Standard Software Research Articles

Comparative characteristics of the dimensions of the pons with the dimensions of the head in human fetes of different gestational age

Annotation. Malformations of human fetuses brains occur in 2-3 cases per 1000 pregnancies and are one of the most common reasons for termination of pregnancy, therefore prenatal diagnosis is extremely important and is aimed at further genetic testing of the fetus and detailed counseling of parents regarding the risk of recurrence. Anthropometric parameters of human fetuses heads allow monitoring the growth of the fetus, estimating the term of pregnancy and determining the method of birth of a pregnant woman. Therefore, the parameters of the head of human fetuses are one of the most important biological characteristics during prenatal research. The purpose of our scientific work is to determine the dimensions of the pons in human fetuses of different gestational ages and compare them with the dimensions of the head. Anatomical research was conducted on 146 human fetuses from 9-10 to 39-40 weeks of gestation. The material for the study was obtained from the maternity hospitals of the city of Vinnytsia and from the communal non-profit enterprise “Vinnytsia Regional Pathological Bureau of the Vinnytsia Regional Council”, and the study was conducted on stillborns who died from various causes not related to brain diseases in relatively healthy mothers. Head circumference, head height, longitudinal and transverse dimensions of the head, pons height, pons width, pons thickness were measured using a ShTs-125 caliper. Statistical processing of digital values was performed using the standard Statsoft software package “Statistica 6.0” on a personal computer using Microsoft Excel 2016, Kolmagorov-Smirnov and Shapiro-Wilk test indicators were determined and histograms were built based on them for visual assessment of the distribution of features. The head circumference of human fetuses of 39-40 weeks compared to fetuses of 9-10 weeks became 5.2 times larger, the longitudinal size of the head – 5 times, the transverse size of the head – 4.9 times, the height of the head – 3.6 times (p<0.01). The height of the pons in human fetuses of 39-40 weeks compared to fetuses of 9-10 weeks became 3.8 times greater, thickness – 3.6 times, width – 3.1 times (p<0.01).

Optical parameters and gamma shielding quality of sodium-borate glasses: The relative contribution of Bi2O3, SrO, and Li2O

The optical quality and compositional flexibility of borate glasses make them attractive materials for optical applications, nuclear waste containment, transparent radiation shields and many other applications in the nuclear and allied industries. This study presents the physical, optical, and gamma transmission data of the sodium borate glass structure: 75B2O3 – 15Na2O – 9.5x – 0.5Nd2O3; for x = Bi2O3 (BiNd), SrO (SrNd), and Li2O (LiNd). The glasses were prepared using the traditional melt-and-quench technique. The influence of Bi2O3, SrO, and Li2O on the physical attributes, optical constants, and gamma radiation interaction coefficients was probed using standard laboratory procedures and software. The density of BiNd, SrNd, and LiNd was 3.32, 2.43, and 2.24 g/cm3, respectively. The molar volume of the glasses followed the trend: BiNd > SrNd > LiNd. The optical constants of the glasses, such as refractive index, metallization criterion, molar refractivity, molar polarizability, reflectance loss, and optical transmission, showed a wide fluctuation with respect to glass composition. The values of the gamma mass attenuation coefficients for 15 keV–15 MeV photons were in the range 0.0316–45.0225 cm2/g for BiNd, 0.0206–5.4940 cm2/g for SrNd, and 0.0184–3.4603 cm2/g for LiNd. Generally, density has a positive correlation with the gamma absorption prowess of the investigated xNd glasses. A correlation between the optical and shielding parameters was highlighted in this study. The xNd glasses, especially SrNd and BiNd, are preferred as transparent radiation protection barriers, in contrast to some conventional Pb-based glasses, from environmental and public health perspectives. This glass composition is therefore unique and its properties are essentially useful in optical and radiation technologies.

