies at 5 years. STUDY DESIGNRetrospective review of a prospectively collected spinal deformity cases database. PATIENT SAMPLEAll consecutive adult patients at a single spine surgery center treated with either a pedicle subtraction osteotomy (PSO) or vertebral column resection (VCR) for spinal deformity, and with a minimum 5-year follow-up were included. OUTCOME MEASURESVisual-analog scale (VAS) for back pain score (0 to 10), Oswestry Disability Index (ODI) score (0 to 100), number of complications, revision rate, sagittal balance, lumbar lordosis at preoperative and at 5-year visit. METHODSData was extracted from a prospectively collected spinal deformity surgery database continuously updated since 2002 with data from operative reports, patients’ medical visit notes and patients’ self-reported VAS and ODI questionnaires completed at each office visit. Radiographic measurements were performed on standing full-length spine radiographs taken at preop and 5-year visits. Descriptive statistics, comparison of means and proportions among groups, and a logistic regression analysis were conducted using the statistical software package SPSS version 28. Statistical significance was set at p<.05. RESULTSOf 127 consecutive adult patients with minimum of 5-year follow-up undergoing a 3-CO posterior spinal surgery for spinal deformity were identified and included in the study, 79 (62%) were treated with PSO, and 48 (38%) with VCR. Both PSO and VCR groups demonstrated significant improvements in VAS (PSO preop: 6.7, 5-year: 4.6, p<.001; VCR preop: 7.1, 5-year: 5.2, p<.001), and ODI (PSO preop: 52.9, 5-year: 45.4, p<.001; VCR preop: 57.5, 5-year 43.0, p<.001) that were maintained at 5 years. Major and minor complications occurring within 5 years were not statistically different between the PSO and VCR groups (major: 59.5% vs 56.3%, p=.85; minor: 45.6% vs 37.5%, p=.46). The rate of revision surgery within 5 years was 39.4% overall. Of the fifty patients requiring revision, 37.5% were for nonunion, 27.1% instrumentation failure, 14.6% proximal junctional kyphosis (PJK), 12.5% vertebral fracture, 6.3% motor weakness, and 2.1% infection. Improvements in lumbar lordosis were maintained at 5 years in both the PSO (29.9° vs 47.2°, p<.001) and VCR (34.6° vs 48.5°, p<.001) groups while sagittal balance maintained significant improvement in the VCR group (9.5 cm vs 6.3 cm, p=.008) but not the PSO (11.4 cm vs 9.3 cm, p=.065). CONCLUSIONPatients undergoing three-column osteotomies had a major complication rate of 57.5% and a minor complication rate of 42.5% after 5 years. Improvements in lumbar lordosis were maintained at 5-year follow-up, but sagittal balance was only maintained in the VCR group. Despite these radiographic findings, both VCR and PSO groups maintained significant clinical improvements in both VAS and ODI scores at 5-year follow up.

A Comparative Study of Central Foveal Thickness in Nondiabetics Versus Diabetics Without Retinopathy Using Spectralis OCT

Abstract Purpose: To compare the central foveal thickness (CFT) in diabetics without retinopathy versus nondiabetics using optical coherence tomography (OCT). Methods: The study was done as a comparative cross-sectional study among two groups with 30 subjects in each group. Group A was of diabetics without retinopathy and Group B was of nondiabetics. Patients with diabetic retinopathy, diabetic macular edema, other macular diseases, history of laser treatment, intra vitreal injections, chronic glaucoma, previous eye surgeries, and hypertension were excluded from the study. CFT of the two groups was measured using OCT. Results: All the data were analyzed with a statistical software package SPSS version 16.0. The mean CFT in the diabetics without retinopathy group was found to be 225.97 ± 21.20 µm, and in nondiabetic group it was 234.57 ± 34.68 µms. Conclusion: The study showed that CFT was slightly lower in diabetics without retinopathy when compared to nondiabetics, but the value was not statistically significant (P-value: 0.091).

