Standardized Scoring Criteria Research Articles

Association between morphological features in the cochlear promontory and mastoid Process: Implications for Identifying middle ear diseases in human skeletal remains

Infectious Middle Ear Disease (IMED) is a group of infections that frequently afflict individuals across all age groups worldwide. Although in today’s clinical practice IMED is efficiently managed, in the past it probably caused severe complications (e.g., hearing loss, balance problems, and facial nerve paralysis), heavily impacting the everyday life of many people. However, despite the valuable insights that studying ear infections in the past can bring, bioarcheology presently lacks a standardized methodology to assess their prevalence in skeletal populations. This can lead to several issues, including incomparability of results, difficulties in replications, and methodological biases.Recently, straightforward and accessible criteria for the observation of the cochlear promontory were presented to successfully assess IMED on skeletal remains. Yet, as otologists rarely examine the impact of ear infections on the bony structures of the middle ear, the results were not supported clinically, and could therefore not be validated. To fill this gap, we propose a study in which computed tomography (CT) of the mastoid process was utilized on the skulls of 50 individuals to verify the results obtained through gross observation of the cochlear promontory. Statistical analysis revealed significant correlation between hypopneumatization (indicative of childhood IMED) and bony changes of the promontory at the level of the individual. This suggests a potential correlation that warrants further investigation to determine whether the observation of the cochlear promontory should be used as a method for IMED assessment. Overall, our study contributes to the study of IMED in past populations, and underscores the importance of clear, standardized scoring criteria in paleopathology.

The Programmed Cell Death Ligand 1 and Lipocalin 2 Expressions in Primary Breast Cancer and Their Associations with Molecular Subtypes and Prognostic Factors.

Breast cancers exhibit molecular heterogeneity, leading to diverse clinical outcomes and therapeutic responses. Immune checkpoint inhibitors targeting PD-L1 have shown promise in various malignancies, including breast cancer. Lipocalin 2 (LCN2) has also been associated with tumor aggressiveness and prognostic potential in breast cancers. However, the expression of PD-L1 and LCN2 in breast cancer subtypes and their prognostic implications remains poorly investigated. A retrospective analysis of 89 primary breast cancer cases was conducted to assess PD-L1 and LCN2 expressions using immunohistochemistry. Cases were classified into four different molecular subtypes based on ER, PR, HER2, and Ki-67 status. Associations between PD-L1 and LCN2 expressions and various prognostic factors were examined. Although low expression of LCN2 (Allred score of <3) was observed even in normal breast tissue, LCN2 expression with increasing Allred score (≥3) positively correlated with the histological grade, high Ki-67 proliferation index, and ER/PR negativity. Significant elevations of LCN2 and PD-L1 expressions were observed in triple-negative and HER2-positive breast cancers. The results of the study highlight the association of LCN2 with known prognostic factors and molecular subtypes. To identify potential immunotherapy recipients, it would be useful to evaluate LCN2 as well as PD-L1 immune targets in different subgroups of breast cancer patients. Further studies with larger patient numbers are warranted to validate these observations and establish standardized scoring criteria for LCN2 expression assessment.

Assessment of life support skills of resident dentists using OSCE: cross-sectional survey

BackgroundThe aim of this cross-sectional survey was to apply the Objective Structured Clinical Examination (OSCE) to evaluate the cardiopulmonary resuscitation (CPR) and endotracheal intubation skills of resident dentists for stage assessment in standardized training.MethodsA total of 146 third-year resident dentists were recruited and randomly assigned to perform either CPR or endotracheal intubation. Their performance was scored by experienced anesthesiologists with standardized scoring criteria. Participants were also asked to rated their self-assessed competence, willingness, and perceptions on training status using Likert-type scales in a questionnaire. Student’s ttest was applied to compare scores for CPR and endotracheal intubation performed by resident dentists with different characteristics. The results of the questionnaires were analyzed and visualized by the R package ‘Likert’. Significance was set at the P < 0.05 level.ResultsThe mean OSCE score for endotracheal intubation (59.1 ± 12.5) was lower than that of CPR (72.4 ± 8.8). Participants with Master’s degrees scored higher than those with Bachelor’s degrees and Doctor of Philosophy (PhD) degrees in the assessment of CPR and endotracheal intubation. Low scores of self-assessed competence and willingness were observed, especially for endotracheal intubation. Resident dentists showed poor satisfaction on training volume and frequency of CPR and endotracheal intubation.ConclusionResident dentists showed poor performance on CPR and endotracheal intubation assessed by the OSCE. Relatively low self-assessed competence and willingness were reported in endotracheal intubation. The medical emergency curriculum for resident dentists should be more consistent and standardized to help resident dentists enhance the proficiency of life support skills.