Applying Artificial Intelligence for Emotional Cognition in Game Testing for Quality Assurance

Artificial intelligence (AI) is a branch of computer science that tries to develop computational tools and systems that can carry out tasks comparable to human decision-making and learning. The subject of AI is expanding quickly, and AI technology is becoming more and more significant in a variety of IT specialties. When more automated and intelligent solutions are employed instead of outdated techniques, the quantity of manpower and resources needed for game testing will be greatly decreased. The aim of this study is to find new models that will make game testing easier by utilising state-of-the-art AI techniques. In an attempt to determine the model base and algorithmic foundation for the new approach, the examination and comparison of existing theories, models, and algorithms is used to infer and identify the viability of certain current mainstream AI models and algorithms in game testing sessions. Standard software testing is not the same as game testing. Further consideration should be given to the whole gaming experience and entertainment value in addition to functional testing. User questionnaires and in-game testing are used in the current standard experience testing methodology. Artificial intelligence eliminates human aspects in emotional cognition. It may produce more objective test results while spending less money for both human and material resources by using massive data sets and its own learning and processing capabilities. This paper examines the state of AI in software testing, game creation, and emotion perception using expertise in using and applying AI approaches in game testing for quality assurance. It also demonstrates how well AI methods work for predicting player emotions during game testing. The AI testing reduces testing expenses related to labour and material resources while guaranteeing total game confidentiality before release. It also increases test accuracy and reduces the impact of subjectivity.

The morphological structure of prostate gland under the condition of experimental prostatopathy and after using of cholecalciferol in the different schemes of hypofertility correction

The impact of negative factors, stress, and modern living conditions damages men's health and leads to infertility. Prostatitis is often a cause of hypofertility. It is now shown that vitamin D may play a role in regulating the functioning of reproductive system organs. The aim of the study was to determine the effect of cholecalciferol on the histological structure of the prostate gland in rats with experimental prostatitis and after its application alone or in combination with a prostate protector. Experimental prostatitis was induced by cold intraoperative damage to the prostate gland. To correct prostatitis, vitamin D3 (cholecalciferol) was administered orally at a dose of 4000 IU. The prostate protector (Prostatilen, Pr) and its pharmaceutical composition, as well as vitamin D3, were administered rectally. Rats with modeled prostatitis were divided into groups: EP (cold experimental prostatitis without treatment); EP + seed oil (on the background of experimental prostatitis, animals received a solvent – apricot kernel oil); EP + vit D3 (per os) (on the background of experimental prostatitis, animals received vitamin D3); EP + Pr (rec) (on the background of experimental prostatitis, males were administered Prostatilen per rectum); EP + vit. D3 (per os) + Pr (rec) (on the background of experimental prostatitis, animals received vitamin D3 (per os) and Prostatilen gel (per rectum)); EP + (vit. D3 + Pr) (rec) (on the background of experimental prostatitis, rats were administered Prostatilen gel with vitamin D3 per rectum). Intact animals (Intact group) and sham-operated rats (Control group) were used as controls. Paraffin sections of the prostate gland were stained with hematoxylin, eosin, and Van Gieson's method. In addition to the review microscopy of the ventral lobes of the prostate gland and the isthmus between them, the power of histochemical reactions was measured, the severity of inflammation and fibrosis was assessed, the number of terminal sections of the prostatic glands with a visually unchanged state, with lumen expansion, and with wall destruction was counted, the longitudinal diameter of the acini and the height of the epithelial cells of the prostatic glands were measured. Statistical analysis of the results was performed using the standard software package "Statistica 6.0" with the use of Student's t-test and nonparametric analog of one-way analysis of variance – Kruskal-Wallis test, as well as Mann-Whitney test. It was found that rats with experimental prostatitis exhibit pronounced changes in the morphological structure of the prostate gland. The prostate-protective effect of vitamin D per os at a dose of 4000 IU was established, which reduced the manifestations of atrophic and destructive processes, signs of tissue inflammation, and coarsening of the prostate gland stroma. Signs of fibrosis development in the prostate gland in males of this group were reduced, and the number of destructive changes and the longitudinal diameter of the terminal sections of the prostatic glands of prostate ventral lobe in rats with experimental prostatitis were decreased. Thus, the addition of cholecalciferol to the basic therapy for infertility has a more pronounced corrective effect on the morphological structure of the prostate than the separate use of cholecalciferol and the prostate protector. Combining basic therapy with vitamin D enhances the prostate-protective properties of the latter and is promising for restoring reproductive function overall.

Investigation and Development of the BODIPY-Embedded Isotopic Signature for Chemoproteomics Labeling and Targeted Profiling.