Hygienic assessment of occupational risk for workers during pre- and post-emergence herbicide treatments of sunflower crops

Modern agriculture extensively uses pesticide formulations at various stages of crop growth. Sunflower cultivation accounts for 31% of the global production. Assessing the occupational risk associated with pesticide application in sunflower farming is of paramount importance. Improper handling and application of pesticide formulations can have immediate adverse effects on workers, leading to acute poisoning, long-term health consequences, and the potential for chronic illnesses, including neurotoxic effects. The aim of this study was to conduct a hygienic assessment of the professional risk faced by workers during pre- and post-emergence herbicide applications in sunflower cultivation. This assessment was carried out to establish the regulations for their safe usage. Research samples after the application of the herbicides AGAT, GARPUN, KORVUS, and PARUS (patches from overalls, gloves, skin swabs from exposed areas (face-neck, hands), air samples (atmospheric air, working zone and drift zone). The assessment of professional risk was conducted in accordance with the methodological recommendations provided by experts from the L.I. Medved's Research Center of Preventive Toxicology, Food and Chemical Safety, Ministry of Health, Ukraine (State Enterprise). Statistical analysis of the results was carried out using the licensed statistical software packages MedStat v.5.2 (Copyright© 2003-2019) and Microsoft® Excel® for Microsoft 365 MSO (Version 2305, Build 16.0.16501.20074). It has been determined that under real conditions, during pre- and post-emergence herbicide applications in sunflower cultivation using AGAT, GARPUN, KORVUS, PARUS preparations, while adhering to recommended agrotechnical and hygiene safety regulations, the inhalation, dermal, complex, and combined (AGAT and PARUS) risks for applicators are 0.0409±0.0179, 0.0429±0.0193, 0.0838±0.0224, and 0.1557±0.1322 a.u., respectively, and for tractor operators – 0.0818±0.0358, 0.0425±0.0192, 0.1243±0.0356, and 0.2347±0.1567 a.u., respectively. There is no observed increase in hygiene standards in the workplace atmosphere and in the air of the potential drift zone. It has been proven that the professional risk of their use does not exceed permissible limits (&lt;1). It has been determined that during the performance of techno­logical operations, the mentioned risks in applicators and tractor operators did not differ significantly (p&gt;0.05). However, a significant difference was found in the proportion of percutaneous risk (42.7±17.4% in applicators compared to 34.8±17.0% in tractor operators; p=0.034). The regulations for the safe use of the investigated pesticide formulations have been substantiated. Statistical analysis of the obtained results revealed that the values of inhalation, dermal, and combined risks during the application of these pesticides did not significantly differ during the various technological operations (applicators and tractor operators) (p&gt;0.05). The values of the combined comprehensive risk associated with the use of the studied preparations also did not show significant differences (p&gt;0.05). The proportion of dermal risk was significantly higher in applicators compared to this parameter determined in tractor operators (p=0.034).

IJCM_359A: Pattern of Congenital Anomalies among newborn babies - A Hospital based study

Background: Congenital anomalies can be defined as structural or functional anomalies that occur during intrauterine life and can be identified prenatally. Some of the congenital anomalies may be life threatening, hence an immediate management is required. This study is to determine the pattern of congenital anomalies among newborn babies and factors associated with it. Methodology: It was a descriptive study carried out at KMC Hospital, Attavar on all the new born babies with congenital abnormalities born or admitted in KMC Attavar. Data extraction sheet had two sections including the maternal details, history of newborn related to type of congenital anomalies and condition of the baby at birth. Data was entered and analyzed by using statistical software Statistical Package for Social Sciences (SPSS) Version 11.5. Descriptive statistics like mean, proportions and standard deviation was used for expressing the results. Results: We found that 56.25% of the cases were of maternal age group &lt;30years. 3.16% were non-consanguinous marriages, 56.46% of mothers were primiparous &amp; 43.53% were multiparous. Only 18.40% had maternal co morbidities &amp; 5.84% had hazardous exposure. 67% of the study population were males and 33% were females. In cases where single system was involved, 66.85% were males and 33.15% were females. In cases with multiple malformations, 67.56% were males and 32.43% were females. In the cases where maternal age was &lt;30yrs, 22.85% of anomalies were in the cardiovascular system, and in ≥30yr, 29.63% were multiple malformations. Conclusion: Among the congenital anomalies affecting the newborns, the most affected single system is gastrointestinal tract followed by cardiovascular system and musculoskeletal system. Multiple malformations were found to be the highest. Congenital anomalies were found to be more in males than females. In maternal age group of less than 30yrs, highest number of anomalies were in the cardiovascular system and for more than/equal 30yrs, highest number was multiple malformations.

