With the deepening and wide application of various emerging technologies and concepts, communication and cooperation between enterprises become more and more frequent. Open development and innovative development have become the inevitable choices for enterprises to realize their sustained and healthy growth. Especially under the guidance of the state's macro-system of strongly encouraging innovation and entrepreneurship, the growth of independent innovation and entrepreneurship enterprises and open innovation issues are increasingly becoming social focus issues. This paper discusses the impact mechanism between the two and puts forward the corresponding open innovation strategy based on the relevant national encouragement system. With the continuous development of high and new technology and its wide application in the production and operation activities of enterprises, economic ties between enterprises are becoming more frequent. It has become an essential choice for most enterprises in the digital economy era to adopt an open attitude to face the competition and the market and to continuously carry out product innovation and technological innovation. Especially for small-scale and late-start independent innovation and entrepreneurship enterprises, openness and innovation are the basic conditions for their survival and development in the new competitive and technological environment. In recent years, China has launched a series of policies to encourage the development of innovative and start-up enterprises, especially pointing out the development direction of "specialization, refinement, particularity, and innovation" for manufacturing enterprises and introducing relevant support and reward systems. Under the influence of these two factors, it is of great practical significance for independent innovation and start-up enterprises to explore what form of open innovation an enterprise should take and how it functions.