A common goal in mass spectrometry-based chemoproteomics is to directly measure the site of conjugation between the target protein and the small molecule ligand. However, these experiments are inherently challenging due to the low abundance of labeled proteins and the difficulty in identifying modification sites using standard proteomics software. Reporter tags that either generate signature fragment ions or isotopically encode target peptides can be used for the preemptive discovery of labeled peptides even in the absence of identification. We investigated the potential of BODIPY FL azide as a click chemistry enabled chemoproteomics reagent due to the presence of boron and the unique 1:4 natural abundance ratio of 10B:11B. The isotopes of boron encode BODIPY-labeled peptides with a predictable pattern between the monoisotopic (M) and M+1 peaks. BODIPY-labeled peptides were identified in MS1 spectra using an R script that filters for the signature 10B:11B intensity ratio and mass defect. Application of the boron detection script resulted in three times the labeled peptide coverage achieved for a BODIPY-conjugated BSA sample compared with untargeted data-dependent acquisition sequencing. Furthermore, we used the inherent HF neutral loss signature from BODIPY to assist with BODIPY-modified peptide identification. Finally, we demonstrate the application of this approach using the BODIPY-conjugated BSA sample spiked into a complex E. coli. digest. In summary, our results show that the commercially available BODIPY FL azide clicked to alkyne-labeled peptides provides a unique isotopic signature for pinpointing the site(s) of modification with the added potential for on- or off-line UV or fluorescence detection.

Certainty in uncertainty: Determining the rate and reasons for reclassification of variants of uncertain significance in haematological malignancies

AbstractIntroductionVariants of uncertain significance (VUS) are commonly reported in cancer with the widespread adoption of diagnostic massive parallel sequencing. The rate of reclassification of VUS in patients with haematological malignancy is not known and we evaluated this retrospectively. We also investigated whether re‐evaluating VUS in 12–24 months or greater than 24 months post‐initial classification was significant.MethodA retrospective audit of patients with haematological malignancies referred to the Molecular Medicine Department at the John Hunter Hospital in Newcastle, Australia between September 2018 and December 2021. Data was analysed for VUS, which was then re‐analysed in standard software using current somatic variant guidelines. Proportions of VUS at baseline were compared to post‐re‐analysis.ResultsThe most common diagnoses in the patient cohort (n = 944) were acute myelogenous leukaemia (41%), myelodysplastic syndrome (31%), and chronic myelomonocytic leukaemia (7%). A total of 210 VUS were re‐analysed. The most common VUS were in the TET2 (20%), RUNX1 (10%) and DNMT3A (9%) genes. A total of 103 were re‐analysed at 24–39 months post‐initial classification and 107 variants were re‐analysed between 12 and 24 months post‐initial classification. Of these, 33 (16%) of VUS were re‐classified at 24–39 months and 12 (11%) were re‐classified at 12–24 months post‐initial classification. The most common variants that were re‐classified in both groups were CSF3R (32%), TET2 (29%), ASXL1 (11%) and ZRSR2 (11%).ConclusionThis study on reclassification of VUS in blood cancers demonstrated that one in seven VUS were re‐classified 12 months post initial classification. This can inform practice guidelines and potentially impact the prognosis, diagnosis and treatment of haematological malignancies.

Effect of RapidShockTM Implementation on Perishock Pause in Out-of-Hospital Cardiac Arrest

Objectives Shorter pauses in cardiopulmonary resuscitation (CPR) are associated with better health outcomes after out-of-hospital cardiac arrest (OHCA). Our primary objective was to examine the effect of a RapidShockTM defibrillator software upgrade compared with standard defibrillator software on the length of perishock pause during care for OHCA among adults. Secondary objectives were to assess the effects of RapidShockTM on other CPR pauses. Methods We conducted a retrospective cohort study between September 1, 2015 and September 30, 2020. “Standard” cardiac defibrillator software in manual interpretation mode was used for CPR delivered on or before November 30, 2018, while “RapidShockTM” software (ZOLL® Medical Corporation) was used after this date. For each study group, we calculated the perishock, perianalysis, and total CPR pause; each CPR cycle was considered an independent event. We then calculated the median and interquartile range (IQR) for observed pauses with the “Standard” and “RapidShockTM” software. Percent change in median perishock pause (shockable rhythms), perianalysis pause (non-shockable rhythms), and total CPR pause were compared between CPR administered with each software using the Mann–Whitney test. Results There were 733 and 782 distinct CPR cycles administered using “Standard” and “RapidShockTM” software, respectively. A 31.8% reduction in median perishock pause was observed with “RapidShockTM” software compared with the “Standard” software (22.0 s (IQR 18.0 − 27.0 s) vs. 15.0 s (IQR 13.0 − 19.0 s); p < 0.01). The decrease in median perishock pause was driven by a reduction in the preshock phase (18 s vs. 10 s; 44.4% decrease in median pause; p < 0.01). No differences were observed in median perianalysis pause between the two groups. When combining shockable and non-shockable rhythms, we observed a reduction of 23.5% in median CPR pause (17.0 s (IQR 11.0 − 24.0 s) vs. 13s (IQR 10.0 − 17.0 s); p < 0.01). Conclusions Overall, we observed that the use of “RapidShockTM” defibrillator software was associated with shorter CPR pauses compared with the “Standard” software. Additional studies are required to examine whether further reductions in CPR pauses may be achieved and to investigate associations between shorter CPR pauses and health outcomes.