IJCM_34A: Usage of complementary / alternative medicine (CAM) and perception towards it among cancer patients admitted in tertiary care hospitals

Background: Cancer being a deadly disease, cancer victims face great challenges with respect to their routines, roles and relationships. The usage of other means to cure illness is called complementary and alternative medicine or CAM. This study is done to determine the proportion and usage pattern of CAM for cancer treatment and to assess the perception towards CAM among cancer patients. Methodologys: It was a Descriptive cross-sectional study, carried out among cancer patients admitted to tertiary care hospitals attached to a medical college. The interview schedule was prepared which consists of four sections including the socio-demographic details, details about the diagnosis and treatment of cancer among the study participants, details about the usage pattern of Complementary medicine, and the perception of cancer victims towards Complementary medicine for cancer treatment. Data will be entered and analyzed by using the statistical software Statistical Package for Social Sciences (SPSS) Version 11.5. Results: Out of 105 participants majority of cancer patients,74 (70%) of them were of the age group between 40- 70 years. 65% of the patients had addictions among which 60 (90.9%) were addicts for more than 10 years. The majority of the patients underwent radiotherapy 85 (81.0%), followed by Chemotherapy 72 (68.6%), The number of patients that have used CAM in our study was found to be 12 (11.4%). Many of them chose Ayurveda as their type of CAM 5 (41.7%) followed by home remedies usage 4 (25%). 39 (38.5%) believe that there should be more evidence that CAM works while 38 (33.8%) don’t need any evidence about it. 45 (42.9%) feel that CAM treatment does not work in the treatment of cancer while 35 (33.3%) remained neutral in this aspect. 85 (81.0%) are satisfied with present cancer treatment. 78 (74.3%) agreed that Modern medicine is most effective for treatment of cancer. Conclusion: The usage of CAM in our study was found to be minimal. The majority of the participants are satisfied with modern medicine and most of the patients are satisfied with allopathic treatment.

IJCM_169A: Correlation of sonographic renal dimensions with anthropometric measurements among individuals without renal disorders

Background: Normal kidney dimensions are suggestive of normal kidney function. Degree of kidney function has a positive correlation with ultrasonic renal measurements. Co-morbid conditions affect the renal size. Therefore it becomes necessary to establish normal values of kidney dimensions for the diagnosis, prognosis and also as an early indication of renal diseases in order to prevent them. Objectives: To study the renal dimensions and association with socio- demographic conditions among the outpatient attendees in the study hospital. Methodology: This was a descriptive cross-sectional study done among the attendees of KMC Hospitals, Mangalore. Data extraction sheet included the socio-demographic details, Anthropometric measurements, personal history, history of comorbidities and sonographic dimensions of Kidney and laboratory findings of Renal Function Test. Data was entered and analyzed by using statistical software Statistical Package for Social Sciences (SPSS) Version 29.0. Results: Out of 194 participants, 118(60.8%) were males. The difference between corresponding kidney lengths of males and females is found to be statistically significant. The length and anteroposterior dimension of left kidney is greater than right kidney and the difference is statistically significant. When the kidney lengths and the heights of the individual were correlated a positive correlation was obtained, (0.278) in case of right kidney and (0.245) in case of left kidney. Conclusion: Kidney length had positive correlation with height and BMI. Female kidney length was significantly smaller than the male kidney length. There was significant variation between right and left kidney lengths.

In vitro evaluation of the bleaching effect on the change of color match of omnichroma composite resin

Aim To in vitro evaluate the bleaching effect on the color match of Omnichroma composite resin restorations to the teeth color. Materials and methods Thirty freshly extracted intact human premolars were collected and mounted in acrylic resin blocks (only roots were embedded). The shade of the selected teeth was measured by (VITA Easyshade V). Class V cavities (4 mm width, 2 mm length, and 2 mm depth) were prepared 2 mm coronal to cement-enamel junction on the cervical third of the facial surface of each tooth. Specimens were randomly divided into two equal groups (n = 15): group I: was restored with nano hybrid Tetric N- ceram while group II: was restored with Omnichroma supra-nano filled composite resin using their respective adhesives. All the specimens were thermocycled for 500 cycles from 5 to 55°C with 15 s dwell time, and 20 s transfer time. The initial data of color measurements for tooth and restoration surfaces were recorded after thermocycling using VITA Easy Shade V. Specimens were then bleached using 40% HP by White smile power whitening YF according to the manufacturer instructions and kept in artificial saliva for 1 week before color re-measuring. All data were collected, tabulated, and statistically analyzed at 95% significance level using a software statistical package for social sciences (SPSS version 26). Results Before bleaching, higher mean ΔΕ values were recorded for the teeth (3.38 and 2.74) compared to (2.24 and 1.82) of the restorations in group I (Tetric N) and group II (Omnichroma) respectively with no statistically significant difference (P = 0.26 and 0.43) in either of the groups denoting the color match between the restorations and the teeth in both groups. After bleaching there was a highly statistically significant difference (P = 0.039) between the mean ΔΕ values of teeth (5.56) and restorations (3.23) in group I, denoting the color mismatch. While in group II there was no significant difference (P = 0.249) between the values of teeth (5.25) and restorations (4.49) denoting the persistence of the color match after bleaching. No significant difference was found between the ΔΕ values of teeth used in both groups neither before (P = 0.62) nor after bleaching (P = 0.802). While there was a significant difference between the recorded values of the restorations after bleaching (P = 0.026) although the difference was not significant before bleaching (P = 0.619). Bleaching significantly affected the teeth color (P = 0.013 and 0.038), and the restoration color (P = 0.049 and 0.012) in groups I and II, respectively. Conclusions Omnichroma class V composite restorations matched the shades of teeth before and after bleaching where it was changed to a lighter shade with the teeth enamel that was within the acceptable clinical range. The color matching of the Tetric N restorations after bleaching was lost where the teeth were lighter in a clinically detectable manner, which necessitates restoration replacement.

