The effect of Triton WR-1339 on induction of liver glucose6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) was investigated. Male rats of the Holtzman strain were starved for 3 days and refed a diet high in carbohydrate (68.9% as glucose monohydrate ). Twenty-four hours prior to refeeding, the experimental rats were injected with 85 mg/100 g body weight of Triton WR-1339 and the control rats were given equal volumes of a physiological saline solution. The induction of the two lipogenesis associated dehydrogenases, G6PDH and 6PGDH, in the liver of the Triton-treated rats, was both delayed and de pressed. Very high triglycA©ridelevels and relatively high hexosaminidase levels were observed in the plasma of the Triton-injected rats, compared with that of plasma of the control rats for most of the experimental period. Three hours after refeeding the diet, a significant elevation in the plasma glucose level was observed in the saline-treated rats but not in the plasma of Triton-intoxicated rats. No significant recompartmentation of lysosomal enzyme activity to liver nuclei occurred as a result of refeeding a carbo hydrate-rich diet when Triton WR-1339 was injected 20 hours before refeed ing. This contrasts with the rapid association of lysosomal enzymes with nuclei from livers of starved rats refed a carbohydrate containing diet, but not treated with the detergent as previously reported from this laboratory. In the present study, the fragility of liver lysosomes of Triton injected, starved rats to homogenization did not change significantly after refeeding a high carbohydrate diet. Thus, Triton inhibited the transient lysosomal fragility previously observed in rats similarly examined, but not injected with Triton WR-1339. J. Nutr. 108: 1566-1571, 1978. INDEXING