Introduction: Cardiovascular disease (CVD) mortality rates are heterogenous among Asian American subgroups. To inform more precise prevention strategies, we identified patterns of hypertension-related CVD mortality in Asian American subgroups. Methods: Among deaths with CVD (ICD-10: I00-I99) as the underlying cause and hypertensive disease (ICD-10: I10-I15) as underlying or contributing cause in 2018-2021 mortality data from CDC WONDER with concurrent population estimates from the IPUMS Current Population Survey, we calculated age standardized mortality rates (ASMR) and proportional mortality for non-Hispanic Asian (Asian Indian, Chinese, Filipino, Japanese, Korean, Vietnamese) and Hispanic adults, with non-Hispanic White as the reference. Results: There were 37,746, 95,404, and 867,599 deaths in non-Hispanic Asian, Hispanic and non-Hispanic White groups, respectively. Among non-Hispanic Asian females, ASMR ranged from 41.6 (95% CI 40.0-43.3) per 100,000 population in Japanese to 52.6 (51.0-54.2) per 100,000 in Filipina women. Among non-Hispanic Asian males, ASMR ranged from 45.8 (43.3-48.2) per 100,000 in Korean to 81.0 (78.5-83.5) in Filipino men (Table). Proportional mortality was higher for all Asian American subgroups vs. non-Hispanic White individuals. Proportional mortality ratios ranged from 1.11 (Korean males) to 1.38 (Filipino males; Chinese and Filipina females), vs. non-Hispanic White individuals. Conclusions: There was substantial variation in hypertension-related cardiovascular mortality among Asian American subgroups. All Asian subgroups had higher proportional mortality compared with non-Hispanic White individuals.