Central Corneal Thickness and Endothelial Cell Changes in Diabetics and Age-Matched Non-diabetics in a Tertiary Care Hospital in Central India.

Background Diabetes has become an epidemic, significantly impacting ocular health as one of its end-organ responses. Among the various ocular complications, alterations in corneal morphology stand out. Central corneal thickness (CCT) and endothelial cell function are vital parameters in assessing intraocular pressure, conducting pre-refractive surgery evaluations, and maintaining corneal transparency. Understanding these changes in diabetic individuals compared to non-diabetics is crucial for managing ocular health in this population. Aim and objective This study evaluates and compares CCT and endothelial cell changes between diabetic individuals and age-matched non-diabetics. By analyzing these parameters, the study seeks to provide insights into the impact of diabetes on corneal morphology and its implications for ocular health. Methods The study recruited 124 patients from the Ophthalmology Outpatient Department (OPD) at Acharya Vinoba Bhave Rural Hospital (AVBRH), Sawangi. A cross-sectional research design was employed to collect data over six months. Patients were carefully selected, and informed consent was obtained from all participants. CCT and endothelial cell parameters were assessed using specular microscopy, a non-invasive imaging technique. Statistical analysis was done using the software Statistical Package for the Social Sciences (SPSS) for inferential statistics, such as t-tests and ANOVA, and comparing parameters between diabetic and non-diabetic groups.Findings were interpreted based on both statistical significance and clinical relevance. Results In diabetic patients, the mean CCT was 547.91 µm, while it was 523.62 µm in non-diabetic individuals.The T statistic for this variable was 5.14, indicating a17 significant differencebetween the two groups. Similarly, significant differences were found between diabetics and non-diabetics for endothelial cell density, coefficient of variation, and hexagonality, as evidenced by their respective T statistics of 7.46, 5.17, and 4.91. Endothelial cell density averaged 2375 cells/mm2 in diabetics and 2666.95 cells/mm2 in non-diabetics. Additionally, the coefficient of variation was higher among people with diabetes (40.87%) compared to non-diabetics (35.09%). Hexagonality, a measure of endothelial cell shape, was lower in diabetic corneas (40.48%) than in non-diabetic corneas (46.46%). Conclusion The study observed significant differences in corneal morphology, including central thickness and endothelial cell changes, between diabetic and non-diabetic individuals. These findings underscore the impact of diabetes on ocular health and emphasize the importance of monitoring corneal parameters in diabetic patients. Understanding these changes can aid in better management and treatment strategies for ocular complications associated with diabetes.

Controlled and uncontrolled arterial hypertension: comparison of clinical and demographic characteristics in patients (according to the National Registry of Hypertension, 2019-2022)

