Abstract We describe the spectrophotometric calibration of the Mid-Infrared Instrument’s (MIRI) Medium Resolution Spectrometer (MRS) aboard the James Webb Space Telescope. This calibration is complicated by a time-dependent evolution in the effective throughput of the MRS; this evolution is strongest at long wavelengths, approximately a factor of 2 at 25 μm over the first 2 yr of the mission. We model and correct for this evolution through regular observations of internal calibration lamps. Pixel flat fields are constructed from observations of the infrared-bright planetary nebula NGC 7027, and photometric aperture corrections from a combination of theoretical models and observations of bright standard stars. We tie the 5–18 μm flux calibration to high signal-to-noise ratio (S/N; ∼600–1000) observations of the O9 V star 10 Lacertae, scaled to the average calibration factor of nine other spectrophotometric standards. We calibrate the 18–28 μm spectral range using a combination of observations of main belt asteroid 515 Athalia and the circumstellar disk around young stellar object SAO 206462. The photometric repeatability is stable to better than 1% in the wavelength range 5–18 μm, and the S/N ratio of the delivered spectra is consistent between bootstrapped measurements, pipeline estimates, and theoretical predictions. The MRS point-source calibration agrees with that of the MIRI imager to within 1% from 7 to 21 μm and is approximately 1% fainter than prior Spitzer observations, while the extended source calibration agrees well with prior Cassini Composite Infrared Spectrometer and Voyager Infrared Interferometer Spectrometer and Radiometer observations.
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