CIRDataset: A large-scale Dataset for Clinically-Interpretable lung nodule Radiomics and malignancy prediction.

Spiculations/lobulations, sharp/curved spikes on the surface of lung nodules, are good predictors of lung cancer malignancy and hence, are routinely assessed and reported by radiologists as part of the standardized Lung-RADS clinical scoring criteria. Given the 3D geometry of the nodule and 2D slice-by-slice assessment by radiologists, manual spiculation/lobulation annotation is a tedious task and thus no public datasets exist to date for probing the importance of these clinically-reported features in the SOTA malignancy prediction algorithms. As part of this paper, we release a large-scale Clinically-Interpretable Radiomics Dataset, CIRDataset, containing 956 radiologist QA/QC'ed spiculation/lobulation annotations on segmented lung nodules from two public datasets, LIDC-IDRI (N=883) and LUNGx (N=73). We also present an end-to-end deep learning model based on multi-class Voxel2Mesh extension to segment nodules (while preserving spikes), classify spikes (sharp/spiculation and curved/lobulation), and perform malignancy prediction. Previous methods have performed malignancy prediction for LIDC and LUNGx datasets but without robust attribution to any clinically reported/actionable features (due to known hyperparameter sensitivity issues with general attribution schemes). With the release of this comprehensively-annotated CIRDataset and end-to-end deep learning baseline, we hope that malignancy prediction methods can validate their explanations, benchmark against our baseline, and provide clinically-actionable insights. Dataset, code, pretrained models, and docker containers are available at https://github.com/nadeemlab/CIR.

Development of the Finnish neurological function testing battery for dogs and its intra- and inter-rater reliability

BackgroundThe Finnish neurological function testing battery for dogs (FINFUN) was developed to meet the increasing demand for objective outcome measures in veterinary physiotherapy. The testing battery should provide consistent, reproducible results and have established face and content validity. Internal consistency and intra- and inter-rater reliability of the FINFUN were also investigated.ResultsThe FINFUN comprised 11 tasks: lying, standing up from lying, sitting, standing up from sitting, standing, proprioceptive positioning, starting to walk, walking, trotting, walking turns and walking stairs. A score from 0 to 4, (0: unable to perform task, 4: performing task with normal motor function) was given for each task, the maximum score being 44. Twenty-six dogs were filmed when performing the FINFUN. Seven observers scored the performances from the video recordings. The FINFUN was considered to have appropriate face and content validity based on a pilot study, clinical experience and critical reflection of the development process. Its internal consistency was excellent, with no Cronbach’s alpha values below 0.922. The intra-rater reliability for total score of experienced observers was almost perfect: 0.999 (observer 1) and 0.994 (observer 2). The inter-rater reliability for both experienced and novice observers’ total scores was also almost perfect (0.919–0.993). Analysis of each individual task showed substantial intra-rater and inter-rater agreement for the tasks “lying” and “sitting”.ConclusionsThe FINFUN is an objective, valid and reliable tool with standardized scoring criteria for evaluation of motor function in dogs recovering from spinal cord injury.

PD-L1 protein expression in tumour cells and immune cells in mismatch repair protein-deficient and -proficient colorectal cancer: the foundation study using the SP142 antibody and whole section immunohistochemistry

AimsRoutine application of PD-L1 immunohistochemistry (IHC) in colorectal cancer (CRC) is limited due to lack of standardized scoring criteria, antibody clones, and intratumoral staining heterogeneity. We assessed PD-L1 protein expression...

Candidate-gene criteria for clinical reporting: diagnostic exome sequencing identifies altered candidate genes among 8% of patients with undiagnosed diseases

Purpose:Diagnostic exome sequencing (DES) is now a commonly ordered test for individuals with undiagnosed genetic disorders. In addition to providing a diagnosis for characterized diseases, exome sequencing has the capacity to uncover novel candidate genes for disease.Methods:Family-based DES included analysis of both characterized and novel genetic etiologies. To evaluate candidate genes for disease in the clinical setting, we developed a systematic, rule-based classification schema.Results:Testing identified a candidate gene among 7.7% (72/934) of patients referred for DES; 37 (4.0%) and 35 (3.7%) of the genes received evidence scores of “candidate” and “suspected candidate,” respectively. A total of 71 independent candidate genes were reported among the 72 patients, and 38% (27/71) were subsequently corroborated in the peer-reviewed literature. This rate of corroboration increased to 51.9% (27/52) among patients whose gene was reported at least 12 months previously.Conclusions:Herein, we provide transparent, comprehensive, and standardized scoring criteria for the clinical reporting of candidate genes. These results demonstrate that DES is an integral tool for genetic diagnosis, especially for elucidating the molecular basis for both characterized and novel candidate genetic etiologies. Gene discoveries also advance the understanding of normal human biology and more common diseases.Genet Med19 2, 224–235.