Aim: to study the clinical and demographic characteristics of patients in a sample of patients with arterial hypertension observed in primary healthcare (20192022). To compare data from patients with uncontrolled and controlled hypertension.Materials and methods. An analysis of medical data of 4543 patients was carried out (history, clinical and laboratory data, concomitant cardiovascular diseases, type 2 diabetes mellitus, chronic kidney disease, revascularization (coronary bypass grafting, transluminal balloon angioplasty of the coronary arteries). For statistical data processing, the SPSS statistical software package was used.Results. The patients in the study sample were middle-aged and elderly. 51,5% of patients did not achieve target blood pressure values. More than 90% of patients in the studied sample are high and very high risk patients. The ratio of groups of patients with controlled and uncontrolled arterial hypertension among patients of different ages did not differ. Higher values of low-density lipoprotein cholesterol, a higher frequency (1,3 times) of failure to achieve target values of low-density lipoprotein cholesterol &lt;2,6 mmol/l, and obesity (1,3 times) were identified in patients with uncontrolled arterial hypertension. More than 80% of patients had low-density lipoprotein cholesterol values higher than recommended. Patients with controlled arterial hypertension were more likely to have coronary heart disease, myocardial infarction and a history of coronary angioplasty and coronary artery bypass grafting.Сonclusions. In hypertensive patients, more careful monitoring of cardiovascular risk factors is required, including blood pressure levels and achieving target LDL cholesterol levels. The association of a higher incidence of obesity, type 2 diabetes mellitus and the severity of dyslipidemia with uncontrolled hypertension may indicate less adherence of patients to both drug and non-drug treatment methods. While the presence of coronary heart disease, surgical interventions performed on the coronary arteries can serve as an illustration of increased adherence to therapy when hypertension is combined with coronary heart disease.

Common predictors of cervical cancer related mortality in Ethiopia. A systematic review and meta-analysis

BackgroundCervical cancer accounts for 7.5% of all female cancer related deaths worldwide; peaking between the ages of 35 and 65, and not only kills young women but also destroys families with young children.ObjectiveThis review was intended to measure national level magnitude and the most common predictors of cervical cancer related mortality in Ethiopia.MethodsCommon Public databases like Science Direct, Embase, the Cochrane Library, and PubMed were thoroughly searched. The STATA 14 and Rev-Manager 5.3 statistical software packages were used for analysis, as well as a standardized data abstraction tool created in Microsoft Excel. The Cochrane Q-test statistics and the I2 test were used to assess non-uniformity. The pooled magnitude and predictors of cervical cancer related mortality were estimated using fixed-effect and random-effect models, respectively.ResultThe pooled mortality among cervical cancer patients was estimated that 16.39% at 95% confidence level fall in 13.89–18.88% in Ethiopia. The most common predictors of cervical cancer related mortality were late diagnosed, radiation therapy alone, and Being anemic were identified by this review. Among cervical cancer treatment modalities effectiveness of surgery with adjuvant therapy was also approved in this meta-analysis.Conclusion and recommendationIn this study high cervical cancer-related mortality was reported as compared to national strategies to alleviate cervical cancer related mortality. Advanced implementation of cervical cancer screening at the national level for early diagnosis, anaemia detection, and combination anticancer therapy during initiation, as well as combination therapy, is critical to improve cervical cancer patient survival and decreasing mortality rates.

The Role of HPV Genotype among Colposcopy Diagnosed Cervical Precancerous Lesions

Background: Cancer is the leading cause of death and a major contributor to reduced life expectancy in every country on Earth [1]. Cervical cancer (CC) is a serious global health concern that is more common in developing countries, especially those on the Indian subcontinent. More and more women are suffering from CC. Cervical cancer is mostly caused by the Human Papillomavirus (HPV), a sexually transmitted virus that is one of the most common illnesses of the reproductive system. Objective: The aim of this study is to evaluate the role of HPV genotype among colposcopy diagnosed cervical precancerous lesions. Methods: The cross-sectional observational study was conducted in the Department of Gynecological Oncology of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from July 2021 to June 2022. A total of 132 subjects were included in the study. Data were collected by face-to-face interview and analyzed by appropriate computer based programmed software Statistical Package for the Social Sciences (SPSS), version 24. Results: In this study, the mean age was found to be 36.7±6.3 years, with a range from 31 to 60 years, the majority 53 (40.2%) of patients completed SSC and 118 (89.4%) were housewives and 125(94.7%) were Muslims. In this study most of the patients 101 (76.5%) came from middle-income families. About 45 (34.1%) patients were married between the ages of 15-17 years, 45 (34.1%) were between 16-18 years during their first delivery and 56 (42.4%) had 3-4 children. Most of the patients 92(69.7%) had history of received OCP. About 10(7.0%) patients were found HPV 16 positive followed by 1(0.7%) HPV 18, 3(2.1%) other HR-HPV, 3(2.1%) HPV 16 &amp; other HR-HPV and 1(0.7%) HPV 16-HPV 18 &amp; other HR-HPV. Most of the 95 (72.0%) patients had CIN I, 30 (22.7%) had CIN II and 7 (5.3%) had CIN III identification by colposcopy reports. In this study 59 (44.7%) patients had CIN I followed by 13 (9.8%) had CIN II, 9 (6.8%) had CIN III, 5 (3.8%) had CIS and 46 (34.8%) ..

