Stasis Type Research Articles

Relationship between various Chinese medicine types and T-cell subsets in patients with ulcerative colitis

To investigate the relationship between various Chinese medicine (CM) types and T-cell subsets (CD4(+) and CD8(+)) in the colonic mucous membranes of patients with ulcerative colitis (UC). Fifty UC patients were enrolled, after differentiation into four types by CM syndromes, i.e., the internal heat-damp accumulation type (IHDA), the qi-stagnancy with blood stasis type (QSBS), the Pi-Shen yang-deficiency type (PSYD) and the yin-blood deficiency type (YBD). From every patient, 3-5 pieces of intestinal mucous membrane tissues were taken through colonoscopy to determine the levels of the T-cell subsets (CD4(+) and CD8(+)) using immunohistochemical method. The results were compared with those in the normal control. The level of CD8(+)increased and the ratio of CD4(+)/CD8(+)decreased mainly in colonic mucous membranous tissues in UC patients. The level of CD4(+)decreased significantly in IHDA types (P<0.01), but decreased only slightly in the PSYD, QSBS and YBD types. CD8(+)increased significantly in the IHDA types (P<0.01), but only slightly in the other three types. The IHDA types of UC are closely related with T-cell subsets. The difference of T-cell subsets in various IHDA types of UC patients has provided a theoretical basis for syndrome differentiation in the CM typing of UC.

Clinical Observation on Warming-needle for Treatment of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis

Objective To observe the therapeutic effect of treating primary dysmenorrhea with cold coagulation and blood stasis with warming-necdle. Methods 60 cases of primary dysmenorrhea with cold cougulation and blood stasis,which were treated during 2007 to 2008, were randomly divided into an acupuncture group and a medication group. The acupuncture group was treated with acupuncture at Ciliao and Sanyinjiao, while the medication group was treated with indomethacin. Results The total effective rate was 100% in the acupuncture group, and 93.3% in the medication group. The effects of the two groups were significantly different (P＜0.05). Conclusion Warming-needle is an effective therapy for primary dysmenorrhea with cold eougulation and blood stasis Key words: Primary Dysmenorrhea; Warming-needle Therapy; Cold Coagulation and Blood Stasis Type

A clinical comparative study on Traditional Chinese Medicine serving as consolidation treatment in patients with advanced non-small cell lung cancer

The role of Traditional Chinese Medicine(TCM) is recognized in treatment of non-small cell lung cancer.The aim of this study is to evaluate the efficacy of TCM serving as consolidation treatment in patients with advanced non-small cell lung cancer. One hundred and sixty-two patients with advanced non-small cell lung cancer were divided into two arms.Arm A(observation arm):81 cases,TCM serving as consolidation treatment after conventional treatment;Arm B(control arm):81 cases,only conventional treatment,no TCM serving as consolidation treatment.The TCM was given according mainly to the syndrome differentiation.Four types were found in the arm A:lung and spleen-qi deficiency type,the lung heat and phlegm-dampness type,the lung-yin and stomach-yin deficiency type,and the qi stagnation with blood stasis type. 1-,2-,3-and 5-year survival rate accounted for 70.3%,37.0%,20.9% and 8.6% in arm A,and 61.7%,20.9%,8.6% and 3.7% in arm B,respectively.Median survival time was 18 months in arm A and 12 months in arm B,respectively.Statistically,2-and 3-year survival rate of arm A and arm B had significant difference(P < 0.05). TCM serving as consolidation treatment in patients with advanced non-small cell lung cancer might be closely related to 2-and 3-year survival rate and median survival time improvement,but not to 5-year survival rate.

Influence on hemorheology of cervical spondylopathy with Xi (cleft) point electroacupuncture

Objective: To observe the curative effect of Xi (Cleft) point electro-acupuncture on acute cervical spondylopathy of blood stasis type.Methods: 32 cases of acute spondylopathy of blood stasis type were treated with electroacupuncture on Huizong (TE 7) point, Xi (Cleft) point of Triple Energizer Meridian of Hand Shaoyang and Yanglao (SI 6) point, Xi (Cleft) point of Small Intestin Meridian of Hand Taiyang. 31 cases were randomly selected as the research subjects for control group and treated with routine treatment. At the same time changes of hemorheology were observed in the two groups before and after treatment. VAS was used for pain evaluation.Results and conclusion: The total curative effect in treatment group was 93.8%, the average duration of course 20.2±3.1d, pain accumulation points 3.47±1.45; The total curative effect in contrast group was 83.9%, the average duration of course 26.5±1.8 d, pain accumulation points 5.67±1.52.P<0.01 after t test. Ridit analysis was used for analysis of the therapeutic effect.P<0.05. There were some improvements in hemorheology in the two groups before and after treatment. It showed that there was a significant difference in the two groups in therapeutic results and average duration of course. The therapeutic results were improved and duration of course shortened in the treatment group.