Assessment of the Accuracy of Online Information Regarding Trigger Finger.

Review of the recent literature suggests substantial use of the Internet by patients seeking health care information despite questionable accuracy and readability of information presented on some websites. The purpose of our study was to assess the accuracy, quality, and readability of online information regarding trigger finger. Three terms ("trigger finger", "stenosing tenosynovitis", and "finger locking") were used to query three Internet search engines to evaluate websites regarding information about trigger finger. Three hand surgery fellows independently assessed website accuracy and quality using standardized scoring criteria. The Fleisch-Kincaid reading grade level score was used to assess website readability. Website authorship and commercial association were also noted. Sixty-nine unique websites were assessed. Internet information obtained using the search term "stenosing tenosynovitis" was written at a significantly higher reading level than information found using "finger locking" or "trigger finger". Website quality and accuracy were both significantly better in websites authored by physicians compared to websites authored by non-physicians. However, website accuracy was significantly poorer in websites featuring commercial association. Additionally, websites presenting information written below the 8(th) grade reading level demonstrated poorer accuracy. Search term has a significant effect on the readability of online information regarding trigger finger. Despite the terminology used in searches, most websites are largely inaccurate and may not be easily understandable by the general population. This demonstrates a substantial barrier to accessing accurate health care information and may impact patient outcomes. Hand surgeons should direct patients towards websites presenting accurate information with easily readable content.

The Pacific Retail Food Store Environment: Findings from the Children's Healthy Living Program

A community's retail food environment (RFE) is an important determinant of health. Healthy food, including fruits/vegetables [F/V], availability, quality, and promotions may influence food choices. This study's purpose was to describe the RFE of 154 stores in 4 jurisdictions from 2012-2014 participating in the Children's Healthy Living (CHL) Program. The CX3 Food Availability and Marketing Survey, a standardized RFE assessment survey, was adapted for the Pacific. About half of the stores (47%) were small markets (SM), 27% convenience stores (CS), 17% supermarket chains (SC), 6% large grocery stores (LG), and 3% of other type. SM was dominant in CNMI (69%) and Guam (75%) compared to SC in Alaska (46%). In Hawaii, the majority were CS (35%) and SM (28%). Among all stores, the majority had unhealthy foods (61%) and promotions for unhealthy foods (93%) present near check-out. The majority (60%) had unhealthy food ads with less than 20% with healthy food ads. Few stores (29%) had health promotion items around the F/V display, or items promoting locally grown produce. Using the CX3 standardized RFE scoring criteria; 32% of stores surveyed met CX3 standards for F variety and quality, 42% met for V variety and quality, and 43% met for other healthy food availability. Significant jurisdiction differences (p<.001) were observed in the percentage of stores meeting CX3 standards on F only, with Alaska (49%) and Hawaii (50%) higher than CNMI (22%) and Guam (11%). Many of the stores surveyed did not meet CX3 RFE standards and present an F/V intervention opportunity. USDA AFRI # 2011-68001-30335

Cyclic alternating pattern (CAP): The marker of sleep instability

Cyclic alternating pattern CAP is the EEG marker of unstable sleep, a concept which is poorly appreciated among the metrics of sleep physiology. Besides, duration, depth and continuity, sleep restorative properties depend on the capacity of the brain to create periods of sustained stable sleep. This issue is not confined only to the EEG activities but reverberates upon the ongoing autonomic activity and behavioral functions, which are mutually entrained in a synchronized oscillation. CAP can be identified both in adult and children sleep and therefore represents a sensitive tool for the investigation of sleep disorders across the lifespan. The present review illustrates the story of CAP in the last 25 years, the standardized scoring criteria, the basic physiological properties and how the dimension of sleep instability has provided new insight into pathophysiolology and management of sleep disorders.

The effect of clomiphene citrate and menopausal gonadotropins on cervical mucus in ovulatory cycles