Morphometrical analysis of myelinated nerve fibers: is there a room for improvement?

Despite advancements in automatic approaches for histomorphometry analysis of peripheral nerves, manual and semi-automated methods are widely utilized. Standard software functions are often unsuitable for analysis due to their irregular shapes, especially in pathological conditions. This study aims to assess the reproducibility of nerves morphometric analysis and compare results obtained using both default and new alternative algorithms. Sciatic nerves from Wistar rats (untreated and after administration of intraperitoneal hydrargyrum chloride), previously embedded in resin, were used. Morphometric analysis (diameters, myelin thickness, g-ratio, and circularity) was conducted using ImageJ on semithin sections, with axon and myelin boundaries manually outlined. Default diameters were calculated as the mean of Feret diameters, with subsequent calculations for myelin thickness and g-ratio. The alternative approach estimated diameters based on the geometric center of axons, iterating through selected coordinates; myelin thickness was obtained using line equations. In the control group, inter-rater agreement was higher or within expected reliability (0.8 ± 0.05). However, in the experimental group, myelin thickness, g-ratio, and axon circularity showed lower agreement (0.66, 0.58, and 0.68, respectively) without visible patterns on Bland-Altman plots. The alternative approach did not reveal significant differences between approaches, except for g-ratio in the control group and fiber diameter in the experimental group (p < 0.05), with effect sizes of 0.29-0.30 and 0.19-0.20, respectively. This study highlights reduced agreement among investigators analyzing nerve fibers under pathological conditions, raising concerns about the current standard measurement methods. The proposed approach, based on a single geometric center, provides more natural estimations for irregular fibers, and can be implemented in automated nerve fibers acquisition systems.

Visual Interpretation of High-Resolution Aerial Imagery: A Tool for Land Managers

Abstract Remotely sensed imagery from various collection platforms (e.g., satellites, crewed and uncrewed aircraft) are used by biologists and other conservation personnel to support management activities ranging from monitoring invasive species to assessing land cover and vegetation characteristics. Although remote sensing–based vegetation indices and models have been developed and used for some management applications, straightforward visual interpretation of imagery by on-the-ground personnel may be a pragmatic approach for obtaining time-sensitive and spatially relevant information to support and guide local management activities. Our primary objective was to qualitatively assess our ability to identify patches of target invasive plant species based on simple visual interpretation of high-resolution aerial imagery. We also sought to compare the high-resolution imagery to widely available imagery (e.g., National Agriculture Imagery Program) to determine the efficacy of each for assessing vegetation communities and land-cover features in support of management activities. To accomplish these objectives, we obtained high-resolution imagery and visually scanned and assessed the imagery by using standard geographic information system software. We were able to differentiate patches of crownvetch Securigera varia (L.) Lassen and wild parsnip Pastinaca sativa L., but not spotted knapweed Centaurea stoebe L. or leafy spurge Euphorbia esula L. The relative success in identifying these species had a relationship to plant characteristics (e.g., flower color and morphology, height), time of year (phenology), patch size and density, and potentially site characteristics such density of the underlying vegetation (e.g., grasses), substrate color characteristics (i.e., color contrast with flowers), and physical disturbance. Our straightforward, qualitative assessment suggests that visual interpretation of high-resolution imagery, but not some lower-resolution imagery, may be an efficient and effective tool for supporting local invasive species management through activities such as monitoring known patches, identifying undetected infestations, assessing management actions, guiding field work, or prioritizing on-the-ground monitoring activities.