Relationship of adrenocortical function and TCM Syndrome typing in elderly patients with severe sepsis

Objective: To explore the relationship between TCM Syndrome typing and adrenocortical function in elderly patients with severe sepsis, and to see whether TCM Syndrome Differentiation can provide clinical clues in identifying relative adrenal insufficiency (RAI) in patients with severe sepsis.Methods: Sixty-one old patients with severe sepsis were classified into four types according to TCM Syndrome Differentiation: The severe invasion of toxic-heat type (Type SITH,n = 21); the Qi stagnation and blood stasis type (Type QSBS,n = 11); the sudden depletion of Yang-Qi type (Type SDYQ,n = 16); and the exhaustion of Qi-Yin type (Type EOQY,n = 13). The base-line level of plasma cortisol in patients of different types and their response to corticotropin stimulation were compared, which were also compared with those of 12 healthy elderly persons synchronously.Results: The base-line level of plasma cortisol was not significantly different between patients of different Syndrome types (P>0.05), but they were all sgnificantly higher than that in the healthy persons (P<0.05). Compared with Type QSBS and Type EOQY, Type SITH and Type SDYQ showed less cortisol concentration increment after corticotropin stimulation (P<0.05). RAI was more prevalent in patients of Type SITH and Type SDYQ than in patients of Type QSBS and Type EOQY (57% vs 25%,P<0.01).Conclusion: In old patients with severe sepsis, different TCM Syndrome types are associated with different adrenocortical function status. TCM Syndrome differentiation can provide clinical clues in identifying old patients with severe sepsis who have also RAI.

Treatment of hysteromyoma by acupuncture-moxibustion plus Tuina: A report of 33 cases

Guided by TCM treatment on the basis of syndrome differentiation, the author has treated 33 cases of hysteromyoma, which are divided into stagnation of liver-qi and blood stasis (SLQBS) type, and qi-deficiency and blood stasis (QDBS) type, by acupuncture-moxibustion and Tuina. After 3 therapeutic courses, the total effective rate is 81.8%. The therapeutic effect has no close relationship with the TCM syndrome differentiation.

Relationship between Traditional Chinese Medicine Syndrome type and coronary arteriography of acute coronary syndrome

Objective: To explore the relationship of Traditional Chinese Medicine (TCM) Syndrome type and coronary arteriography (CAG) with respect to the number and degree of stenosed branches of coronary artery (CA) and ACC/AHA stage of acute coronary syndrome (ACS), to provide an objective evidence for TCM Syndrome typing on ACS.Methods: Ninety patients of ACS with their TCM Syndrome typing and CAG successfully conducted were enrolled in this study. They were classified into 3 Syndrome types, the blood stasis type (type I), the phlegm stagnant with blood stasis type (type II), and the endogenous collateral Wind type (type III) The scores of the number and severity of the stenosis branch of CA and ACC/AHA lesion stage in different Syndrome types were calculated respectively and analysed statistically byRidit analysis.Results: The number of stenosed branches increased gradually with the Syndrome type changing from I → II → III, compared the type III with the other two types(P<C0.01). The severity of stenosis in type I and II were similar, but that of Type III, much aggravated was significantly different from that in the former two (P<0. 01). The ACC/AHA stage of coronary lesion tended to be more complex as the Syndrome type changed, patients of TCM type I and II had mostly lesion of stage A or Bl, while lesion in majority of patients of type III belonged to stage B2 or C, comparison between the three types showed significant difference (P<0.01).Conclusion: Most ACS patients of TCM Syndrome type III with tri-branch, severe stenosed coronary arteries, belong to the complex ACC/AHA stage of B2 and C.

Integrated traditional Chinese and western medicine in treating 37 psoriatic patients

Psoriasis is a kind of chronic relaptic skin disease, and at present there are no appropriate therapeutical methods. From March 1998 to May 1999, we used the traditional Chinese and western medicine (TCM-WM) approach in treating this disease, and satisfactory result was obtained. We clinically observed this method in treating psoriasis, with hemorrheological examinations performed, and it is reported as follows. METHODS Diagnostic Standard According to the diagnosis standard in “Modern Dermatology” (chiefly edited by YANG Guo-liang, WANG Xia-sheng. Shanghai: Shanghai Medical University Press, 1996∶513-514), the patients were confirmed to suffer from psoriasis vulgaris; and according to TCM syndrome differentiation as blood stasis type.

