Droughts have become more severe and frequent due to global warming. In this context, it is widely accepted that for drought assessments, both water supply (rainfall) and demand (standardized precipitation evapotranspiration index, SPEI) should be considered. Using SPEI, we explored the spatial-temporal patterns of dry and wet annual and seasonal changes in five sub-regions of East Asia during 1902–2018. These factors are linked to excess drought frequency and severity on the regional scale, and their effect on vegetation remains an important topic for climate change studies. Our results show that the SPEI significantly improved extreme drought and mostly affected the SPEI-06 and SPEI-12 growing seasons in East Asia during 1981–2018. The dry and wet annual SPEI trends mostly affect the five sub-regions of East Asia. The annual SPEI had two extremely dry spells during 1936–1947 and 1978–2018. Japan, South Korea, and North Korea are wet in the summer compared to other regions of East Asia, with drought frequency occurring at 51.4%, respectively. The mean drought frequencies in China and Mongolia are 57.4% and 54.6%. China and Mongolia are the driest regions in East Asia due to high drought frequency and duration. The spatial seasonal analysis of solar radiation (SR), water vapor pressure (WVP), wind speed (WS), vegetation condition index (VCI), temperature condition index (TCI), and vegetation health index (VHI) have confirmed that the East Asia region suffered from maximum drought events. The seasonal variation of SPEI shows no clear drying trends during summer and autumn seasons. During the winter and spring seasons, there was a dry trend in East Asia region. During 1902–1990, a seasonal SPEI presented diverse characteristics, with clear wet trends in Japan, Mongolia, and North Korea in four different growing seasons, with dry trends in China and South Korea. During 1991–2018, seasonal SPEI presented clear dry trends in Japan, Mongolia, and North Korea in different growing seasons, while China and South Korea showed a wet trend during the spring, autumn, and winter seasons. This ecological and climatic mechanism provides a good basis for the assessment of vegetation and drought-change variations within East Asia. An understandings of long-term vegetation trends and the effects of rainfall and SPEI on droughts of varying severity is essential for water resource management and climate change adaptation. Based on the results, water resources will increase under global warming, which may alleviate the water scarcity issue in the East Asia region.