WP7.17 - Routine Use of Validated Risk Prediction Model in the Management of Acute Appendicitis in a District General Hospital

Abstract Aim Acute appendicitis is the most common general surgery emergency in the UK. Currently, there is no optimal diagnostic pathway for managing the right iliac fossa (RIF) pain. The right iliac fossa pain treatment (RIFT) study group has previously performed an analysis of different risk prediction models to search for the most specific one and made a website (appy-risk.org) to calculate risk scores on presentation. We aimed to look into our practice in a DGH and see how compliant we are in documenting risk scores on presentation with acute RIF pain. Method A list of patients presenting with acute RIF pain to the surgical assessment unit in September was prepared. Admission clerking notes were reviewed from the electronic patient record to look for the documentation of the appendicitis risk score. Standard statistical packages were used for data analysis. Results A total of 95 patients were presented with RIF pain. Of them, 17 were excluded from the analysis for being over 45 years old. Of the remaining 78 patients' records, only 7 (8.97%) had appendicitis risk scores documented in the clerking notes. Conclusions The RIFT study highlighted a high normal appendicectomy rate (NAR) in the UK in comparison to other European countries. In our hospital, NAR was 9.74% in the first six months of 2023. We are in the process of implementing a pathway to manage acute RIF pain using a risk prediction model as advised by the RIFT group to reduce our NAR to less than 5%.

Investigation of Introns in Proteus Mirabilis Bacteria and Extent of their Resistance to Antibiotics

Proteus mirabilis is an opportunistic pathogen meaning that causes infection in people with reduced natural immunity. These bacteria possess many virulence factors or pathogens which is essential for colonizing new areas, including tissues and hosts. The study aimed to investigate phenotypically or genetically the introns (MIs) in P. mirabilis by estimate the extent of its resistance to antibiotics. The results showed that the appearance of genetic packages for all migrated isolates at one level. This is an indication of the binding of the primer to its complementary sequence in the DNA strand. The molecular weights of the resulting genetic packages were estimated based on known standard packages, the apparent molecular weights in the path (M) with a graduated size (100- 200 bp). The results also showed a clear similarity of the molecular weight of the resulting bands (1500 bp) with the molecular weight of the diagnostic gene rRNA 16s. In addition, 20 isolates were examined using PCR technology for the three classes of introns gene. All isolates were carried the chromosome intron gene. The appearance of the intron 1 gene on all isolates was (100%).

P204 BANGLADESH HEARTS: LESSONS LEARNED FROM A NATIONAL HYPERTENSION CONTROL PROGRAM, 2018-2024

Background and Objective: In Bangladesh, 21% of all adults aged &gt;=18 years have hypertension but among hypertensives, only 14.1% have blood pressure (BP) controlled (&lt;140/90 mmHg) .1 To improve hypertension control and prevent cardiovascular disease, the Non-Communicable Disease Control Program under the Ministry of Health &amp; Family Welfare launched the Bangladesh Hypertension Control Initiative (BHCI) with technical support from the National Heart Foundation of Bangladesh and Resolve to Save Lives. Method: The BHCI gradually implemented the World Health Organization (WHO) HEARTS standardized hypertension control package in 172 sub-district facilities (35% of all sub-district facilities) &amp; 10 district-level facilities in 23 districts from 2018 to 2024. BHCI facilities implemented a simple, evidence-based, step-by-step, and drug &amp; dose-specific hypertension treatment protocol, a reliable supply of protocol medicines free of charge to patients, team-based care including non-physician members, and the Simple digital hypertension management app to collect real-time data and facilitate patient and program monitoring over time. A continuous quality improvement initiated in 2020 focused on lowering missed visit rate and raising blood pressure control. Missed visit rate was the proportion of all enrolled patients failing to attend a scheduled clinic visit in the prior three months; BP control was proportion with BP &lt;140/90 mmHg at their last visit in the prior three months. Results: From March 2019 to February 2024, the BHCI had enrolled 364,038 hypertensive patients in treatment (Figure). Facility-based BP control increased from 37% in July 2020 when the quality improvement program started to 57% by April 2024. Missed visits decreased from 53% in July 2020 to 29% by April 2024. Conclusion: BHCI is on track for national scale-up in Bangladesh and can serve as a model for WHO-HEARTS hypertension control programs in other LMIC countries. Reference: 1. World Health Organization. National STEPS survey for non-communicable diseases risk factors in Bangladesh 2018. Panel A: number of hypertension patients enrolled in treatment. Panel B: rates of missed hypertension management visits and blood pressure controlled &lt;140/90

Higher Order Geometric Algebras and Their Implementations Using Bott Periodicity

Using the classification of Clifford algebras and Bott periodicity, we show how higher geometric algebras can be realized as matrices over classical low dimensional geometric algebras. This matrix representation allows us to use standard geometric algebra software packages more easily. As an example, we express the geometric algebra for conics (GAC) as a matrix over the Compass ruler algebra (CRA).