To determine the effect of clomiphene citrate (CC) and hMG on cervical mucus (CM), optimally sampled in the periovulatory period from confirmed ovulatory cycles, in the dosage range commonly employed for ovulation induction. Controlled, observational. Infertility treatment center at a university medical center. One hundred fifty-four infertile patients undergoing 161 treatment cycles in which postcoital test was performed in a documented ovulatory cycle. One hundred six patients received CC at dosages of 50 to 200 mg. Twenty patients received hMG at dosages of 75 to 225 IU. Thirty-seven patients sampled during spontaneous ovulatory cycles served as controls. Cervical mucus score using standardized scoring criteria. Subjects receiving CC at all dosages had significantly lower CM scores 8.6 +/- 0.5, compared with patients receiving hMG 11.0 +/- 0.6 or spontaneous cycles 12.1 +/- 0.5. The incidence of unfavorable CM (score < 10/15) was similar in patients receiving CC at dosages of 50 mg (48.1%), 100 mg (48.6%), and 150 to 200 mg (60%). Cervical mucus scores are reduced in ovulatory cycles after CC administration compared with both spontaneous ovulatory cycles and in patients undergoing superovulation with hMG. The reduction in CM scores was similar at all dosages of CC studied. The lack of adverse effects on CM during hMG therapy supports a local antiestrogenic effect of CC at the level of the cervix.

Screening and identifying gifted/talented students in the visual arts with Clark's drawing abilities test

There are a number of problems about identification procedures generally used in arts programs for gifted/talented students and specific problems with identification of gifted/talented students in the visual arts. Part of these problems are procedural, some are attitudinal. This article outlines several years of research conducted at Indiana University (IU) that has been designed to alleviate or circumvent these problems. The major thrust of this research has been design and testing of anew achievement‐type test in the visual arts, Clark's Drawing Abilities Test (CDAT). This research has led to development of the new instrument and of a standardized Scoring Criteria Scale used to score the instrument. The CDAT has been used in a series of field testing situations and specifically with students entering the Indiana University Summer Arts Institute. Findings from field tests and use of the instrument with IU Summer Arts Institute students are discussed and their implications for more efficient and effective...

Psychometric properties of non-specific electrodermal response frequency for a sample of male students

In the present study data on the frequency of non-specific electrodermal responses (NSRs) are presented for a large and, with regard to sex, age and educational level, homogeneous sample of male students ( n = 590). These data were obtained in 9 independent experiments in which NSRs were recorded under equivalent conditions. NSRs were scored as skin conductance changes greater than 0.02 μSiemens. A recording period of 5 min prior to experimental manipulations was chosen. A systematic comparison between the 9 studies, the distribution of NSRs for the total sample, as well as descriptive data for stabile and labile subgroups are presented. For 213 subjects NSR-frequency was recorded twice, with a retest interval of one day. For these subjects retest analyses and data on the degree of stability of the classification into stabile and labile groups are also presented. In the discussion the necessity to develop standardized scoring criteria for NSRs is emphasized.

Scoring Criteria for Electrodermal Habituation: Further Research

ABSTRACTIn the context of Levinson and Edelberg's critique of scoring criteria for electrodermal habituation, the present study examined the question of whether trials‐to‐habituation scores based on two no‐response trials are superior to scores based on three no‐response trials. Male students (N=120) performed two identical habituation experiments on two consecutive days and their skin conductance responses based on a short latency window of 1–3 s were analyzed. In each experiment subjects received 20 presentations of a 1000 Hz tone at 65dB. Results showed that three‐trials scores were higher overall and that the distributions of three‐ and two‐trials scores differed. On the other hand, the twoscores had comparable retest‐reliabilities, displayed similar correlations with regression indices and resting nonspecific activity, and reliably reflected the changes in habituation speed from the first to the second session. Furthermore, three‐ and two‐trials scores were found to be highly interrelated. It was concluded that the findings obtained for our particular sub‐population of male students do not favor one or the other of the two scoring methods for trials‐to‐habituation scores and that the establishment of standardized scoring criteria should be attempted.

Longitudinal studies in clinical psychoendocrinology: methodology.

There are five universal exigencies of being human, against which a person's existence can be evaluated: pairbondage, troopbondage, abidance, ycleptance, and foredoomance. They constitute a template from which a standardized agenda or schedule of inquiry is generated, as needed, for a particular research investigation. The schedule of inquiry is painstakingly designed ahead of time so as to ensure coverage of all the variables relevant to a particular study. For economy of expense and effort, subjects conclude their own prior interviews by summarizing it on tape, with the interviewer making a written record, verbatim, of what will become subheadings in the transcript. Inquiry progresses from an open-ended to a forced choice interrogatory. Topics in the public domain open the way to inquiry on personally sensitive issues. So also do parables drawn from actual cases and used as personalized narrative projective tests. A cumulative record, covering as many as 25 years, is indexed so that relevant material can be located, abstracted, and classified for any particular study. A jury of two or more then uses the abstracted data to fill out a prepared data schedule, using its own standardized scoring or rating criteria. By contrast, an ordinary questionnaire uses standardized questions, and each subject applies his or her own unstandardized scoring or rating criteria in answering them. In the final step, the jury's ratings are tabulated on a master chart that consolidates the scores of a group of subjects and controls, ready for statistical analysis.