Diagnostic Performance between Colposcopy Findings and Histopathology Reports

Background: Cervical cancer is the most frequent cancer in women worldwide. With appropriate screening, the condition can be prevented and treated. Colposcopy is a useful tool in the diagnosis and management of precancerous cervical lesions following primary screening. The gold standard for identifying precancerous lesions is histopathology. Objective: The aim of this study is to evaluate the diagnostic performance between colposcopy findings and histopathology reports Methods: The cross-sectional observational study was conducted in the Department of Colposcopy Clinic of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from July 2022 to June 2023. A total of 62 subjects were included in the study. The questionnaire was pretested, corrected and finalized. Data were collected by face-to-face interview and analyzed by appropriate computer based programmed software Statistical Package for the Social Sciences (SPSS), version 24. Results: In this study, the mean age was found to be 36.8±11.9 years, with a range from 20 to &gt;51 years maximum 44 (71.0%) of the patients were within the age group of 20 - 40 years. The majority 37 (59.7%) of patients completed SSC and most of the patients 56 (90.3%) were housewives. Most of the patients 59 (95.2%) were Muslims and about 32 (51.6%) came from middle-income families. About 25 (40.3%) patients were married between the ages of 15-17 years. About 25 (40.3%) were between 16-18 years during their first delivery and about 26 (41.9%) had 3-4 children and 21 (33.9%) had more than 4 children. Most of the patients 43(69.4%) had history of received OCP. Regarding colposcopic diagnosis, 12.9% (n=8) were normal, 69.4% (n=43) were CIN I, 9.7% (n=6) were CIN II and 8.1% (n=5) were CIN III and 30.6% (n=19) chronic cervicitis, 46.8% (n=29) CIN I, 6.5% (n=4) CIN II, 6.5% (n=4) CIN III, 4.8% (n=3) carcinoma in situ and 4.8% (n=3) were invasive squamous cell carcinoma by the histopathological diagnosis. Conclusion: Colposcopy had a rather high diagnostic accuracy for histopathologically verified precancerous cervical lesions. Even if the results of the screening tests are normal, patients who report with postcoital and postmenopausal bleeding should have colposcopies and biopsies. Colposcopy also has a high sensitivity, therefore it is simple to use the "see and treat" approach to lower dropout rates.

Evaluation of the Efficacy and Safety of Dienogest in the Treatment of Primary Dysmenorrhea: A Study in a District-Level Hospital in Bangladesh

Background: Dysmenorrhea is a common symptom secondary to various gynecological disorders, but it is also represented in most women as a primary form of disease. Pain associated with dysmenorrhea is caused by hypersecretion of prostaglandins and an increased uterine contractility. The primary dysmenorrhea is quite frequent in young women and remains with a good prognosis, even though it is associated with low quality of life. Objectives: The aim of this study is to evaluate of the efficacy and safety of dienogest in the treatment of primary dysmenorrhea: a study in a district-level hospital in Bangladesh. Methods: The cross-sectional observational study was conducted in the Department of Gynae and Obs, Naogaon Sadar Hospital from July 2022 to June 2023. A total of 100 subjects who received DNG (1 mg/day, orally) were included in the study. Data were collected by face-to-face interview and analyzed by appropriate computer based programmed software Statistical Package for the Social Sciences (SPSS), version 24. Results: In this study, most of the patients 43% lies between 21 years to 25 years and body weight of 24% patients were between 51 to 55 kg. In this study, most of the patients 41% body mass index were 18.5 – 24.9 kg/m2. Most of the patients’ clinical symptoms were cramping pain in the lower abdomen (89%), low back pain (86%), pain spreading down to the leg (73%), fatigue (64%). About (56%) adverse effects were body weight gain and irregular uterine bleeding occurred in 35 of 100 cases (35%). Conclusion: Primary dysmenorrhea is one of the most common illnesses in women of childbearing age. When severe, it may interfere with the activities of daily living and may lead to school and work absenteeism. Primary dysmenorrhea is also one of the most underdiagnosed diseases, so clinicians should suspect the diagnosis in a timely manner and provide appropriate treatment.