Small animal brain surgery with neither a brain atlas nor a stereotaxic frame

BackgroundStereotaxic surgery is a cornerstone in brain research for the precise positioning of electrodes and probes, but its application is limited to species with available brain atlases and tailored stereotaxic frames. Addressing this limitation, we introduce an alternative technique for small animal brain surgery that requires neither an aligned brain atlas nor a stereotaxic frame. New methodThe new method requires an ex-vivo high-contrast MRI brain scan of one specimen and access to a micro-CT scanner. The process involves attaching miniature markers to the skull, followed by CT scanning of the head. Subsequently, MRI and CT images are co-registered using standard image processing software and the targets for brain recordings are marked in the MRI image. During surgery, the animal's head is stabilized in any convenient orientation, and the probe’s 3D position and angle are tracked using a multi-camera system. We have developed a software that utilizes the on-skull markers as fiducial points to align the CT/MRI 3D model with the surgical positioning system, and in turn instructs the surgeon how to move the probe to reach the targets within the brain. ResultsOur technique allows the execution of insertion tracks connecting two points in the brain. We successfully applied this method for neuropixels probe positioning in owls, quails, and mice, demonstrating its versatility. Comparison with existing methodsWe present an alternative to traditional stereotaxic brain surgeries that does not require established stereotaxic tools. Thus, this method is especially of advantage for research in non-standard and novel animal models.

Climate Change Adaptation Information Usability Among Maize Farmers in Ido Local Government Area of Oyo State, Nigeria

The availability of climate change information has not always led to more successful adaptation; even when climate change adaptation information is available, there are still obstacles to its efficient use. Furthermore, the tactics required to communicate climate information to end-users for successful adaptation have received less attention. This study focuses on utilization of available climate change adaptation information among maize farmers in the study area. Simple random sampling technique was used to select 203 respondents for data collection. The data were collected using a questionnaire and analysed through the use of the standard statistical package for social sciences. The communication strategies used include inter-personal, audio, visual and social media. The results revealed that the strategies used in communicating climate change adaptation information to maize farmers in the study area yielded great influence in terms of benefits to the farmers such as the increase in income, prevention of yield loss, reduced soil degradation, maintaining good human health status, and improved weed management. The information that is popularly utilised is mixed cropping (61.6%), water management (58.1%), and early warning (58.1%). A significant relationship existed between communication channels (r=0.8, p&amp;lt;.05) and respondents’ climate change adaptation information utilization. Poor understanding of the message and lack of funds to put the information into practice hinders some respondents from utilising adaptation information. Hence, extension agents need to locate these category farmers and link them with service providers that could provide incentives or credit facilities for sustainable utilisation of available information to combat climate change.

A proposal for a simple characterization of stainless steel connections through an equivalent yield strength

Notwithstanding some recent contributions, there still appears to be a gap in the literature regarding the express evaluation of the moment–rotation performance of some connections fabricated from austenitic, duplex, or ferritic stainless steel, such as flush end-plate connections (FEP). In the present work, moving from a previous proposal, the authors investigate a simple approach for the practical characterization of these connections. The results from industry standard software, which is dedicated to the analysis of connections based on the component method and widely used in engineering practice, are compared with the results from a more refined numerical model. It is found that, by using conventional carbon steel procedures with an ad hoc ideal material model, the results can be made in line with some experimentally validated numerical simulations for stainless steel. The findings are discussed in detail and may turn useful from both a design and an assessment standpoint.