Effects of Qarlicin on unstable angina pectoris and its relationship with blood lipid and granule membrane protein-140

Objective: To observe the clinical effects of Garlicin on unstable angina pectoris (UAP) and explore how the Garlicin’s effects vary among syndromes as defined by traditional Chinese medicine (TCM).Methods: Fifty-five patients with UAP were randomly divided into the Garlicin group (34 patients) and the control group (21 patients). Each patient was classified according to TCM Syndrome Differentiation as having Cold Syndrome type, Heat Syndrome type, severe blood stasis (SBS) type, and mild blood stasis (MBS) type of UAP. Garlicin 60 mg or nitroglycerin 5 mg was given to the two groups respectively by intravenous drip for 10 days as one therapeutic course. The curative effect was evaluated by symptomatic changes and electrocardiogram. The effective rates as well as indexes such as blood lipid, lipoprotein, apolipoprotein, and granule membrane protein-140 (GMP-140) were compared between groups and types.Results: Garlicin and nitroglycerin group did not differ significantly in effective rate, while that of Garlicin group was higher for the Cold Syndrome type than that of Heat Syndrome type (P < 0. 01). The high density lipoprotein/low density lipoprotein ratio and apolipoprotein A-I level rose markedly in the former type (P < 0.05), while an opposite trend was seen in the Heat Syndrome type. Garlicin was more effective in the SBS type than that in the MBS type, and it markedly decreased GMP-140 in the MBS type.Conclusions: Garlicin is effective in UAP, especially the Cold Syndrome and SBS types. Its mechanism may involve improving blood lipid levels and inhibiting platelet activation.

Blood-Aqueous Barrier in Eyes with Retinal Vein Occlusion

The purpose of this study is to examine the changes of blood-aqueous barrier function in cases of central or branch retinal vein occlusion. In addition to fluorophotometry of the aqueous humor and posterior vitreous, the authors used a method that quantifies protein in the aqueous (aqueous flare) by measuring the intensity of scattered laser light. Aqueous and posterior vitreous fluorescein concentrations and aqueous flare were significantly higher than in unaffected fellow eyes or eyes of visually normal age-matched controls both in central and branch retinal vein occlusions. They also were significantly higher in eyes with central vein occlusion than in those with branch vein occlusion. Among those eyes with central vein occlusion, aqueous and posterior vitreous fluorescein concentrations and aqueous flare were significantly higher in the hemorrhagic than in the venous stasis type of disease. Among eyes with branch vein occlusion, cases at the acute stage showed significantly higher amounts of aqueous and posterior vitreous fluorescein concentrations and aqueous flare than did those with chronic occlusion. The authors believe that increased amounts mainly reflect blood-ocular barrier disruption. Not only the blood-retinal barrier but also the blood-aqueous barrier disruption is a common sequela in the disorder.

Non-tropical sprue-like syndrome caused by a dilated pouch following side-to-side anastomosis

1. 1. A brief resume of the literature, experimental and clinical, on the formation of a blind loop following side-to-side anastomosis has been presented. 2. 2. Examples of the inflammatory and/or obstructive type, and of the stasis type with failure of absorption of hematinic principles have been presented. 3. 3. A mechanism has been described following resection with side-to-side anastomosis in which a small blind loop acts as a “trigger” area, resulting in a chronic recurring progressive diarrhea and anemia simulating non-tropical sprue. This has not previously been described. 4. 4. A case has been described in detail in which this mechanism was present, and two others reported from literature. Removal of the loop resulted in complete cure in two cases. One case was not treated surgically.

Enzyme debridement of indolent infected cutaneous ulcers.

Within the past few years there have been many reports 1 on the enzymatic debridement of fibrinopurulent exudates in empyema, hemothorax, miscellaneous chronic ulcerative lesions, and local infections, such as osteomyelitis and sinusitis. The present study was undertaken to evaluate the efficacy of the lysing enzymes, trypsin, streptodornase, and streptokinase, in the treatment of various indolent infected cutaneous ulcerations. The majority of the ulcerations treated with these substances were of the varicose stasis type, although decubitus, traumatic, arteriosclerotic, and other types of cutaneous ulcers were included in this series. Streptokinase and streptodornase (varidase) are used together, although their physiological action is somewhat different. Purified crystalline trypsin (tryptar®) was sometimes used on a patient who was also given streptokinase-streptodornase or on alternating patients. Tillett and his associates 2 showed that hemolytic streptococci produce a fibrin-lysing substance known as streptokinase that acts as a catalytic agent. The fibrin-lysing system is activated by