Abstract: This study presents the results of the calculation of the mass fractions of isotopes from hydrogen to nickel during the entire core burning phases of a 25 M⊙ star. A simple stellar model was used, considering four main parameters: temperature, density, initial composition, and time, without accounting for mass loss or mixing. The mass fractions of the isotopes were calculated using the open-source package NucNet Tools and the updated reaction rates from the JINA Reaclib database. A comparison of our results with existing similar data is performed and acceptable agreement is conspicuous. Hydrodynamic conditions in massive stars favor the production of 26Al, therefore particular attention was given to the isotopes 26Al and 27Al and the ratio of their mass fractions R_Al for comparison with the literature. The averaged value of the controversial R_Al during the star's lifetime is found to be 1.68×10-4. Keywords: Elemental abundances in stars, Evolution, Stellar, Nuclear astrophysics, Hydrostatic stellar nucleosynthesis, Nucleosynthesis: stellar, Stars formation. PACS: 97.10.Tk, 87.23.-n, 97.10.Cv, 26.20.-f, 7.10.Cv, 97.10.Bt.