Software Project Management and Their Economic Evaluation in terms of Enterprise Sustainability

Nowadays, we are witnessing that projects, computers and software as an integral part of them infiltrates or rather ruthlessly penetrates all spheres of business and daily life of a modern society and directs enterprise development, efficiency, productivity, competitiveness, image and ultimately in a way their very existence. In recent decades, the software industry and its products have become one of the factors without which the normal operation of contemporary economies cannot be imagined, however, software development often presents almost insurmountable difficulties.The research is related exactly to the analysis of software projects and their impact in the sustainability of enterprises. It is difficult to imagine any enterprise that claims to be competitive, to prepare, realize and monitor their projects without software support, be it standard software or specially developed for the needs of the enterprise, where software development comes into play. During the research combined methods are utilized. The methodology used includes the theoretical analysis which is based on the current literature from this field, followed by "case studies" that deal with the development of software projects in Kosovo by conducting interviews with their IT managers using face to face and semi structured interviews and finally based on gathered data the development of a concrete software project has been simulated. Finally the outcome from research is that always software development has to be identified with the project objectives of the project contractors and aims to meet their requirements and expectations. Software project team’s work for years in the development of complex and professional software projects, where competence in the relevant field as well as motivation play a key role in the development of successful business projects.

A 77 GHz Transmit Array for In-Package Automotive Radar Applications

A packaged transmit array (TA) antenna is designed for automotive radar applications operating at 77 GHz. The compact dimensions of the proposed configuration make it compatible with standard quad flat no-lead package (QFN) technology. The TA placed inside the package cover is used to focus the field radiated by a feed placed in the same package. The unit cell of the array is composed of two pairs of stacked patches separated by a central ground plane. A planar patch antenna surrounded by a mushroom-type EBG (Electromagnetic Band Gap) structure is used as the primary feed. An analytical approach is employed to evaluate the primary parameters of the suggested TA, including its directivity, gain and spillover efficiency. The final design has been refined using comprehensive full-wave simulations. The simulated gain is 14.2 dBi at 77 GHz, with a half-power beamwidth of 22°. This proposed setup is a strong contender for highly integrated mid-gain applications in the automotive sector.

Standardization of a Novel Semi-Automatic Software for Neurite Outgrowth Measurement.

Effective live-imaging techniques are crucial to assess neuronal morphology in order to measure neurite outgrowth in real time. The proper measurement of neurite outgrowth has been a long-standing challenge over the years in the neuroscience research field. This parameter serves as a cornerstone in numerous in vitro experimental setups, ranging from dissociated cultures and organotypic cultures to cell lines. By quantifying the neurite length, it is possible to determine if a specific treatment worked or if axonal regeneration is enhanced in different experimental groups. In this study, the aim is to demonstrate the robustness and accuracy of the Incucyte Neurotrack neurite outgrowth analysis software. This semi-automatic software is available in a time-lapse microscopy system which offers several advantages over commonly used methodologies in the quantification of the neurite length in phase contrast images. The algorithm masks and quantifies several parameters in each image and returns neuronal cell metrics, including neurite length, branch points, cell-body clusters, and cell-body cluster areas. Firstly, we validated the robustness and accuracy of the software by correlating its values with those of the manual NeuronJ, a Fiji plug-in. Secondly, we used the algorithm which is able to work both on phase contrast images as well as on immunocytochemistry images. Using specific neuronal markers, we validated the feasibility of the fluorescence-based neurite outgrowth analysis on sensory neurons in vitro cultures. Additionally, this software can measure neurite length across various seeding conditions, ranging from individual cells to complex neuronal nets. In conclusion, the software provides an innovative and time-effective platform for neurite outgrowth assays, paving the way for faster and more reliable quantifications.

High Throughput Quality Control Tools for Carbon-Related Materials: A Raman Approach

Carbon-based materials play a pivotal role in battery technology, serving as negative electrode materials, conductive additives, and coating layers for both positive and negative electrode materials. Traditional characterization methods, such as transmission electron microscopy (TEM) and X-ray diffraction (XRD), fall short in providing comprehensive quality control, especially when distinguishing the structure of amorphous carbon materials. Raman spectroscopy as a convenient, simple tool is widely used to study the structure of carbon materials. It provides insights into the degree of crystallization, doping degree, and subtle structural differences arising from various preparation processes. By quantifying Raman spectrum testing results through statistical methods and providing relevant statistical outcomes, we demonstrate the potential of Raman spectroscopy as a quality control method for carbon material characterization. With extensive sample testing and automation, along with standardized spectral data processing and analysis software, we propose Raman spectroscopy as a suitable tool for high-throughput quality control in industrial production.