In our continuing systematic studies concerning the synthesis, surface properties, and hydrolysis of chemodegradable, diastereomerically pure surface active 2,5-disubstituted 1,3-dioxane derivatives, two new groups of anionic surfactants, sodiumcis- andtrans-(2-n-undecyl-1,3-dioxan-5-yl)methyl sulfates and sodiumcis- andtrans-3-[(2-n-undecyl-1,3-dioxan-5-yl)oxy]propanesulfonates, were synthesized and investigated. Surface properties of these surfactants, i.e., surface excess concentration, Γ, surface area demand per molecule,A, effectiveness of surface tension reduction, Π, critical micelle concentration, CMC, and standard free energies of adsorption, ΔGads0, and of micellization, ΔGmic0, were determined. It was shown that thetrans-isomers, in which the configuration of the polar group is equatorial, are more surface active than thecis-isomers with axial configuration of the polar group at the C-5 carbon atom of the 1,3-dioxane ring. The surfactants under study undergo easy hydrolysis reaction in DCl/D2O solution with cleavage of the 1,3-dioxane ring to nonsurface active intermediates. Thetrans-isomers are hydrolyzed faster thancis-isomers.